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TSLAGNLIEGARRHPNRIALRLDEIEIPYGALDTASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYG VLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFVPAAQAGADEAGAECILVKPGEFEELIQAAEP LEEAAVREDDDTAVILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHAFGQTAGL NAAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHSTERPDTGSLRLCVSGGAAMPVEVM RGFEQAFGTMVLEGYGLSETSPTASFNHPDRERKPGSIGTPIAGVQMKLLEVDTHGIGEIAIRGHNVMKG YWNRPDATAAVIDAEGWFRTGDLARIDEDGYYFIVDRSKDMIILSDFVKERVAAYKYPRRIWFVDELPKG PTGKILKRDITVPQASPAQQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3431 | - | - | 100% (441) | fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-48 | 33.91% (404) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_0943 | fadD36 | 2e-41 | 29.11% (481) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-56 | 32.29% (511) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4250 | - | 1e-55 | 31.46% (480) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-56 | 32.29% (511) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 5e-39 | 29.41% (442) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 3e-52 | 32.48% (428) | AMP-binding domain protein |
| M. marinum M | MMAR_1606 | - | 0.0 | 87.27% (495) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_5018 | - | 9e-53 | 30.69% (505) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 3e-50 | 30.27% (479) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4599 | - | 9e-84 | 60.94% (256) | PUTATIVE fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_2110 | - | 2e-54 | 35.31% (388) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4250|M.gilvum_PYR-GCK -------MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPVLDRVALIDAKS
Mvan_2110|M.vanbaalenii_PYR-1 -------MTFLSPFPEVDIPTASVYDYLFSGLAGPEDSVLDRVALIDAKS
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVSG
MSMEG_5649|M.smegmatis_MC2_155 ----------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEALVEVAT
MUL_3431|M.ulcerans_Agy99 --------------------------MTSLAGNLIEGARRHPNRIALRLD
MMAR_1606|M.marinum_M --------------------------MTSLAGNLIEGARRHPNRIALRLD
TH_4599|M.thermoresistible__bu --------------------------------------------------
MAV_5018|M.avium_104 ---MLSLTAQLAHHPTQANEQPYLSRRQNWVNQLERHALMQPNATALRFL
MLBr_01051|M.leprae_Br4923 --------------------------------MLLASLNPSVVTATDIAD
Mflv_4250|M.gilvum_PYR-GCK GRQTTYREMVARIDSFAGALAARGVGVGDVVGLLAPNSSAFAVAFHGILR
Mvan_2110|M.vanbaalenii_PYR-1 GRQTTYREMVARIDSFAGALAARGIGVGDVVALLAPNSSVFAVAFHGILR
Mb2533c|M.bovis_AF2122/97 RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAE
Rv2505c|M.tuberculosis_H37Rv RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAE
MAB_4377c|M.abscessus_ATCC_199 DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLVQYATAK
MSMEG_5649|M.smegmatis_MC2_155 GRRWTYAELNDEIDATARGLMALGVDKGDRVGIWAPNCAEWIMTQFAAAK
MUL_3431|M.ulcerans_Agy99 EIEIPYGALDTASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLR
MMAR_1606|M.marinum_M EIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLR
TH_4599|M.thermoresistible__bu --------------------------------------------------
MAV_5018|M.avium_104 GKGLTWGELHGRVRALADALSRRGVGFGDRVMVLMLNRPEFMESVLAINM
MLBr_01051|M.leprae_Br4923 AVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLI
Mflv_4250|M.gilvum_PYR-GCK AGATATTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREGAALAGLSD
Mvan_2110|M.vanbaalenii_PYR-1 AGATATTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAGAAAAGLSD
Mb2533c|M.bovis_AF2122/97 IGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGP-
Rv2505c|M.tuberculosis_H37Rv IGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGP-
MAB_4377c|M.abscessus_ATCC_199 IGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMASQVMP-
MSMEG_5649|M.smegmatis_MC2_155 VGAILVNINPAYRTHEVAYVLRQSGVRTLVSASSFKTSDYASMIAEVRP-
MUL_3431|M.ulcerans_Agy99 AGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFVP-----AAQAGAD-
MMAR_1606|M.marinum_M AGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAP-----AAQAGAD-
TH_4599|M.thermoresistible__bu --------------------------------------------------
MAV_5018|M.avium_104 LGAIAVPLNFRLTAAEIAFLVQDCQARVVITEAVLAP-----VATGVRD-
MLBr_01051|M.leprae_Br4923 AGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQ-
Mflv_4250|M.gilvum_PYR-GCK EDVIVLDGPGRDGSGDGAGHPNAADILAPGTPAPQVNFAPSSHLAVLPYS
Mvan_2110|M.vanbaalenii_PYR-1 EDVVVLDGAGRDGSGEGAGHPNAADLLAAGTPAPQVDFAPSSHLAVLPYS
Mb2533c|M.bovis_AF2122/97 -RCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVNIQYT
Rv2505c|M.tuberculosis_H37Rv -RCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVNIQYT
MAB_4377c|M.abscessus_ATCC_199 -DAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNTDPINIQYT
MSMEG_5649|M.smegmatis_MC2_155 -ECPDLLDVVFLDNDDWDRLRA--NQVDDAAFHERMATLANTDPINIQYT
MUL_3431|M.ulcerans_Agy99 -EAGAECILVKPGE--------FEELIQAAEPLEEAAVREDDDTAVILYT
MMAR_1606|M.marinum_M -EAGAECILVKPGE--------FEELIQAAEPLEEAAVREDDDTAVILYT
TH_4599|M.thermoresistible__bu ------------------------------------VIR---TIPVILYT
MAV_5018|M.avium_104 -IESLLDTVVVAGGSSDDAVLGYDDLIDETGAAHQPVDIPNDAAALIMYT
MLBr_01051|M.leprae_Br4923 ---------------------------LDARSWNRYPEPSPDATAMVIYT
: *:
Mflv_4250|M.gilvum_PYR-GCK SGTTGNPKGVMLTHRNLVANVAQIRPLHGMEPD-DVVLAVLPFFHIYGMT
Mvan_2110|M.vanbaalenii_PYR-1 SGTTGNPKGVMLTHRNLVANVAQIRPLHGMVAD-DVVLAVLPFFHIYGMT
Mb2533c|M.bovis_AF2122/97 SGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQ-DRICIPVPFYHCFGMV
Rv2505c|M.tuberculosis_H37Rv SGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQ-DRICIPVPFYHCFGMV
MAB_4377c|M.abscessus_ATCC_199 SGTTGYPKGATLSHRNVLNNGFFVAESIQLQAG-DRLCIPVPFYHCFGMV
MSMEG_5649|M.smegmatis_MC2_155 SGTTGFPKGATLSHRNILNNGFFVTELIALGPD-DRLCIVPPFYHCFGMV
MUL_3431|M.ulcerans_Agy99 SGTTGKPKGAELTHANLRRNVEVIVQMLQVGPD-DVILGALPLFHAFGQT
MMAR_1606|M.marinum_M SGTTGKPKGAELTHANLRRNVEVIVQMLQVGPD-DVILGALPLFHAFGQT
TH_4599|M.thermoresistible__bu SGTTGAPKGAQLTHSNLYRNALAFTGLFGLNRT-DVVLGTLPLFHAFGQS
MAV_5018|M.avium_104 SGTTGRPKGAVLTHTNLTGQTMTGLYTNGADINNDVGFIGVPFFHIAGIG
MLBr_01051|M.leprae_Br4923 SGTTGPPKGVLLSRRAIAVDLDALAQAWQWTAD-DVLVHGLPLFHVHGLV
****. ***. *:: : : * *::* *
Mflv_4250|M.gilvum_PYR-GCK VLLN-AALHARARLVIMPSFDLGDFLGNIAEHRCTIAFIAPPVAVALAKH
Mvan_2110|M.vanbaalenii_PYR-1 VLLN-AALHARARLVIMPSFDLGEFLGNIAEHRCTIAFIAPPVAVALAKH
Mb2533c|M.bovis_AF2122/97 MGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGL
Rv2505c|M.tuberculosis_H37Rv MGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGL
MAB_4377c|M.abscessus_ATCC_199 MGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLAD
MSMEG_5649|M.smegmatis_MC2_155 MGTLGAVSHGTTIVIPAPGFDPGITLSAVESEKCTGLYGVPTMFIAMLGH
MUL_3431|M.ulcerans_Agy99 AGLN-AAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHS
MMAR_1606|M.marinum_M AGLN-AAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHS
TH_4599|M.thermoresistible__bu NALN-ASIAVGACVSLVPRFDAAAVLRLIERHRVTVFAGVPTMYTAVLQA
MAV_5018|M.avium_104 NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAAEKVTGIFLVPAQWQAVCAE
MLBr_01051|M.leprae_Br4923 LGLL-GSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVAD
. .*.
Mflv_4250|M.gilvum_PYR-GCK PLVDDHDLSSLQVVMSGAAPLDADLGHAVAKRLD-CKVVQGYGMSELSPV
Mvan_2110|M.vanbaalenii_PYR-1 PLVDEHDLSSLNVVMSGAAPLDADLGHAVAKRLG-CKVVQGYGMSELSPV
Mb2533c|M.bovis_AF2122/97 PDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPV
Rv2505c|M.tuberculosis_H37Rv PDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPV
MAB_4377c|M.abscessus_ATCC_199 PGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPV
MSMEG_5649|M.smegmatis_MC2_155 PDFANFDLSSLRTGIMAGSVCPIEVMKRVVADMHMAEVAICYGMTETSPV
MUL_3431|M.ulcerans_Agy99 TERP--DTGSLRLCVSGGAAMPVEVMRGFEQAFG-TMVLEGYGLSETSPT
MMAR_1606|M.marinum_M TERP--DTGSLRLCVSGGAAMPVEVMRGFEQAFG-TMVLEGYGLSETSPT
TH_4599|M.thermoresistible__bu EAGPT-DTSSLRICVSGGAPLPVEVLREFESTFG-AQILEGHGLSETSPT
MAV_5018|M.avium_104 QRARP-RDLKLRVISWGAAPAPDALLREMSAMFPGTQILAAFGQTEMSPV
MLBr_01051|M.leprae_Br4923 EAVAR-ALRPARLLVSGSASLPVPVFDRLAHLTG-HRPIERYGSTESLIT
. ..: : .* :* .
Mflv_4250|M.gilvum_PYR-GCK SHITPFDGGRLNMHDDAPLASVGWTVSNAASKLVDPETGAEIEIPDEGLS
Mvan_2110|M.vanbaalenii_PYR-1 SHITPFDGGLVDMHEDAPLSSVGWTVSNAASKLVDPETGDEIPIPEEGLS
Mb2533c|M.bovis_AF2122/97 STQT-----RADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGV----
Rv2505c|M.tuberculosis_H37Rv STQT-----RADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGV----
MAB_4377c|M.abscessus_ATCC_199 SCQT-----LFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQRGQ----
MSMEG_5649|M.smegmatis_MC2_155 SCQT-----LIDDDLDRRTATIGRAHPHVEIKIIDPDTGETVERGQ----
MUL_3431|M.ulcerans_Agy99 ASFN-----HPDRERKPGS-IGTPI-AGVQMKLL------EVDTHG----
MMAR_1606|M.marinum_M ASFN-----HPDRERKPGS-IGTPI-AGVQMKLL------EVDTHG----
TH_4599|M.thermoresistible__bu ASFN-----PAGR-TKPGS-IGLPLDAGIEMKVVD-GDGIEVPTGD----
MAV_5018|M.avium_104 TCML-----LGEDAIRKRG-SVGKVIPTVAARVVD-ENMNDVPVGE----
MLBr_01051|M.leprae_Br4923 LSTL--------ADGERRAGWVGLPLAGVQTRLVDESGGPVPYDGET---
. :::
Mflv_4250|M.gilvum_PYR-GCK KTGELWFKGPNVMAGYLNNEEATKETIDEDGWLHTGDLAQIDDRGLVYIV
Mvan_2110|M.vanbaalenii_PYR-1 KTGELWFKGPNVMAGYLNNDEATRSTIDEDGWLHTGDLAQVDARGLVYIV
Mb2533c|M.bovis_AF2122/97 -VGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIA
Rv2505c|M.tuberculosis_H37Rv -VGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIA
MAB_4377c|M.abscessus_ATCC_199 -SGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTII
MSMEG_5649|M.smegmatis_MC2_155 -PGEFCTRGYSVMLGYWNDDEKTREAVDADGWMHTGDLAVMREDGYCTIV
MUL_3431|M.ulcerans_Agy99 -IGEIAIRGHNVMKGYWNRPDATAAVIDAEGWFRTGDLARIDEDGYYFIV
MMAR_1606|M.marinum_M -IGEIAIRGHNVMKGYWNRPDATAAAIDAEGWFRTGDLARIDEDGYYFIV
TH_4599|M.thermoresistible__bu -VGEIVIRGHNVMKGYWNRPDETAAAIN-DGWFHTGDMAVRDEDGFFFIV
MAV_5018|M.avium_104 -VGEIVYRAPTLMSGYWNNPEATAEAFA-GGWFHSGDLVRMDEDGYVWVV
MLBr_01051|M.leprae_Br4923 -VGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIV
*.: :. .:: ** * * .. ** ::**:. * :
Mflv_4250|M.gilvum_PYR-GCK DR-LKELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVRDEEGEEVPKAF
Mvan_2110|M.vanbaalenii_PYR-1 DR-LKELIKYKGYQVPPAELEALLLSHPGIADAAVVGVHDEEGEEVPKAF
Mb2533c|M.bovis_AF2122/97 GR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAV
Rv2505c|M.tuberculosis_H37Rv GR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAV
MAB_4377c|M.abscessus_ATCC_199 GR-LKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAW
MSMEG_5649|M.smegmatis_MC2_155 GR-IKDMVIRGGENIYPREIEEFLYTHPDIDDAQVIGVPDERYGEEICAW
MUL_3431|M.ulcerans_Agy99 DR-SKDMII-----------------------------------------
MMAR_1606|M.marinum_M DR-SKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDMLGEEVGAA
TH_4599|M.thermoresistible__bu DR-KKDVIIR----------------------------------------
MAV_5018|M.avium_104 DR-KKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAHEKWG-EVPIA
MLBr_01051|M.leprae_Br4923 GRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAF
.* :::
Mflv_4250|M.gilvum_PYR-GCK VVTQAN------SELTETDVIEFVAGQVAPYKKVRKVEFIDAIPKSASGK
Mvan_2110|M.vanbaalenii_PYR-1 VVRQASTDADGGAALTEADVIEFVAGQVAPYKKVRQVEFIDAIPKSASGK
Mb2533c|M.bovis_AF2122/97 VKLRNDAP-----ELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGK
Rv2505c|M.tuberculosis_H37Rv VKLRNDAP-----ELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGK
MAB_4377c|M.abscessus_ATCC_199 VRMRPDRV-----VIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTVTGK
MSMEG_5649|M.smegmatis_MC2_155 IRMKPGRP-----PLDADKVREFASGKLAHYKIPRYVHVVDEFPMTVTGK
MUL_3431|M.ulcerans_Agy99 -------------------LSDFVKERVAAYKYPRRIWFVDELPKGPTGK
MMAR_1606|M.marinum_M IALIPGA------TSDAAALSDFVKERVAAYKYPRRIWFVDELPKGPTGK
TH_4599|M.thermoresistible__bu --------------------GGYTSIRVNSRRSS----------------
MAV_5018|M.avium_104 VAAVAND------NLALEDLDEFLTERLARYKHPKALEIVDALPRNPAGK
MLBr_01051|M.leprae_Br4923 VVGAEALD--------ADELINYVAQQLSIHKRPREVRFVDALPRNAMGK
: :: :
Mflv_4250|M.gilvum_PYR-GCK ILRKDLRTG----------------
Mvan_2110|M.vanbaalenii_PYR-1 ILRKDLRNGG---------------
Mb2533c|M.bovis_AF2122/97 VRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv VRKVEMRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 VRKIEMRQQTIQIFGLPEPGRTDEQ
MSMEG_5649|M.smegmatis_MC2_155 IRKVQMREETVALLGLEA-------
MUL_3431|M.ulcerans_Agy99 ILKRDITVPQASPAQQ---------
MMAR_1606|M.marinum_M ILKRDITVPQASPAQQ---------
TH_4599|M.thermoresistible__bu -----TNIPRCGRPR----------
MAV_5018|M.avium_104 VLKTELRIRYGGG------------
MLBr_01051|M.leprae_Br4923 VLKKQLLFEG---------------