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MTNLLSGRTALVTGSSRGIGRAVAQRLAAEGAVVAVTARSYEPSPSVRAGQATALPGTIGETIELIEAAG GKAFGIAADLEDAEQRAALVDQVIERTGRIDILVNNAGFADYSIIEDMPMDTFDRTVEHYLRTPFVLTQA AVPHMRNQGAGWIVNIGSVTGLAPVRPYREYNKSSGDVIYASMKAALHRFTQGVAAELLDANIAVNAVGP SSAVRTPGAASLIPDTFPTEPVEYLAETVLAMCHRPAAERTGLVAFSLHYPWSQGLAVHSLDGRDLLPPL EPPASANPNILPAGI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2885 | - | - | 100% (295) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4872 | - | 3e-31 | 36.47% (255) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1894 | - | 2e-29 | 34.13% (252) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 2e-26 | 29.88% (251) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4556 | - | 1e-144 | 84.75% (295) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3224 | - | 2e-26 | 29.88% (251) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-16 | 31.03% (203) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2032 | - | 5e-25 | 35.04% (234) | 3-oxoacyl- |
| M. marinum M | MMAR_1395 | - | 3e-33 | 36.33% (278) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3027 | - | 1e-145 | 85.42% (295) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_0319 | - | 1e-123 | 87.14% (241) | short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2546 | - | 1e-26 | 31.96% (219) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2884 | - | 1e-145 | 85.42% (295) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3251|M.bovis_AF2122/97 -MS--LNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEP------
Rv3224|M.tuberculosis_H37Rv -MS--LNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEP------
MUL_2546|M.ulcerans_Agy99 -MS--LNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEP------
MSMEG_2885|M.smegmatis_MC2_155 -MTNLLSGRTALVTGSSRGIGRAVAQRLAAEGAVVAVTARSYEPSPSVRA
TH_0319|M.thermoresistible__bu --------------------------------------------------
MAV_3027|M.avium_104 -MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSPSTRA
Mvan_2884|M.vanbaalenii_PYR-1 -MSGILSGKTALVTGSSRGIGRAVAQRLAAEGATVAVTARSYQPSVSTRA
Mflv_4556|M.gilvum_PYR-GCK -MTGLLTGRTALVTGSSRGIGRAIAQRLAAEGATVAVTARAHQPSESVRA
MMAR_1395|M.marinum_M -MTGALAGRAAIVTGASRGLGRAIALALAAEGAAVVVAGRTEQVWDSR--
MAB_2032|M.abscessus_ATCC_1997 MSGKEFEGQVALVTGASRGIGRSIALALAEHGADIALHYGNSKP------
MLBr_01807|M.leprae_Br4923 ----MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARR------
Mb3251|M.bovis_AF2122/97 --HPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGG
Rv3224|M.tuberculosis_H37Rv --HPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGG
MUL_2546|M.ulcerans_Agy99 --HPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQFGG
MSMEG_2885|M.smegmatis_MC2_155 GQATALPGTIGETIELIEAAGGKAFGIAADLEDAEQRAALVDQVIERTGR
TH_0319|M.thermoresistible__bu ----VLPGTIGETIELIEAAGGKAFGIVADLEDPRQRADLIDQVVQHTGR
MAV_3027|M.avium_104 GTATALPGTIGETIELIEAAGGSAFGIAADLEDADQRDGLVDAVLDRTGR
Mvan_2884|M.vanbaalenii_PYR-1 GKDAELPGTIGETVELIEASGGMAFGIACDLEIAGQRASLVDQVVERTGR
Mflv_4556|M.gilvum_PYR-GCK GVSAALPGTIDETIALIEQSGGTAFGLAADLENSEDRAALVDRVVERTGR
MMAR_1395|M.marinum_M -----LPGTIGDTVAQIEAAGGRAVAVRADLTDRDDVATLVTGARDSLGP
MAB_2032|M.abscessus_ATCC_1997 --------AAEEVAEKISALGRRVLLCQGDIADPAVPELLADTVHAEFGR
MLBr_01807|M.leprae_Br4923 ---LVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGP
. . . *: . *
Mb3251|M.bovis_AF2122/97 IDICVNNASAIN------------------------LGSITEVPMKRFDL
Rv3224|M.tuberculosis_H37Rv IDICVNNASAIN------------------------LGSITEVPMKRFDL
MUL_2546|M.ulcerans_Agy99 IDICVNNASAIN------------------------LGSITEVPMKRFDL
MSMEG_2885|M.smegmatis_MC2_155 IDILVNNAGFAD------------------------YSIIEDMPMDTFDR
TH_0319|M.thermoresistible__bu IDILVNNAGFAD------------------------YSMVEKMSLETFDR
MAV_3027|M.avium_104 IDILVNNAGFAD------------------------YSLVEDMSLETFDR
Mvan_2884|M.vanbaalenii_PYR-1 LDILVNNAGYAD------------------------YSIIEDMPMETFDR
Mflv_4556|M.gilvum_PYR-GCK VDILVNNAGFAD------------------------YSVVADMSMATFER
MMAR_1395|M.marinum_M ITILVNNAAFTAPGRPPVPGAAPRAKSSRTAVGKPGWPGFVSVPLAAYRR
MAB_2032|M.abscessus_ATCC_1997 IDVLVNNAGTHG------------------------AGLLLDIAPDYLEE
MLBr_01807|M.leprae_Br4923 VEVLVANAGITS------------------------DMLIMRMSEEQFQK
: : * **. . :.
Mb3251|M.bovis_AF2122/97 MNGIQVRGTYAVSQACIPHMKGRENPHILTLS--------PPILLEKKWL
Rv3224|M.tuberculosis_H37Rv MNGIQVRGTYAVSQACIPHMKGRENPHILTLS--------PPILLEKKWL
MUL_2546|M.ulcerans_Agy99 MNGIQVRGTYAVSQACIPHLKGRENPHILTLS--------PPVQLDKKWL
MSMEG_2885|M.smegmatis_MC2_155 TVEHYLRTPFVLTQAAVPHMRNQGAGWIVNIGSVTGLAPVRPYREYNKSS
TH_0319|M.thermoresistible__bu TVEHYLRTPFVLTQAAIPHMRAQGAGWIVNIGSVTGLPPIRPYRDYNKTS
MAV_3027|M.avium_104 TVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVTGVAPVRPYREYNKAS
Mvan_2884|M.vanbaalenii_PYR-1 TVEHYVRTPFVLTQKAVPHMRRQGAGWIVNIGSVTGLAPARPYRDYNKTS
Mflv_4556|M.gilvum_PYR-GCK TVEHYVRTPFVLTQAAVPHMKTQGQGWIVNIGSVTGLAPARPYREYNKTS
MMAR_1395|M.marinum_M HFETSVFAAYELMQLSCPDMIAAGAGSIINITSVASRLPGDGPYPDRSGG
MAB_2032|M.abscessus_ATCC_1997 TVATNLLGPIRMTKAVVAHMLGQRYGRIINIS---------SVAADKPDS
MLBr_01807|M.leprae_Br4923 VIDVNLTGVFRVAKLASRNMIKQRFGRYIFMG---------SVVGLSGVP
: : : .: : :
Mb3251|M.bovis_AF2122/97 RPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGG
Rv3224|M.tuberculosis_H37Rv RPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGG
MUL_2546|M.ulcerans_Agy99 KPTAYMMAKFGMTLCALGIAEEMRDEGIASNTLWPRTLVATAAVQNLLGG
MSMEG_2885|M.smegmatis_MC2_155 GDVIYASMKAALHRFTQGVAAELLDANIAVNAVGPSSAVRTPGAASLIP-
TH_0319|M.thermoresistible__bu GDVIYASLKAALHRFTQGVAAELLDSNIAVNAVGPSSAVRTPGAASLIP-
MAV_3027|M.avium_104 GDVVYAAMKAALHRFTQGVAAELLDANIAVNCVGPSTAVRTPGAAQLIP-
Mvan_2884|M.vanbaalenii_PYR-1 GDVVYASMKAALHRFTQGVAAELLDSNIAVNVVGPSSAVRTPGAASLIP-
Mflv_4556|M.gilvum_PYR-GCK GDVIYASMKAALHRFTQGVAAELLDADIAVNAVGPSSAVRTPGAAALIP-
MMAR_1395|M.marinum_M VLPGYGGSKAALEHLTQCAAFDLADHHIAVNALAPSKPIPTPGLSYYAR-
MAB_2032|M.abscessus_ATCC_1997 GQSTYAATKGGLESFTKAIAVEFASRNIISNAVAPG--VVYTDMAEITR-
MLBr_01807|M.leprae_Br4923 GQANYAASKSGLIGMARSLARELGSRSITANVVAPG--FIDTEMTRAMD-
* * .: : * :: * * : * . .
Mb3251|M.bovis_AF2122/97 DEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVY
Rv3224|M.tuberculosis_H37Rv DEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVY
MUL_2546|M.ulcerans_Agy99 EEAMGRARKPDVYADAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIY
MSMEG_2885|M.smegmatis_MC2_155 --DTFPTEPVEYLAETVLAMCHRPAAERTGLVAFSLHYPWSQGLAVHSLD
TH_0319|M.thermoresistible__bu --DTFPTEPVEYLAETVLAMCHRPAAERTGLVAFSLHYPWSQRIPVHTLD
MAV_3027|M.avium_104 --ESFPTEPVEYLAETVLAMCHLPAAERTGLVAFSLHYPWSQQLPVHSLD
Mvan_2884|M.vanbaalenii_PYR-1 --DTFPTEPVEYLAETVLAMCHLPAVERTGLVAFSLHYPWSHRLTVHSLD
Mflv_4556|M.gilvum_PYR-GCK --DSFPTEPVEYLAETVLAMCHRPAAERTGLVAFSLHYPWSQKLPVHSLD
MMAR_1395|M.marinum_M --EFDDTASAEEFARAAVVLASVDADLVTG-RTIGHHEVLDGSFRAFGRD
MAB_2032|M.abscessus_ATCC_1997 --THVPATFERLKAQILAKDFAKPEIVADAVLYLASPHNTYITGEVLHID
MLBr_01807|M.leprae_Br4923 -----SKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVD
. :
Mb3251|M.bovis_AF2122/97 DCVPGATLGVDLWVEDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv DCVPGATLGVDLWVEDANPPGYLPA
MUL_2546|M.ulcerans_Agy99 NCVPGAKLGVDLWVEEVNPPGYTQP
MSMEG_2885|M.smegmatis_MC2_155 GRDLLPPLEPPASANPNILPAGI--
TH_0319|M.thermoresistible__bu GREVLPPLEPPATANPNILPGGM--
MAV_3027|M.avium_104 GANLLPPLRPPANANPNILPAGV--
Mvan_2884|M.vanbaalenii_PYR-1 GTTTLPPLEPPANANPNILPLGL--
Mflv_4556|M.gilvum_PYR-GCK GATVLPPLEPPATANPNILPAGL--
MMAR_1395|M.marinum_M -------------------------
MAB_2032|M.abscessus_ATCC_1997 GGYKMK-------------------
MLBr_01807|M.leprae_Br4923 GGLGMGH------------------