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AGRTEQVWDSRLPGTIGDTVAQIEAAGGRAVAVRADLTDRDDVAALVTAARDSLGPITILVNNAAFTAPG RPPVPGAAPRAKSSRAAVGKPGWPGFVSVPLAAYRRHFETSVFAAYELMQLSCPDMIAAGAGSIINITSV ASRLPGDGPYPDRSGGVLPGYGGSKAALEHLTQCAAFDLADHHIAVNALAPSKPIPTPGLSYYAREFDDT ASAEEFARAAVVLASVDADLVTGRTIGHHEVLDGSFRAFGRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2481 | - | - | 100% (253) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 3e-14 | 33.15% (184) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 8e-14 | 28.05% (221) | 3-oxoacyl- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 6e-14 | 30.42% (240) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4556 | - | 4e-21 | 33.04% (224) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0927c | - | 6e-14 | 30.42% (240) | short chain dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4632 | - | 1e-15 | 29.29% (239) | short chain dehydrogenase |
| M. marinum M | MMAR_1395 | - | 1e-143 | 98.81% (253) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_4056 | - | 1e-110 | 73.31% (281) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2885 | - | 2e-22 | 34.38% (224) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_0319 | - | 5e-22 | 36.00% (225) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2884 | - | 4e-21 | 32.89% (228) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2481|M.ulcerans_Agy99 --------------------------------------MAGRTEQVWDSR
MMAR_1395|M.marinum_M ---MTGALAGRAAIVTGASRGLGRAIALALAAEGAAVVVAGRTEQVWDSR
MAV_4056|M.avium_104 ---MTGRLAGRAAIVTGASRGLGRAIALALASEGAAVAVAGRTEQVWDDR
MSMEG_2885|M.smegmatis_MC2_155 ---MTNLLSGRTALVTGSSRGIGRAVAQRLAAEGAVVAVTARSYEPSPSV
TH_0319|M.thermoresistible__bu --------------------------------------------------
Mvan_2884|M.vanbaalenii_PYR-1 ---MSGILSGKTALVTGSSRGIGRAVAQRLAAEGATVAVTARSYQPSVST
Mflv_4556|M.gilvum_PYR-GCK ---MTGLLTGRTALVTGSSRGIGRAIAQRLAAEGATVAVTARAHQPSESV
Mb0950c|M.bovis_AF2122/97 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSS-----
Rv0927c|M.tuberculosis_H37Rv MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSS-----
MAB_4632|M.abscessus_ATCC_1997 MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTES-----
MUL_2481|M.ulcerans_Agy99 -------LPGTIGDTVAQIEAAGGRAVAVRADLTDRDDVAALVTAARDSL
MMAR_1395|M.marinum_M -------LPGTIGDTVAQIEAAGGRAVAVRADLTDRDDVATLVTGARDSL
MAV_4056|M.avium_104 -------LPGTIGSTVADIEAAGGRAVPVRADLTDRDDVARLVDSAREAL
MSMEG_2885|M.smegmatis_MC2_155 RAGQATALPGTIGETIELIEAAGGKAFGIAADLEDAEQRAALVDQVIERT
TH_0319|M.thermoresistible__bu ------VLPGTIGETIELIEAAGGKAFGIVADLEDPRQRADLIDQVVQHT
Mvan_2884|M.vanbaalenii_PYR-1 RAGKDAELPGTIGETVELIEASGGMAFGIACDLEIAGQRASLVDQVVERT
Mflv_4556|M.gilvum_PYR-GCK RAGVSAALPGTIDETIALIEQSGGTAFGLAADLENSEDRAALVDRVVERT
Mb0950c|M.bovis_AF2122/97 ----------ELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAF
Rv0927c|M.tuberculosis_H37Rv ----------ELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAF
MAB_4632|M.abscessus_ATCC_1997 ----------QLREVAAKVQAAGRQAEVVVADLSDTEASAALAQKAVDRF
: . :. :* * : .** * * .
MUL_2481|M.ulcerans_Agy99 GPITILVNNAAFTAPGRPPVPGAAPRAK--------------SSRAAVG-
MMAR_1395|M.marinum_M GPITILVNNAAFTAPGRPPVPGAAPRAK--------------SSRTAVG-
MAV_4056|M.avium_104 GPITILVNNAAFTAPGRPPAPGGEARAKPAAGGEARAKPASGGAKPASGG
MSMEG_2885|M.smegmatis_MC2_155 GRIDILVNNAGFAD------------------------------------
TH_0319|M.thermoresistible__bu GRIDILVNNAGFAD------------------------------------
Mvan_2884|M.vanbaalenii_PYR-1 GRLDILVNNAGYAD------------------------------------
Mflv_4556|M.gilvum_PYR-GCK GRVDILVNNAGFAD------------------------------------
Mb0950c|M.bovis_AF2122/97 GKLDIVVNNVGGTMP-----------------------------------
Rv0927c|M.tuberculosis_H37Rv GKLDIVVNNVGGTMP-----------------------------------
MAB_4632|M.abscessus_ATCC_1997 GRLDVVVNNVGGTMP-----------------------------------
* : ::***.. :
MUL_2481|M.ulcerans_Agy99 ---------------KPGWPGFVSVPLAAYRRHFETSVFAAYELMQLSCP
MMAR_1395|M.marinum_M ---------------KPGWPGFVSVPLAAYRRHFETSVFAAYELMQLSCP
MAV_4056|M.avium_104 AKPASGGAKPASGGAKPGWPGFVSTPLHAYRRHFDIAVFAAYELMQRVCP
MSMEG_2885|M.smegmatis_MC2_155 ------------------YSIIEDMPMDTFDRTVEHYLRTPFVLTQAAVP
TH_0319|M.thermoresistible__bu ------------------YSMVEKMSLETFDRTVEHYLRTPFVLTQAAIP
Mvan_2884|M.vanbaalenii_PYR-1 ------------------YSIIEDMPMETFDRTVEHYVRTPFVLTQKAVP
Mflv_4556|M.gilvum_PYR-GCK ------------------YSVVADMSMATFERTVEHYVRTPFVLTQAAVP
Mb0950c|M.bovis_AF2122/97 -------------------NTLLSTSTKDLADAFAFNVGTAHALTVAAVP
Rv0927c|M.tuberculosis_H37Rv -------------------NTLLSTSTKDLADAFAFNVGTAHALTVAAVP
MAB_4632|M.abscessus_ATCC_1997 -------------------KPFLDTTNDDLAEAFSFNVLSGHALLRAAVP
. . . . : : . * *
MUL_2481|M.ulcerans_Agy99 DMIA-AGAGSIINITSVASRLPGDGPYPDRSGGVLPGYGGSKAALEHLTQ
MMAR_1395|M.marinum_M DMIA-AGAGSIINITSVASRLPGDGPYPDRSGGVLPGYGGSKAALEHLTQ
MAV_4056|M.avium_104 DMIG-AGGGAIINITSVASRLPGDGPYADRSGGVLPGYGGSKAALEHLTQ
MSMEG_2885|M.smegmatis_MC2_155 HMRN-QGAGWIVNIGSVTGLAPVRPYREYNKSSGDVIYASMKAALHRFTQ
TH_0319|M.thermoresistible__bu HMRA-QGAGWIVNIGSVTGLPPIRPYRDYNKTSGDVIYASLKAALHRFTQ
Mvan_2884|M.vanbaalenii_PYR-1 HMRR-QGAGWIVNIGSVTGLAPARPYRDYNKTSGDVVYASMKAALHRFTQ
Mflv_4556|M.gilvum_PYR-GCK HMKT-QGQGWIVNIGSVTGLAPARPYREYNKTSGDVIYASMKAALHRFTQ
Mb0950c|M.bovis_AF2122/97 LMLEHSGGGSVINISSTMGRLAAR---------GFAAYGTAKAALAHYTR
Rv0927c|M.tuberculosis_H37Rv LMLEHSGGGSVINISSTMGRLAAR---------GFAAYGTAKAALAHYTR
MAB_4632|M.abscessus_ATCC_1997 HLLK-SDNASVINITSTMGRLPGR---------AFLGYCTAKGALAHYTR
: . . ::** *. . . * *.** : *:
MUL_2481|M.ulcerans_Agy99 CAAFDLADHHIAVNALAPSKPIPTPGLSYYAREFDDTASAEEFARAAVVL
MMAR_1395|M.marinum_M CAAFDLADHHIAVNALAPSKPIPTPGLSYYAREFDDTASAEEFARAAVVL
MAV_4056|M.avium_104 CVAYDLADHRIAVNALSPSKPILTPGLSYYARDFDDTASADEFARAAVEL
MSMEG_2885|M.smegmatis_MC2_155 GVAAELLDANIAVNAVGPSSAVRTPGAASLIPDTFPTEPVEYLAETVLAM
TH_0319|M.thermoresistible__bu GVAAELLDSNIAVNAVGPSSAVRTPGAASLIPDTFPTEPVEYLAETVLAM
Mvan_2884|M.vanbaalenii_PYR-1 GVAAELLDSNIAVNVVGPSSAVRTPGAASLIPDTFPTEPVEYLAETVLAM
Mflv_4556|M.gilvum_PYR-GCK GVAAELLDADIAVNAVGPSSAVRTPGAAALIPDSFPTEPVEYLAETVLAM
Mb0950c|M.bovis_AF2122/97 LAALDLCPR-VRVNAIAPGSILTS----ALEVVAANDELRAPMEQATPLR
Rv0927c|M.tuberculosis_H37Rv LAALDLCPR-VRVNAIAPGSILTS----ALEVVAANDELRAPMEQATPLR
MAB_4632|M.abscessus_ATCC_1997 TAAMDLSPR-IRVNGIAPGSILTS----ALEVVAGNDEMRNTLEQNTPLH
.* :* : ** :.*.. : : : . .
MUL_2481|M.ulcerans_Agy99 ASVDADLVTGRTIGHHEVLDGSFRAFGRD---------------------
MMAR_1395|M.marinum_M ASVDADLVTGRTIGHHEVLDGSFRAFGRD---------------------
MAV_4056|M.avium_104 ALVDPGRVTGRTIGHLQVLDGSFRPSGWTRLWRLGLGSSGPHHRGGGGVA
MSMEG_2885|M.smegmatis_MC2_155 CHRPAAERTG-LVAFSLHYPWSQGLAVHSLDGRDLLPPLEPPASANPNIL
TH_0319|M.thermoresistible__bu CHRPAAERTG-LVAFSLHYPWSQRIPVHTLDGREVLPPLEPPATANPNIL
Mvan_2884|M.vanbaalenii_PYR-1 CHLPAVERTG-LVAFSLHYPWSHRLTVHSLDGTTTLPPLEPPANANPNIL
Mflv_4556|M.gilvum_PYR-GCK CHRPAAERTG-LVAFSLHYPWSQKLPVHSLDGATVLPPLEPPATANPNIL
Mb0950c|M.bovis_AF2122/97 RLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL----
Rv0927c|M.tuberculosis_H37Rv RLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL----
MAB_4632|M.abscessus_ATCC_1997 RLGDPADIAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA---
. :. :
MUL_2481|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1395|M.marinum_M --------------------------------------------------
MAV_4056|M.avium_104 PSPTAAHGFSDPEARQVQVRQVRPVRRADPPAPERRVRPARREVLPPPAR
MSMEG_2885|M.smegmatis_MC2_155 PAGI----------------------------------------------
TH_0319|M.thermoresistible__bu PGGM----------------------------------------------
Mvan_2884|M.vanbaalenii_PYR-1 PLGL----------------------------------------------
Mflv_4556|M.gilvum_PYR-GCK PAGL----------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2481|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1395|M.marinum_M --------------------------------------------------
MAV_4056|M.avium_104 REVLPPLARRVAPPRPERPALREVRAAREDRAVQVARVAAGCSAGSSPRG
MSMEG_2885|M.smegmatis_MC2_155 --------------------------------------------------
TH_0319|M.thermoresistible__bu --------------------------------------------------
Mvan_2884|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4556|M.gilvum_PYR-GCK --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2481|M.ulcerans_Agy99 ----------------------
MMAR_1395|M.marinum_M ----------------------
MAV_4056|M.avium_104 RLRCPASRGTRLPTRPPRRVLR
MSMEG_2885|M.smegmatis_MC2_155 ----------------------
TH_0319|M.thermoresistible__bu ----------------------
Mvan_2884|M.vanbaalenii_PYR-1 ----------------------
Mflv_4556|M.gilvum_PYR-GCK ----------------------
Mb0950c|M.bovis_AF2122/97 ----------------------
Rv0927c|M.tuberculosis_H37Rv ----------------------
MAB_4632|M.abscessus_ATCC_1997 ----------------------