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VKAVWRNWAREQYCAPSEIVRPASEAELAELVAKAGQRGERVRAVGSGHSFTDCACTDGVMVDMAGMQRI VNVDPEAGLATVEGGAKLRPLFSQLAEHGLALENQGDIDKQSITGATATATHGTGARFANVAAQIVALRL VTASGEVLELSEGDDYLAARVSIGALGVISQLTLKVVPLFTLHRDDELKPLAETLERLDEHVDNNDHFEF FVFPYAETALTRTTRRSEEPPMPVPEWRRRVGDQFENVGLGLVCRTGRQFPSTAPKLNRLLTSLMSPSSV QDRGWKVYPSPRNVKFTEMEYAIPRENAREAVRRVIEVVRRRDLPIMYPLEVRFSAPDDAFLSTAYERDT CYIAVHQYTGMEFETYFRAVEAIMDEYRGRPHWGKRHYQRAASLRERYPAWDRFTAVRDRLDPNRVFLND YTRRVLGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3124 | - | - | 100% (428) | oxidoreductase |
| M. ulcerans Agy99 | MUL_1431 | - | 8e-08 | 27.06% (170) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4485 | - | 4e-05 | 26.29% (175) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1800 | - | 0.0 | 75.00% (424) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1178 | - | 6e-08 | 25.82% (182) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1771 | - | 0.0 | 75.00% (424) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 3e-05 | 25.71% (175) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_0105c | - | 1e-92 | 42.48% (412) | oxidoreductase |
| M. marinum M | MMAR_2648 | - | 0.0 | 99.07% (428) | oxidoreductase |
| M. avium 104 | MAV_1405 | - | 8e-06 | 27.43% (175) | oxidoreductase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_6382 | - | 8e-09 | 25.82% (182) | oxidoreductase, FAD-binding |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5627 | - | 5e-13 | 21.93% (456) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1178|M.gilvum_PYR-GCK -----MSTGPQAVPSVTMLSTEFPTTAQRLTGWGRTAPSVAQVLSTPDPE
Mvan_5627|M.vanbaalenii_PYR-1 -----------------MLSTEFPTTARRLTGWGRTAPSVARVLATPDPE
MSMEG_6382|M.smegmatis_MC2_155 ---------MGAVPSLTMSTTEFPTTTKRLMGWGRTAPTVASVLSTSDPE
MUL_3124|M.ulcerans_Agy99 -------------------------MKAVWRNWAREQYCAPSEIVRPASE
MMAR_2648|M.marinum_M -------------------------MKTVWRNWAGEQYCAPSEIVRPASE
Mb1800|M.bovis_AF2122/97 -------------------------MSPIWSNWPGEQVCAPSAIVRPTSE
Rv1771|M.tuberculosis_H37Rv -------------------------MSPIWSNWPGEQVCAPSAIVRPTSE
MAB_0105c|M.abscessus_ATCC_199 ------------------------------------------MLVRPRSE
MLBr_01103|M.leprae_Br4923 MG--VLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRT
MAV_1405|M.avium_104 MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRT
: .
Mflv_1178|M.gilvum_PYR-GCK -VIVKAVTRAAENP---GRGVLARGLGRSYGDNAQNGGGLVIDMSSLDRI
Mvan_5627|M.vanbaalenii_PYR-1 -VIVKAVARAAESGKGGGRGVIARGLGRSYGDNAQNGGGLVVDMSVLNRI
MSMEG_6382|M.smegmatis_MC2_155 -VIVRAVTRAAEEG---GRGVIARGLGRSYGDNAQNGGGLVIDMPALNRI
MUL_3124|M.ulcerans_Agy99 AELAELVAKAGQRG----ERVRAVGSGHSFTDCACTDG-VMVDMAGMQRI
MMAR_2648|M.marinum_M AELAELVAKAGQRG----ERVRAVGSGHSFTDCACTDG-VMVDMAGMQRI
Mb1800|M.bovis_AF2122/97 AELADVIAQAAKRG----ERVRAVGSGHSFTDIACTDG-VMIDMTGLQRV
Rv1771|M.tuberculosis_H37Rv AELADVIAQAAKRG----ERVRAVGSGHSFTDIACTDG-VMIDMTGLQRV
MAB_0105c|M.abscessus_ATCC_199 DELAFALRRSAGR------TVRPIGSSHSFTQLCVTED-VQIDVSEMRRL
MLBr_01103|M.leprae_Br4923 DEVQTVLRWASANR----VPVVARGAGSGLSGGATALDDGIVLSTEKMRD
MAV_1405|M.avium_104 EEVQTVLRWASAHG----VPVVTRGAGSGLSGGATALDNGIVLSTEKMRD
: : :. * . * . . . . : . *
Mflv_1178|M.gilvum_PYR-GCK HSMDADSRLVDVDGGVNLDQLMRAALPLGLWVP-VLPGTRQVTIGGAIAC
Mvan_5627|M.vanbaalenii_PYR-1 HSMDSDSHLVDVDGGVNLDQLMRAALPLGLWVP-VLPGTRQVTVGGAIAC
MSMEG_6382|M.smegmatis_MC2_155 HSIDSGTRLVDVDAGVSLDQLMKAALPHGLWVP-VLPGTRQVTVGGAIGC
MUL_3124|M.ulcerans_Agy99 VNVDPEAGLATVEGGAKLRPLFSQLAEHGLALE-NQGDIDKQSITGATAT
MMAR_2648|M.marinum_M VNVDPEAGLATVEGGAKLRPLFSQLAEHGLALE-NQGDIDKQSITGATAT
Mb1800|M.bovis_AF2122/97 LDVDQPTGLVTVEGGAKLRALGPQLAQRRLGLE-NQGDVDPQSITGATAT
Rv1771|M.tuberculosis_H37Rv LDVDQPTGLVTVEGGAKLRALGPQLAQRRLGLE-NQGDVDPQSITGATAT
MAB_0105c|M.abscessus_ATCC_199 ISIDAQD-RVRVQAGISLHELNRTLLRHGLALP-NLGDIDVQTLAGAAAT
MLBr_01103|M.leprae_Br4923 ITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVAT
MAV_1405|M.avium_104 ITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIAT
:* . : * : * . :: * .
Mflv_1178|M.gilvum_PYR-GCK DIHGKNHHSAGSFGNHVRSIDLLTADGRVRTITPDGPESPLFWATVGGNG
Mvan_5627|M.vanbaalenii_PYR-1 DIHGKNHHSAGSFGNHVRSMDLLTADGEVRTLTPSGPDADLFWATVGGNG
MSMEG_6382|M.smegmatis_MC2_155 DIHGKNHHSAGSFGNHVRSMELLTANGEVRHLTPAGPDSDLFWATVGGNG
MUL_3124|M.ulcerans_Agy99 ATHGTGAR-FANVAAQIVALRLVTASGEVLELS----EGDDYLAARVSIG
MMAR_2648|M.marinum_M ATHGTGAR-FANVSAQIVALRLVTASGEVLELS----EGDDYLAARVSIG
Mb1800|M.bovis_AF2122/97 ATHGTGVR-FQNLSARIVSLRLVTAGGEVLSLS----EGDDYLAARVSLG
Rv1771|M.tuberculosis_H37Rv ATHGTGVR-FQNLSARIVSLRLVTAGGEVLSLS----EGDDYLAARVSLG
MAB_0105c|M.abscessus_ATCC_199 GTHGTGLK-FGNISQTILSMRIMTADGTIHELD----DGDALRAARISLG
MLBr_01103|M.leprae_Br4923 NAGGLCCVKYGVTGDYVLGIQVVLADGTAVRLG----GPRLKDVAGLSLT
MAV_1405|M.avium_104 NAGGLCCVKYGVTTDYVLGMQVVLADGTAVRLG----GPRLKDVAGLSLT
* : .: :: *.* : .: .
Mflv_1178|M.gilvum_PYR-GCK LTGIILRATIEMTPTETAYFIADGDVTSGLDETIAFHSDGTEDNYTYSSA
Mvan_5627|M.vanbaalenii_PYR-1 LTGIILRATIEMTPTETAYFIADGDVTSGLEETIAFHSDGTEDNYTYSSA
MSMEG_6382|M.smegmatis_MC2_155 LTGIILRATIEMTPTETAYFIADGDVTGSLDETIAFHSDGSEANYTYSSA
MUL_3124|M.ulcerans_Agy99 ALGVISQLTLKVVP---LFTLHRDDELKPLAETLERLDEHVDNNDHFEFF
MMAR_2648|M.marinum_M ALGVISQLTLKVVP---LFTLHRDDELKPLAETLERLDEHVDNNDHFEFF
Mb1800|M.bovis_AF2122/97 ALGVISQVTLQTVP---LFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFF
Rv1771|M.tuberculosis_H37Rv ALGVISQVTLQTVP---LFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFF
MAB_0105c|M.abscessus_ATCC_199 ALGVVTEFTLQCVP---AFRLHRSQSVHDLDTVLADLPTLLADTDHLELY
MLBr_01103|M.leprae_Br4923 KLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR
MAV_1405|M.avium_104 KLFVGSEGTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVTGR
: . *: . : : : :
Mflv_1178|M.gilvum_PYR-GCK WFDAISPPPKLGRAAISRGSLATVDQLPKKLQKNPLKFDAPQLLTFPDLF
Mvan_5627|M.vanbaalenii_PYR-1 WFDAISAPPKLGRAVISRGSLATVDQLPRKLQKNPLKFDAPQYFTAPEIF
MSMEG_6382|M.smegmatis_MC2_155 WFDAISKPPKLGRAAISRGSLAKLDQLPSKLQKDPLKFDAPQLLTLPDIF
MUL_3124|M.ulcerans_Agy99 VF------PYAETALTRTTRRSEEPPMPVPEWRRRVG-DQFENVGLGLVC
MMAR_2648|M.marinum_M VF------PYAETALTRTTRRSEEPPMPVPEWRRRVG-DQFENVGLGLVC
Mb1800|M.bovis_AF2122/97 VF------PYADKALTRTMHRSDEQPKPTPGWQRMVG-ENFENGGLSLIC
Rv1771|M.tuberculosis_H37Rv VF------PYADKALTRTMHRSDEQPKPTPGWQRMVG-ENFENGGLSLIC
MAB_0105c|M.abscessus_ATCC_199 LF------PHTRRVLLLQSTRTDEAPWPRNPVKHWVERDLVENGALGALM
MLBr_01103|M.leprae_Br4923 LR------PAMLEFMDSVAINAVEDTFRMGLDR----------EAAAMLV
MAV_1405|M.avium_104 LR------PSMLEFMDSVAINAVEDTLRMDLDR----------GAAAMLV
* : : :
Mflv_1178|M.gilvum_PYR-GCK PNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGA
Mvan_5627|M.vanbaalenii_PYR-1 PNGLGNKYTFGPMTEVWYRLGKTYRGKAQNLTQFYHPLDMVGDWNRAYGS
MSMEG_6382|M.smegmatis_MC2_155 PNGLANKFTFMPIGELWYRKSGTYRNKVQNLTQFYHPLDMFGEWNRAYGS
MUL_3124|M.ulcerans_Agy99 RTGRQFPSTAPKLNRLLTSLMSPSSVQDRGWKVYPSPRNVK---------
MMAR_2648|M.marinum_M RTGRQFPSTAPKLNRLLTSLMSPSSVQDRGWKVYPSPRNVK---------
Mb1800|M.bovis_AF2122/97 QTGRRFPSVAPRLNRLMTNMMSSSTVQDRAYKVFATQRKVR---------
Rv1771|M.tuberculosis_H37Rv QTGRRFPSVAPRLNRLMTNMMSSSTVQDRAYKVFATQRKVR---------
MAB_0105c|M.abscessus_ATCC_199 WTAGRLPAAAPRISKLVAALASSNESQDESAAVFASPRKVK---------
MLBr_01103|M.leprae_Br4923 AGSDELGHAGTDEAKLIGAVFAENGATQVSSTNDPDEGEAF---------
MAV_1405|M.avium_104 AGSDERGRAGSEDAEIMAKVFAENAATEVFSTDDPDEGEAF---------
. . .: .
Mflv_1178|M.gilvum_PYR-GCK AGFTQYQFVVP-TTAVDEFKAIIVDIQRSGFYSFLNVFKLFGPGNQAPLS
Mvan_5627|M.vanbaalenii_PYR-1 VGFAQYQFVVP-TEAVDEFKRIMYDIQRSGHYSFLNVFKLFGPGNDAPLS
MSMEG_6382|M.smegmatis_MC2_155 AGFLQYQFVVP-TEAVEEFKSIIVDIQRSGHYSFLNVFKLFGPGNQAPLS
MUL_3124|M.ulcerans_Agy99 --FTEMEYAIPRENAREAVRRVIEVVRRRDLPIMYPLEVRFSAPDDAFLS
MMAR_2648|M.marinum_M --FTEMEYAIPRENAREAVRRVIEVVRRRDLPIMYPLEVRFSAPDDAFLS
Mb1800|M.bovis_AF2122/97 --FTEMEYAIPRENGREALQRVIDLVRRRSLPIMFPIEVRFSAPDDSFLS
Rv1771|M.tuberculosis_H37Rv --FTEMEYAIPRENGREALQRVIDLVRRRSLPIMFPIEVRFSAPDDSFLS
MAB_0105c|M.abscessus_ATCC_199 --FTEMEYSLPLTNAREAIETALATIERDRHQVAFPLEVRFTQADDALLA
MLBr_01103|M.leprae_Br4923 --VAARRFCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNLMIS
MAV_1405|M.avium_104 --VVARRFCIPAVEAKGSLLLEDVGVPLPALGRLVTGIAAIAAERDLMIS
. .: :* . . : : : ::
Mflv_1178|M.gilvum_PYR-GCK --FPIPG-------WNVCVDFPITAGLNEFLNGLDKRVLQFGGRLYTAKD
Mvan_5627|M.vanbaalenii_PYR-1 --FPIPG-------WNVCVDFQINPGLNEFLNGLDKRVLEFGGRLYTAKD
MSMEG_6382|M.smegmatis_MC2_155 --FPIPG-------WNVCVDFPIKAGLHEFVTELDRRVLEFGGRLYTAKD
MUL_3124|M.ulcerans_Agy99 TAYERDT-------CYIAVHQYTGMEFETYFRAVEAIMDEYRGRPHWGKR
MMAR_2648|M.marinum_M TAYERDT-------CYIAVHQYTGMEFETYFRAVEAIMDEYGGRPHWGKR
Mb1800|M.bovis_AF2122/97 TAYGRDT-------CYIAVHQYAGMEFESYFRAVEEIMDDYAGRPHWGKR
Rv1771|M.tuberculosis_H37Rv TAYGRDT-------CYIAVHQYAGMEFESYFRAVEEIMDDYAGRPHWGKR
MAB_0105c|M.abscessus_ATCC_199 PAYGRES-------VYLAVHQTVHGSWESYFGGLEPILIGLGGRPHWGKR
MLBr_01103|M.leprae_Br4923 VIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDMAVGLGGTITGEHG
MAV_1405|M.avium_104 VIAHAGDGNTHPLIVYDPADADMTERAHLAFGEIMDLAVGLGGTITGEHG
.. . . : * :
Mflv_1178|M.gilvum_PYR-GCK SRTTAETFHAMYP---RIDEWIAVRRNVDPDGVFASDMARRLELL---
Mvan_5627|M.vanbaalenii_PYR-1 SRTTAETFHAMYP---RIDEWIALRRKVDPDGVFASDMARRLELL---
MSMEG_6382|M.smegmatis_MC2_155 SRTTAETFHAMYP---RIDEWIRIRRSVDPDGVFASDMARRLQLL---
MUL_3124|M.ulcerans_Agy99 HYQRAASLRERYP---AWDRFTAVRDRLDPNRVFLNDYTRRVLGA---
MMAR_2648|M.marinum_M HYQRAASLRERYP---AWDRFTAVRDRLDPNRVFLNDYTRRVLGA---
Mb1800|M.bovis_AF2122/97 HYQTAATLRERYP---QWDRFAAVRDRLDPDRVFLNDYTRRVLGP---
Rv1771|M.tuberculosis_H37Rv HYQTAATLRERYP---QWDRFAAVRDRLDPDRVFLNDYTRRVLGP---
MAB_0105c|M.abscessus_ATCC_199 HTLTAQQLSERYP---EWGTFQDIRARLDPGGTFSGGYLNRLLGPVSP
MLBr_01103|M.leprae_Br4923 VGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI--------
MAV_1405|M.avium_104 VGRLKRPWLAGYLGPEVMDLNRRIKQALDPQGILNPGSGI--------
* :: :** : .