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MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAAVAEELGALLAAVQAGVWQGPSAESFA AACLPYLSWLTQASADCAAAAARLEAVTAAYAAALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVN EADYVRMWLQAATTMATYQAVADSAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKII TGGRVIWDPEAGTVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILFDWPT HMLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAVVPTVLPLAGTATPTTA PASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPGIDFDAGTPAGSRRAQPAADNVTAVAAAQ VSARHQARRRRRAAAKERGNADEFVDMDSGPAIPPSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTT LADDEFQCGPRMPMLPGAWDLGTWDRGD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0461 | PPE11 | - | 100% (518) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | e-146 | 53.93% (521) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1422 | PPE20 | e-140 | 50.56% (534) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-84 | 38.90% (545) | PPE protein |
| M. tuberculosis H37Rv | Rv0453 | PPE11 | 0.0 | 100.00% (518) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 1e-137 | 49.90% (523) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-98 | 44.23% (520) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-148 | 52.58% (523) | PPE family protein, PPE3 |
| M. avium 104 | MAV_4349 | - | 1e-140 | 52.29% (524) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-93 | 42.99% (542) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-71 | 38.61% (518) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-148 | 52.40% (521) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-88 | 39.60% (548) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSP-VWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSA
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSP-VWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSA
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAP-IWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSA
Mb0461|M.bovis_AF2122/97 ----------MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGR
Rv0453|M.tuberculosis_H37Rv ----------MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGR
MLBr_00539|M.leprae_Br4923 ----------MTNP--WMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSA
MMAR_0538|M.marinum_M ----------MVAP-VWFASPPEVHSALLSSGPGPASLLSGAAAWAGLST
MUL_1202|M.ulcerans_Agy99 ---------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLST
MAV_4349|M.avium_104 ----MTTVPAMTAP-IWMASPPEVHSALLSSGPGPASVFAAAAAWSALGA
MAB_0809c|M.abscessus_ATCC_199 ----------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGA
TH_3113|M.thermoresistible__bu -----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSD
:: ****:*::* *.* ..: .. *.
Mflv_0325|M.gilvum_PYR-GCK EYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAAT
Mvan_0415|M.vanbaalenii_PYR-1 EYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAA
MSMEG_0619|M.smegmatis_MC2_155 EYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAA
Mb0461|M.bovis_AF2122/97 EYAAVAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAA
Rv0453|M.tuberculosis_H37Rv EYAAVAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAA
MLBr_00539|M.leprae_Br4923 EYRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDV
MMAR_0538|M.marinum_M EYASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQA
MUL_1202|M.ulcerans_Agy99 EYASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQA
MAV_4349|M.avium_104 EYASAAEELSGLLASAQAGAWQGPSAASYVAAHGPYLAWLTRASAHSAAA
MAB_0809c|M.abscessus_ATCC_199 HYSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNAR
TH_3113|M.thermoresistible__bu EYRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAA
.* .* *: .:: . . *.* . :..: *:* ** :
Mflv_0325|M.gilvum_PYR-GCK AVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALN
Mvan_0415|M.vanbaalenii_PYR-1 AAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMT
MSMEG_0619|M.smegmatis_MC2_155 AVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALN
Mb0461|M.bovis_AF2122/97 AARLEAVTAAYAAALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVN
Rv0453|M.tuberculosis_H37Rv AARLEAVTAAYAAALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVN
MLBr_00539|M.leprae_Br4923 ATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALN
MMAR_0538|M.marinum_M AAQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAAN
MUL_1202|M.ulcerans_Agy99 AAQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAAN
MAV_4349|M.avium_104 AAQHETAGTAYTAALAAMPTLPELAANHAVHGALVATNFFGINTIPIAVN
MAB_0809c|M.abscessus_ATCC_199 AVQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILAT
TH_3113|M.thermoresistible__bu GAQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVN
..: .. *:::*: .*** **: *:. :..::.***:*:***** .
Mflv_0325|M.gilvum_PYR-GCK EADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPG--------
Mvan_0415|M.vanbaalenii_PYR-1 EADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPG--------
MSMEG_0619|M.smegmatis_MC2_155 EADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPG--------
Mb0461|M.bovis_AF2122/97 EADYVRMWLQAATTMATYQAVADSAVRSIPDSVPPPRILKSN-------A
Rv0453|M.tuberculosis_H37Rv EADYVRMWLQAATTMATYQAVADSAVRSIPDSVPPPRILKSN-------A
MLBr_00539|M.leprae_Br4923 EEEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEK
MMAR_0538|M.marinum_M EADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAP-------A
MUL_1202|M.ulcerans_Agy99 EADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAP-------A
MAV_4349|M.avium_104 EADYARMWVQAAGTMATYQAVSTAAVAAVPQPDPAPSILRST-------A
MAB_0809c|M.abscessus_ATCC_199 EADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHD------H
TH_3113|M.thermoresistible__bu EADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAG--------
* :*.:**::** **:**.: : *: : * . ..* :*
Mflv_0325|M.gilvum_PYR-GCK -VGEAGRAAADMS-----------AFAAQPMAAQAGAAFDVSNIIADIIR
Mvan_0415|M.vanbaalenii_PYR-1 -VGEAGRAAADVT-----------AFAAQAQAAEAGSALDLSNIIADLIR
MSMEG_0619|M.smegmatis_MC2_155 -VGEAGSASASVQ-----------QMSAQATAAESGSSLDLSSIISDLLN
Mb0461|M.bovis_AF2122/97 QSQHSSSNNSGGA-------DPVDDFIAEILKIITGGRVIWDPEAGTVNG
Rv0453|M.tuberculosis_H37Rv QSQHSSSNNSGGA-------DPVDDFIAEILKIITGGRVIWDPEAGTVNG
MLBr_00539|M.leprae_Br4923 DSRHDGHSHGGHA-------SAMDRVFADILRNVSGGRLVWDPLNGTLNG
MMAR_0538|M.marinum_M AAHDHDHDHGGDP-------TPIDYFVAEVLRIISGGRIIWDPAEGTVNG
MUL_1202|M.ulcerans_Agy99 AAHDHDHDHGGDP-------TPIDYFVAEVLRIISGGRIIWDPAEGTVNG
MAV_4349|M.avium_104 AHDHDDHEHGDDHDHDHGFDSPLNQFVAQILRLFG---IDWDPVEGTLNG
MAB_0809c|M.abscessus_ATCC_199 GHDDHDHEHGHDD----------------------------DHGHGDLD-
TH_3113|M.thermoresistible__bu -TGESATAAITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADA
. .
Mflv_0325|M.gilvum_PYR-GCK LYGEVLRFLFEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLL
Mvan_0415|M.vanbaalenii_PYR-1 AYGELLRFLFEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLA
MSMEG_0619|M.smegmatis_MC2_155 QYLQGVPGG-QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLF
Mb0461|M.bovis_AF2122/97 LPYDAYTNPGTLMWWIARS-LELLQDFQEFAKLLFTNPVKAFQFLVDLIL
Rv0453|M.tuberculosis_H37Rv LPYDAYTNPGTLMWWIARS-LELLQDFQEFAKLLFTNPVKAFQFLVDLIL
MLBr_00539|M.leprae_Br4923 LDYDDYVYPGQPIWWLARG-LEFFQDGEQFWELLFINPTAAFQFLLYIVV
MMAR_0538|M.marinum_M IPYDDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVL
MUL_1202|M.ulcerans_Agy99 IPYDDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVL
MAV_4349|M.avium_104 LPYEAYTSPADPLWWVVRA-LELFSDFQQFGALLQENPAAAFQFITELVL
MAB_0809c|M.abscessus_ATCC_199 --------PTDPEWWVHVA-GEMVEHFELLLNNLLTDPAALLTNLP-MVL
TH_3113|M.thermoresistible__bu LPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLF
: :* : ::
Mflv_0325|M.gilvum_PYR-GCK AVVYQA----VSWVGASI-LYPSLFLLPLLATT--LAIVAGVGQHLL---
Mvan_0415|M.vanbaalenii_PYR-1 AVAYQA----VSWVGASI-LYPSLLLLPLVATT--LAIVLGVGAYLL---
MSMEG_0619|M.smegmatis_MC2_155 GVAYQVFFNLVGWPTWGM-IFASPFLIPALAALGITGLVLLIDHVLN---
Mb0461|M.bovis_AF2122/97 FDWPTHMLQLATWLAEN----PQLLVAALTPAISGLGAVSGLAGLTG---
Rv0453|M.tuberculosis_H37Rv FDWPTHMLQLATWLAEN----PQLLVAALTPAISGLGAVSGLAGLTG---
MLBr_00539|M.leprae_Br4923 LDLPTHIVQLGTWLAEY----PQLLLVALGGTIANLGAVTGLAGLSSGLS
MMAR_0538|M.marinum_M FDWPTHIAQIIQALAQS----PQLLAVALGGVVANLGAISGLAGLSG---
MUL_1202|M.ulcerans_Agy99 FDWPTHIAQIIQALAQS----PQLLAVALGGVVANLGAISGLAGLSG---
MAV_4349|M.avium_104 LDWPTHLAQLASWLPTQ----PQLLLVPALVAAAPFGALAGFAGVAG---
MAB_0809c|M.abscessus_ATCC_199 ADVAFHAAQLASTIGQFA---PALIQPALALAIANLGWAAGFAGLAG---
TH_3113|M.thermoresistible__bu TGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAG---
. : . . .
Mflv_0325|M.gilvum_PYR-GCK ----SLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIA
Mvan_0415|M.vanbaalenii_PYR-1 ----ENLPAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAAT
MSMEG_0619|M.smegmatis_MC2_155 ----NPVDVPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATA
Mb0461|M.bovis_AF2122/97 ---LVPQPP-VVPAPAPDAVVPTVLPLAGTATPTTAPASAPAAGAAPGPP
Rv0453|M.tuberculosis_H37Rv ---LVPQPP-VVPAPAPDAVVPTVLPLAGTATPTTAPASAPAAGAAPGPP
MLBr_00539|M.leprae_Br4923 AGPSAAIPT-VVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASA
MMAR_0538|M.marinum_M ---LAGLHS-AALPAAIAPIAPPMPPGVALAPTVATSVAAPTPPSAPPSA
MUL_1202|M.ulcerans_Agy99 ---LAGLHS-AALPAAIAPIAPPMPPGVALAPTVAASVAAPTPPSAPPSA
MAV_4349|M.avium_104 ---QPPLPAPVAEPATPSAAAPTGLPATAGATPIAASAAASVPAPTPAPT
MAB_0809c|M.abscessus_ATCC_199 --IQPSPEILAVEPGSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAP
TH_3113|M.thermoresistible__bu -----LAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTG
... .
Mflv_0325|M.gilvum_PYR-GCK ANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPA
Mvan_0415|M.vanbaalenii_PYR-1 VGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPA
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPA
Mb0461|M.bovis_AF2122/97 AGTAT--ATSAS--VPTSAGGFPPYLV-GSGPGIDFDAG--TPAGSRRAQ
Rv0453|M.tuberculosis_H37Rv AGTAT--ATSAS--VPTSAGGFPPYLV-GSGPGIDFDAG--TPAGSRRAQ
MLBr_00539|M.leprae_Br4923 ASAAA--AAPAP--PGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSE
MMAR_0538|M.marinum_M TSTVANAAPPPP--PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR
MUL_1202|M.ulcerans_Agy99 ASTVANAAPPPP--PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR
MAV_4349|M.avium_104 AATVSSPAPPAP--PAPGAAPFAPPYAVPP-PGVGFGSKARASVDTRAKS
MAB_0809c|M.abscessus_ATCC_199 TASGTAPAPPSP--PPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSA
TH_3113|M.thermoresistible__bu TAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGA
. . : .. *
Mflv_0325|M.gilvum_PYR-GCK GTIPAAASGIAASAAERRKRRR--RQKEEIKGRGYADAYADYEEL-PDDG
Mvan_0415|M.vanbaalenii_PYR-1 SGIPAAASGVAASAAERRKRRR--RQKDEIAGRAYADAYADYEPE-PDDE
MSMEG_0619|M.smegmatis_MC2_155 SGVPAAASGVAASLASRRKRRR--KKGAQIEERGYADAYMDYEE--PDED
Mb0461|M.bovis_AF2122/97 PAADNV-TAVAAAQVSARHQAR-RRRRAAAKERGNADEFVDMDSG--PAI
Rv0453|M.tuberculosis_H37Rv PAADNV-TAVAAAQVSARHQAR-RRRRAAAKERGNADEFVDMDSG--PAI
MLBr_00539|M.leprae_Br4923 SVSDSA-VAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAI
MMAR_0538|M.marinum_M KAPEPD-SAALAAAAAAREEAR-RRRRKRKTERGYGEEFMDVEV--DPDW
MUL_1202|M.ulcerans_Agy99 KAPEPD-SAALAAAAAVREEAR-RRRRKRKTERGYGEEFMDVEV--DPDW
MAV_4349|M.avium_104 KSPQPD-SNAVGAGSAVREAAH-ARRRQRSRRR--GEEFMDMNVGVDPDW
MAB_0809c|M.abscessus_ATCC_199 AARSSAREQAAAAETAAARQAR--RRRDKGKQQGRGIEYMDMNATARCEE
TH_3113|M.thermoresistible__bu RRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQP-----
.: : :
Mflv_0325|M.gilvum_PYR-GCK PPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ-AGGLTTLAGDSFGGGPRE
Mvan_0415|M.vanbaalenii_PYR-1 PPVRQEPRIAATERGAGPMGFAGTVSRDAAQ-AGGLTTLPGDPFGGGPKA
MSMEG_0619|M.smegmatis_MC2_155 PAPQPEPRVRASERGSDAMGFTGTVTRHDVT-AAGLTTLTGDTFDDRPVT
Mb0461|M.bovis_AF2122/97 P-PSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRM
Rv0453|M.tuberculosis_H37Rv P-PSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRM
MLBr_00539|M.leprae_Br4923 PSPVDQTGSRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTM
MMAR_0538|M.marinum_M GGPRDD-EPVASTQGAGRLGFAGTVHSESAATAAGLTTLVADEFGGGPKM
MUL_1202|M.ulcerans_Agy99 GGPLDD-EPVASTQGAGRLGFAGTVHSESAATAAGLTTLVADEFGGGPKM
MAV_4349|M.avium_104 DEP----ATTASPRGAGNLGFAGTAPRETVA-AAGMTQLAGDEFGGGAGM
MAB_0809c|M.abscessus_ATCC_199 PAP----DTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRA
TH_3113|M.thermoresistible__bu --ASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITP------GDPTE
: * :* :*
Mflv_0325|M.gilvum_PYR-GCK PMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 PMLPGTWDGDENPAP------SPDDPEGGPRR
Mb0461|M.bovis_AF2122/97 PMLPGAWDLG--TWDRGD--------------
Rv0453|M.tuberculosis_H37Rv PMLPGAWDLG--TWDRGD--------------
MLBr_00539|M.leprae_Br4923 PMVPGTWAPARESSDEGR--------------
MMAR_0538|M.marinum_M PMLPGTWDTD-SDAPSD---------------
MUL_1202|M.ulcerans_Agy99 PMLPGTWDTD-SDAPSD---------------
MAV_4349|M.avium_104 PLLPGSWAPP-DPRDSGV--------------
MAB_0809c|M.abscessus_ATCC_199 PMVPNTWDPEHGRQD-----------------
TH_3113|M.thermoresistible__bu PSSPTDRAHRPAEPN-----------------
* *