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SFVITAPEALTAAATDLASLGSTIGAANAAAVAPTTAVLAAGADEVSAAVAAMFDAQGQAYQLLSARAAA FHEQFLQALSGGGASYAAGEAAAVSPLLDAINAPVLADTGRPLIGNGANGGAAGWLIGNGGAGGSGTPGT ASVAGGNGGNGGAGGLLFGTGGAGGAGGTASSLVGAIPGGNGGYGGDGGLLFGRGGAGGAGGFGNNTTGG IGGLGGAGGLFGAGGDGGVGGFGTFAGNGGDGGTGLFAAGGDSGAGGDSVGGADGGDGGNGGKAGLVGQG GDGGAGGNNNSGFGTGGSGGKGGDAVLIGNGGNGGNAGSGGVGPGIAGAAGIGGLLIGEDGMAGLTP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0570 | - | - | 100% (348) | PE_PGRS family protein |
M. ulcerans Agy99 | MUL_3056 | - | 4e-95 | 52.01% (398) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_4524 | - | 4e-94 | 50.12% (423) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0286c | PE_PGRS3 | 1e-106 | 56.74% (393) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-53 | 51.07% (233) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1759c | wag22 | 1e-110 | 57.80% (391) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-11 | 37.36% (91) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-29 | 38.15% (270) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_0608 | - | 1e-160 | 82.87% (356) | PE-PGRS family protein |
M. avium 104 | MAV_1346 | - | 3e-22 | 35.85% (265) | PE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 7e-45 | 37.68% (345) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_4332 | - | 8e-37 | 33.24% (373) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-53 | 52.30% (239) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------------------------------- Mb0286c|M.bovis_AF2122/97 -------------------------------------------------- Rv1759c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------------------------------- Mb0286c|M.bovis_AF2122/97 -------------------------------------------------- Rv1759c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------------------------------- Mb0286c|M.bovis_AF2122/97 -------------------------------------------------- Rv1759c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------------------------------- Mb0286c|M.bovis_AF2122/97 -------------------------------------------------- Rv1759c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 ------------------------------------MSFVITAPEALTAA MMAR_0608|M.marinum_M ------------------------------------MSFVITAPEALTAA Mb0286c|M.bovis_AF2122/97 ------------------------------------MSFVIAAPEVIAAA Rv1759c|M.tuberculosis_H37Rv ------------------------------------MSFVIAVPETIAAA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -----------------------------------MPLFLNAEPQALTAA MAV_1346|M.avium_104 -----------------------------------MS-FVTTRPEALLAV MUL_0570|M.ulcerans_Agy99 ATDLASLGSTIGAANAAAVAPTTAVLAAGADEVSAAVAAMFDAQGQAYQL MMAR_0608|M.marinum_M ATDLASLGSTIGAANAAAVAPTTAVLAAGADEVSAAVAALFDAQGQAYQL Mb0286c|M.bovis_AF2122/97 ATDLASLGSSISAANAAAAANTTALMAAGADEVSTAIAALFGAHGQAYQA Rv1759c|M.tuberculosis_H37Rv ATDLADLGSTIAGANAAAAANTTSLLAAGADEISAAIAALFGAHGRAYQA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_4332|M.thermoresistible__bu ---------MPFITSGAAFVGGAAMLLAGPGGVSALEAAGSAPR------ MAB_4284c|M.abscessus_ATCC_199 ---MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPV MLBr_01183|M.leprae_Br4923 ANTLEGLSAATVASNAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQA MAV_1346|M.avium_104 ASMLEGLGSSMDAQNAAAAAPTTSIAPAAADEVSALQAAQFSAYGTWYQQ . . . MUL_0570|M.ulcerans_Agy99 LSARAAAFHEQFLQALSGGGASYAAGEAAAVSPLLDAINAPVLADTGRPL MMAR_0608|M.marinum_M LSARAATFHEQFLQALSGGGASYAAAEAAAVSPLLDAINAPVLAATGRPL Mb0286c|M.bovis_AF2122/97 LSAQAQAFHAQFVQALTSGGGAYAAAEAAAVSPLLDPINEFFLANTGRPL Rv1759c|M.tuberculosis_H37Rv ASAEAAAFHGRFVQALTTGGGAYAAAEAAAVTPLLNSINAPVLAATGRPL Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG----------APGV Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG----------APGV MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG--------TGGT TH_4332|M.thermoresistible__bu ----------------------------------------------TVEY MAB_4284c|M.abscessus_ATCC_199 VAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPD--------GPSI MLBr_01183|M.leprae_Br4923 HASQGATNHQDLIQSLLTSSSAYAGTETAN-------------------- MAV_1346|M.avium_104 VSAQAKAIHQTLVQNLDTNADSYGATEAANRVNTSAAALQGLAPNVIPNA MUL_0570|M.ulcerans_Agy99 IGNGAN--------GGAAGWLIGNGGAGGSGTPGTASVAGGNG------- MMAR_0608|M.marinum_M IGNGANGAPGTGADGGAAGWLIGNGGAGGSGTPGTASVAGGNG------- Mb0286c|M.bovis_AF2122/97 IGNGANGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG---- Rv1759c|M.tuberculosis_H37Rv IGNGANGAPGTGANGGDAGWLIGNGGAGGSGAKGANGGAGGPGGAA---- Mflv_5091|M.gilvum_PYR-GCK AGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------- Mvan_1264|M.vanbaalenii_PYR-1 AGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------- MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV TH_4332|M.thermoresistible__bu EYSLVACDSTLPLMCEAGDSVGGLGGASHDRSAFSASALGMAS------- MAB_4284c|M.abscessus_ATCC_199 LSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFN------ MLBr_01183|M.leprae_Br4923 ----------HDSL------------------------------------ MAV_1346|M.avium_104 APAADPPPAGTTSLGTSIGWAQNVGAAASDFITLGEGQFAPVPGAAG--- MUL_0570|M.ulcerans_Agy99 ------------GNGGAGG------------------------------- MMAR_0608|M.marinum_M ------------GNGGAGG------------------------------- Mb0286c|M.bovis_AF2122/97 ---------GLIGNGGAGGAGGVASS------------------------ Rv1759c|M.tuberculosis_H37Rv ---------GLFGNGGAGGAGGTATANN---------------------- Mflv_5091|M.gilvum_PYR-GCK -------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-------- Mvan_1264|M.vanbaalenii_PYR-1 -------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-------- MSMEG_0868|M.smegmatis_MC2_155 LIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGA TH_4332|M.thermoresistible__bu --------FGPDWNPGGAFLG----------------------------- MAB_4284c|M.abscessus_ATCC_199 --------RGPLLDLSFGDLQ----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ---------IPNFNPGLTAATTAGPP------------------------ MUL_0570|M.ulcerans_Agy99 --------------------LLFGTGGAGGAGGTASSLVGAIP------- MMAR_0608|M.marinum_M --------------------LLFGTGGAGGAGGTASSLVGAIP------- Mb0286c|M.bovis_AF2122/97 --------GIGGSGGAGGNAMLFGAGGAGGAGGGVVALTGGAG--GFTNG Rv1759c|M.tuberculosis_H37Rv --------GIGGAGGAGGSAMLFGAGGAGGAGGAATSLVGGIGGTGGTGG Mflv_5091|M.gilvum_PYR-GCK --------AVGAAGAAG------TVGTAGATGGTG--------------- Mvan_1264|M.vanbaalenii_PYR-1 --------AIGTAGVAG------AAGTAGATGGTG--------------- MSMEG_0868|M.smegmatis_MC2_155 NGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGS------ TH_4332|M.thermoresistible__bu -----------------------LIGPGGLLIGDG--------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------FGNRDTTAIGDG--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----------------------APAAPAAAAGAP--------------- MUL_0570|M.ulcerans_Agy99 ----------------------GGNGGYGGDG------------------ MMAR_0608|M.marinum_M ----------------------GGNGGYGGDG------------------ Mb0286c|M.bovis_AF2122/97 -------------------SALGGAGGAGGAGGLFATGGVGGSGGAGSSG Rv1759c|M.tuberculosis_H37Rv NAGMLAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGHTG Mflv_5091|M.gilvum_PYR-GCK ---------------------TGANGGAGGVGGVGGTGAAG--------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------VGGNGGAGQAGGIGGTGAAG--------- MSMEG_0868|M.smegmatis_MC2_155 ---------------TAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNG TH_4332|M.thermoresistible__bu ---------------------LNGTDAYIDENGVFHEATRG--------- MAB_4284c|M.abscessus_ATCC_199 ------------------AVAVGGSNSGPIASGQGSTAVNG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 --------------------VLASMGRGPSIGGLSVPPSWAP-------- MUL_0570|M.ulcerans_Agy99 ----------GLLFGRGGAGGAGGFGNN---TTGGIGGLGGAGGLFGAGG MMAR_0608|M.marinum_M ----------GLLFGRGGAGGAGGFGNN---TTGGIGGLGGAGGLFGAGG Mb0286c|M.bovis_AF2122/97 GAG--GAGGAGGLFGAGGTGGHGGFADS---SFGGVGGAGGAGGLFGAGG Rv1759c|M.tuberculosis_H37Rv GAG--GAGGAGGLFGAGGMGGAGGFGDHGTLGTGGAGGDGGGGGLFGAGG Mflv_5091|M.gilvum_PYR-GCK -----AAGGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGA Mvan_1264|M.vanbaalenii_PYR-1 -----AAGQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGG MSMEG_0868|M.smegmatis_MC2_155 AVSGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATG TH_4332|M.thermoresistible__bu -------------GNGGLLWGNGGKGGN--GLDAGLYTVPDPDNPGSTIQ MAB_4284c|M.abscessus_ATCC_199 -------DVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ----------GGVAPAANATPAQLVGAGFTSAAPDTAPVTAVPGGVPSMA MUL_0570|M.ulcerans_Agy99 DGGVGG--------------------------FGTFAGNGGDGGTG---- MMAR_0608|M.marinum_M DGGVGG--------------------------FGTFAGNGGDGGTG---- Mb0286c|M.bovis_AF2122/97 EGGSGGHSLVAGGDGGAGGNAG-------MLALGAAGGAGGIGGDGGTLT Rv1759c|M.tuberculosis_H37Rv DGGAGGSGLTTGGAAGNGGNAG-------TLSLGAAGGAGGTGGAGGTVF Mflv_5091|M.gilvum_PYR-GCK VGGVGGKG----IQGGQG-------------LQGGKGGDGGAGGKGGDAD Mvan_1264|M.vanbaalenii_PYR-1 AGGVGGKG----IQGGQG-------------LQGGQGGDGGTGGTGGDAT MSMEG_0868|M.smegmatis_MC2_155 ADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDAL TH_4332|M.thermoresistible__bu MYFEASDG-----------------------------ADGGRGG------ MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNINDS-------------FNTDRSTNIGSGNTTNTEI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 TAGRGGYG--------------------------LGAPRYGVKPTVMPKP MUL_0570|M.ulcerans_Agy99 ----------------------------------------LFA------- MMAR_0608|M.marinum_M ----------------------------------------LFA------- Mb0286c|M.bovis_AF2122/97 AGGI------------------------GGAGGAGGNAGLLFG------- Rv1759c|M.tuberculosis_H37Rv GGGK------------------------GGAGGAGGNAGMLFG------- Mflv_5091|M.gilvum_PYR-GCK SMGS------------------AGATGGKGGNGGNGGRGGLFG------- Mvan_1264|M.vanbaalenii_PYR-1 SMGE------------------AGATGGKGGNGGNGGRGSLFG------- MSMEG_0868|M.smegmatis_MC2_155 VMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSA TH_4332|M.thermoresistible__bu ---------------------------------------FLFG------- MAB_4284c|M.abscessus_ATCC_199 GSHN------------------------------QANIGTSTS------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 AI------------------------------------------------ MUL_0570|M.ulcerans_Agy99 --------AGGDSGAGG--------------------------------- MMAR_0608|M.marinum_M --------AGGDGGAGGSGL------------------TQGGDGGIGGAA Mb0286c|M.bovis_AF2122/97 --------SGGSGGAGGFGF------------------ADGGQGGPGGNA Rv1759c|M.tuberculosis_H37Rv --------SGGGGGTGGFGF------------------AAGGQGGVGGSA Mflv_5091|M.gilvum_PYR-GCK --------KGGNAGNGAD----------------------GGTGGAGGAG Mvan_1264|M.vanbaalenii_PYR-1 --------RGGNAGNGGN----------------------GGTGGNGGNG MSMEG_0868|M.smegmatis_MC2_155 TSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFN TH_4332|M.thermoresistible__bu --------NGGDGGNGGN---------------------------VGGKN MAB_4284c|M.abscessus_ATCC_199 --------AGGSAAVGGN----------------------AGLAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M LGLFGAGGAGGTGGEGG--------------------------------- Mb0286c|M.bovis_AF2122/97 GTVFGSGGAGGNGGVG------------------QGFAGGIGGAGGTPGL Rv1759c|M.tuberculosis_H37Rv GMLSGSGGSGGAGGSGGP---------------AGTAAGGAGGAGGAPGL Mflv_5091|M.gilvum_PYR-GCK GTGG-TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GTGG-TGGNGGTGG-----------------TGGTGGIGGAGSTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGA TH_4332|M.thermoresistible__bu GADPVTATVAADKS----------------------------------VA MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGN---------------------------AGLAGNAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------------------------------- Mb0286c|M.bovis_AF2122/97 IGNGGNGGNGGASAVTGGNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGV Rv1759c|M.tuberculosis_H37Rv IGNGGNGGNGGESGGTGGVGGAGGNAVLIGNGGEGGIGAL-AGKSGFGGF Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGAGGTG--------- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGDGGTG--------- MSMEG_0868|M.smegmatis_MC2_155 NGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGV------- TH_4332|M.thermoresistible__bu GGNGGNGGRGGLLFGLGGNGGNGGWSTTSYLDARGGNGGNG--------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M ------------------------------------------------LF Mb0286c|M.bovis_AF2122/97 SGLLLGLDGFNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGT Rv1759c|M.tuberculosis_H37Rv GGLLLGADGYNAPESTSPWHNLQQDILSFINEPTEALTGRPLIGNGDSGT Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------------GD Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------------GT MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------------------GLGN TH_4332|M.thermoresistible__bu ------------------------------------------------GL MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------LAGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M GGAGGMGGSAGMLF--------GNGGDGGAGAAA---------TIGNAAG Mb0286c|M.bovis_AF2122/97 PGTGADGGAGGWLF--------GNGGNGGSGATG---------TNGGDGG Rv1759c|M.tuberculosis_H37Rv PGTGDDGGAGGWLF--------GNGGNGGAGAAG---------TNGSAGG Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGTGG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGLGG MSMEG_0868|M.smegmatis_MC2_155 GGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGG TH_4332|M.thermoresistible__bu GGVLRPGGLLSLLLP--------SGAASEPGGLF-------------TGG MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAG--------LAGNAGLAGNAG-------------LAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M NGGAGGNAGMLIGAGGAGGNGGF--------------------------- Mb0286c|M.bovis_AF2122/97 DGGAGGIFFGTGGTGGAGGVGTTG------------TGGDGGAGGAAFLV Rv1759c|M.tuberculosis_H37Rv AGGAGGILFGTGGAGGAGGVGTAG------------AGGAGGAGGSAFLI Mflv_5091|M.gilvum_PYR-GCK TGGTGG----TGGQGGQGGQGG-----------------TGGTGGQGG-L Mvan_1264|M.vanbaalenii_PYR-1 TGGTGG----TGGFGGQGGQGG-----------------TGGTGGQGG-L MSMEG_0868|M.smegmatis_MC2_155 NGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTL TH_4332|M.thermoresistible__bu NGGNGGLAIANHWVG-----------------------ITDGVPGPDDDA MAB_4284c|M.abscessus_ATCC_199 NAGLAG----NAGLAGNAGLAG-----------------NAAVAGNAAVA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0608|M.marinum_M -------------------------GFSASDGGAGGAGGNAGFLYGAGGA Mb0286c|M.bovis_AF2122/97 GSGGNGG----------------SGGAGLTAGGDGGDGGNAGSFFGAAGT Rv1759c|M.tuberculosis_H37Rv GSGGTGG----------------VGGAATTTGGVGGAGGNAGLLIGAAGL Mflv_5091|M.gilvum_PYR-GCK GGGGGTG-----------------------GQGGTGGTGGQGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GGVGGTG-----------------------GTGGTGGTGGQGGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTI TH_4332|M.thermoresistible__bu VSSSAYG-----------------------GHGGHGAGPGSGGNGGSAVA MAB_4284c|M.abscessus_ATCC_199 GNAAVAG---------------------NAAVGGVLNTGVSGAIGGSSHV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -----------------DSVGG-----ADGGDGGNGGK------------ MMAR_0608|M.marinum_M GGAGG------------DSVGG-----ADGGDGGNGGK------------ Mb0286c|M.bovis_AF2122/97 GGAG-----ASTKAGGTGGTGGNGGLFANGGAGGSGGLGGDAG-TGGAGG Rv1759c|M.tuberculosis_H37Rv GGCGGGAFTAGVTTGGAGGTGGAAGLFANGGAGGAGGTGSTAGGAGGAGG Mflv_5091|M.gilvum_PYR-GCK GGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGG Mvan_1264|M.vanbaalenii_PYR-1 GGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGG MSMEG_0868|M.smegmatis_MC2_155 EANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGT TH_4332|M.thermoresistible__bu NSLG-------NAIAGNGGDAGRFVLIGPGGNGGNGGTGLXXXPRPRR-- MAB_4284c|M.abscessus_ATCC_199 GGAIN------ESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -----------------------------------------AGLVGQGGD MMAR_0608|M.marinum_M -----------------------------------------AGLVGQGGD Mb0286c|M.bovis_AF2122/97 NGGLFGAGGTGGAGG-------------SLGPG-AGGAGGNGGLFGAGGT Rv1759c|M.tuberculosis_H37Rv AGGLYAHGGTGGPGGN----------GGSTGAGGTGGAGGPGGLYGAGGS Mflv_5091|M.gilvum_PYR-GCK AGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGAT Mvan_1264|M.vanbaalenii_PYR-1 AGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGAT MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASN TH_4332|M.thermoresistible__bu ------------------------------RRNHRRTRRRPNGRRPRPPP MAB_4284c|M.abscessus_ATCC_199 --------------------------GISESLGGSGSVGGSTAVGGGAHT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 GGAGGNN------------------------------------------- MMAR_0608|M.marinum_M GGAGGNN------------------------------------------- Mb0286c|M.bovis_AF2122/97 GGSGGHGTPAAVPGGAGGAGGNAGLFSLGASGGAGGSGGSSLTDS----- Rv1759c|M.tuberculosis_H37Rv GGAGGHG---GMAGGGGGVGGNAGSLTLNASGGAGGSGGSSLSGK----- Mflv_5091|M.gilvum_PYR-GCK GAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG------ Mvan_1264|M.vanbaalenii_PYR-1 GAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG------ MSMEG_0868|M.smegmatis_MC2_155 GGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIA TH_4332|M.thermoresistible__bu GR------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GVGGGVS------TGVGVGSHVGGGISESLGGSGSVGGSTAVGG------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 -------------------------------------------------N MMAR_0608|M.marinum_M -------------------------------------------------N Mb0286c|M.bovis_AF2122/97 ----GGIGGVGGAGGLLFGYGGAGGAGGYSNIGAGGAGGAGGN---AGML Rv1759c|M.tuberculosis_H37Rv ----AGAGGAGGSAGLFYGSGGAGGNGGYSLNGTGGDGGTGGAGQITGLR Mflv_5091|M.gilvum_PYR-GCK -----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------- Mvan_1264|M.vanbaalenii_PYR-1 -----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------- MSMEG_0868|M.smegmatis_MC2_155 AIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSA TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------GAHTGVGGGVNTGVGVGSHVGGGISESLGGSGSVG-------G MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 SGFG------------TGGSGGKGG-----------DAVLIGNGG----- MMAR_0608|M.marinum_M SGFG------------TGGSGGKGG-----------DAVLIGNGG----- Mb0286c|M.bovis_AF2122/97 SGSGGSGGTGGASGAAKGGVGGNGG-----------TAGVFGNGGDGGAG Rv1759c|M.tuberculosis_H37Rv SGFGGAGGAGGASDTGAGGNGGAGG-----------KAGLYGNGGDGGAG Mflv_5091|M.gilvum_PYR-GCK AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKG Mvan_1264|M.vanbaalenii_PYR-1 AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 VAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNG TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTSAINDALGGSGSVGG----------STAVGGGAHTSAINE MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 --------------------NGGNAGSGGVGPGIAGAAGIGGLLIGEDGM MMAR_0608|M.marinum_M --------------------NGGNAGSGGVGPGIAGAAGIGGLLIGEDGM Mb0286c|M.bovis_AF2122/97 GFGAGTGGNGGVGGNAVLIGNGGNGGNGGKAGGTPGAGGTSGLLIGENGL Rv1759c|M.tuberculosis_H37Rv GDGA-TSGKGGAGGNAVVIGNGGNGGNAGKAGGTAGAGGAGGLVLGRDGQ Mflv_5091|M.gilvum_PYR-GCK GAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGS Mvan_1264|M.vanbaalenii_PYR-1 GDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGS MSMEG_0868|M.smegmatis_MC2_155 GDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGT TH_4332|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MUL_0570|M.ulcerans_Agy99 AGLTP---- MMAR_0608|M.marinum_M AGLTP---- Mb0286c|M.bovis_AF2122/97 NGLP----- Rv1759c|M.tuberculosis_H37Rv HGLT----- Mflv_5091|M.gilvum_PYR-GCK GGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 AGTTGANNP TH_4332|M.thermoresistible__bu --------- MAB_4284c|M.abscessus_ATCC_199 PGAEHH--- MLBr_01183|M.leprae_Br4923 --------- MAV_1346|M.avium_104 ---------