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MYTGPGSASLRAASASWNGVSVGLHSAAESYRAMIADLTSFQWLGPSSAAMVASVLPYVGWLEATAVQAG HSAMQASAAAAAYEQAFAMTVPPPAIAVNRAELAALIATDFFGQNTAAIAANEAEYAEMWATDATAMTSY SSTSAAARALTPFSSPHQTTNPAGLGAQSAAVAHSTANVAADSGNWLGNLIDAIGVALLPIAPELSAILI PLGELINMIPFPSFLADDFTVLDGLLAFYATIGSMQNIQSMGSGIIGTDDTLGLIPHAAAATADAPNALA ALGGEPALGAELGPIAAELTSGNRIGQMSVPPSWTDPKVTTIKALQATPLTTLPTDEVPASGIPGMPGMA MTGTGRGGVAPRYGVRLTVMPRPFSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2718 | - | - | 100% (377) | PPE family protein |
| M. ulcerans Agy99 | MUL_2737 | - | 8e-94 | 48.96% (384) | PPE family protein |
| M. ulcerans Agy99 | MUL_2427 | - | 1e-92 | 48.70% (384) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3562 | PPE61 | 1e-127 | 58.97% (390) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-32 | 30.10% (382) | PPE protein |
| M. tuberculosis H37Rv | Rv3532 | PPE61 | 1e-127 | 58.97% (390) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-36 | 31.71% (410) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-27 | 40.26% (154) | PPE family protein |
| M. marinum M | MMAR_3443 | - | 0.0 | 97.08% (377) | PPE family protein, PPE61_1 |
| M. avium 104 | MAV_4015 | - | 7e-75 | 44.42% (385) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-28 | 37.04% (189) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-28 | 30.41% (388) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-33 | 31.35% (386) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2718|M.ulcerans_Agy99 ---------------------------MYTGPGSASLRAASASWNGVSVG
MMAR_3443|M.marinum_M -------------MSFMMLPPEINSTRMYSGPGSASLRAASASWNSVSVG
Mb3562|M.bovis_AF2122/97 -----------MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAE
Rv3532|M.tuberculosis_H37Rv -----------MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: ***...: :*. * :.
MUL_2718|M.ulcerans_Agy99 LHSAAESYRAMIADLTSFQWLGPSSAAMVASVLPYVGWLEATAVQAGHSA
MMAR_3443|M.marinum_M LHSAAESYRAMIADLTSFQWLGPSSAAMVASVLPYVGWLEATAVQAGHSA
Mb3562|M.bovis_AF2122/97 LQSAAETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTA
Rv3532|M.tuberculosis_H37Rv LQSAAETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* : : : * .: ** ** : . .
MUL_2718|M.ulcerans_Agy99 MQASAAAAAYEQAFAMTVPPPAIAVNRAELAALIATDFFGQNTAAIAANE
MMAR_3443|M.marinum_M MQASAAAAAYEQAFAMTVPPPAIAVNRAELAALIATNFFGQNTAAIAANE
Mb3562|M.bovis_AF2122/97 TQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALE
Rv3532|M.tuberculosis_H37Rv TQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* .** .. * : . : *:: *: ::::* *: .* *
MUL_2718|M.ulcerans_Agy99 AEYAEMWATDATAMTSYSSTSAAARALTPFSSPHQTTNPAGLGAQSAAVA
MMAR_3443|M.marinum_M AEYAEMWATDATAMTSYSSTSAAARALTPFTSPHQTTNPAGLGAQSAAVA
Mb3562|M.bovis_AF2122/97 TQYAEMWEQDATAMYDYAATSAAARTLTPFTSPQQDTNSAGLPAQSAEVS
Rv3532|M.tuberculosis_H37Rv TQYAEMWEQDATAMYDYAATSAAARTLTPFTSPQQDTNSAGLPAQSAEVS
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAAQFSPFASPRRTTDPGGVTAQQAAVA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
::*.. * *::* * : * : .
MUL_2718|M.ulcerans_Agy99 HSTANVAADSGNWLGN----------------------------------
MMAR_3443|M.marinum_M NSTANVAADSGNWLGN----------------------------------
Mb3562|M.bovis_AF2122/97 RATANAGAADGNWLGN----------------------------------
Rv3532|M.tuberculosis_H37Rv RATANAGAADGNWLGN----------------------------------
MAV_4015|M.avium_104 AAETGSTGTDS---------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS---------------------------------
MUL_2718|M.ulcerans_Agy99 ------------LIDAIGVALLPIAPELSAILIPLGELINMIPFPSFLAD
MMAR_3443|M.marinum_M ------------LIDAIGVALLPIAPELSAILIPLGELINMIPFPSFLAD
Mb3562|M.bovis_AF2122/97 ------------LLEEIGILLLPIAPELTPFFLEAGEIVNAIPFPSIVGD
Rv3532|M.tuberculosis_H37Rv ------------LLEEIGILLLPIAPELTPFFLEAGEIVNAIPFPSIVGD
MAV_4015|M.avium_104 -----------------GTQVIPPTAGAS-----------EIPL------
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 -------------QAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPD
:
MUL_2718|M.ulcerans_Agy99 DFTVLDGLLA--FYATIGSMQNIQSMGSGIIGTDDTLGLIPHAAAATADA
MMAR_3443|M.marinum_M DFTILDGLLA--FYATIGSMQNIQSMASGIIGTDDTLGLIPHAAAAAADA
Mb3562|M.bovis_AF2122/97 EFCLLDGLLA--WYATIGSINNINSMGTGIIGAEKNLGILPELGSAAAAA
Rv3532|M.tuberculosis_H37Rv EFCLLDGLLA--WYATIGSINNINSMGTGIIGAEKNLGILPELGSAAAAA
MAV_4015|M.avium_104 DFRILDTILG--AQTTFRSIFTTEGIPAGIIQADKNLGILPNLATIPAAL
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILY--PSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAE
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILY--PSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAED
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIF--ASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAED
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQF--APALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVE
TH_3113|M.thermoresistible__bu SGMLAQLVPL--MPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAAD
MLBr_01182|M.leprae_Br4923 SSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKS
: :
MUL_2718|M.ulcerans_Agy99 PN-----------ALAALGGEPALGAELGP--IAAELTSGNRIG---QMS
MMAR_3443|M.marinum_M PN-----------ALAALGGEPGLGAELGP--IAAELTSGNRIG---QMS
Mb3562|M.bovis_AF2122/97 APPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIG---QMS
Rv3532|M.tuberculosis_H37Rv APPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIG---QMS
MAV_4015|M.avium_104 PR------------TPALSASPTG---LGR--IDAVLARAARIG---PMS
Mflv_0325|M.gilvum_PYR-GCK EAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPG
Mvan_0415|M.vanbaalenii_PYR-1 APAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPG
MSMEG_0619|M.smegmatis_MC2_155 EAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVA
MAB_0809c|M.abscessus_ATCC_199 PGSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-
TH_3113|M.thermoresistible__bu GGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSV
MLBr_01182|M.leprae_Br4923 LAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLR
MUL_2718|M.ulcerans_Agy99 VPPSWTDPKVTTIKALQATPLTTLPTDEV-PASGIPG-----MPGMAMTG
MMAR_3443|M.marinum_M VPPSWTEPKVTTIKALQATPLTTLPTDEV-PASGIPG-----MPGMAMTG
Mb3562|M.bovis_AF2122/97 VPPAWKAPAVTTVRAFDATPMTTLPGGDA-PAAGVPG-----LPGMPASG
Rv3532|M.tuberculosis_H37Rv VPPAWKAPAVTTVRAFDATPMTTLPGGDA-PAAGVPG-----LPGMPASG
MAV_4015|M.avium_104 VPAGWTAATGNPVAAAPVTGWSEPSAADARPGVTAPG-----LPGIPGAT
Mflv_0325|M.gilvum_PYR-GCK APAAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAP-----AGTIPAAA
Mvan_0415|M.vanbaalenii_PYR-1 APAAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAP-----ASGIPAAA
MSMEG_0619|M.smegmatis_MC2_155 APAPAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAP-----ASGVPAAA
MAB_0809c|M.abscessus_ATCC_199 PPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAA-----ARSSAREQ
TH_3113|M.thermoresistible__bu PPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRA-----ASIVEPAG
MLBr_01182|M.leprae_Br4923 VPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGG
* .
MUL_2718|M.ulcerans_Agy99 TGRGG--VAPRYGVRLTVMPRPFSGG------------------------
MMAR_3443|M.marinum_M TGRGG--VAPRYGVRLTVMTRPFSGG------------------------
Mb3562|M.bovis_AF2122/97 AGRAG--VVPRYGVRLTVMTRPLSGG------------------------
Rv3532|M.tuberculosis_H37Rv AGRAG--VVPRYGVRLTVMTRPLSGG------------------------
MAV_4015|M.avium_104 LRRAAL-VVPRYGVRITVMARPPAAG------------------------
Mflv_0325|M.gilvum_PYR-GCK SGIAAS-AAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRV
Mvan_0415|M.vanbaalenii_PYR-1 SGVAAS-AAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRI
MSMEG_0619|M.smegmatis_MC2_155 SGVAAS-LASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRV
MAB_0809c|M.abscessus_ATCC_199 AAAAET-AAARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDT
TH_3113|M.thermoresistible__bu SAAAAA-AARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAAT
MLBr_01182|M.leprae_Br4923 SGTGGVNTALRLQPRAFVMPRNPAAG------------------------
. . . .
MUL_2718|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3443|M.marinum_M --------------------------------------------------
Mb3562|M.bovis_AF2122/97 --------------------------------------------------
Rv3532|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TASTRGAGPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDP
Mvan_0415|M.vanbaalenii_PYR-1 AATERGAGPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDP
MSMEG_0619|M.smegmatis_MC2_155 RASERGSDAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDG
MAB_0809c|M.abscessus_ATCC_199 TASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP
TH_3113|M.thermoresistible__bu APSAAGIRVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEP
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MUL_2718|M.ulcerans_Agy99 -----------------------
MMAR_3443|M.marinum_M -----------------------
Mb3562|M.bovis_AF2122/97 -----------------------
Rv3532|M.tuberculosis_H37Rv -----------------------
MAV_4015|M.avium_104 -----------------------
Mflv_0325|M.gilvum_PYR-GCK DATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DENPAP------SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ------------EHGRQD-----
TH_3113|M.thermoresistible__bu N----------------------
MLBr_01182|M.leprae_Br4923 -----------------------