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TGLLTGRTALVTGSSRGIGRAIAQRLAAEGATVAVTARAHQPSESVRAGVSAALPGTIDETIALIEQSGG TAFGLAADLENSEDRAALVDRVVERTGRVDILVNNAGFADYSVVADMSMATFERTVEHYVRTPFVLTQAA VPHMKTQGQGWIVNIGSVTGLAPARPYREYNKTSGDVIYASMKAALHRFTQGVAAELLDADIAVNAVGPS SAVRTPGAAALIPDSFPTEPVEYLAETVLAMCHRPAAERTGLVAFSLHYPWSQKLPVHSLDGATVLPPLE PPATANPNILPAGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4556 | - | - | 100% (295) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4691 | - | 2e-24 | 31.05% (219) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2396 | - | 2e-24 | 31.37% (255) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 5e-23 | 28.29% (251) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 5e-23 | 28.29% (251) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-15 | 29.86% (211) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 7e-22 | 28.97% (252) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1395 | - | 2e-33 | 36.33% (278) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3027 | - | 1e-137 | 80.00% (295) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_2885 | - | 1e-144 | 84.75% (295) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_0319 | - | 1e-116 | 82.16% (241) | short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2546 | - | 7e-23 | 29.22% (219) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2884 | - | 1e-140 | 82.03% (295) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3251|M.bovis_AF2122/97 --MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEP-------
Rv3224|M.tuberculosis_H37Rv --MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEP-------
MUL_2546|M.ulcerans_Agy99 --MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEP-------
MAB_3946c|M.abscessus_ATCC_199 -MGSLAGKTIIMSGGSRGIGLAIALRAARDGANVAIMAKTAEP-------
MSMEG_2885|M.smegmatis_MC2_155 MTNLLSGRTALVTGSSRGIGRAVAQRLAAEGAVVAVTARSYEPSPS----
TH_0319|M.thermoresistible__bu --------------------------------------------------
MAV_3027|M.avium_104 MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSPS----
Mvan_2884|M.vanbaalenii_PYR-1 MSGILSGKTALVTGSSRGIGRAVAQRLAAEGATVAVTARSYQPSVS----
Mflv_4556|M.gilvum_PYR-GCK MTGLLTGRTALVTGSSRGIGRAIAQRLAAEGATVAVTARAHQPSES----
MMAR_1395|M.marinum_M MTGALAGRAAIVTGASRGLGRAIALALAAEGAAVVVAGRTEQVWDS----
MLBr_02565|M.leprae_Br4923 -MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLL
Mb3251|M.bovis_AF2122/97 -------HPKLPGTVFTAAKELEEAGG--------------QALPIVGDI
Rv3224|M.tuberculosis_H37Rv -------HPKLPGTVFTAAKELEEAGG--------------QALPIVGDI
MUL_2546|M.ulcerans_Agy99 -------HPKLPGTVYTAAKELEEAGG--------------QALPIVGDV
MAB_3946c|M.abscessus_ATCC_199 -------HPKLPGTIYTAAEEIEAAGG--------------HALPLLGDV
MSMEG_2885|M.smegmatis_MC2_155 --VRAGQATALPGTIGETIELIEAAGG--------------KAFGIAADL
TH_0319|M.thermoresistible__bu ---------VLPGTIGETIELIEAAGG--------------KAFGIVADL
MAV_3027|M.avium_104 --TRAGTATALPGTIGETIELIEAAGG--------------SAFGIAADL
Mvan_2884|M.vanbaalenii_PYR-1 --TRAGKDAELPGTIGETVELIEASGG--------------MAFGIACDL
Mflv_4556|M.gilvum_PYR-GCK --VRAGVSAALPGTIDETIALIEQSGG--------------TAFGLAADL
MMAR_1395|M.marinum_M --R-------LPGTIGDTVAQIEAAGG--------------RAVAVRADL
MLBr_02565|M.leprae_Br4923 IGGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAEL
* .*: :. * .. ::
Mb3251|M.bovis_AF2122/97 RDPDAVASAVATTVEQFGGIDICVNNASAIN-------------------
Rv3224|M.tuberculosis_H37Rv RDPDAVASAVATTVEQFGGIDICVNNASAIN-------------------
MUL_2546|M.ulcerans_Agy99 RDPDSVSAAVAKTVEQFGGIDICVNNASAIN-------------------
MAB_3946c|M.abscessus_ATCC_199 RDDEVVASAVAQTVEKFGGIDIVVNNASALN-------------------
MSMEG_2885|M.smegmatis_MC2_155 EDAEQRAALVDQVIERTGRIDILVNNAGFAD-------------------
TH_0319|M.thermoresistible__bu EDPRQRADLIDQVVQHTGRIDILVNNAGFAD-------------------
MAV_3027|M.avium_104 EDADQRDGLVDAVLDRTGRIDILVNNAGFAD-------------------
Mvan_2884|M.vanbaalenii_PYR-1 EIAGQRASLVDQVVERTGRLDILVNNAGYAD-------------------
Mflv_4556|M.gilvum_PYR-GCK ENSEDRAALVDRVVERTGRVDILVNNAGFAD-------------------
MMAR_1395|M.marinum_M TDRDDVATLVTGARDSLGPITILVNNAAFTAPGRPPVPGAAPR-------
MLBr_02565|M.leprae_Br4923 KGLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLG
: . : : ...
Mb3251|M.bovis_AF2122/97 ----------------------------------------------LGSI
Rv3224|M.tuberculosis_H37Rv ----------------------------------------------LGSI
MUL_2546|M.ulcerans_Agy99 ----------------------------------------------LGSI
MAB_3946c|M.abscessus_ATCC_199 ----------------------------------------------LAPS
MSMEG_2885|M.smegmatis_MC2_155 ----------------------------------------------YSII
TH_0319|M.thermoresistible__bu ----------------------------------------------YSMV
MAV_3027|M.avium_104 ----------------------------------------------YSLV
Mvan_2884|M.vanbaalenii_PYR-1 ----------------------------------------------YSII
Mflv_4556|M.gilvum_PYR-GCK ----------------------------------------------YSVV
MMAR_1395|M.marinum_M ----------------------------------AKSSRTAVGKPGWPGF
MLBr_02565|M.leprae_Br4923 KELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAA
Mb3251|M.bovis_AF2122/97 TEVPMKRFDLMNGIQVRGTYAVSQ---ACIPHMKGRENPHILTLSPPILL
Rv3224|M.tuberculosis_H37Rv TEVPMKRFDLMNGIQVRGTYAVSQ---ACIPHMKGRENPHILTLSPPILL
MUL_2546|M.ulcerans_Agy99 TEVPMKRFDLMNGIQVRGTYAVSQ---ACIPHLKGRENPHILTLSPPVQL
MAB_3946c|M.abscessus_ATCC_199 ESISMKAYDLMQDINARGSFSLST---SAIGALKEADNPHILTLSPPITL
MSMEG_2885|M.smegmatis_MC2_155 EDMPMDTFDRTVEHYLRTPFVLTQ---AAVPHMRNQGAGWIVNIGSVTGL
TH_0319|M.thermoresistible__bu EKMSLETFDRTVEHYLRTPFVLTQ---AAIPHMRAQGAGWIVNIGSVTGL
MAV_3027|M.avium_104 EDMSLETFDRTVEHYLRVPFVLTK---CAVPHMRKQGAGWIVNIGSVTGV
Mvan_2884|M.vanbaalenii_PYR-1 EDMPMETFDRTVEHYVRTPFVLTQ---KAVPHMRRQGAGWIVNIGSVTGL
Mflv_4556|M.gilvum_PYR-GCK ADMSMATFERTVEHYVRTPFVLTQ---AAVPHMKTQGQGWIVNIGSVTGL
MMAR_1395|M.marinum_M VSVPLAAYRRHFETSVFAAYELMQ---LSCPDMIAAGAGSIINITSVASR
MLBr_02565|M.leprae_Br4923 DSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAA
. . : . : :: :
Mb3251|M.bovis_AF2122/97 EKKWLR--------PTAYMMAKYGMTLCALGIAEEMR-------------
Rv3224|M.tuberculosis_H37Rv EKKWLR--------PTAYMMAKYGMTLCALGIAEEMR-------------
MUL_2546|M.ulcerans_Agy99 DKKWLK--------PTAYMMAKFGMTLCALGIAEEMR-------------
MAB_3946c|M.abscessus_ATCC_199 EPKWFERT------TTAYTISKFSMSLVAIGLAAELR-------------
MSMEG_2885|M.smegmatis_MC2_155 APVRPYREYNKSSGDVIYASMKAALHRFTQGVAAELL-------------
TH_0319|M.thermoresistible__bu PPIRPYRDYNKTSGDVIYASLKAALHRFTQGVAAELL-------------
MAV_3027|M.avium_104 APVRPYREYNKASGDVVYAAMKAALHRFTQGVAAELL-------------
Mvan_2884|M.vanbaalenii_PYR-1 APARPYRDYNKTSGDVVYASMKAALHRFTQGVAAELL-------------
Mflv_4556|M.gilvum_PYR-GCK APARPYREYNKTSGDVIYASMKAALHRFTQGVAAELL-------------
MMAR_1395|M.marinum_M LPGDGPYPDRSGGVLPGYGGSKAALEHLTQCAAFDLA-------------
MLBr_02565|M.leprae_Br4923 EALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGIT
. .: :
Mb3251|M.bovis_AF2122/97 -------------ADGIASNTLWPR---------TMVATAAVQNLLGGDE
Rv3224|M.tuberculosis_H37Rv -------------ADGIASNTLWPR---------TMVATAAVQNLLGGDE
MUL_2546|M.ulcerans_Agy99 -------------DEGIASNTLWPR---------TLVATAAVQNLLGGEE
MAB_3946c|M.abscessus_ATCC_199 -------------QYGIASNALWPR---------TTIDTAAIRNILG-AE
MSMEG_2885|M.smegmatis_MC2_155 -------------DANIAVNAVGPS---------SAVRTPGAASLIPDTF
TH_0319|M.thermoresistible__bu -------------DSNIAVNAVGPS---------SAVRTPGAASLIPDTF
MAV_3027|M.avium_104 -------------DANIAVNCVGPS---------TAVRTPGAAQLIPESF
Mvan_2884|M.vanbaalenii_PYR-1 -------------DSNIAVNVVGPS---------SAVRTPGAASLIPDTF
Mflv_4556|M.gilvum_PYR-GCK -------------DADIAVNAVGPS---------SAVRTPGAAALIPDSF
MMAR_1395|M.marinum_M -------------DHHIAVNALAPS---------KPIPTPGLSYYAREFD
MLBr_02565|M.leprae_Br4923 RDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMA
: * : * : . .
Mb3251|M.bovis_AF2122/97 AMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDV-LVESGVTDLSVYD
Rv3224|M.tuberculosis_H37Rv AMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDV-LVESGVTDLSVYD
MUL_2546|M.ulcerans_Agy99 AMGRARKPDVYADAAYVILNKNSREYTGNSALCEDV-LLESGVSDLSIYN
MAB_3946c|M.abscessus_ATCC_199 LVARCRSAQIMADAAYEILTKPSREVSGNCFIDDEV-LREAGVTDFSQYR
MSMEG_2885|M.smegmatis_MC2_155 PTEP---VEYLAETVLAMCHRPAAERTGLVAFSLHY-PWSQGLAVHSLDG
TH_0319|M.thermoresistible__bu PTEP---VEYLAETVLAMCHRPAAERTGLVAFSLHY-PWSQRIPVHTLDG
MAV_3027|M.avium_104 PTEP---VEYLAETVLAMCHLPAAERTGLVAFSLHY-PWSQQLPVHSLDG
Mvan_2884|M.vanbaalenii_PYR-1 PTEP---VEYLAETVLAMCHLPAVERTGLVAFSLHY-PWSHRLTVHSLDG
Mflv_4556|M.gilvum_PYR-GCK PTEP---VEYLAETVLAMCHRPAAERTGLVAFSLHY-PWSQKLPVHSLDG
MMAR_1395|M.marinum_M DTAS---AEEFARAAVVLASVDADLVTG-RTIGHHE-VLDGSFRAFGRD-
MLBr_02565|M.leprae_Br4923 GIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTA
* : : .* .
Mb3251|M.bovis_AF2122/97 CVPGATLGVDLWVEDANPPGYLPA--------------------------
Rv3224|M.tuberculosis_H37Rv CVPGATLGVDLWVEDANPPGYLPA--------------------------
MUL_2546|M.ulcerans_Agy99 CVPGAKLGVDLWVEEVNPPGYTQP--------------------------
MAB_3946c|M.abscessus_ATCC_199 ECAEEDLELDFWMERA----------------------------------
MSMEG_2885|M.smegmatis_MC2_155 RDLLPPLEPPASANPNILPAGI----------------------------
TH_0319|M.thermoresistible__bu REVLPPLEPPATANPNILPGGM----------------------------
MAV_3027|M.avium_104 ANLLPPLRPPANANPNILPAGV----------------------------
Mvan_2884|M.vanbaalenii_PYR-1 TTTLPPLEPPANANPNILPLGL----------------------------
Mflv_4556|M.gilvum_PYR-GCK ATVLPPLEPPATANPNILPAGL----------------------------
MMAR_1395|M.marinum_M --------------------------------------------------
MLBr_02565|M.leprae_Br4923 AIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQ
Mb3251|M.bovis_AF2122/97 -----
Rv3224|M.tuberculosis_H37Rv -----
MUL_2546|M.ulcerans_Agy99 -----
MAB_3946c|M.abscessus_ATCC_199 -----
MSMEG_2885|M.smegmatis_MC2_155 -----
TH_0319|M.thermoresistible__bu -----
MAV_3027|M.avium_104 -----
Mvan_2884|M.vanbaalenii_PYR-1 -----
Mflv_4556|M.gilvum_PYR-GCK -----
MMAR_1395|M.marinum_M -----
MLBr_02565|M.leprae_Br4923 AMLGA