For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSYLVAVPEMLASAALDLDNIGSTITAANAAAAAPTTAVLAAGADEISAAVAALFTGHAQAYQWLGAQAG AFHSQFIQALTGSGSAYAAAEAANASPLQTAAQELLAVINTPTQTLLGRPLIGNGADGALGQAGGDGGLL YGNGGAGGWLFGQGGVGGNGGTGGIGLDGVAGHIGGGNAGNAGNGGTGGSGGLLFGDGGDGGHGGAGFGG GNGSGNPIGGQGGNAGVAGNGGAGGSAAMLFGNGGAGGNGGSGGDGGHGGNSALSVPGSIGGDAGAGGTG GSAGKSGLLFGAGGAGGQGGGGGTGGDGGDCAGANIGGDGGAGGAGGLGGNGTDGGWLYGNGGGGAGGQG GDGGHGGSPVGFDGKSGVGGDGGDGGNARIIGNGGNGGNGGNGGVGSTDGDGGQGGAAGLLFGQPGSMGT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4524 | - | - | 100% (420) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3292 | - | e-117 | 51.90% (474) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3247 | - | e-116 | 51.91% (497) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 1e-121 | 54.58% (469) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 3e-72 | 42.92% (424) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | 1e-121 | 54.58% (469) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 8e-14 | 39.58% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-39 | 37.58% (330) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4223 | - | 1e-151 | 62.74% (467) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 3e-22 | 43.71% (167) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-52 | 38.03% (376) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_4332 | - | 6e-39 | 35.45% (378) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 7e-73 | 42.58% (458) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------MSIIDFILNL MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 ------------------------------------MSYLVAVPEMLASA MMAR_4223|M.marinum_M ------------------------------------MSYLVAVPEMLASA Mb1121|M.bovis_AF2122/97 ------------------------------------MSFVIAAPEALVAV Rv1091|M.tuberculosis_H37Rv ------------------------------------MSFVIAAPEALVAV TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 FR-----------------------DPVEAASYVADPEAALANAGLSAVS MAV_4827|M.avium_104 ---------------------------------MNIVLGVSMAPSSIQMV MUL_4524|M.ulcerans_Agy99 ALDLDNIGSTITAANAAAAAPTTAVLAAGA--DEISAAVAALFTGHAQAY MMAR_4223|M.marinum_M ALDLDNIGSTITAANAAAAAPTTAVLAAGA--DEISAAVAALFTGHAQAY Mb1121|M.bovis_AF2122/97 ASDLAGIGSALAEANAAALAPTTALLAAGA--DEVSAAIAALFGAHGQAY Rv1091|M.tuberculosis_H37Rv ASDLAGIGSALAEANAAALAPTTALLAAGA--DEVSAAIAALFGAHGQAY TH_4332|M.thermoresistible__bu ---------MPFITSGAAFVGGAAMLLAGP--GGVSALEAAGSAPR---- Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGN--GGNGGLFGGNGGNGGNGL Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGN--GGNAGLFGGNGGNGGNGL MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGN--GGNAGLFG-NGGNGGVGW MLBr_01183|M.leprae_Br4923 -------MPLFLNAEPQALTAAANTLEGLS--AATVASNAAAAQLTT--- MAB_4284c|M.abscessus_ATCC_199 AAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGP MAV_4827|M.avium_104 VLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGL . MUL_4524|M.ulcerans_Agy99 QWLGAQAGAFHSQFIQALTGSGSAYAAAEAANAS------PLQTAAQELL MMAR_4223|M.marinum_M QWLGAQAGAFHSQFIQALTGSGIAYAGAEAANAS------PLQTAAQELL Mb1121|M.bovis_AF2122/97 QTVSAQASAFHAQFVQALTGGGGAYAAAEAANVS------AAQSTDQRLL Rv1091|M.tuberculosis_H37Rv QTVSAQASAFHAQFVQALTGGGGAYAAAEAANVS------AAQSTDQRLL TH_4332|M.thermoresistible__bu ----------------------------------------TVEYEYSLVA Mflv_5091|M.gilvum_PYR-GCK GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA Mvan_1264|M.vanbaalenii_PYR-1 GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA MSMEG_0868|M.smegmatis_MC2_155 AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG MLBr_01183|M.leprae_Br4923 ----------------------------------------EIAPPAADDV MAB_4284c|M.abscessus_ATCC_199 SILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPL MAV_4827|M.avium_104 QLSSIGVTWTDQLEAAALRDALAARRIDNVMLVS--------AFLAAAAL MUL_4524|M.ulcerans_Agy99 AVINTPTQTLLGRPLIGNGADGALGQAGGDGGLLYGNGG----------- MMAR_4223|M.marinum_M AVINTPTQTLLGRPLIGNGADGAPGQAGGDGGLLYGNGGNGGTSTTAGVA Mb1121|M.bovis_AF2122/97 DLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVA Rv1091|M.tuberculosis_H37Rv DLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVA TH_4332|M.thermoresistible__bu CDSTLPLMCEAGDSVGGLGGASHDRSAFSAS--ALGMAS----------- Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAG--AAGAAG----------- Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAG--AAGKAG----------- MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAG--NGGDGGNGGFGYVLIAG MLBr_01183|M.leprae_Br4923 SILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSA----------- MAB_4284c|M.abscessus_ATCC_199 LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNG------ MAV_4827|M.avium_104 AQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIR------ MUL_4524|M.ulcerans_Agy99 -----------------------------AGGWLFGQG------------ MMAR_4223|M.marinum_M GGDGGAAGLIGNGGAGGGGGAGALGGNGGAGGWLFGQGGAGGNGGTATLA Mb1121|M.bovis_AF2122/97 GGNGGAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIP Rv1091|M.tuberculosis_H37Rv GGNGGAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIP TH_4332|M.thermoresistible__bu ----FGPDWNPGGAFLG---------LIGPGGLLIGDG------------ Mflv_5091|M.gilvum_PYR-GCK ---AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG-- Mvan_1264|M.vanbaalenii_PYR-1 ---AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG-- MSMEG_0868|M.smegmatis_MC2_155 PNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGT MLBr_01183|M.leprae_Br4923 --------------------------YAGTETANHDSL------------ MAB_4284c|M.abscessus_ATCC_199 --DVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVD MAV_4827|M.avium_104 ----AESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQT . MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M GGAGGAGGVGGSAGLWGTGGAGGNGGFGALNLA--GDGGAGAGGGDGGRG Mb1121|M.bovis_AF2122/97 GVAGGNGGAGGSAGLWGTGGAGGDGGNGRSGPV--NVAGSAGGNGGAGGA Rv1091|M.tuberculosis_H37Rv GVAGGNGGAGGSAGLWGTGGAGGDGGNGRSGPV--NVAGSAGGNGGAGGA TH_4332|M.thermoresistible__bu -----LNGTDAYIDENGVFHEATRGGNG---------------------- Mflv_5091|M.gilvum_PYR-GCK -----AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGA Mvan_1264|M.vanbaalenii_PYR-1 -----VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQA MSMEG_0868|M.smegmatis_MC2_155 VDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 DHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIG-------SHNQANIGTS MAV_4827|M.avium_104 TTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQ MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M GWLYGNGGVGGTGGTGGIG-----------------LQGASGGDGGAGGG Mb1121|M.bovis_AF2122/97 AGLFGDAGAGGNGGKGGAGG-------AAFSINFTAGDGGAGGAGGSGGH Rv1091|M.tuberculosis_H37Rv AGLFGDAGAGGNGGKGGAGG-------AAFSINFTAGDGGAGGAGGSGGH TH_4332|M.thermoresistible__bu ------GLLWGNGGKG--------------------GNGLDAGLYTVP-- Mflv_5091|M.gilvum_PYR-GCK GGLGETGTTGGAGGVG--------------------GQGTAGGTGGVGGI Mvan_1264|M.vanbaalenii_PYR-1 GTAGETGVTGGVGGIG--------------------GQGTEGGTGGVGGV MSMEG_0868|M.smegmatis_MC2_155 GGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGM MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TSAGGSAAVGGNAGLAG-------------------NAGLAGNAGLAGNA MAV_4827|M.avium_104 YSLPDYLYVPVDPEPG--------------------DDELAYSAVGEEDA MUL_4524|M.ulcerans_Agy99 ---------------------------GVGGNGG---------------- MMAR_4223|M.marinum_M TGLW--------------------GTGGVGGNGG---------------- Mb1121|M.bovis_AF2122/97 ALLW--------------------GAGGAGGNGGSGGTGGAGGSTAGAGG Rv1091|M.tuberculosis_H37Rv ALLW--------------------GAGGAGGNGGSGGTGGAGGSTAGAGG TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGAG----------STGAVGG-------VGGKG----IQGGQG------- Mvan_1264|M.vanbaalenii_PYR-1 GGVG----------ATGGAGG-------VGGKG----IQGGQG------- MSMEG_0868|M.smegmatis_MC2_155 GEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GLAG---------------------------------------------- MAV_4827|M.avium_104 ESPT---------------------------------------------- MUL_4524|M.ulcerans_Agy99 -----------------------------------------------TGG MMAR_4223|M.marinum_M -----------------------------------------------TGG Mb1121|M.bovis_AF2122/97 NGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGG Rv1091|M.tuberculosis_H37Rv NGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGG TH_4332|M.thermoresistible__bu -------------DPDNPGSTIQMYFEAS--------------------- Mflv_5091|M.gilvum_PYR-GCK ------LQGGKGGDGGAGGKGGDADSMGS------------------AGA Mvan_1264|M.vanbaalenii_PYR-1 ------LQGGQGGDGGTGGTGGDATSMGE------------------AGA MSMEG_0868|M.smegmatis_MC2_155 SGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------NAGLAGNAGLAGNAGLAGN------------------AGL MAV_4827|M.avium_104 ------VVIEKLFLPEDSEPRRRPVLLVG-------------------SG MUL_4524|M.ulcerans_Agy99 IGLDGVAGHIG--------------------------------------- MMAR_4223|M.marinum_M IGLDGVAGHIG--------------------------------------- Mb1121|M.bovis_AF2122/97 AGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLSGNANGGA Rv1091|M.tuberculosis_H37Rv AGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLSGNANGGA TH_4332|M.thermoresistible__bu DGADGGRGG-----FLFG-------------------------------N Mflv_5091|M.gilvum_PYR-GCK TGGKGGNGGNGGRGGLFG-------------------------------K Mvan_1264|M.vanbaalenii_PYR-1 TGGKGGNGGNGGRGSLFG-------------------------------R MSMEG_0868|M.smegmatis_MC2_155 NGAVGGNGGFTNIAAIHGSI----------------TDSSATSGHGGAAQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAG--------------------------------------L MAV_4827|M.avium_104 LAVVGISAVLALEIALAIG----------------------------IRT MUL_4524|M.ulcerans_Agy99 GGNAGNAGN----------------------GGTGGSG------------ MMAR_4223|M.marinum_M GGNAGNAGN----------------------GGTGGSGGLLLGNGGDGGH Mb1121|M.bovis_AF2122/97 GGDSGRGGT----------------------GGAGGEGGAAGLLVGTGGH Rv1091|M.tuberculosis_H37Rv GGDSGRGGT----------------------GGAGGEGGAAGLLVGTGGH TH_4332|M.thermoresistible__bu GGDGGNGGN---------------------------VGGKNGADPVTATV Mflv_5091|M.gilvum_PYR-GCK GGNAGNGAD----------------------GGTGGAGGAGGTGG-TGGA Mvan_1264|M.vanbaalenii_PYR-1 GGNAGNGGN----------------------GGTGGNGGNGGTGG-TGGN MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGN----------------------AGLAGNAGLAGNAGLAGNA MAV_4827|M.avium_104 TGTVALQPTP---------------------NQHLIVPTEQAPAPPPVQA MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M GGTGGGGGRGINGADG--------------------GHGGDGGTGGAAGS Mb1121|M.bovis_AF2122/97 GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGP Rv1091|M.tuberculosis_H37Rv GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGP TH_4332|M.thermoresistible__bu AADKS----------------------------------VAGGNGGNGGR Mflv_5091|M.gilvum_PYR-GCK GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GLAGN---------------------------------AGLAGNAGLAGN MAV_4827|M.avium_104 SAPQP----------------------KISVPEPVAAPKPLSPPVAAPLP MUL_4524|M.ulcerans_Agy99 -GLLFGDGGDGGHGGAGFGGGNG----SGNPIGGQG----GNAGVAGNGG MMAR_4223|M.marinum_M AGLLFGDGGTGGHGGAGFGGGNG----SDSPQGGQG----GNAGVAGNGG Mb1121|M.bovis_AF2122/97 AGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNG----GNGGNGGNGG Rv1091|M.tuberculosis_H37Rv AGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNG----GNGGNGGNGG TH_4332|M.thermoresistible__bu GGLLFGLGGNGGNGGWSTTSYLD----ARGGNGGNG----GLGGVLRPGG Mflv_5091|M.gilvum_PYR-GCK GGTG-GTGGTGGTGGTGGKGGTG----GTGGAGGTG----GDGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GGTG-GTGGTGGTGGTGGKGGTG----GTGGDGGTG----GTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 GGVSEGEGGTGGHGGDGGRGGDG----ALGGNGGTGGVGLGNGGKGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAGNAGLAG--NAAVAGNAAVAG-NAAVAGNAAVGG MAV_4827|M.avium_104 AAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQ MUL_4524|M.ulcerans_Agy99 AGGSAA--------MLFGNGGAGGN------------------------- MMAR_4223|M.marinum_M AGGSAA--------MLFGNGGAGGN------------------------- Mb1121|M.bovis_AF2122/97 NGATGG--------WLYGNGGAGGQGATAGAGGAGANGVSSTNGG---GN Rv1091|M.tuberculosis_H37Rv NGATGG--------WLYGNGGAGGQGATAGAGGAGANGVSSTNGGGTGGN TH_4332|M.thermoresistible__bu LLSLLLP--------SGAASEPGGLF------------------------ Mflv_5091|M.gilvum_PYR-GCK TGGTG---------GTGGTGGTGGAG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 TGGTG---------GTGGTGGTGGAG------------------------ MSMEG_0868|M.smegmatis_MC2_155 NGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATG------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VLNTGVSG------AIGGSSHVGGAIN----------------------- MAV_4827|M.avium_104 LLAPPR---------LSVPQPVQPPVR----------------------- MUL_4524|M.ulcerans_Agy99 ---GGSGGDGGHGGNS---------------------------ALSVPGS MMAR_4223|M.marinum_M ---GGSGGDGGHGGNS---------------------------TVSVPGG Mb1121|M.bovis_AF2122/97 GGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGG Rv1091|M.tuberculosis_H37Rv GGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGG TH_4332|M.thermoresistible__bu -----TGGNGGNGGLAI--------------------------ANHWVG- Mflv_5091|M.gilvum_PYR-GCK ---DGTGGTGGTGG------------------------------TGGQGG Mvan_1264|M.vanbaalenii_PYR-1 ---DGLGGTGGTGG------------------------------TGGFGG MSMEG_0868|M.smegmatis_MC2_155 ---TATGGNGGNGGNGD--------------------------ADGHRGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---ESLGGSGSVGG------------------------------STAVGG MAV_4827|M.avium_104 --VPQPPSPPQVGGTVP---------------------------QSPPQH MUL_4524|M.ulcerans_Agy99 IGGDAG-----------------AGGTGGSAGKSGLLFGAG--------- MMAR_4223|M.marinum_M IGGDAG-----------------AGGTGGSAGKSGLLFGAG--------- Mb1121|M.bovis_AF2122/97 AGGDGG-----------------DGGNGGAGGTGGLLFGAG--------- Rv1091|M.tuberculosis_H37Rv AGGDGG-----------------DGGNGGAGGTGGLLFGAG--------- TH_4332|M.thermoresistible__bu ----------------------ITDGVPGPDDDAVSSSAYG--------- Mflv_5091|M.gilvum_PYR-GCK QGGQGG-----------------TGGTGGQGG-LGGGGGTG--------- Mvan_1264|M.vanbaalenii_PYR-1 QGGQGG-----------------TGGTGGQGG-LGGVGGTG--------- MSMEG_0868|M.smegmatis_MC2_155 KGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GAHTG------------------VGGGVSTGVGVGSHVGGG--------- MAV_4827|M.avium_104 QTPPGE-------------------GTPPKPDGPGNYGG----------- MUL_4524|M.ulcerans_Agy99 --------------GAGGQGGGGGTGGDGGD-CAGAN----------IGG MMAR_4223|M.marinum_M --------------GAGGQGGGGGTGGDGGNNIIGAN----------VGG Mb1121|M.bovis_AF2122/97 --------------GNGGPGGSGGAADIGGNGGAGNGG--------GTDG Rv1091|M.tuberculosis_H37Rv --------------GNGGPGGSGGAADIGGNGGAGNGG--------GTDG TH_4332|M.thermoresistible__bu --------------GHGGHGAGPGSGGNGGSAVANSLG-------NAIAG Mflv_5091|M.gilvum_PYR-GCK --------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGG Mvan_1264|M.vanbaalenii_PYR-1 --------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGG MSMEG_0868|M.smegmatis_MC2_155 VVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------ISESLGGSGSVGGSTAVGGGAHTGVGG--GVSTGVGVGS MAV_4827|M.avium_104 --------------GHVPTPGAGGSGGSGGGHVPTPGAG---------GS MUL_4524|M.ulcerans_Agy99 DGGAGGAGGLGGNGTDGG-------WLYGNGG-GGAGGQG---------- MMAR_4223|M.marinum_M DGGAGGAGGLGGNGTDGG-------WLSGNGGDGGAGGQG---------- Mb1121|M.bovis_AF2122/97 NGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKG---------- Rv1091|M.tuberculosis_H37Rv NGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKG---------- TH_4332|M.thermoresistible__bu NGGDAGRFVLIGPGGNGGNGGTGLXXXPRPRR------------------ Mflv_5091|M.gilvum_PYR-GCK AGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKG Mvan_1264|M.vanbaalenii_PYR-1 AGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKG MSMEG_0868|M.smegmatis_MC2_155 NGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 HVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVNTGVGVG--------- MAV_4827|M.avium_104 GGSGGGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGG---------- MUL_4524|M.ulcerans_Agy99 ----------GD---GGHGGSPVGFDGKSGVGGDGGDGGN---------- MMAR_4223|M.marinum_M ----------GD---GGHGGSPGGFDGKSGVGGDGGDGGN---------- Mb1121|M.bovis_AF2122/97 ----------GNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGN Rv1091|M.tuberculosis_H37Rv ----------GNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGN TH_4332|M.thermoresistible__bu --------------RRNHRRTRRRPNGRRPRPPPGR-------------- Mflv_5091|M.gilvum_PYR-GCK GLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQG Mvan_1264|M.vanbaalenii_PYR-1 GLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQG MSMEG_0868|M.smegmatis_MC2_155 GNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------SHVGGGISESLGGSGSVGGSTAVGGGAHTS--------- MAV_4827|M.avium_104 ----------GHLPFPGAGSTPGGSGGGHLPTPGAGTPGGG--------- MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 GGAGGQGSSGGIGGPGATGGAGGKGGDG---------------------- Rv1091|M.tuberculosis_H37Rv GGAGGQGSSGGIGGPGATGGAGGKGGDG---------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTN Mvan_1264|M.vanbaalenii_PYR-1 ATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTN MSMEG_0868|M.smegmatis_MC2_155 TTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AINDALGGSGSVGGSTAVGGGAHTSAIN---------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4223|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-I Mvan_1264|M.vanbaalenii_PYR-1 GA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-I MSMEG_0868|M.smegmatis_MC2_155 GAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4524|M.ulcerans_Agy99 ------------------------ARIIGNGGNG--------------GN MMAR_4223|M.marinum_M ------------------------ARIIGNGGNG--------------GN Mb1121|M.bovis_AF2122/97 ----------------------GDAQLIGDGGNG--------------GN Rv1091|M.tuberculosis_H37Rv ----------------------GDAQLIGDGGNG--------------GN TH_4332|M.thermoresistible__bu -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK NGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE--------GGA Mvan_1264|M.vanbaalenii_PYR-1 NGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE--------GGA MSMEG_0868|M.smegmatis_MC2_155 SGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------ESMNSSINASHSSS-------------MNE MAV_4827|M.avium_104 -----------------------LGGFGGGHAPAP-------------GG MUL_4524|M.ulcerans_Agy99 GGNGGVGSTDGDGG---QGGAAGLLFGQPGSMGT--------- MMAR_4223|M.marinum_M G---GAGSTDGEGG---QGGAAGLLFGQPGSMGT--------- Mb1121|M.bovis_AF2122/97 GGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP------- Rv1091|M.tuberculosis_H37Rv GGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP------- TH_4332|M.thermoresistible__bu ------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP MLBr_01183|M.leprae_Br4923 ------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH--- MAV_4827|M.avium_104 GLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK-------