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STVLPSGPSPVVHHPLARAAAYLIGPRGLRGTERLRSEVAGKIVVITGASYGLGAATAELFAQAGAQVVL AARSLEQLRLVAAGIAEKGGEAAVYRLDLTSEESITEFTEAVLHDFGEVDYLIHNAGKSLRRSIHLSYDR PKDVNATSGANYVGPMRLTLALLPGMRARGSGHIVNVSTVGVMFGVVPKWGFYLSSKAAFDIWMRAVGME ARGDGVTLTTFYAGLMHTRMSAPSRWMRLLPGQTPLDAAKVLARAVVDKPRTLTPAYGHPFAILAPVLRF PLEPILGFVYRRLGDTQASLARVTAGQSTTTRIDAPERIGVHAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2540c | - | - | 100% (325) | putative Short-chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_3710 | - | 9e-41 | 38.91% (239) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2943c | - | 4e-39 | 39.92% (243) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1570 | - | 6e-49 | 40.41% (292) | fatty acyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 4e-42 | 41.30% (230) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1543 | - | 6e-49 | 40.41% (292) | fatty acyl-CoA reductase |
| M. leprae Br4923 | MLBr_01094 | - | 9e-21 | 29.36% (235) | short chain alcohol dehydrogenase |
| M. marinum M | MMAR_0295 | - | 7e-62 | 45.45% (275) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5221 | - | 7e-63 | 44.77% (277) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_1623 | - | 2e-39 | 40.43% (230) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 4e-20 | 33.82% (207) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4828 | - | 5e-62 | 45.45% (275) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_1527 | - | 1e-39 | 40.00% (230) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4896|M.gilvum_PYR-GCK MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRRGSLGRFERLARDWDD
Mvan_1527|M.vanbaalenii_PYR-1 ----------------MTRLLSDPGTAAVHVLVRRDSLGRFERLALNWDD
MSMEG_1623|M.smegmatis_MC2_155 MRYVVTGGTGFIGRRVVSEILVRDASAEVWVLVRRESLNRFEHLALDWGE
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RVHALVGDLTDPDLGLTDATVAELGPVDHVVHCAAIYDMTAPENRQRAAN
Mvan_1527|M.vanbaalenii_PYR-1 RVQPLVGELTVPGLGTSDVTVAELGRIDHVVHCAAVYDITAPEDRQRAAN
MSMEG_1623|M.smegmatis_MC2_155 RAKPLVGDLRADDLGLTGADVADLGDVTHVVHCAAIYDITVDEAAQRAAN
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK VEGTRAVIALSRRLGATLHHVSSIAVAGTHPGVFTEDDVDVGQELPTPYH
Mvan_1527|M.vanbaalenii_PYR-1 VDGTGAVVALSRRLGATLHHVSSIAVAGTYRGVFTEDDFDVAQDLPTPYH
MSMEG_1623|M.smegmatis_MC2_155 VDGTRAVIALARRLEATLHHVSSIAVAGNHRGVFTEDDFDVAQDLPTPYH
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK RTKFEAEQLVRAADGLRFRIYRPAVVVGDSRTGEIDKIDGPYYFFGVLSA
Mvan_1527|M.vanbaalenii_PYR-1 RTKFEAELLVRSAEGLRFRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLSA
MSMEG_1623|M.smegmatis_MC2_155 QTKFEAEMLVRATTDVPHRIYRPAVVVGDSRTGEMDKIDGPYYFFGVLAR
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK LAALPRFTPMMLPDVGRTNLVPVDFVVDALDVLMHADGRDGQTFHLTAPK
Mvan_1527|M.vanbaalenii_PYR-1 LAALPGFTPMLLPDVGRTNIVPVDFVVEAVAALMHVDGRDGQTFHLTAPK
MSMEG_1623|M.smegmatis_MC2_155 LAALPRFTPMALPDTGRTNVVPVDFVAKALVHLMHVEGADGQTFHLTAPN
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK NTGLRGIYRGVARAAGLPPLVGVLPRAAAAPLLQVSGRAKAIRNMAATQL
Mvan_1527|M.vanbaalenii_PYR-1 TTGLRGIYRGIAAAAGLPPLVGSLPRATAAPLLHVTGRAKVLRNMVATQL
MSMEG_1623|M.smegmatis_MC2_155 TVGLVDIYRGVAGAAGLPPLRAKLPRVTAAPVLDARGRARIVRNMVATQL
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1570|M.bovis_AF2122/97 --------------------------------------------------
Rv1543|M.tuberculosis_H37Rv --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK GIPGEVLDVVELAPTFTSERTDEALCDSGISVPEFASYAPGLWRYWAEHL
Mvan_1527|M.vanbaalenii_PYR-1 GIPAEILDIVELAPTFTSEHTDEALRGTGISVPEFASYAPALWRYWAQHL
MSMEG_1623|M.smegmatis_MC2_155 GIPGEVFDVAELRPTFTADNTDTALRGTGIAVPEFASYAPQLFRYWAEHL
MMAR_0295|M.marinum_M ------------------------MNLATQALAKAFERASNGLANPATLA
MUL_4828|M.ulcerans_Agy99 ------------------------MNLATQALAKAFERASNGLANPATLA
MAV_5221|M.avium_104 ------------MVQAARTNAAAKVNAIAQALDKVLNTVADRVANPARVS
MAB_2540c|M.abscessus_ATCC_199 -------------------MSTVLPSGPSPVVHHPLARAAAYLIGPRGLR
Mb1570|M.bovis_AF2122/97 --------MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAV
Rv1543|M.tuberculosis_H37Rv --------MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAV
TH_3707|M.thermoresistible__bu --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mflv_4896|M.gilvum_PYR-GCK DPNRARQDDPAGPLVGRHVVITGASSGIGRASAVAVAARGATVFALARNA
Mvan_1527|M.vanbaalenii_PYR-1 DPDRARRDDPAGPLVGKHVIITGASSGIGRAAAIAVAARGATVFALARNA
MSMEG_1623|M.smegmatis_MC2_155 DPDRARRCDPAGPLVGRHVIITGASSGIGRASAIAVARRGAVVFALARNG
MMAR_0295|M.marinum_M DPDRLR-----GAVTGKTALVTGASYGIGEATARKLAAAGATVLMVARSA
MUL_4828|M.ulcerans_Agy99 DPDRLR-----GAVTGKTALVTGASYGIGEATARKLAAAGATVLMVARSA
MAV_5221|M.avium_104 DPDRLR-----GAVGGRTVLVTGASYGIGEATARRLAAAGATVLVVARSE
MAB_2540c|M.abscessus_ATCC_199 GTERLR-----SEVAGKIVVITGASYGLGAATAELFAQAGAQVVLAARSL
Mb1570|M.bovis_AF2122/97 QGRNLN-----DAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTL
Rv1543|M.tuberculosis_H37Rv QGRNLN-----DAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTL
TH_3707|M.thermoresistible__bu ------------------------------VRADGRADQG----------
MLBr_01094|M.leprae_Br4923 ----------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDG
. * * *
Mflv_4896|M.gilvum_PYR-GCK EALDDL---IAEIRESGGDAHAFTCDVTDPSAVEHTVKDILGRFGHVDYL
Mvan_1527|M.vanbaalenii_PYR-1 EALDDL---IAEIRAAGGDAHAFTCDVTDSAAVEHTVKDILGRFDHVDYL
MSMEG_1623|M.smegmatis_MC2_155 EALDEL---IAEIRADGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYL
MMAR_0295|M.marinum_M ERLEDL---VSAIAAGGGAAVAYPTDLTDEAAVGVLTKQVNQNHGPLDIV
MUL_4828|M.ulcerans_Agy99 ERLEDL---VSAIAAGGGAAVAYPTDLTDEAAVGVLTKQVNQNHGPLDIV
MAV_5221|M.avium_104 ERLGEL---TAAINAGGGRAVAYPTDLTDESAVSALTKQITEEHGPLDVV
MAB_2540c|M.abscessus_ATCC_199 EQLRLV---AAGIAEKGGEAAVYRLDLTSEESITEFTEAVLHDFGEVDYL
Mb1570|M.bovis_AF2122/97 ENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGVDIL
Rv1543|M.tuberculosis_H37Rv ENLENVANDIRAIRGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGVDIL
TH_3707|M.thermoresistible__bu ---------LDAARX-GGTGRALACDLTDLDAIDELVLKIEQDLGGVDIL
MLBr_01094|M.leprae_Br4923 EGLAQT---EGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQI
*. . . *::. :. . : . :: :
Mflv_4896|M.gilvum_PYR-GCK VNNAGRSIRRSVTASTDRFHDYERVMAVNYFGAVRMVLALLPHWRERRFG
Mvan_1527|M.vanbaalenii_PYR-1 VNNAGRSIRRSVAASTDRLHDYERVMAVNYFGSVRMVLALLPHWRERRFG
MSMEG_1623|M.smegmatis_MC2_155 VNNAGRSIRRSVANSTDRLHDYERVMAVNYFGAVRMVLALLPHWRERRFG
MMAR_0295|M.marinum_M VSNAGKSLRRSLHDQYDRPHDFQRTIDINYLGPIWLLLGLLPAMRESGRG
MUL_4828|M.ulcerans_Agy99 VSNAGKSLRRSLHDQYDRPHDFQRTIDINYLGPIWLLLGLLPAMRESGRG
MAV_5221|M.avium_104 VSNAGKSLRRSLHHQYDRPHDFQRTIDVNYLGPVRLLLGLLPAMRDNGRG
MAB_2540c|M.abscessus_ATCC_199 IHNAGKSLRRSIHLSYDRPKDVNATSGANYVGPMRLTLALLPGMRARGSG
Mb1570|M.bovis_AF2122/97 INNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERHFG
Rv1543|M.tuberculosis_H37Rv INNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERHFG
TH_3707|M.thermoresistible__bu INNAGKSIRRPLAESLERWHDVERTMNLNYYAPLRLIRGLAPGMRET-WG
MLBr_01094|M.leprae_Br4923 YNNAGIAFTGDVEVSH--FKDIERVMDVDYWGVVNGTKAFLPYLISSGDG
*** :: : . :* : . :* . : : * *
Mflv_4896|M.gilvum_PYR-GCK HVVNVSSAGVQAN-NPRYSAYIPSKAALDAFSEVVGAETLSDH--ITFTN
Mvan_1527|M.vanbaalenii_PYR-1 HVVNVSSAGVQAN-NPRYSAYIPSKAALDAFAEVVGTETLSDH--ITFTN
MSMEG_1623|M.smegmatis_MC2_155 HVVNVSSAGVQAH-TPKYSAYLPSKAALDAFSDVVSTETLSDH--ITFTN
MMAR_0295|M.marinum_M HVVNVSSVGVRLVPGPQWGAYQASKGAFDRWLRSVAPELHGDG--VDVTS
MUL_4828|M.ulcerans_Agy99 HVVNVSSVGVRLVPGPQWGAYQASKGAFDRWLRSVAPELHGDG--VDVTS
MAV_5221|M.avium_104 HVVNVSSVGVRVVPGPQWGAYQASKGAFDRWLRSVAPELHADG--VHVST
MAB_2540c|M.abscessus_ATCC_199 HIVNVSTVGVMFGVVPKWGFYLSSKAAFDIWMRAVGMEARGDG--VTLTT
Mb1570|M.bovis_AF2122/97 HIVNVSSVGVQTR-APRFGAYIASKAALDSLCDALQAETVHDN--VRFTT
Rv1543|M.tuberculosis_H37Rv HIVNVSSVGVQTR-APRFGAYIASKAALDSLCDALQAETVHDN--VRFTT
TH_3707|M.thermoresistible__bu VLSEAS---------PLFSVYNASKAALTAVSRVVETEWSQFG--VHSTT
MLBr_01094|M.leprae_Br4923 HVINISSVFGLFS-VPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTT
: : * * . * .:* *. : * : :.
Mflv_4896|M.gilvum_PYR-GCK IHMPLVKTPMIAPSGRLNPAPAISPEHAAAMVVRALVDKPARIDTPIGTV
Mvan_1527|M.vanbaalenii_PYR-1 IHMPLVRTPMIAPSGRLNPAPAISAEHAAAMVVRALVDKPARIDTPIGTL
MSMEG_1623|M.smegmatis_MC2_155 IHMPLVKTPMIAPSRRLNPVPPISAEHAAAMVVRALVEKPPRIDTPLGTF
MMAR_0295|M.marinum_M VYFALVRTRMIEPTPMLGRLPGLEPDQAADAVAKAIVERPRTNEPPWLWP
MUL_4828|M.ulcerans_Agy99 VYFALVRTRMIEPTPMLGRLPGLEPDQAADAVAKAIVERPRTNEPPWLWP
MAV_5221|M.avium_104 VYFALVRTRMIAPTPVLGRLPGLSPDQAADVIAKAVIERPRTLEPPWVLP
MAB_2540c|M.abscessus_ATCC_199 FYAGLMHTRMSAPSRWMRLLPGQTPLDAAKVLARAVVDKPRTLTPAYGHP
Mb1570|M.bovis_AF2122/97 VHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQF
Rv1543|M.tuberculosis_H37Rv VHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQF
TH_3707|M.thermoresistible__bu LFYPLVKTPMIAPTREYDNLPALSAEEAADWMISAARYRPIQIAPRMAVT
MLBr_01094|M.leprae_Br4923 VYPGGIKTAIARNATAAEGLDVS--KIASRFDTWVAHTSPQHAARIILKA
.. ::* : : *: . *
Mflv_4896|M.gilvum_PYR-GCK ADLGMYLTPKLARRVLHQLYLGFPDSAAAQGIAENDRVHSATRTP---ER
Mvan_1527|M.vanbaalenii_PYR-1 ADVGMYFTPKLARRVLHQLYLGFPDSAAARGITQ-DRSR-PRQAP---VR
MSMEG_1623|M.smegmatis_MC2_155 ADFGNYLTPRVARRFLHQLYLGYPDSAAARGLAPAEPRPASTAGPGLPER
MMAR_0295|M.marinum_M AELASVLLAGPAEQAARVWHRRFFAPTAEAGKS-----------------
MUL_4828|M.ulcerans_Agy99 AELASVLLAGPAEQAARVWHRRFFAPTAEAGKS-----------------
MAV_5221|M.avium_104 AELASVLLAGPADRAARLWHRRFFTDAEEAGRER----------------
MAB_2540c|M.abscessus_ATCC_199 FAILAPVLRFPLEPILGFVYRRLGDTQASLARVTAGQSTTTRIDAP----
Mb1570|M.bovis_AF2122/97 AAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSE----
Rv1543|M.tuberculosis_H37Rv AAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSE----
TH_3707|M.thermoresistible__bu ARALNVVAPGVVNAVMKR-----------------------QRIQP----
MLBr_01094|M.leprae_Br4923 VRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR-----
Mflv_4896|M.gilvum_PYR-GCK KPWPPRRPVPSVRIP----SAVKQAIRLVPGVHW
Mvan_1527|M.vanbaalenii_PYR-1 RPKRPSRPMPSVRVP----GPVKRAARLLPGLHW
MSMEG_1623|M.smegmatis_MC2_155 RPKRPARSRRGVRVPRAVGRPVKRAVRTLPGVHW
MMAR_0295|M.marinum_M ----------------------------------
MUL_4828|M.ulcerans_Agy99 ----------------------------------
MAV_5221|M.avium_104 ----------------------------------
MAB_2540c|M.abscessus_ATCC_199 -----------------------ERIGVHAE---
Mb1570|M.bovis_AF2122/97 -----------------------TFVRATRGIHW
Rv1543|M.tuberculosis_H37Rv -----------------------TFVRATRGIHW
TH_3707|M.thermoresistible__bu -----------------------VFV--------
MLBr_01094|M.leprae_Br4923 ----------------------------------