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MSGILSGKTALVTGSSRGIGRAVAQRLAAEGATVAVTARSYQPSVSTRAGKDAELPGTIGETVELIEASG GMAFGIACDLEIAGQRASLVDQVVERTGRLDILVNNAGYADYSIIEDMPMETFDRTVEHYVRTPFVLTQK AVPHMRRQGAGWIVNIGSVTGLAPARPYRDYNKTSGDVVYASMKAALHRFTQGVAAELLDSNIAVNVVGP SSAVRTPGAASLIPDTFPTEPVEYLAETVLAMCHLPAVERTGLVAFSLHYPWSHRLTVHSLDGTTTLPPL EPPANANPNILPLGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2884 | - | - | 100% (295) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4252 | - | 8e-30 | 35.94% (256) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | 2e-24 | 34.12% (296) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 1e-23 | 29.48% (251) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4556 | - | 1e-140 | 82.03% (295) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3224 | - | 1e-23 | 29.48% (251) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-15 | 29.56% (203) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_3946c | - | 2e-22 | 31.67% (221) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1395 | - | 2e-32 | 35.48% (279) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3027 | - | 1e-138 | 81.69% (295) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_2885 | - | 1e-145 | 85.42% (295) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_0319 | - | 1e-117 | 83.40% (241) | short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2546 | - | 4e-23 | 29.68% (219) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3251|M.bovis_AF2122/97 ----------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIAL
Rv3224|M.tuberculosis_H37Rv ----------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIAL
MUL_2546|M.ulcerans_Agy99 ----------------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIAL
MAB_3946c|M.abscessus_ATCC_199 ---------------MGSLAGKTIIMSGGSRGIGLAIALRAARDGANVAI
MSMEG_2885|M.smegmatis_MC2_155 --------------MTNLLSGRTALVTGSSRGIGRAVAQRLAAEGAVVAV
TH_0319|M.thermoresistible__bu --------------------------------------------------
MAV_3027|M.avium_104 --------------MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAV
Mvan_2884|M.vanbaalenii_PYR-1 --------------MSGILSGKTALVTGSSRGIGRAVAQRLAAEGATVAV
Mflv_4556|M.gilvum_PYR-GCK --------------MTGLLTGRTALVTGSSRGIGRAIAQRLAAEGATVAV
MMAR_1395|M.marinum_M --------------MTGALAGRAAIVTGASRGLGRAIALALAAEGAAVVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
Mb3251|M.bovis_AF2122/97 IAKTAEPHP--------KLPGTVFTAAKELEEAGGQALPIVGDIRDPDAV
Rv3224|M.tuberculosis_H37Rv IAKTAEPHP--------KLPGTVFTAAKELEEAGGQALPIVGDIRDPDAV
MUL_2546|M.ulcerans_Agy99 IAKTAEPHP--------KLPGTVYTAAKELEEAGGQALPIVGDVRDPDSV
MAB_3946c|M.abscessus_ATCC_199 MAKTAEPHP--------KLPGTIYTAAEEIEAAGGHALPLLGDVRDDEVV
MSMEG_2885|M.smegmatis_MC2_155 TARSYEPSPSVRAGQATALPGTIGETIELIEAAGGKAFGIAADLEDAEQR
TH_0319|M.thermoresistible__bu -----------------VLPGTIGETIELIEAAGGKAFGIVADLEDPRQR
MAV_3027|M.avium_104 TARSHSSSPSTRAGTATALPGTIGETIELIEAAGGSAFGIAADLEDADQR
Mvan_2884|M.vanbaalenii_PYR-1 TARSYQPSVSTRAGKDAELPGTIGETVELIEASGGMAFGIACDLEIAGQR
Mflv_4556|M.gilvum_PYR-GCK TARAHQPSESVRAGVSAALPGTIDETIALIEQSGGTAFGLAADLENSEDR
MMAR_1395|M.marinum_M AGRTEQVWDS-------RLPGTIGDTVAQIEAAGGRAVAVRADLTDRDDV
MLBr_01807|M.leprae_Br4923 THRAS--------------------------VVPDWFFGVECDVTDNDAI
. . : *:
Mb3251|M.bovis_AF2122/97 ASAVATTVEQFGGIDICVNNASAINLGS----------------------
Rv3224|M.tuberculosis_H37Rv ASAVATTVEQFGGIDICVNNASAINLGS----------------------
MUL_2546|M.ulcerans_Agy99 SAAVAKTVEQFGGIDICVNNASAINLGS----------------------
MAB_3946c|M.abscessus_ATCC_199 ASAVAQTVEKFGGIDIVVNNASALNLAP----------------------
MSMEG_2885|M.smegmatis_MC2_155 AALVDQVIERTGRIDILVNNAGFADYSI----------------------
TH_0319|M.thermoresistible__bu ADLIDQVVQHTGRIDILVNNAGFADYSM----------------------
MAV_3027|M.avium_104 DGLVDAVLDRTGRIDILVNNAGFADYSL----------------------
Mvan_2884|M.vanbaalenii_PYR-1 ASLVDQVVERTGRLDILVNNAGYADYSI----------------------
Mflv_4556|M.gilvum_PYR-GCK AALVDRVVERTGRVDILVNNAGFADYSV----------------------
MMAR_1395|M.marinum_M ATLVTGARDSLGPITILVNNAAFTAPGRPPVPGAAPRAKSSRTAVGKPGW
MLBr_01807|M.leprae_Br4923 GAAFKAVEEHQGPVEVLVANAGITSDML----------------------
. . : * : : * **.
Mb3251|M.bovis_AF2122/97 --ITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLS-----
Rv3224|M.tuberculosis_H37Rv --ITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLS-----
MUL_2546|M.ulcerans_Agy99 --ITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHILTLS-----
MAB_3946c|M.abscessus_ATCC_199 --SESISMKAYDLMQDINARGSFSLSTSAIGALKEADNPHILTLS-----
MSMEG_2885|M.smegmatis_MC2_155 --IEDMPMDTFDRTVEHYLRTPFVLTQAAVPHMRNQGAGWIVNIGSVTGL
TH_0319|M.thermoresistible__bu --VEKMSLETFDRTVEHYLRTPFVLTQAAIPHMRAQGAGWIVNIGSVTGL
MAV_3027|M.avium_104 --VEDMSLETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVTGV
Mvan_2884|M.vanbaalenii_PYR-1 --IEDMPMETFDRTVEHYVRTPFVLTQKAVPHMRRQGAGWIVNIGSVTGL
Mflv_4556|M.gilvum_PYR-GCK --VADMSMATFERTVEHYVRTPFVLTQAAVPHMKTQGQGWIVNIGSVTGL
MMAR_1395|M.marinum_M PGFVSVPLAAYRRHFETSVFAAYELMQLSCPDMIAAGAGSIINITSVASR
MLBr_01807|M.leprae_Br4923 --IMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGL
:. : : : . : : :
Mb3251|M.bovis_AF2122/97 PPILLEKKWLR---PTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRT
Rv3224|M.tuberculosis_H37Rv PPILLEKKWLR---PTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRT
MUL_2546|M.ulcerans_Agy99 PPVQLDKKWLK---PTAYMMAKFGMTLCALGIAEEMRDEGIASNTLWPRT
MAB_3946c|M.abscessus_ATCC_199 PPITLEPKWFERT-TTAYTISKFSMSLVAIGLAAELRQYGIASNALWPRT
MSMEG_2885|M.smegmatis_MC2_155 APVRPYREYNKSSGDVIYASMKAALHRFTQGVAAELLDANIAVNAVGPSS
TH_0319|M.thermoresistible__bu PPIRPYRDYNKTSGDVIYASLKAALHRFTQGVAAELLDSNIAVNAVGPSS
MAV_3027|M.avium_104 APVRPYREYNKASGDVVYAAMKAALHRFTQGVAAELLDANIAVNCVGPST
Mvan_2884|M.vanbaalenii_PYR-1 APARPYRDYNKTSGDVVYASMKAALHRFTQGVAAELLDSNIAVNVVGPSS
Mflv_4556|M.gilvum_PYR-GCK APARPYREYNKTSGDVIYASMKAALHRFTQGVAAELLDADIAVNAVGPSS
MMAR_1395|M.marinum_M LPGDGPYPDRSGGVLPGYGGSKAALEHLTQCAAFDLADHHIAVNALAPSK
MLBr_01807|M.leprae_Br4923 SGVPG---------QANYAASKSGLIGMARSLARELGSRSITANVVAPG-
* * .: : * :: *: * : *
Mb3251|M.bovis_AF2122/97 MVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCED
Rv3224|M.tuberculosis_H37Rv MVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCED
MUL_2546|M.ulcerans_Agy99 LVATAAVQNLLGGEEAMGRARKPDVYADAAYVILNKNSREYTGNSALCED
MAB_3946c|M.abscessus_ATCC_199 TIDTAAIRNILG-AELVARCRSAQIMADAAYEILTKPSREVSGNCFIDDE
MSMEG_2885|M.smegmatis_MC2_155 AVRTPGAASLIPDTFPTEP---VEYLAETVLAMCHRPAAERTGLVAFSLH
TH_0319|M.thermoresistible__bu AVRTPGAASLIPDTFPTEP---VEYLAETVLAMCHRPAAERTGLVAFSLH
MAV_3027|M.avium_104 AVRTPGAAQLIPESFPTEP---VEYLAETVLAMCHLPAAERTGLVAFSLH
Mvan_2884|M.vanbaalenii_PYR-1 AVRTPGAASLIPDTFPTEP---VEYLAETVLAMCHLPAVERTGLVAFSLH
Mflv_4556|M.gilvum_PYR-GCK AVRTPGAAALIPDSFPTEP---VEYLAETVLAMCHRPAAERTGLVAFSLH
MMAR_1395|M.marinum_M PIPTPGLSYYAREFDDTAS---AEEFARAAVVLASVDADLVTG-RTIGHH
MLBr_01807|M.leprae_Br4923 FIDTEMTRAMDSKYQEAAL----QAIPLGRIGAVEEIAGAVSFLASEDAG
: * : . : :
Mb3251|M.bovis_AF2122/97 VLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv VLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
MUL_2546|M.ulcerans_Agy99 VLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQP
MAB_3946c|M.abscessus_ATCC_199 VLREAGVTDFSQYRECAEEDLELDFWMERA--------
MSMEG_2885|M.smegmatis_MC2_155 YPWSQGLAVHSLDGRDLLPPLEPPASANPNILPAGI--
TH_0319|M.thermoresistible__bu YPWSQRIPVHTLDGREVLPPLEPPATANPNILPGGM--
MAV_3027|M.avium_104 YPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV--
Mvan_2884|M.vanbaalenii_PYR-1 YPWSHRLTVHSLDGTTTLPPLEPPANANPNILPLGL--
Mflv_4556|M.gilvum_PYR-GCK YPWSQKLPVHSLDGATVLPPLEPPATANPNILPAGL--
MMAR_1395|M.marinum_M EVLDGSFRAFGRD-------------------------
MLBr_01807|M.leprae_Br4923 YISGAVIPVDGGLGMGH---------------------
.