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MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGARRQIPTEARVYAEHHNIRLIGVDRPG IGASTPHQYETILAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPD AISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDD LLNGSRKQLAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESH LAGLGRGEEILSTLMQIWDRDLRK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1223 | - | - | 100% (304) | hypothetical protein Mb1223 |
| M. bovis AF2122 / 97 | Mb3340c | - | 2e-26 | 32.96% (270) | hypothetical protein Mb3340c |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 7e-05 | 31.09% (119) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3278 | - | 1e-129 | 73.00% (300) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1191 | - | 1e-177 | 100.00% (304) | hypothetical protein Rv1191 |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-05 | 26.87% (134) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 2e-06 | 31.45% (124) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4245 | - | 1e-160 | 89.37% (301) | hypothetical protein MMAR_4245 |
| M. avium 104 | MAV_1342 | - | 1e-138 | 77.93% (299) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_3508 | - | 1e-138 | 77.26% (299) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2940 | - | 2e-69 | 45.49% (288) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_2678 | - | 6e-25 | 31.25% (272) | hypothetical protein MUL_2678 |
| M. vanbaalenii PYR-1 | Mvan_2997 | - | 1e-128 | 72.33% (300) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3278|M.gilvum_PYR-GCK --MAVEIARPKLEGNILVGTDRRLGFAEFGDP-QGRAIFWLHGT-PGARR
Mvan_2997|M.vanbaalenii_PYR-1 --MAVDIARPKLEGKVLVDTDRQLGFAEFGDP-QGRAIFWLHGT-PGARR
Mb1223|M.bovis_AF2122/97 --MAVAIARPKLEGNIAVGEDRRIGFAEFGAP-QGRAVFWLHGT-PGARR
Rv1191|M.tuberculosis_H37Rv --MAVAIARPKLEGNIAVGEDRRIGFAEFGAP-QGRAVFWLHGT-PGARR
MMAR_4245|M.marinum_M --MAVAIARPKLEGNIAVGEDRQIGFAEFGAP-QGRAVFWFHGT-PGARR
MAV_1342|M.avium_104 --MAIEIARPKLEGNVAVGEDRQIGFAEFGDP-QGRAMFWLHGT-PGARR
MSMEG_3508|M.smegmatis_MC2_155 MAMVIPIDRPKLEGNVAVGDDRRLGFAEFGDP-QGRAIFWLHGT-PGARR
TH_2940|M.thermoresistible__bu ---VPPTEKPRAEGRVHLPTGRRLGFAEFGDP-AGVPVVWLHGT-PGGRR
MUL_2678|M.ulcerans_Agy99 MQTLPEDIRADEANVVTLPDGRELACLEWGDP-TGYPTFYFHGT-LSSRL
MAB_3810|M.abscessus_ATCC_1997 ----MDVTYEGTKRELATDEG-TLRYHEAGTAGEGEPLILLHGSGPGVTG
MLBr_00862|M.leprae_Br4923 -MPATQSIHKVPHQFVESPDGVRLAIYQSGQP-EGPAIVLVHGF---PDS
: . : : * . * . . .**
Mflv_3278|M.gilvum_PYR-GCK QVPVEARIFAEKNGIRLIGVDRPGIGSS---TPHEYSKVIDFADDLRTVA
Mvan_2997|M.vanbaalenii_PYR-1 QIPVEARVFAERNSIRLIGVDRPGIGSS---TPHEYEKVIDFADDLRTVA
Mb1223|M.bovis_AF2122/97 QIPTEARVYAEHHNIRLIGVDRPGIGAS---TPHQYETILAFADDLRTIA
Rv1191|M.tuberculosis_H37Rv QIPTEARVYAEHHNIRLIGVDRPGIGAS---TPHQYETILAFADDLRTIA
MMAR_4245|M.marinum_M QIPTEARVYAEHHDVRLIGVDRPGIGSS---TPHQYGTVSAFADDLRTIA
MAV_1342|M.avium_104 QIPVEARLYAENHKIRLIGLDRPGIGSS---TPHRYQNIRAFGEDLRTIA
MSMEG_3508|M.smegmatis_MC2_155 QIPTEARAYAEQNGVRLIGVDRPGIGSS---TPHQYECVLDFASDLRTIA
TH_2940|M.thermoresistible__bu QFPLTGRRAAEQLGLRVVLLERPGAGLS---DPYRYRSVADWVTDVTYVA
MUL_2678|M.ulcerans_Agy99 EG-AFADGAARRARFRLIAVDRPGYGRS---TFQEGRTLRDWPADVCALA
MAB_3810|M.abscessus_ATCC_1997 WRNYRGNLGVFAKHFHTYVLEFPGFGVS---DAVPGHPVLTAGASVIRFM
MLBr_00862|M.leprae_Br4923 HVLWDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVI
. .: : * * * : .. .
Mflv_3278|M.gilvum_PYR-GCK DTLGIHK-MQVIGLSGGGPYTLGCAAAMP--DRVVSVGILGGVAPTRGAD
Mvan_2997|M.vanbaalenii_PYR-1 DTLGISK-MQVIGLSGGGPYTLGAAAAMP--DRVVAVGVLGGVAPTRGSD
Mb1223|M.bovis_AF2122/97 DTLGIDK-MAVVGLSGGGPYTLACAAGLP--DRVVAAGVLGGVAPTRGPD
Rv1191|M.tuberculosis_H37Rv DTLGIDK-MAVVGLSGGGPYTLACAAGLP--DRVVAAGVLGGVAPTRGPD
MMAR_4245|M.marinum_M DTLGIDK-MAVVGLSGGGPYTLACAAGLP--DRVVAAGVLGGVAPTRGPD
MAV_1342|M.avium_104 DTLGIDK-MAVIGLSGGGPYALASAAVLP--DRVVAAGILGGVAPFLGDE
MSMEG_3508|M.smegmatis_MC2_155 DTLGIDK-LAVIGLSGGGPYTLACAAAMP--DRVVAAGVLGGVAPMVGPD
TH_2940|M.thermoresistible__bu DAIGAER-LAVVGLSGGGPYALACGAVAPLAERVRSIAVLGGVTPSVGPD
MUL_2678|M.ulcerans_Agy99 DALGLDK-FGVVGHSGAGTHLFACGARIA-LSRLAFIGALGPWGPLATPE
MAB_3810|M.abscessus_ATCC_1997 DGLGISS-AAVVGNSMGGVVGINLAIKHP--DRITKLVTIGGVGPNIFSP
MLBr_00862|M.leprae_Br4923 DELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVD
* :. *:. . .. .*: :.
Mflv_3278|M.gilvum_PYR-GCK GIGGGVMGH-VGLPVAPLLEHVGTPLSFVATGLIRLIKPVAEPALYLYAS
Mvan_2997|M.vanbaalenii_PYR-1 AIGGGIMGN-IGLPVAPVLERVGTPLSLVATGLIRLIKPVAEPALYLYAS
Mb1223|M.bovis_AF2122/97 AISGGLMR--LGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGL
Rv1191|M.tuberculosis_H37Rv AISGGLMR--LGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGL
MMAR_4245|M.marinum_M AISGGLMD--LGRRVAPLLRVGGSPLRLSASVLIRMARPVASPALDVYGL
MAV_1342|M.avium_104 GITSGLMN--LGKRVAPLLKLGGDPLRIGASLVVRAIRPVANPALYLYAA
MSMEG_3508|M.smegmatis_MC2_155 AISSPLMQ--LGAVVAPVLQVAGGPIRLVASGMIRLIRPVASPALEIYAR
TH_2940|M.thermoresistible__bu ASATGAIE--LARRFTSLLGTLRGPLATTLAGLVTPVLPFAHFACQAYAS
MUL_2678|M.ulcerans_Agy99 IMGS--LNL-ADRSYARLAQHGPRLFHALFAPLGWCAKYAPGLFTKLITA
MAB_3810|M.abscessus_ATCC_1997 SPSEG---------LRLLQEFTDNPDRD------KLIRWLNSMVWDPAVV
MLBr_00862|M.leprae_Br4923 YILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATI
Mflv_3278|M.gilvum_PYR-GCK ISPEGDRRLLVRPEFKAMFLDDLLNGSRKQLA------------------
Mvan_2997|M.vanbaalenii_PYR-1 ISPEGDRRLLVRPEFKAMFLDDLLNGSRRQLA------------------
Mb1223|M.bovis_AF2122/97 LSPRADRHLLARPEFKAMFLDDLLNGSRKQLA------------------
Rv1191|M.tuberculosis_H37Rv LSPRADRHLLARPEFKAMFLDDLLNGSRKQLA------------------
MMAR_4245|M.marinum_M MSPQADRHLLARPEFKAMFLDDLLNGSRKQLA------------------
MAV_1342|M.avium_104 ISPEGDRRLLTRPEFGAMFLDDLLNGSRKQLA------------------
MSMEG_3508|M.smegmatis_MC2_155 LSPEGDRRMLGRPEFKAMFLDDLLNGSRKQLA------------------
TH_2940|M.thermoresistible__bu ISPESDRRVLHDPEMEAMFIDDLVLAARGGLR------------------
MUL_2678|M.ulcerans_Agy99 SVPAVDKHRMRDKRFVQHFQAVQLEAFRQGSR------------------
MAB_3810|M.abscessus_ATCC_1997 TDELIEERWEAAINPDAHKTAQLMYGSKAFAM------------------
MLBr_00862|M.leprae_Br4923 RRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVV
:. . . :
Mflv_3278|M.gilvum_PYR-GCK -----APFADVVVFARDWGFRLDEVKVPVRWWHGDCD-HIVPFEHGKHVV
Mvan_2997|M.vanbaalenii_PYR-1 -----APFADVVVFARDWGFRLDEVKVPVHWWHGDCD-HIVPFAHGKHVA
Mb1223|M.bovis_AF2122/97 -----APFADVIAFARDWGFRLDEVKVPVRWWHGDHD-HIVPFSHGEHVV
Rv1191|M.tuberculosis_H37Rv -----APFADVIAFARDWGFRLDEVKVPVRWWHGDHD-HIVPFSHGEHVV
MMAR_4245|M.marinum_M -----APFNDVIVFARDWGFRLEDVSVPVRWWHGDHD-HIIPFSHGEHVV
MAV_1342|M.avium_104 -----APFNDIILFTQDWGFRLDQVKVPVRWWHGDSD-HIVPFAHGQHVV
MSMEG_3508|M.smegmatis_MC2_155 -----APFYDIVVFERDWGFRLDEVTVPVRWWHGDHD-HIVPFAHGQHVV
TH_2940|M.thermoresistible__bu -----AIVDDARLFGRDWGFRLADVRAPVRWWHGDSD-HIVTLTDAQKAV
MUL_2678|M.ulcerans_Agy99 -----GAAYEAFLEYRPWEFDPSEVDVPTHIWLGTHD-SFVPREMGEYLE
MAB_3810|M.abscessus_ATCC_1997 -----QQQFLANADIPPYWAMMHKIKCPTLLTWGRDD-RVSPPDMAIVPM
MLBr_00862|M.leprae_Br4923 NVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMA
: * . . .
Mflv_3278|M.gilvum_PYR-GCK ALLPDAEFHPLPGES-----------------------------------
Mvan_2997|M.vanbaalenii_PYR-1 ALLPDAQFYPLPGES-----------------------------------
Mb1223|M.bovis_AF2122/97 SRLPDAKLLHLPGES-----------------------------------
Rv1191|M.tuberculosis_H37Rv SRLPDAKLLHLPGES-----------------------------------
MMAR_4245|M.marinum_M SRLPNAELFHLPGES-----------------------------------
MAV_1342|M.avium_104 SLLPDAELFVLPGES-----------------------------------
MSMEG_3508|M.smegmatis_MC2_155 SRLQDAKLTELPYES-----------------------------------
TH_2940|M.thermoresistible__bu ERLPDAELVLRLEES-----------------------------------
MUL_2678|M.ulcerans_Agy99 RVIPNVELHWAAGKG-----------------------------------
MAB_3810|M.abscessus_ATCC_1997 RLIPNAELHIFPNSG-----------------------------------
MLBr_00862|M.leprae_Br4923 AAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETA
: : .
Mflv_3278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2997|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1223|M.bovis_AF2122/97 --------------------------------------------------
Rv1191|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4245|M.marinum_M --------------------------------------------------
MAV_1342|M.avium_104 --------------------------------------------------
MSMEG_3508|M.smegmatis_MC2_155 --------------------------------------------------
TH_2940|M.thermoresistible__bu --------------------------------------------------
MUL_2678|M.ulcerans_Agy99 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAF
Mflv_3278|M.gilvum_PYR-GCK ---------------HLGGLGEAEAIMGAMGELWDGAGQS----------
Mvan_2997|M.vanbaalenii_PYR-1 ---------------HLGGLGEAEAIMQSMSDLWDAFEKTR---------
Mb1223|M.bovis_AF2122/97 ---------------HLAGLGRGEEILSTLMQIWDRDLRK----------
Rv1191|M.tuberculosis_H37Rv ---------------HLAGLGRGEEILSTLMQIWDRDLRK----------
MMAR_4245|M.marinum_M ---------------HLAGLGRGEEILATLMKIWDEEA------------
MAV_1342|M.avium_104 ---------------HLGGLGRGEEILSTLTKIWDEQN------------
MSMEG_3508|M.smegmatis_MC2_155 ---------------HLGGLGCAQEIMGTMLQIWDETSALT---------
TH_2940|M.thermoresistible__bu ---------------HLGGFAAADEVLTFVRESL----------------
MUL_2678|M.ulcerans_Agy99 ---------------HFNVEDWDAIFAACAADI-----------------
MAB_3810|M.abscessus_ATCC_1997 ---------------HWVMIEAKQAFEQTVVDFLRR--------------
MLBr_00862|M.leprae_Br4923 AEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCR
: . .
Mflv_3278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2997|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1223|M.bovis_AF2122/97 --------------------------------------------------
Rv1191|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4245|M.marinum_M --------------------------------------------------
MAV_1342|M.avium_104 --------------------------------------------------
MSMEG_3508|M.smegmatis_MC2_155 --------------------------------------------------
TH_2940|M.thermoresistible__bu --------------------------------------------------
MUL_2678|M.ulcerans_Agy99 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAE
Mflv_3278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2997|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1223|M.bovis_AF2122/97 --------------------------------------------------
Rv1191|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4245|M.marinum_M --------------------------------------------------
MAV_1342|M.avium_104 --------------------------------------------------
MSMEG_3508|M.smegmatis_MC2_155 --------------------------------------------------
TH_2940|M.thermoresistible__bu --------------------------------------------------
MUL_2678|M.ulcerans_Agy99 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLR
Mflv_3278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2997|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1223|M.bovis_AF2122/97 --------------------------------------------------
Rv1191|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4245|M.marinum_M --------------------------------------------------
MAV_1342|M.avium_104 --------------------------------------------------
MSMEG_3508|M.smegmatis_MC2_155 --------------------------------------------------
TH_2940|M.thermoresistible__bu --------------------------------------------------
MUL_2678|M.ulcerans_Agy99 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRV
Mflv_3278|M.gilvum_PYR-GCK -
Mvan_2997|M.vanbaalenii_PYR-1 -
Mb1223|M.bovis_AF2122/97 -
Rv1191|M.tuberculosis_H37Rv -
MMAR_4245|M.marinum_M -
MAV_1342|M.avium_104 -
MSMEG_3508|M.smegmatis_MC2_155 -
TH_2940|M.thermoresistible__bu -
MUL_2678|M.ulcerans_Agy99 -
MAB_3810|M.abscessus_ATCC_1997 -
MLBr_00862|M.leprae_Br4923 I