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M. ulcerans Agy99 MUL_4524 (-)

annotation: PE-PGRS family protein
coordinates: 5018940 - 5020202
length: 420

MSYLVAVPEMLASAALDLDNIGSTITAANAAAAAPTTAVLAAGADEISAAVAALFTGHAQAYQWLGAQAG
AFHSQFIQALTGSGSAYAAAEAANASPLQTAAQELLAVINTPTQTLLGRPLIGNGADGALGQAGGDGGLL
YGNGGAGGWLFGQGGVGGNGGTGGIGLDGVAGHIGGGNAGNAGNGGTGGSGGLLFGDGGDGGHGGAGFGG
GNGSGNPIGGQGGNAGVAGNGGAGGSAAMLFGNGGAGGNGGSGGDGGHGGNSALSVPGSIGGDAGAGGTG
GSAGKSGLLFGAGGAGGQGGGGGTGGDGGDCAGANIGGDGGAGGAGGLGGNGTDGGWLYGNGGGGAGGQG
GDGGHGGSPVGFDGKSGVGGDGGDGGNARIIGNGGNGGNGGNGGVGSTDGDGGQGGAAGLLFGQPGSMGT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_4524--100% (420)PE-PGRS family protein
M. ulcerans Agy99MUL_3292-e-11751.90% (474) PE-PGRS family protein
M. ulcerans Agy99MUL_3247-e-11651.91% (497) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1121PE_PGRS221e-12154.58% (469) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-3e-7242.92% (424) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1091PE_PGRS221e-12154.58% (469) PE-PGRS family protein
M. leprae Br4923MLBr_01183-8e-1439.58% (96) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-1e-3937.58% (330) hypothetical protein MAB_4284c
M. marinum MMMAR_4223-1e-15162.74% (467) PE-PGRS family protein
M. avium 104MAV_4827-3e-2243.71% (167) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-2e-5238.03% (376) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_4332-6e-3935.45% (378) PUTATIVE -
M. vanbaalenii PYR-1Mvan_1264-7e-7342.58% (458) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------MSIIDFILNL
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           ------------------------------------MSYLVAVPEMLASA
MMAR_4223|M.marinum_M               ------------------------------------MSYLVAVPEMLASA
Mb1121|M.bovis_AF2122/97            ------------------------------------MSFVIAAPEALVAV
Rv1091|M.tuberculosis_H37Rv         ------------------------------------MSFVIAAPEALVAV
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      FR-----------------------DPVEAASYVADPEAALANAGLSAVS
MAV_4827|M.avium_104                ---------------------------------MNIVLGVSMAPSSIQMV
                                                                                      

MUL_4524|M.ulcerans_Agy99           ALDLDNIGSTITAANAAAAAPTTAVLAAGA--DEISAAVAALFTGHAQAY
MMAR_4223|M.marinum_M               ALDLDNIGSTITAANAAAAAPTTAVLAAGA--DEISAAVAALFTGHAQAY
Mb1121|M.bovis_AF2122/97            ASDLAGIGSALAEANAAALAPTTALLAAGA--DEVSAAIAALFGAHGQAY
Rv1091|M.tuberculosis_H37Rv         ASDLAGIGSALAEANAAALAPTTALLAAGA--DEVSAAIAALFGAHGQAY
TH_4332|M.thermoresistible__bu      ---------MPFITSGAAFVGGAAMLLAGP--GGVSALEAAGSAPR----
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGN--GGNGGLFGGNGGNGGNGL
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGN--GGNAGLFGGNGGNGGNGL
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGN--GGNAGLFG-NGGNGGVGW
MLBr_01183|M.leprae_Br4923          -------MPLFLNAEPQALTAAANTLEGLS--AATVASNAAAAQLTT---
MAB_4284c|M.abscessus_ATCC_199      AAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGP
MAV_4827|M.avium_104                VLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGL
                                                                        .             

MUL_4524|M.ulcerans_Agy99           QWLGAQAGAFHSQFIQALTGSGSAYAAAEAANAS------PLQTAAQELL
MMAR_4223|M.marinum_M               QWLGAQAGAFHSQFIQALTGSGIAYAGAEAANAS------PLQTAAQELL
Mb1121|M.bovis_AF2122/97            QTVSAQASAFHAQFVQALTGGGGAYAAAEAANVS------AAQSTDQRLL
Rv1091|M.tuberculosis_H37Rv         QTVSAQASAFHAQFVQALTGGGGAYAAAEAANVS------AAQSTDQRLL
TH_4332|M.thermoresistible__bu      ----------------------------------------TVEYEYSLVA
Mflv_5091|M.gilvum_PYR-GCK          GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1       GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155      AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
MLBr_01183|M.leprae_Br4923          ----------------------------------------EIAPPAADDV
MAB_4284c|M.abscessus_ATCC_199      SILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPL
MAV_4827|M.avium_104                QLSSIGVTWTDQLEAAALRDALAARRIDNVMLVS--------AFLAAAAL
                                                                                      

MUL_4524|M.ulcerans_Agy99           AVINTPTQTLLGRPLIGNGADGALGQAGGDGGLLYGNGG-----------
MMAR_4223|M.marinum_M               AVINTPTQTLLGRPLIGNGADGAPGQAGGDGGLLYGNGGNGGTSTTAGVA
Mb1121|M.bovis_AF2122/97            DLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVA
Rv1091|M.tuberculosis_H37Rv         DLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVA
TH_4332|M.thermoresistible__bu      CDSTLPLMCEAGDSVGGLGGASHDRSAFSAS--ALGMAS-----------
Mflv_5091|M.gilvum_PYR-GCK          TGVTSGVVGGNGEDAVGYGATGAAGAAGAAG--AAGAAG-----------
Mvan_1264|M.vanbaalenii_PYR-1       TGVTSNVTGGNGADAVGYGATGAAGAAGAAG--AAGKAG-----------
MSMEG_0868|M.smegmatis_MC2_155      TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAG--NGGDGGNGGFGYVLIAG
MLBr_01183|M.leprae_Br4923          SILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSA-----------
MAB_4284c|M.abscessus_ATCC_199      LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNG------
MAV_4827|M.avium_104                AQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIR------
                                                                                      

MUL_4524|M.ulcerans_Agy99           -----------------------------AGGWLFGQG------------
MMAR_4223|M.marinum_M               GGDGGAAGLIGNGGAGGGGGAGALGGNGGAGGWLFGQGGAGGNGGTATLA
Mb1121|M.bovis_AF2122/97            GGNGGAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIP
Rv1091|M.tuberculosis_H37Rv         GGNGGAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIP
TH_4332|M.thermoresistible__bu      ----FGPDWNPGGAFLG---------LIGPGGLLIGDG------------
Mflv_5091|M.gilvum_PYR-GCK          ---AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG--
Mvan_1264|M.vanbaalenii_PYR-1       ---AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG--
MSMEG_0868|M.smegmatis_MC2_155      PNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGT
MLBr_01183|M.leprae_Br4923          --------------------------YAGTETANHDSL------------
MAB_4284c|M.abscessus_ATCC_199      --DVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVD
MAV_4827|M.avium_104                ----AESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQT
                                                                       .              

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               GGAGGAGGVGGSAGLWGTGGAGGNGGFGALNLA--GDGGAGAGGGDGGRG
Mb1121|M.bovis_AF2122/97            GVAGGNGGAGGSAGLWGTGGAGGDGGNGRSGPV--NVAGSAGGNGGAGGA
Rv1091|M.tuberculosis_H37Rv         GVAGGNGGAGGSAGLWGTGGAGGDGGNGRSGPV--NVAGSAGGNGGAGGA
TH_4332|M.thermoresistible__bu      -----LNGTDAYIDENGVFHEATRGGNG----------------------
Mflv_5091|M.gilvum_PYR-GCK          -----AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGA
Mvan_1264|M.vanbaalenii_PYR-1       -----VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQA
MSMEG_0868|M.smegmatis_MC2_155      VDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      DHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIG-------SHNQANIGTS
MAV_4827|M.avium_104                TTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQ
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               GWLYGNGGVGGTGGTGGIG-----------------LQGASGGDGGAGGG
Mb1121|M.bovis_AF2122/97            AGLFGDAGAGGNGGKGGAGG-------AAFSINFTAGDGGAGGAGGSGGH
Rv1091|M.tuberculosis_H37Rv         AGLFGDAGAGGNGGKGGAGG-------AAFSINFTAGDGGAGGAGGSGGH
TH_4332|M.thermoresistible__bu      ------GLLWGNGGKG--------------------GNGLDAGLYTVP--
Mflv_5091|M.gilvum_PYR-GCK          GGLGETGTTGGAGGVG--------------------GQGTAGGTGGVGGI
Mvan_1264|M.vanbaalenii_PYR-1       GTAGETGVTGGVGGIG--------------------GQGTEGGTGGVGGV
MSMEG_0868|M.smegmatis_MC2_155      GGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGM
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TSAGGSAAVGGNAGLAG-------------------NAGLAGNAGLAGNA
MAV_4827|M.avium_104                YSLPDYLYVPVDPEPG--------------------DDELAYSAVGEEDA
                                                                                      

MUL_4524|M.ulcerans_Agy99           ---------------------------GVGGNGG----------------
MMAR_4223|M.marinum_M               TGLW--------------------GTGGVGGNGG----------------
Mb1121|M.bovis_AF2122/97            ALLW--------------------GAGGAGGNGGSGGTGGAGGSTAGAGG
Rv1091|M.tuberculosis_H37Rv         ALLW--------------------GAGGAGGNGGSGGTGGAGGSTAGAGG
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGAG----------STGAVGG-------VGGKG----IQGGQG-------
Mvan_1264|M.vanbaalenii_PYR-1       GGVG----------ATGGAGG-------VGGKG----IQGGQG-------
MSMEG_0868|M.smegmatis_MC2_155      GEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAG----------------------------------------------
MAV_4827|M.avium_104                ESPT----------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           -----------------------------------------------TGG
MMAR_4223|M.marinum_M               -----------------------------------------------TGG
Mb1121|M.bovis_AF2122/97            NGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGG
Rv1091|M.tuberculosis_H37Rv         NGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGG
TH_4332|M.thermoresistible__bu      -------------DPDNPGSTIQMYFEAS---------------------
Mflv_5091|M.gilvum_PYR-GCK          ------LQGGKGGDGGAGGKGGDADSMGS------------------AGA
Mvan_1264|M.vanbaalenii_PYR-1       ------LQGGQGGDGGTGGTGGDATSMGE------------------AGA
MSMEG_0868|M.smegmatis_MC2_155      SGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------NAGLAGNAGLAGNAGLAGN------------------AGL
MAV_4827|M.avium_104                ------VVIEKLFLPEDSEPRRRPVLLVG-------------------SG
                                                                                      

MUL_4524|M.ulcerans_Agy99           IGLDGVAGHIG---------------------------------------
MMAR_4223|M.marinum_M               IGLDGVAGHIG---------------------------------------
Mb1121|M.bovis_AF2122/97            AGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLSGNANGGA
Rv1091|M.tuberculosis_H37Rv         AGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLSGNANGGA
TH_4332|M.thermoresistible__bu      DGADGGRGG-----FLFG-------------------------------N
Mflv_5091|M.gilvum_PYR-GCK          TGGKGGNGGNGGRGGLFG-------------------------------K
Mvan_1264|M.vanbaalenii_PYR-1       TGGKGGNGGNGGRGSLFG-------------------------------R
MSMEG_0868|M.smegmatis_MC2_155      NGAVGGNGGFTNIAAIHGSI----------------TDSSATSGHGGAAQ
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGNAG--------------------------------------L
MAV_4827|M.avium_104                LAVVGISAVLALEIALAIG----------------------------IRT
                                                                                      

MUL_4524|M.ulcerans_Agy99           GGNAGNAGN----------------------GGTGGSG------------
MMAR_4223|M.marinum_M               GGNAGNAGN----------------------GGTGGSGGLLLGNGGDGGH
Mb1121|M.bovis_AF2122/97            GGDSGRGGT----------------------GGAGGEGGAAGLLVGTGGH
Rv1091|M.tuberculosis_H37Rv         GGDSGRGGT----------------------GGAGGEGGAAGLLVGTGGH
TH_4332|M.thermoresistible__bu      GGDGGNGGN---------------------------VGGKNGADPVTATV
Mflv_5091|M.gilvum_PYR-GCK          GGNAGNGAD----------------------GGTGGAGGAGGTGG-TGGA
Mvan_1264|M.vanbaalenii_PYR-1       GGNAGNGGN----------------------GGTGGNGGNGGTGG-TGGN
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGR
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGN----------------------AGLAGNAGLAGNAGLAGNA
MAV_4827|M.avium_104                TGTVALQPTP---------------------NQHLIVPTEQAPAPPPVQA
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               GGTGGGGGRGINGADG--------------------GHGGDGGTGGAAGS
Mb1121|M.bovis_AF2122/97            GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGP
Rv1091|M.tuberculosis_H37Rv         GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGP
TH_4332|M.thermoresistible__bu      AADKS----------------------------------VAGGNGGNGGR
Mflv_5091|M.gilvum_PYR-GCK          GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      GGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAGN---------------------------------AGLAGNAGLAGN
MAV_4827|M.avium_104                SAPQP----------------------KISVPEPVAAPKPLSPPVAAPLP
                                                                                      

MUL_4524|M.ulcerans_Agy99           -GLLFGDGGDGGHGGAGFGGGNG----SGNPIGGQG----GNAGVAGNGG
MMAR_4223|M.marinum_M               AGLLFGDGGTGGHGGAGFGGGNG----SDSPQGGQG----GNAGVAGNGG
Mb1121|M.bovis_AF2122/97            AGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNG----GNGGNGGNGG
Rv1091|M.tuberculosis_H37Rv         AGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNG----GNGGNGGNGG
TH_4332|M.thermoresistible__bu      GGLLFGLGGNGGNGGWSTTSYLD----ARGGNGGNG----GLGGVLRPGG
Mflv_5091|M.gilvum_PYR-GCK          GGTG-GTGGTGGTGGTGGKGGTG----GTGGAGGTG----GDGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       GGTG-GTGGTGGTGGTGGKGGTG----GTGGDGGTG----GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GGVSEGEGGTGGHGGDGGRGGDG----ALGGNGGTGGVGLGNGGKGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGLAGNAGLAGNAGLAGNAGLAG--NAAVAGNAAVAG-NAAVAGNAAVGG
MAV_4827|M.avium_104                AAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQ
                                                                                      

MUL_4524|M.ulcerans_Agy99           AGGSAA--------MLFGNGGAGGN-------------------------
MMAR_4223|M.marinum_M               AGGSAA--------MLFGNGGAGGN-------------------------
Mb1121|M.bovis_AF2122/97            NGATGG--------WLYGNGGAGGQGATAGAGGAGANGVSSTNGG---GN
Rv1091|M.tuberculosis_H37Rv         NGATGG--------WLYGNGGAGGQGATAGAGGAGANGVSSTNGGGTGGN
TH_4332|M.thermoresistible__bu      LLSLLLP--------SGAASEPGGLF------------------------
Mflv_5091|M.gilvum_PYR-GCK          TGGTG---------GTGGTGGTGGAG------------------------
Mvan_1264|M.vanbaalenii_PYR-1       TGGTG---------GTGGTGGTGGAG------------------------
MSMEG_0868|M.smegmatis_MC2_155      NGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATG-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VLNTGVSG------AIGGSSHVGGAIN-----------------------
MAV_4827|M.avium_104                LLAPPR---------LSVPQPVQPPVR-----------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           ---GGSGGDGGHGGNS---------------------------ALSVPGS
MMAR_4223|M.marinum_M               ---GGSGGDGGHGGNS---------------------------TVSVPGG
Mb1121|M.bovis_AF2122/97            GGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGG
Rv1091|M.tuberculosis_H37Rv         GGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGG
TH_4332|M.thermoresistible__bu      -----TGGNGGNGGLAI--------------------------ANHWVG-
Mflv_5091|M.gilvum_PYR-GCK          ---DGTGGTGGTGG------------------------------TGGQGG
Mvan_1264|M.vanbaalenii_PYR-1       ---DGLGGTGGTGG------------------------------TGGFGG
MSMEG_0868|M.smegmatis_MC2_155      ---TATGGNGGNGGNGD--------------------------ADGHRGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---ESLGGSGSVGG------------------------------STAVGG
MAV_4827|M.avium_104                --VPQPPSPPQVGGTVP---------------------------QSPPQH
                                                                                      

MUL_4524|M.ulcerans_Agy99           IGGDAG-----------------AGGTGGSAGKSGLLFGAG---------
MMAR_4223|M.marinum_M               IGGDAG-----------------AGGTGGSAGKSGLLFGAG---------
Mb1121|M.bovis_AF2122/97            AGGDGG-----------------DGGNGGAGGTGGLLFGAG---------
Rv1091|M.tuberculosis_H37Rv         AGGDGG-----------------DGGNGGAGGTGGLLFGAG---------
TH_4332|M.thermoresistible__bu      ----------------------ITDGVPGPDDDAVSSSAYG---------
Mflv_5091|M.gilvum_PYR-GCK          QGGQGG-----------------TGGTGGQGG-LGGGGGTG---------
Mvan_1264|M.vanbaalenii_PYR-1       QGGQGG-----------------TGGTGGQGG-LGGVGGTG---------
MSMEG_0868|M.smegmatis_MC2_155      KGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GAHTG------------------VGGGVSTGVGVGSHVGGG---------
MAV_4827|M.avium_104                QTPPGE-------------------GTPPKPDGPGNYGG-----------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------GAGGQGGGGGTGGDGGD-CAGAN----------IGG
MMAR_4223|M.marinum_M               --------------GAGGQGGGGGTGGDGGNNIIGAN----------VGG
Mb1121|M.bovis_AF2122/97            --------------GNGGPGGSGGAADIGGNGGAGNGG--------GTDG
Rv1091|M.tuberculosis_H37Rv         --------------GNGGPGGSGGAADIGGNGGAGNGG--------GTDG
TH_4332|M.thermoresistible__bu      --------------GHGGHGAGPGSGGNGGSAVANSLG-------NAIAG
Mflv_5091|M.gilvum_PYR-GCK          --------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGG
Mvan_1264|M.vanbaalenii_PYR-1       --------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGG
MSMEG_0868|M.smegmatis_MC2_155      VVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------ISESLGGSGSVGGSTAVGGGAHTGVGG--GVSTGVGVGS
MAV_4827|M.avium_104                --------------GHVPTPGAGGSGGSGGGHVPTPGAG---------GS
                                                                                      

MUL_4524|M.ulcerans_Agy99           DGGAGGAGGLGGNGTDGG-------WLYGNGG-GGAGGQG----------
MMAR_4223|M.marinum_M               DGGAGGAGGLGGNGTDGG-------WLSGNGGDGGAGGQG----------
Mb1121|M.bovis_AF2122/97            NGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKG----------
Rv1091|M.tuberculosis_H37Rv         NGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKG----------
TH_4332|M.thermoresistible__bu      NGGDAGRFVLIGPGGNGGNGGTGLXXXPRPRR------------------
Mflv_5091|M.gilvum_PYR-GCK          AGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKG
Mvan_1264|M.vanbaalenii_PYR-1       AGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKG
MSMEG_0868|M.smegmatis_MC2_155      NGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      HVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVNTGVGVG---------
MAV_4827|M.avium_104                GGSGGGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGG----------
                                                                                      

MUL_4524|M.ulcerans_Agy99           ----------GD---GGHGGSPVGFDGKSGVGGDGGDGGN----------
MMAR_4223|M.marinum_M               ----------GD---GGHGGSPGGFDGKSGVGGDGGDGGN----------
Mb1121|M.bovis_AF2122/97            ----------GNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGN
Rv1091|M.tuberculosis_H37Rv         ----------GNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGN
TH_4332|M.thermoresistible__bu      --------------RRNHRRTRRRPNGRRPRPPPGR--------------
Mflv_5091|M.gilvum_PYR-GCK          GLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQG
Mvan_1264|M.vanbaalenii_PYR-1       GLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQG
MSMEG_0868|M.smegmatis_MC2_155      GNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------SHVGGGISESLGGSGSVGGSTAVGGGAHTS---------
MAV_4827|M.avium_104                ----------GHLPFPGAGSTPGGSGGGHLPTPGAGTPGGG---------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            GGAGGQGSSGGIGGPGATGGAGGKGGDG----------------------
Rv1091|M.tuberculosis_H37Rv         GGAGGQGSSGGIGGPGATGGAGGKGGDG----------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTN
Mvan_1264|M.vanbaalenii_PYR-1       ATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTN
MSMEG_0868|M.smegmatis_MC2_155      TTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AINDALGGSGSVGGSTAVGGGAHTSAIN----------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4223|M.marinum_M               --------------------------------------------------
Mb1121|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-I
Mvan_1264|M.vanbaalenii_PYR-1       GA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-I
MSMEG_0868|M.smegmatis_MC2_155      GAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4524|M.ulcerans_Agy99           ------------------------ARIIGNGGNG--------------GN
MMAR_4223|M.marinum_M               ------------------------ARIIGNGGNG--------------GN
Mb1121|M.bovis_AF2122/97            ----------------------GDAQLIGDGGNG--------------GN
Rv1091|M.tuberculosis_H37Rv         ----------------------GDAQLIGDGGNG--------------GN
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          NGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE--------GGA
Mvan_1264|M.vanbaalenii_PYR-1       NGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE--------GGA
MSMEG_0868|M.smegmatis_MC2_155      SGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------ESMNSSINASHSSS-------------MNE
MAV_4827|M.avium_104                -----------------------LGGFGGGHAPAP-------------GG
                                                                                      

MUL_4524|M.ulcerans_Agy99           GGNGGVGSTDGDGG---QGGAAGLLFGQPGSMGT---------
MMAR_4223|M.marinum_M               G---GAGSTDGEGG---QGGAAGLLFGQPGSMGT---------
Mb1121|M.bovis_AF2122/97            GGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP-------
Rv1091|M.tuberculosis_H37Rv         GGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP-------
TH_4332|M.thermoresistible__bu      -------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       GGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      GGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
MLBr_01183|M.leprae_Br4923          -------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH---
MAV_4827|M.avium_104                GLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK-------