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MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAELQSAAETYRSVIASLTGWQWLGPSSVRMGAA VTPYVEWLTTTAAQARQTATQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALET QYAEMWEQDATAMYDYAATSAAARTLTPFTSPQQDTNSAGLPAQSAEVSRATANAGAADGNWLGNLLEEI GILLLPIAPELTPFFLEAGEIVNAIPFPSIVGDEFCLLDGLLAWYATIGSINNINSMGTGIIGAEKNLGI LPELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIGQMSVPPAWKAPAVTT VRAFDATPMTTLPGGDAPAAGVPGLPGMPASGAGRAGVVPRYGVRLTVMTRPLSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3532 | PPE61 | - | 100% (406) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 9e-99 | 47.55% (408) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 3e-77 | 43.37% (415) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3562 | PPE61 | 0.0 | 100.00% (406) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-34 | 31.79% (390) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-47 | 33.57% (423) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-31 | 29.97% (337) | PPE family protein |
| M. marinum M | MMAR_3444 | - | 1e-137 | 61.14% (404) | PPE family protein, PPE61 |
| M. avium 104 | MAV_4014 | - | 1e-84 | 46.21% (409) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-31 | 41.84% (196) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-32 | 37.75% (249) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2718 | - | 1e-127 | 58.97% (390) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-36 | 31.01% (416) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
Rv3532|M.tuberculosis_H37Rv -----------MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAE
Mb3562|M.bovis_AF2122/97 -----------MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAE
MMAR_3444|M.marinum_M -------------MSFMMLPPEINSTRMYTGPGSASLRAASASWNSVSVG
MUL_2718|M.ulcerans_Agy99 ---------------------------MYTGPGSASLRAASASWNGVSVG
MAV_4014|M.avium_104 -------------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: *.*...: :*. * :.
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
Rv3532|M.tuberculosis_H37Rv LQSAAETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTA
Mb3562|M.bovis_AF2122/97 LQSAAETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTA
MMAR_3444|M.marinum_M LHSAAESYRAMIADLTSFQWLGPSSAAMIASVLPYVGWLEATAVQAGHSA
MUL_2718|M.ulcerans_Agy99 LHSAAESYRAMIADLTSFQWLGPSSAAMVASVLPYVGWLEATAVQAGHSA
MAV_4014|M.avium_104 LTATADGYESVLSGLG-LQWHGPAADAMAFAAARYLTWLRATAEQTKQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : : : * :: * ** : *
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
Rv3532|M.tuberculosis_H37Rv TQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALE
Mb3562|M.bovis_AF2122/97 TQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALE
MMAR_3444|M.marinum_M MQASAAAAAYEQAFAMTVPPPAIAVNRAELAALIATNFFGQNTAAIAANE
MUL_2718|M.ulcerans_Agy99 MQASAAAAAYEQAFAMTVPPPAIAVNRAELAALIATDFFGQNTAAIAANE
MAV_4014|M.avium_104 MQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .** .: * : . : *:: *: ::::* *: .* *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
Rv3532|M.tuberculosis_H37Rv TQYAEMWEQDATAMYDYAATSAAAR-TLTPFTSPQQDTNS---------A
Mb3562|M.bovis_AF2122/97 TQYAEMWEQDATAMYDYAATSAAAR-TLTPFTSPQQDTNS---------A
MMAR_3444|M.marinum_M AEYAEMWATDATAMTSYSSTSAAAR-ALTPFTSPQQTTNP---------A
MUL_2718|M.ulcerans_Agy99 AEYAEMWATDATAMTSYSSTSAAAR-ALTPFSSPHQTTNP---------A
MAV_4014|M.avium_104 AQYADFWAQDTAAMAGYSASSTAAT-QLPRFASANNSTNE---------S
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNE---------V
::*. :* :::* * : * :..
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEMV
Rv3532|M.tuberculosis_H37Rv GLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIAPELTPFFLEAG
Mb3562|M.bovis_AF2122/97 GLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIAPELTPFFLEAG
MMAR_3444|M.marinum_M GLGAQSAAVANSTANVAADSGNWLGNLIDAIGVALLPIAPELSAILIPLG
MUL_2718|M.ulcerans_Agy99 GLGAQSAAVAHSTANVAADSGNWLGNLIDAIGVALLPIAPELSAILIPLG
MAV_4014|M.avium_104 GVTAQNAAVSAANANAAAN---------KAVTQSFSPLADNPPGTTINN-
MLBr_01182|M.leprae_Br4923 GLAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQV
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_0809c|M.abscessus_ATCC_199 EHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPA
Rv3532|M.tuberculosis_H37Rv EIVNAIPFPSIVGDEFCLLDGLLA-WYATIGSINNINSMGTGIIGAEKN-
Mb3562|M.bovis_AF2122/97 EIVNAIPFPSIVGDEFCLLDGLLA-WYATIGSINNINSMGTGIIGAEKN-
MMAR_3444|M.marinum_M ELINMIPFPSFFADDFTILDGLLA-FYATIGSIKNIQSMGSGIIGTENT-
MUL_2718|M.ulcerans_Agy99 ELINMIPFPSFLADDFTVLDGLLA-FYATIGSMQNIQSMGSGIIGTDDT-
MAV_4014|M.avium_104 YYVDASSTSAANSNAFRVLDVIQG-TGLGFSAPYNMEQFVSGIIGAENN-
MLBr_01182|M.leprae_Br4923 NVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAG
MSMEG_0619|M.smegmatis_MC2_155 LIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQP
TH_3569|M.thermoresistible__bu LIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAAP-----
Mflv_0325|M.gilvum_PYR-GCK LATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQS
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPS
MAB_0809c|M.abscessus_ATCC_199 LALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPS
Rv3532|M.tuberculosis_H37Rv LGILPELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPG--EVS
Mb3562|M.bovis_AF2122/97 LGILPELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPG--EVS
MMAR_3444|M.marinum_M LGLIPHAAAATAAAPN-----------ALAALGGEPALGAELGP----IA
MUL_2718|M.ulcerans_Agy99 LGLIPHAAAATADAPN-----------ALAALGGEPALGAELGP----IA
MAV_4014|M.avium_104 LGMLAKPGAAAANIAPALAAP------ALRGATAGLGGGLGGGLG--NVT
MLBr_01182|M.leprae_Br4923 LSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVT
: .
MSMEG_0619|M.smegmatis_MC2_155 LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPG
TH_3569|M.thermoresistible__bu --------------VRAEPQNPLPLTXXX---------------------
Mflv_0325|M.gilvum_PYR-GCK FPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPY
Mvan_0415|M.vanbaalenii_PYR-1 PAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPG
MAB_0809c|M.abscessus_ATCC_199 PPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLG
Rv3532|M.tuberculosis_H37Rv AAMRGAGTIGQMSVPPAWKAPAVTTVRAFDATPMTTLPGGDAP------A
Mb3562|M.bovis_AF2122/97 AAMRGAGTIGQMSVPPAWKAPAVTTVRAFDATPMTTLPGGDAP------A
MMAR_3444|M.marinum_M AELTSGNRIGQMSVPPSWTEPKVTTIKALQATPLTTLPTDEVP------A
MUL_2718|M.ulcerans_Agy99 AELTSGNRIGQMSVPPSWTDPKVTTIKALQATPLTTLPTDEVP------A
MAV_4014|M.avium_104 ATLSHAGTIGPMSVPATWSAPTSTHVSPLAPAGFTTLPGTEEPM-----A
MLBr_01182|M.leprae_Br4923 AQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLG
.
MSMEG_0619|M.smegmatis_MC2_155 EGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGY
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGY
Mvan_0415|M.vanbaalenii_PYR-1 TGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAY
MAB_0809c|M.abscessus_ATCC_199 TGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG-
Rv3532|M.tuberculosis_H37Rv AGVP---------GLPGMPASGAGR---AGVVPRYGVRLTVMTRPLSGG-
Mb3562|M.bovis_AF2122/97 AGVP---------GLPGMPASGAGR---AGVVPRYGVRLTVMTRPLSGG-
MMAR_3444|M.marinum_M SGIP---------GIPGMAMTGTGR---GGVTPRYGVRLTVMPRPFSGG-
MUL_2718|M.ulcerans_Agy99 SGIP---------GMPGMAMTGTGR---GGVAPRYGVRLTVMPRPFSGG-
MAV_4014|M.avium_104 SGYP---------GYPGMPGGGAARSAGVGVPPRYGVRLTVMPRPPAAG-
MLBr_01182|M.leprae_Br4923 GGLP---------MAPMVPGGGSGTG-GVNTALRLQPRAFVMPRNPAAG-
MSMEG_0619|M.smegmatis_MC2_155 ADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 ADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLT
MAB_0809c|M.abscessus_ATCC_199 ----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLA
Rv3532|M.tuberculosis_H37Rv --------------------------------------------------
Mb3562|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3444|M.marinum_M --------------------------------------------------
MUL_2718|M.ulcerans_Agy99 --------------------------------------------------
MAV_4014|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 MLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------
Rv3532|M.tuberculosis_H37Rv ----------------------------------------------
Mb3562|M.bovis_AF2122/97 ----------------------------------------------
MMAR_3444|M.marinum_M ----------------------------------------------
MUL_2718|M.ulcerans_Agy99 ----------------------------------------------
MAV_4014|M.avium_104 ----------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------------------------------------------