For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLVAAQDEVSTAIAALFGSHGQHYQAISAQVAA YQERFVLALSQAGSTYAVAEAASATPLQQIEQALLGVINTPTEALVGRKLIGDGAHGAPGTGQAGGAGGI LWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAA GAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFV TNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1003c | PE_PGRS17 | - | 100% (335) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1006c | PE_PGRS18 | e-135 | 63.33% (450) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb2648c | PE_PGRS45 | 7e-90 | 66.90% (281) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 2e-20 | 55.68% (88) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0978c | PE_PGRS17 | 1e-176 | 93.73% (335) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-09 | 38.71% (93) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_0321c | - | 5e-14 | 41.26% (143) | hypothetical protein MAB_0321c |
M. marinum M | MMAR_2100 | - | 1e-68 | 64.93% (211) | PE-PGRS family protein |
M. avium 104 | MAV_1346 | - | 4e-15 | 32.35% (272) | PE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 3e-21 | 44.10% (161) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_4332 | - | 8e-15 | 35.53% (152) | PUTATIVE - |
M. ulcerans Agy99 | MUL_0572 | - | 2e-68 | 64.02% (214) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_3865 | - | 7e-26 | 44.85% (165) | hypothetical protein Mvan_3865 |
CLUSTAL 2.0.9 multiple sequence alignment Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPA TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------MVTFGGGATPTPTSLGAAAVDLSGTSCGLICNGQDGTGQN MMAR_2100|M.marinum_M MSFVSVTPEMVVAAASDLSGINSAIAQANSVAAAATTTVLPAAADEVSAA MUL_0572|M.ulcerans_Agy99 MSYVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTGVMAAADDEVSVA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ALAPESPLPDLKPRWERPTTAPDSETPSIT-------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGILFGNGGSGWNSDVVGMDGGNGGNGGLF-------------------- MMAR_2100|M.marinum_M IAALFGTHAQQYQAISAELAAFHDRFVQSLNTGAGSYLRAEAANAEQGLL MUL_0572|M.ulcerans_Agy99 IAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAAEAAN------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------QPQGRDTAADPAEQQATSTNTTDQPTSDSLGA TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------GGNGGNGGNGLGGGNGGNGGNAGAFALFGNGG MMAR_2100|M.marinum_M GLVNAPTQALFGRPLIGDGANGAPGSGQAGGAGGLLYGNGGAGGSGGVGQ MUL_0572|M.ulcerans_Agy99 -------------ASPLQAAEQEVLAVINAPTNALLGRPLIGNGTDGLAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------MSFVNVAPQLVSTAAADAA Rv0978c|M.tuberculosis_H37Rv -------------------------------MSFVNVAPQLVSTAAADAA MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 QPTAQVAR-QVQAPATDPAPAAPSLRPISGLLSVVTLG--TTLIPNAPTE TH_4332|M.thermoresistible__bu -------------------------------MPFITSG--AAFVGGAAML Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK NGGNGGVG-VVGATGAVGAPGVAGATGATGVTSGVVGGNGEDAVGYGATG MMAR_2100|M.marinum_M AGGAGGAAGLIGSGGAGGAGGAGGTGGAGGAGGWLYGNGGAGGVGGAGAV MUL_0572|M.ulcerans_Agy99 TGAAGGAGGLLWGNGGNGGSGAAGQAGGAGGAAGLIGTGGAGGMGGAGGG MLBr_01183|M.leprae_Br4923 -------------------------------MPLFLNAEPQALTAAANTL MAV_1346|M.avium_104 -------------------------------MS-FVTTRPEALLAVASML Mb1003c|M.bovis_AF2122/97 R----------------IGSAINTANTAAAATTQVLVAAQDEVSTAIAAL Rv0978c|M.tuberculosis_H37Rv R----------------IGSAINTANTAAAATTQVLAAAQDEVSTAIAAL MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 P----------ADMPGVW--AVMAWARRQPMYSDPAMRTTVNPQAQLPVP TH_4332|M.thermoresistible__bu L----------AGPGGVS--ALEAAGSAPRTVEYEYSLVACDSTLPLMCE Mvan_3865|M.vanbaalenii_PYR-1 ------------------------------MIDRLLALLRPTSRVSLLSP Mflv_5091|M.gilvum_PYR-GCK A----------AGAAGAAGAAGAAGAVGSAGAAGEAGETGTWGNAGLPGK MMAR_2100|M.marinum_M GGAGGNTWLWGNGGAGGSGGVGSGSGGAGGSGGWLYGNGGAGGTGGVADG MUL_0572|M.ulcerans_Agy99 AGG-------MGGSGGWLLGNGGAGGAGGVGCAGVSGGVGGTGGNAMLFG MLBr_01183|M.leprae_Br4923 EG---------------LSAATVASNAAAAQLTTEIAPPAADDVSILLAH MAV_1346|M.avium_104 EG---------------LGSSMDAQNAAAAAPTTSIAPAAADEVSALQAA Mb1003c|M.bovis_AF2122/97 FGSHG--------------------------------------------- Rv0978c|M.tuberculosis_H37Rv FGSHG--------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYL TH_4332|M.thermoresistible__bu AGDSVG-------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 TGAFLG-------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK AGDAGGAGAVGAAGAAGTVGTAGATGGTGTGANGGAGGVGGVGGTGAAGA MMAR_2100|M.marinum_M VGEGGGHGGAGGNARLLGTGGAGGDGGAGLAGAAGISGIAAGEAGTGGGI MUL_0572|M.ulcerans_Agy99 NGGAGGMGGAGADGAVGAAGTAGTSTSAGGVGGAGWDATAAGVLAATGGD MLBr_01183|M.leprae_Br4923 FFSGHG-------------------------------------------- MAV_1346|M.avium_104 QFSAYG-------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------QHYQAISAQVAAYQERFVLALSQAG Rv0978c|M.tuberculosis_H37Rv -------------------------QHYQAISAQVAAYQQRFVLALSQAG MAB_0321c|M.abscessus_ATCC_199 -----------------------------------------MAN-IISNG MSMEG_0868|M.smegmatis_MC2_155 IGNGINGTADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAG-LFGNG TH_4332|M.thermoresistible__bu --------------------------GLGGASHDRSAFSASALG-MASFG Mvan_3865|M.vanbaalenii_PYR-1 ------------------------LIGPGGLLIGNGVLPGQNGGLLIGNG Mflv_5091|M.gilvum_PYR-GCK AGGAGGLGETGTTGGAGGVGGQGTAGGTGGVGGIGGAGSTGAVGGVGGKG MMAR_2100|M.marinum_M GGDGGVGGDGGAGGWLFGNGGAGGIGGAGGAGGAGGFGASGDLVINQGSG MUL_0572|M.ulcerans_Agy99 GGDSGGGGAGGNGGAGGAGGHGSALFGADGANGNGGAGGAGGNPGAPGNG MLBr_01183|M.leprae_Br4923 -------------------------RQYQAHASQGATNHQDLIQSLLTS- MAV_1346|M.avium_104 -------------------------TWYQQVSAQAKAIHQTLVQNLDTN- Mb1003c|M.bovis_AF2122/97 STYAVAEAASATP--------LQQIEQALLGVINTPTEALVG-------- Rv0978c|M.tuberculosis_H37Rv STYAVAEAASATP--------LQN----VLDAINAPVQSLTG-------- MAB_0321c|M.abscessus_ATCC_199 PDG--------------------------DAGATGAQGS----------- MSMEG_0868|M.smegmatis_MC2_155 GNGGVGWAGLDGG-NGGSGGLLMGIGGAGGAGGVGADGTSAHVDGGTGGT TH_4332|M.thermoresistible__bu PDWN---------------------PGGAFLGLIGPGGLLIG-------- Mvan_3865|M.vanbaalenii_PYR-1 ADGAPG------------------VLPGEAGGKGGNGGLLMG-------- Mflv_5091|M.gilvum_PYR-GCK IQGGQGLQGGKGG-DGGAGGKGGDADSMGSAGATGGKGGNGGNGGRGGLF MMAR_2100|M.marinum_M ADGGSGGAGGAGG-AGGNGGAGGWLFSAHGAGGVGGAGGTGGTPGDGGGG MUL_0572|M.ulcerans_Agy99 GTGGVGPDAATSGGMGGTGGDPGAVGGRGNSGAAGGAGAVAGASGAAGTI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 ---------------------------RKLIGDGAHGAPG---------- Rv0978c|M.tuberculosis_H37Rv ---------------------------RPLIGDGANGIDG---------- MAB_0321c|M.abscessus_ATCC_199 --------------------------QGATGAAGAMANCN---------- MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV TH_4332|M.thermoresistible__bu --------------------------DGLNGTDAYIDENG---------- Mvan_3865|M.vanbaalenii_PYR-1 --------------------------NGGAGGAGAPGVAG---------- Mflv_5091|M.gilvum_PYR-GCK GKGGNAG-------------------NGADGGTGGAGGAGG--------- MMAR_2100|M.marinum_M AHGSMAVNPGAGFGTGGNGGNGGDPGAGGAGGTGGSGAGGSRAATG---- MUL_0572|M.ulcerans_Agy99 IAG-----------------------NGGNGGAGGAGYAADGPAGP---- MLBr_01183|M.leprae_Br4923 --------------------------SSAYAGTETAN------------- MAV_1346|M.avium_104 --------------------------ADSYGATEAANRVN---------- Mb1003c|M.bovis_AF2122/97 ----------TGQAGGAGGILWGNG------------------------- Rv0978c|M.tuberculosis_H37Rv ----------TGQAGGNGGWLWGNG------------------------- MAB_0321c|M.abscessus_ATCC_199 -----WIDDDCATRGGTGGTGGNGG------------------------- MSMEG_0868|M.smegmatis_MC2_155 LIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGA TH_4332|M.thermoresistible__bu -------VFHEATRGGNGGLLWGNG------------------------- Mvan_3865|M.vanbaalenii_PYR-1 ---------GAGGAGGNGGFFAGNG------------------------- Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGAGGTGGTGGTGG------------------------- MMAR_2100|M.marinum_M ------ATGSTPSSGGNGGAGGAGADSITTGGAGAAGGTGGDGGLVGDGG MUL_0572|M.ulcerans_Agy99 ----AIGNGGDGGHGGAGGFYGNGGAG----------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------TSAAALQGLAPNVIPNAA------------------------- Mb1003c|M.bovis_AF2122/97 ----------------------------------GNGGSGAPGQAGG--- Rv0978c|M.tuberculosis_H37Rv ----------------------------------GNGGSGAPGQAGG--- MAB_0321c|M.abscessus_ATCC_199 --------------------------------PGGAGGPGGHGGVID--- MSMEG_0868|M.smegmatis_MC2_155 NGGTVDG--------HAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIA--- TH_4332|M.thermoresistible__bu ----------------------------------GKGGNGLDAGLYT--- Mvan_3865|M.vanbaalenii_PYR-1 ----------------------------------GAGGAGGNGSTVN--- Mflv_5091|M.gilvum_PYR-GCK --------------------------IGGAGSTGGTGGTGGTGGTGG--- MMAR_2100|M.marinum_M AGGDGGAGLGGAPGTSVIFPGGQPGSSGGDGGAGGAGGAGGDGGLVAGNG MUL_0572|M.ulcerans_Agy99 ---------------------GAGGNSAPGGGTGGNGGTGGDSGAMGSSG MLBr_01183|M.leprae_Br4923 -----------------------------------------HDSL----- MAV_1346|M.avium_104 --------------------------------PAADPPPAGTTSLGT--- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ----FEVETFMDG--------------------------------VTLQA MSMEG_0868|M.smegmatis_MC2_155 ----EGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTA TH_4332|M.thermoresistible__bu ----VPDPDNPGS-------------------------TIQMYFEASDGA Mvan_3865|M.vanbaalenii_PYR-1 ----GPTSGGHGG------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGTGG-------------------------TGGTGGTGGKGG MMAR_2100|M.marinum_M GVGGAGGIGGVGGTGGDGSVGVDAAGAGQDGGVGGAGGAGGAGGAGGAGG MUL_0572|M.ulcerans_Agy99 GRGGDGGVGTNGG---------------------AGGGGGNATSYGTANA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 AGGAAG-------------------------------------------- Rv0978c|M.tuberculosis_H37Rv AGGAAG-------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 KGGRGG-------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGG TH_4332|M.thermoresistible__bu DGGRGG-------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 DGGKAG-------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TGGTGGAG------------------------------------------ MMAR_2100|M.marinum_M EGGAGGHALAAGYADGSQGAGGAGGAGGIGGDGAAGGKGAEGAAAAGAGA MUL_0572|M.ulcerans_Agy99 TGGAGGDGGTG--------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 RGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGA TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2100|M.marinum_M DGNDGGNGGRGGAGGRGGDGGVGGAGPEGQTGMQGVGGAGGDGGLGGQAG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGG TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2100|M.marinum_M NGSDGADAIVGGGKGGDGGDGGDPGLGGAGGQGGAGSTAGMEGLTAGDDG MUL_0572|M.ulcerans_Agy99 ----------------------------------------------STGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 --LIGNGGAGGTG------------------------------------- Rv0978c|M.tuberculosis_H37Rv --LIGNGGAGGTG------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -----NGGHGG--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AAQGGNGGNGGNGWVQAYD------------------------------- TH_4332|M.thermoresistible__bu -FLFGNGGDGGNG------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -LFRGDGGAGG--------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -GTGGDGGTGGTG------------------------------------- MMAR_2100|M.marinum_M PGHGGDGGAGGDGAAAVTTGSAGGDGGAGGDGGLVGDGGVGGNGGTGADG MUL_0572|M.ulcerans_Agy99 GGSGGDGGNGGTG------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 --SIGWAQNVG--------------------------------------- Mb1003c|M.bovis_AF2122/97 ----------------------------GAVSLARAGTAGGAGRGPVGGI Rv0978c|M.tuberculosis_H37Rv ----------------------------GAVSLARAGTAGGAGRGPVGGI MAB_0321c|M.abscessus_ATCC_199 ---------------------------AGGTGG----------TGGKGGD MSMEG_0868|M.smegmatis_MC2_155 -------------PNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGD TH_4332|M.thermoresistible__bu ------------------------GNVGGKNGADPVTATVAADKSVAGGN Mvan_3865|M.vanbaalenii_PYR-1 ---------------------------AGGAAVRTGNGPDGQVYAGRGGD Mflv_5091|M.gilvum_PYR-GCK -----------------------GTGGTGGTGGTGGTGGAGDGTGGTGGT MMAR_2100|M.marinum_M SPGITFISPGGLSGTDGGAGSIGGTGGAGGAGGLHAGDGGAGGIGGTGGD MUL_0572|M.ulcerans_Agy99 ------------------------HGGGGGPGGTAINYGAGDAFGGAAGK MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ---------------------------AAASDFITLGEGQFAPVPGAAGI Mb1003c|M.bovis_AF2122/97 G------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv G------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ---------------------------GDDCEFG---------------- MSMEG_0868|M.smegmatis_MC2_155 GAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGV TH_4332|M.thermoresistible__bu --------------------------GGNGGRGG---------------- Mvan_3865|M.vanbaalenii_PYR-1 ---------------------------GGDAVVG---------------- Mflv_5091|M.gilvum_PYR-GCK G-----------------------GTGGQGGQGGQG-------------- MMAR_2100|M.marinum_M GGHGGSGSAGADATIAG-AAGQTGGDGGDGGAGGAGGAGGAGGLAQATGY MUL_0572|M.ulcerans_Agy99 GGTG--------------------VVGGNGGSGGAAYNYGTG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 P------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -----GAGGVGGAGGAAG------------AVTTITHASFNDP------- Rv0978c|M.tuberculosis_H37Rv -----GAGGVGGAGGAAG------------AVTTITHASFNDP------- MAB_0321c|M.abscessus_ATCC_199 -----RTGGNGGTGGRGG-------------DGNFAGTGGNG-------- MSMEG_0868|M.smegmatis_MC2_155 SEGEGGTGGHGGDGGRGG-------------DGALGGNGGTGGVG----- TH_4332|M.thermoresistible__bu --LLFGLGGNGGNGGWST-------------TSYLDARGGNGG------- Mvan_3865|M.vanbaalenii_PYR-1 ------SGGQGGVGGDAT-------------SQGGPATSGGGG------- Mflv_5091|M.gilvum_PYR-GCK --GTGGTGGQGGLGGGGG-------------TGGQGGTGGTGG------- MMAR_2100|M.marinum_M LDGSHGSGGSGGAGGQAGNAGDGGDGADATVAGGKGGAGGNGGDAGVGGS MUL_0572|M.ulcerans_Agy99 --NATGAGGSSGSGGAASVPNSASTATATSGSGGAGGDGTDGG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----NFNPGLTAATTAG-------------PPAPAAPAAAAG------- Mb1003c|M.bovis_AF2122/97 --------------HGVAVNPGGNVYVTN-----------FGSGTVSVIN Rv0978c|M.tuberculosis_H37Rv --------------HGVAVNPGGNVYVTN-----------FGSGTVSVIN MAB_0321c|M.abscessus_ATCC_199 ---------------GAILVKCQHD---------------LSLGTHPMDV MSMEG_0868|M.smegmatis_MC2_155 LGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTA TH_4332|M.thermoresistible__bu -----------NGGLGGVLRPGGLLS------------LLLPSGAASEPG Mvan_3865|M.vanbaalenii_PYR-1 --------------HGGSVAVFGDAG----------------DGGFGGYA Mflv_5091|M.gilvum_PYR-GCK -----------QGGTGGTGGTGGTGG----------------TGGAGGDG MMAR_2100|M.marinum_M GGLGGDSGNGTHAANGASAGAYGTGGNGGAGGDGADATAAGQAGGAGGAG MUL_0572|M.ulcerans_Agy99 -----------NGGSGGFAFTFGTGN------------IIAGVGGGGGTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ---------------APVLASMGRGP---------------SIGGLSVPP Mb1003c|M.bovis_AF2122/97 PAT-------NTVTGSP-------------------------------IT Rv0978c|M.tuberculosis_H37Rv PAT-------NTVTGSP-------------------------------IT MAB_0321c|M.abscessus_ATCC_199 SAG-------TGGNGG---------------------------------I MSMEG_0868|M.smegmatis_MC2_155 TGG-------NGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTAT TH_4332|M.thermoresistible__bu GLF-------TGGNGG---------------------------------N Mvan_3865|M.vanbaalenii_PYR-1 GSQ-------NQATGR---------------------------------S Mflv_5091|M.gilvum_PYR-GCK GLGGLGGFGGSGGTGG---------------------------------Q MMAR_2100|M.marinum_M GDGGVVGDGGVGGNGGDGKAG-----VDGTSAVTFGASGADGGDGGAGGA MUL_0572|M.ulcerans_Agy99 STG----VGGIGGSGGGADIN--------------------NGAFTVVPQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 SWA----------------------------------------------P Mb1003c|M.bovis_AF2122/97 IGNGPSGVAVSPVTGLVFVTN----------------------------- Rv0978c|M.tuberculosis_H37Rv IGNGPSGVAVSPVTGLVFVTN----------------------------- MAB_0321c|M.abscessus_ATCC_199 GGGGGGGGSVGANGAT---------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGG TH_4332|M.thermoresistible__bu GGLAIANHWVGITDGVPGP------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 GGDGGRGGVLSGNGGD---------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGLGGPGGSTGGAGGAGGQAG----------------------------- MMAR_2100|M.marinum_M GGAGGDGGAVAGDGGRGGAGGDGAMGGNGGNGFDG--------------- MUL_0572|M.ulcerans_Agy99 GGAGGHGGDGATDGGAGGAGG----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 GGVAPAANATPAQLVGAGFTS----------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------FDSNTVS Rv0978c|M.tuberculosis_H37Rv -------------------------------------------FDSNTVS MAB_0321c|M.abscessus_ATCC_199 -----------------------------------------TGVFSSSSD MSMEG_0868|M.smegmatis_MC2_155 HGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTAN TH_4332|M.thermoresistible__bu ----------------------------------------DDDAVSSSAY Mvan_3865|M.vanbaalenii_PYR-1 ------------------------------------------GGIGGYAT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------TAGKGGLFGGSGS MMAR_2100|M.marinum_M ---------------------LHGTTPGANGQYGGDGGEGGRGGVGGAGG MUL_0572|M.ulcerans_Agy99 ----------------------------------FTEIDSSASVIAATGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ------------------------------------------AAPDTAPV Mb1003c|M.bovis_AF2122/97 VIDPTTNTVTGSPITVG-----------------------------TAPT Rv0978c|M.tuberculosis_H37Rv VIDPTTNTVTGSPITVG-----------------------------TAPT MAB_0321c|M.abscessus_ATCC_199 CSGPGPQPNPGSPGDPG-----------------------------TSVA MSMEG_0868|M.smegmatis_MC2_155 AANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTA TH_4332|M.thermoresistible__bu GGHGGHGAGPGSGGNGG-----------------------------SAVA Mvan_3865|M.vanbaalenii_PYR-1 SIGTGPAEG-GAGGYGG-----------------------------SGGA Mflv_5091|M.gilvum_PYR-GCK AGKAGATGAAGASGGKGAQGATGAQGATG------------AQGATGATG MMAR_2100|M.marinum_M AGGAAAAGQAGSQGDGGNGGDGGDGGTPGNGGSGADGANSAIGVSAGDGG MUL_0572|M.ulcerans_Agy99 AGGDGGSGGTGRGGTGGGGTGGGGTGGGGGVG----------INNGSGEA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 TAVPGGVPSMATAGRGGYG------------------------------- Mb1003c|M.bovis_AF2122/97 GVAVNPVTGEVYVTNFAGDTVSVIS------------------------- Rv0978c|M.tuberculosis_H37Rv GVAVNPVTGEVYVTNFAGDTVSVIS------------------------- MAB_0321c|M.abscessus_ATCC_199 VSG---------AQGNPGQAQFLIVP------------------------ MSMEG_0868|M.smegmatis_MC2_155 TAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGAT TH_4332|M.thermoresistible__bu NSLG------NAIAGNGGDAGRFVLIGP---------------------- Mvan_3865|M.vanbaalenii_PYR-1 FSRG-------GDGGAGGNGLSATAPGN---------------------- Mflv_5091|M.gilvum_PYR-GCK AAGKAGATGAAGAAGAAGSAGTTGAQGSAGTNGANGANGSQGAAGKAGAT MMAR_2100|M.marinum_M YGGAGGNAGAGGLGGEGGAGSTSGASGLDGSQAAGGDGGNGGFGGTGGLF MUL_0572|M.ulcerans_Agy99 IGGAPGAGGTGAVGGDGGQGGAAYSYGTGDATGSAGAAGTAGTTGVGGTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ----------LGAPRYGVKPTVMPKPAI---------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGP TH_4332|M.thermoresistible__bu ---------------------------GGNGGNGGTGLX----------- Mvan_3865|M.vanbaalenii_PYR-1 ---------------------------GGSGGRGGDGGP----------- Mflv_5091|M.gilvum_PYR-GCK GTTG----------------ATGAAGEDGDAGSGGSGINGG--------- MMAR_2100|M.marinum_M EAAGSGGAGG----------VGGDGSQGGDGGDGGAGGSSPGATGGWGGQ MUL_0572|M.ulcerans_Agy99 GAGGAAYTLNG---------ASTATATGGIGGNGGDGGTAN--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGE TH_4332|M.thermoresistible__bu -----------------------------------------XXPRPRRRR Mvan_3865|M.vanbaalenii_PYR-1 ------------------------------------------GGDGGLGG Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------AGGAGGAGGE MMAR_2100|M.marinum_M GGLGGVGTAGVGGHGGDGGDAGDSGSSAFGVGSPGGGGGQGGFGVAGGGD MUL_0572|M.ulcerans_Agy99 -------------------------------GSNGGNGGAGGYASTTGTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 HNTGGNGGNGGDGSEPGPGGNGAG---------------GAGGNGGTGGT TH_4332|M.thermoresistible__bu NHRRTRRRPNGRRPRPPPGR------------------------------ Mvan_3865|M.vanbaalenii_PYR-1 KGGVGSTNNGADGPDGGPAD------------------------------ Mflv_5091|M.gilvum_PYR-GCK GGEGGDGGKGGAGAEGGAGGGGGA---------------GGSGAGGAG-- MMAR_2100|M.marinum_M GGDGGNGGAGGFGQNGGPGGRGGGGGHSLVGPGGDGGLGGTGGNGGNGSQ MUL_0572|M.ulcerans_Agy99 TASVGNGGRGGDGTATVATGGTGG--------------VGGNAHAPAGSP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 -------------------------------------------------- Rv0978c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP---------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mvan_3865|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -----GAGGSGGSGGSGGSGGSGGAAGDSDD------------------- MMAR_2100|M.marinum_M PPFGSTPAGSGGDGGNGGAGGSSGFVSGQSGTDGQDGGDPSGQFGGTGGA MUL_0572|M.ulcerans_Agy99 VPGVGGKGGNPGPGGKPGPNGADGIVV----------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mb1003c|M.bovis_AF2122/97 ---------- Rv0978c|M.tuberculosis_H37Rv ---------- MAB_0321c|M.abscessus_ATCC_199 ---------- MSMEG_0868|M.smegmatis_MC2_155 ---------- TH_4332|M.thermoresistible__bu ---------- Mvan_3865|M.vanbaalenii_PYR-1 ---------- Mflv_5091|M.gilvum_PYR-GCK ---------- MMAR_2100|M.marinum_M GGSGGAGAGT MUL_0572|M.ulcerans_Agy99 ---------- MLBr_01183|M.leprae_Br4923 ---------- MAV_1346|M.avium_104 ----------