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LAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSALGGKVLQPDDGPQFATAKQVFNTNYN GYTPAVIVTPTSQLDVQKAMAFAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVT VTPATGLYAMHQVLAAAGRGIPTGTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTAS ATDHPDLFWALRGGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALAD ATVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLAVGNLNPSPLGYVGGSD VFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVETSGSPSEA TSWLNTAHQAVRAYSVGGYVNYLEVNQPPARYFGPNLSRLSAVRQKYDPSRVMFSGLNF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0063 | - | - | 100% (479) | POSSIBLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv3351c | - | 3e-55 | 54.74% (190) | hypothetical protein Rv3351c |
| M. tuberculosis H37Rv | Rv3352c | - | 7e-47 | 71.54% (123) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0064 | - | 0.0 | 100.00% (479) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 8e-22 | 24.47% (425) | FAD linked oxidase domain-containing protein |
| M. leprae Br4923 | MLBr_01103 | - | 7e-07 | 27.62% (181) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 8e-53 | 30.18% (487) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_0110 | - | 0.0 | 84.94% (478) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 0.0 | 82.46% (479) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 6e-30 | 29.78% (450) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 2e-17 | 32.14% (168) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 1e-176 | 63.54% (480) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | 5e-30 | 37.27% (220) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0063|M.tuberculosis_H37Rv -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
Mb0064|M.bovis_AF2122/97 -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
MMAR_0110|M.marinum_M -----MAREISRQAFLRGAAGALAAG---AVFGSVRAAAEPNPSGWEGLS
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mvan_4048|M.vanbaalenii_PYR-1 -----------------------------MGGSHATAQPPPTQAALADLT
Mflv_4651|M.gilvum_PYR-GCK -------------------------------------MTVPTDLRRDEAL
MSMEG_1746|M.smegmatis_MC2_155 -------------------------------------MLQVHPTMVDELA
TH_1540|M.thermoresistible__bu -------------------------------------------------M
MLBr_01103|M.leprae_Br4923 ------------------------------------------MGVLTSLI
Rv0063|M.tuberculosis_H37Rv SALGGKVLQPDDGPQFATAKQVFNTNYNG-YTPAVIVTPTSQLDVQKAMA
Mb0064|M.bovis_AF2122/97 SALGGKVLQPDDGPQFATAKQVFNTNYNG-YTPAVIVTPTSQLDVQKAMA
MMAR_0110|M.marinum_M SALGGKVLRPDDGPQFATAKQVFNTNYND-FTPAAVVTPTSAADVQKAMA
MAV_0089|M.avium_104 TALGGKVLLPDS-PQFAGAKQVFNTNYNG-STPAAVVTPTSAADVQKAMA
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNN-SNPAAVVTVTSQADVEKAVA
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVRGDAAMDESGR-AFNPLFDV-NHPGAVAFCASDQDVARCVE
Mvan_4048|M.vanbaalenii_PYR-1 RTLRGSVIGPDG-GRFTELATPRNLRFAA-TMPRAVVLCADADDVAKTVL
Mflv_4651|M.gilvum_PYR-GCK RSLRDQVATPVALPGEPGYERCRPWNVVAPVEPAAVVLATSPEDVAGTVR
MSMEG_1746|M.smegmatis_MC2_155 MSMPERVHLPGS-PEYGDAVAIWNGAVTE--RPAAVVRPTSSGDVRNVVR
TH_1540|M.thermoresistible__bu AALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVR
MLBr_01103|M.leprae_Br4923 AGLPDGMVVTDSAVTDGYRHDRALDPSAG--KPLAVVQPRRTDEVQTVLR
: * .:. :* :
Rv0063|M.tuberculosis_H37Rv FAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTV
Mb0064|M.bovis_AF2122/97 FAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTV
MMAR_0110|M.marinum_M FATAHNLKVAPRSGGHSYIGASTANGAMVLDLRQLPGDINYDAATGQVTV
MAV_0089|M.avium_104 FAAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVTV
MUL_1431|M.ulcerans_Agy99 FAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
MAB_2456|M.abscessus_ATCC_1997 FATSARLPIAARGGGHSYAAYCIPNDGLVVDLARMAAVS---VTGTRAVV
Mvan_4048|M.vanbaalenii_PYR-1 WARNTGTSFAIRGGGHNYAEASSSRG-VIISTRQMTAATIDGATLRAHAG
Mflv_4651|M.gilvum_PYR-GCK FAAAHGFRVTVQATGHGAVGVG---PDTILIQTSAMRHVSVDVVNGTARV
MSMEG_1746|M.smegmatis_MC2_155 FAHEQRIPITVRAGGHDWGGRALNEGGLVIDLS-SMRKVYIDPAAREALV
TH_1540|M.thermoresistible__bu YAADNDLRIGVCSGGHSWAASHLRDGGMLLDVSRLDHCG-IDADRMVAVA
MLBr_01103|M.leprae_Br4923 WASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDITVDPVTRTAVC
:* . . * . ::
Rv0063|M.tuberculosis_H37Rv TPATGLYAMHQVLAAAGRGIPT--GTCPTVGVAGHALGGGLGANSRHAGL
Mb0064|M.bovis_AF2122/97 TPATGLYAMHQVLAAAGRGIPT--GTCPTVGVAGHALGGGLGANSRHAGL
MMAR_0110|M.marinum_M TPSTGLYEMHQVLAGAGRGIPT--GTCPSVGAAGHALGGGLGAHSRHAGL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPT--GTCPSVGAAGHALGGGMGAQSRHAGL
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPT--GSCPTVGVGGLALGGGMGADSRHAGL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAG--GSCPTVGIAGLTLGGGVGVLTRRFGL
Mvan_4048|M.vanbaalenii_PYR-1 VRNADLAALLPQGGGGRLLLPG--GNCPGVGVVGLTLGGGIGPNAPWAGL
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLC--GSAPGVGVIGYLTGGGIGPLVRTYGL
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAA--PNLADVGFTGFTLGGGYGPLNGIAGL
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPA--GHCEGICLGGYLLQGGYGWNSRVLGP
MLBr_01103|M.leprae_Br4923 QPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGV
: * .. * *
Rv0063|M.tuberculosis_H37Rv LCDQLTSASVVLPSGQAVTASATDHPDLF----WALRGGGGGNFGVTTSL
Mb0064|M.bovis_AF2122/97 LCDQLTSASVVLPSGQAVTASATDHPDLF----WALRGGGGGNFGVTTSL
MMAR_0110|M.marinum_M LCDALTSAAVVLPSGQAVTASAASNPDLF----WALRGGGGGNFGVTTSL
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTASTASNPDLF----WALRGGGGGNFGVTTSL
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASAEDHPDLF----WALRGGGGGNFGVTTAM
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSADTESDLF----WAIRGVGGGNFCIATEL
Mvan_4048|M.vanbaalenii_PYR-1 TADRLRKVTMVTAHGDVVTASPTENPDLF----WGLRGGAGGNFGVVTDL
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAPDENADLF----WGLRG-GKATLGIVTSA
MSMEG_1746|M.smegmatis_MC2_155 GVDNLLEAHVVLADGRSVTANAADEADLL----WALRG-GGANFGVVTHL
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDDETNADLF----WAARGSGPGFFAVVTSF
MLBr_01103|M.leprae_Br4923 TGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEV
: : :* * *: . . : : *
Rv0063|M.tuberculosis_H37Rv TFATFPS--GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGS---WALAD
Mb0064|M.bovis_AF2122/97 TFATFPS--GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGS---WALAD
MMAR_0110|M.marinum_M TFATFAT--KDLDAVNLDFPPESFAQVLLGWQQWLRTADRNN---WALAD
MAV_0089|M.avium_104 TFATFPT--KDVDAVNLNFPPQSFAQVLVGWQNWLRTADPNS---WALAD
MUL_1431|M.ulcerans_Agy99 TFETFPV--ADSDVVRVDFTPSSAAQVLAGWQTWLAAADRDT---WGLVD
MAB_2456|M.abscessus_ATCC_1997 AFETAAS--TDLTVFTLDYAAGEMAPIVHRWLTFMAGAPDEL---WTTLH
Mvan_4048|M.vanbaalenii_PYR-1 EYELVEVPVRRATTAELSVTGADAATRVALAFQQLRADAERI---VTGNL
Mflv_4651|M.gilvum_PYR-GCK EIDLLPVP--EFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQ
MSMEG_1746|M.smegmatis_MC2_155 RVRLHPVP--HLATGVLMFPWEQAADVMRRYDALAPSLPDGLT---AQIG
TH_1540|M.thermoresistible__bu HLRLHPRP-PVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIASR
MLBr_01103|M.leprae_Br4923 TLRLLPTQNTSSIVVATFASVQAAVDAVLGVAARLRPAMLEFMDSVAINA
.
Rv0063|M.tuberculosis_H37Rv ATVDP--LGTHCRILATCPAGSGGSVAAAIVSAVGTQPT-GTENHTFNYL
Mb0064|M.bovis_AF2122/97 ATVDP--LGTHCRILATCPAGSGGSVAAAIVSAVGTQPT-GTENHTFNYL
MMAR_0110|M.marinum_M ATVDQ--MGTHCRILATCPVGSGGSVASAITSAVGVQPI-GTDHHTFNYL
MAV_0089|M.avium_104 ATVDA--MGVHCRILATCPAGSGNSAAAAITQAVGIQPS-GVETHTFNYM
MUL_1431|M.ulcerans_Agy99 MSVSA--AQANCHVLATCPAGAGRGVADAIKSAVGAQPT-GIETKTFNHM
MAB_2456|M.abscessus_ATCC_1997 AIGGA--IPQCRIVGCVAQGVNSQDVIESLRGGIGVRAA-DSFIAEMTFL
Mvan_4048|M.vanbaalenii_PYR-1 YLGHA--AGDVEAALTTQLLVDEADARDLLAPLTAIPGL-TAEITEQPWW
Mflv_4651|M.gilvum_PYR-GCK LPPLP--EVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTV
MSMEG_1746|M.smegmatis_MC2_155 VIPAP--DGGPVVFVAPYWVGDPDEGDRWVAELRRLGTPVVDQVAPMSPS
TH_1540|M.thermoresistible__bu DLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIKIPYAT
MLBr_01103|M.leprae_Br4923 VEDTFR-MGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQVSS
Rv0063|M.tuberculosis_H37Rv DLVRYLAVGNLNPSPLGYVGGSD-----------VFTTITPATAQGIASA
Mb0064|M.bovis_AF2122/97 DLVRYLAVGNLNPSPLGYVGGSD-----------VFTTITPATAQGIASA
MMAR_0110|M.marinum_M DLVRYLAVGNLNPAPLGYVGGSD-----------VLPTINAGAAKGIASA
MAV_0089|M.avium_104 DLVNYLAVGNLNPQPLGYVGGSD-----------VFPTVNAAVAQGIAAA
MUL_1431|M.ulcerans_Agy99 ELVKYLAGGSSASSPRGFVAGSD-----------VIGTVNSAAAQAIVAA
MAB_2456|M.abscessus_ATCC_1997 DAMKFMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTAR
Mvan_4048|M.vanbaalenii_PYR-1 GAYAWYVTPPSPAYPFWDRSLYAD--------QFLSGDALAAALEVVRRF
Mflv_4651|M.gilvum_PYR-GCK GVLPYAAIGAVHADPVDPMPINED---------QALLRELPPEAVEALLA
MSMEG_1746|M.smegmatis_MC2_155 AQLRLLDPLVPRGRHYEMR---------------TVNVDTLSPGVIDALV
TH_1540|M.thermoresistible__bu TDLAGWYGAIMTNYPTGHRYATDN----------MWTSASPEALLPGIHR
MLBr_01103|M.leprae_Br4923 TNDPDEGEAFVAARR-------------------FCIPAVESKGSLLLED
Rv0063|M.tuberculosis_H37Rv VDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVETS--
Mb0064|M.bovis_AF2122/97 VDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVETS--
MMAR_0110|M.marinum_M IDAFPRGAGRALAIMHALDGALATVAPGATAFPWRRQSALVQWYVETP--
MAV_0089|M.avium_104 VNAFPRNAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVETS--
MUL_1431|M.ulcerans_Agy99 VGKSPPASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSS
MAB_2456|M.abscessus_ATCC_1997 IETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG--
Mvan_4048|M.vanbaalenii_PYR-1 PAGNDPERYGALGLYGWVGGAVNDVAPDATAYVHRTARILVEMSSGWSPA
Mflv_4651|M.gilvum_PYR-GCK AAGPESGSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAP-
MSMEG_1746|M.smegmatis_MC2_155 AAGSSRTSPASVLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDAD
TH_1540|M.thermoresistible__bu IIETLPPAPSHFLMFNWSP-----TSTRDNLFYGLEADFNLALYAVWN--
MLBr_01103|M.leprae_Br4923 VGVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADAT-
:
Rv0063|M.tuberculosis_H37Rv -------GSPSEATSWLNTAHQAVRAYS-VGGYVNYLEVNQP--PARYFG
Mb0064|M.bovis_AF2122/97 -------GSPSEATSWLNTAHQAVRAYS-VGGYVNYLEVNQP--PARYFG
MMAR_0110|M.marinum_M -------GSPAAASGWLNTAHQAVQPYS-AGGYVNYLEANQP--ASRYFG
MAV_0089|M.avium_104 -------GDPAAATNWLASAHQAVQQYS-VGGYVNYLEANQS--PARYFG
MUL_1431|M.ulcerans_Agy99 -------GQTAAATKWINSAHQAVQQFS-VGGYVNYLEANTA--LSRYFG
MAB_2456|M.abscessus_ATCC_1997 -------ADPAVAHERVSQARDGLGDICGPAAYVNYIDPGMPDWATAYYG
Mvan_4048|M.vanbaalenii_PYR-1 PSGAPVAPIPPDIRDWEDELWETVLPHTTGRSYQNFPDPELADWPRAYYG
Mflv_4651|M.gilvum_PYR-GCK -------EIADMVIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYT
MSMEG_1746|M.smegmatis_MC2_155 SD-----DDGERHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAYG
TH_1540|M.thermoresistible__bu --------DPEDDERFSAWPGTNMAALAHLAMGVGLADENLGRRPARFAT
MLBr_01103|M.leprae_Br4923 --------MTERAHRAFGEIMDMAVGLGGTITGEHGVGRLKRPWLDDYLG
Rv0063|M.tuberculosis_H37Rv PN-LSRLSAVRQKYDPSRVMFSGLNF------
Mb0064|M.bovis_AF2122/97 PN-LSRLSAVRQKYDPSRVMFSGLNF------
MMAR_0110|M.marinum_M PN-LSRLSAVRQKYDPGRVMFSGLNL------
MAV_0089|M.avium_104 PN-LSRLSAVRQKYDPGRVMFSGLNY------
MUL_1431|M.ulcerans_Agy99 SN-LSRLTQIRQRYDPSRLMYSGLNF------
MAB_2456|M.abscessus_ATCC_1997 DN-LPRLRGIAAAYDPKGIFRFAQAVRP----
Mvan_4048|M.vanbaalenii_PYR-1 AN-LDRLTRVKATWDPEDVFRYPQGIPPR---
Mflv_4651|M.gilvum_PYR-GCK DDTLHWLAGLADRYDPARTLATGQVIRTVV--
MSMEG_1746|M.smegmatis_MC2_155 PN-AERLLAAKDRWDAGNVFTAIPLPSRSSTS
TH_1540|M.thermoresistible__bu DANMARLDGIRARRDPAGRFHGWMGRV-----
MLBr_01103|M.leprae_Br4923 PDVMELNQRIKHALDPYGILNPGAAI------
*. :