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SFVIAVPETIAAAATDLADLGSTIAGANAAAAANTTSLLAAGADEISAAIAALFGAHGRAYQAASAEAAA FHGRFVQALTTGGGAYAAAEAAAVTPLLNSINAPVLAATGRPLIGNGANGAPGTGANGGDAGWLIGNGGA GGSGAKGANGGAGGPGGAAGLFGNGGAGGAGGTATANNGIGGAGGAGGSAMLFGAGGAGGAGGAATSLVG GIGGTGGTGGNAGMLAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGHTGGAGGAGGAGG LFGAGGMGGAGGFGDHGTLGTGGAGGDGGGGGLFGAGGDGGAGGSGLTTGGAAGNGGNAGTLSLGAAGGA GGTGGAGGTVFGGGKGGAGGAGGNAGMLFGSGGGGGTGGFGFAAGGQGGVGGSAGMLSGSGGSGGAGGSG GPAGTAAGGAGGAGGAPGLIGNGGNGGNGGESGGTGGVGGAGGNAVLIGNGGEGGIGALAGKSGFGGFGG LLLGADGYNAPESTSPWHNLQQDILSFINEPTEALTGRPLIGNGDSGTPGTGDDGGAGGWLFGNGGNGGA GAAGTNGSAGGAGGAGGILFGTGGAGGAGGVGTAGAGGAGGAGGSAFLIGSGGTGGVGGAATTTGGVGGA GGNAGLLIGAAGLGGCGGGAFTAGVTTGGAGGTGGAAGLFANGGAGGAGGTGSTAGGAGGAGGAGGLYAH GGTGGPGGNGGSTGAGGTGGAGGPGGLYGAGGSGGAGGHGGMAGGGGGVGGNAGSLTLNASGGAGGSGGS SLSGKAGAGGAGGSAGLFYGSGGAGGNGGYSLNGTGGDGGTGGAGQITGLRSGFGGAGGAGGASDTGAGG NGGAGGKAGLYGNGGDGGAGGDGATSGKGGAGGNAVVIGNGGNGGNAGKAGGTAGAGGAGGLVLGRDGQH GLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1759c | wag22 | - | 100% (914) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0278c | PE_PGRS3 | 0.0 | 67.70% (904) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv0279c | PE_PGRS4 | 0.0 | 62.35% (895) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1789c | wag22b | 0.0 | 100.00% (820) | hypothetical protein Mb1789c |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-165 | 44.72% (852) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 2e-13 | 39.56% (91) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 2e-46 | 36.87% (377) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_0755 | - | 0.0 | 54.45% (1012) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 7e-24 | 44.94% (158) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-130 | 36.46% (1067) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 1e-41 | 41.14% (299) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 53.53% (949) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-163 | 43.79% (854) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1759c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1789c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0755|M.marinum_M --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv ------------------MSFVIAVPETIAAAATDLADLGS---------
Mb1789c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 ------------------MAFVLAVPDMVAEAAADLAGVGS---------
MMAR_0755|M.marinum_M ------------------MSYLIATPDLLSAAATDLAGIGN---------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv -------------------------------TIAGANAAAAANTTSLLAA
Mb1789c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 -------------------------------VIDAANTAAAGSTTGIVAA
MMAR_0755|M.marinum_M -------------------------------TIGQASYAAAAPTTAVISA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv GADEISAAIAALFGAHGRAYQAASAEAAAFHGRFVQALTTGGGAYAAAEA
Mb1789c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 AEDEVSAAIAALFSGHGQAYQQISTRVAEFHAQFERVFAAGVQAYSGAEA
MMAR_0755|M.marinum_M AADEISMQIAALFGAHGQSFQAVSSQAALFHDQFVQALTTGASSYASAEA
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv A-------------------AVTPLLNSINAPVLAATGRPLIGNGANGAP
Mb1789c|M.bovis_AF2122/97 ---------------------MTPLLNSINAPVLAATGRPLIGNGANGAP
MUL_3062|M.ulcerans_Agy99 ANASFLQD------------PLQTALNATNKPVQDLTGRPLVGNGANGVP
MMAR_0755|M.marinum_M AS--------------------QNLLNLVNAPTQALLNRPLIGNGANGAA
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGT-
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGT-
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGT-
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------MSIIDFILNLFRDPVEAASYVAD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ------------------------MNIVLGVSMAPSSIQMVVLEG-----
Rv1759c|M.tuberculosis_H37Rv GTGANGGDAGWLIGNGGAGGSGAKGANGGAGGPGGAAGLFG-NGGAGGAG
Mb1789c|M.bovis_AF2122/97 GTGANGGDAGWLIGNGGAGGSGAKGANGGAGGPGGAAGLFG-NGGAGGAG
MUL_3062|M.ulcerans_Agy99 GTGANGAAGGWLLGNGGAGGS---GAAGQAGGDGGAAGLIG-AGGAGGAG
MMAR_0755|M.marinum_M GTGASGGDGGILIGNGGAGGSGATGLTGGAGGNGGAAGLLAGTAGAGGSG
Mflv_5091|M.gilvum_PYR-GCK GQN-----GGILFGNGGSGWNS--DVVGMDGGNGGNGGLFGGNGGNGGNG
Mvan_1264|M.vanbaalenii_PYR-1 GQN-----GGILFGNGGSGWNS--EIAGVSGGNGGNAGLFGGNGGNGGNG
MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDG--SAAGLAGGNGGNAGLFG-NGGNGGVG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 PEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -----EYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAG
Rv1759c|M.tuberculosis_H37Rv GTATANNGIGGAGGAGGSAMLFGAGGAGGAGGAATSLVGGIGGTGGTG--
Mb1789c|M.bovis_AF2122/97 GTATANNGIGGAGGAGGSAMLFGAGGAGGAGGAATSLVGGIGGTGGTG--
MUL_3062|M.ulcerans_Agy99 GNSPLRNTAN-------------------------------GGNGGTG--
MMAR_0755|M.marinum_M GLGAAG--AGGAGGQGGTGGLFSAGGAGGTGG--------VGASGGTG--
Mflv_5091|M.gilvum_PYR-GCK ----LGGGNGGNGGNAGAFALFGNGGN--------------GGNGGVGVV
Mvan_1264|M.vanbaalenii_PYR-1 ----LGSGDGGNGGDAGLFSLFGRGGN--------------GGNGGVGIA
MSMEG_0868|M.smegmatis_MC2_155 ----WAGLDGGNGGSGG--LLMGIGGA--------------GGAGGVGAD
TH_3810|M.thermoresistible__bu -----VDGDGGSGGRTGLFSKLSRGGD--------------GGDGGLG--
MAB_4284c|M.abscessus_ATCC_199 GNLQNYYAAQPDGPSILSPSLLSPRDND-------------FLSHNDTDF
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 LQLSSIGVTWTDQLEAAALRDALAARR----------------IDNVMLV
Rv1759c|M.tuberculosis_H37Rv GNAGM-LAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGH
Mb1789c|M.bovis_AF2122/97 GNAGM-LAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGH
MUL_3062|M.ulcerans_Agy99 GAGGL-LFGPGGVGGAGGASFLTGG-TGGDGGAGGLFGAGGLGGVGGSGN
MMAR_0755|M.marinum_M GAGGLGLFGAGGAGGAGGMANATVGGTGGAGGASLLFGNGGAGGLGGGGA
Mflv_5091|M.gilvum_PYR-GCK GATGAVG--APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAG
Mvan_1264|M.vanbaalenii_PYR-1 GATGAVG--APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAG
MSMEG_0868|M.smegmatis_MC2_155 GTSAHVDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAG
TH_3810|M.thermoresistible__bu -----------GNGGHGGGTGIIS--------------------LLSLAG
MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 SAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQ
Rv1759c|M.tuberculosis_H37Rv -TGGAGGAGG-----------AGGLFGAGGMGGAGGFGDHGTLG-TGGAG
Mb1789c|M.bovis_AF2122/97 -TGGAGGAGG-----------AGGLFGAGGMGGAGGFGDHGTLG-TGGAG
MUL_3062|M.ulcerans_Agy99 -VGGNGGAGG-----------AGGLL-AGLVGAGGGDGGSGGLGAAGGDG
MMAR_0755|M.marinum_M TAGGAGGQGGD----------AGTFYGDGGVGGAGGAGGN-IPGSSGGAG
Mflv_5091|M.gilvum_PYR-GCK -AAGAAG--------------AVGSAGAAGEAGETGTWG--NAGLPGKAG
Mvan_1264|M.vanbaalenii_PYR-1 -AAGKAG--------------AVGSAGTAGSAGAPGVWG--NAGLPGAAG
MSMEG_0868|M.smegmatis_MC2_155 -NGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGG
TH_3810|M.thermoresistible__bu -NGGNGG---------------NGYRTTDNNALDGGHGG-----------
MAB_4284c|M.abscessus_ATCC_199 AVGGSNS---------------GPIASGQGSTAVNGDVRDSNIINADHGS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 QIRAESYG------------------DAAGQLSAMVAGLEKLESLPGGLL
Rv1759c|M.tuberculosis_H37Rv GDGGGGG---------------LFG-AGGDGGAGGSGLTTGGAAGNGGNA
Mb1789c|M.bovis_AF2122/97 GDGGGGG---------------LFG-AGGDGGAGGSGLTTGGAAGNGGNA
MUL_3062|M.ulcerans_Agy99 GNGGRAG---------------LFGGAGGAGGMGATGGHSGGDGGAGGDA
MMAR_0755|M.marinum_M GAGGNAG---------------LFHGDGGAGGTGGVATSAGGAGGAGGNA
Mflv_5091|M.gilvum_PYR-GCK DAGGAG----------------AVGAAGAAG-------TVGTAGATGGTG
Mvan_1264|M.vanbaalenii_PYR-1 AAGGAG----------------AIGTAGVAG-------AAGTAGATGGTG
MSMEG_0868|M.smegmatis_MC2_155 GGGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGST-TAAGGNGGTGGTG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NVGVDQS-------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 LVGSGVD-------------------------------------------
Rv1759c|M.tuberculosis_H37Rv GTLSLGAAGGAGG--TGGAGGTVFGGGKGGAGGAGG-------------N
Mb1789c|M.bovis_AF2122/97 GTLSLGAAGGAGG--TGGAGGTVFGGGKGGAGGAGG-------------N
MUL_3062|M.ulcerans_Agy99 GLL-----FGTGG--AGGAGGHAFDG-DGGAGGAGG-------------N
MMAR_0755|M.marinum_M ADL-----VGTGG--VGGAGGTSFDA--GGAGGIGG-------------S
Mflv_5091|M.gilvum_PYR-GCK ---------------TGANGGAGGVGGVGGTGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 ---------------VGGNGGAGQAGGIGGTGAAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 RVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTA
TH_3810|M.thermoresistible__bu ---------------NGGNVGFFSLFNLGG--------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------QTRVGGDYTNVSGHGSADIDK-------------S
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------VAPLKQVLQTTTFLDVSVAEE--------------
Rv1759c|M.tuberculosis_H37Rv AGMLFGSGGGGGTGGFGFAAGGQGGVGGSAGMLSGSGGSGGAGGSGGPAG
Mb1789c|M.bovis_AF2122/97 AGMLFGSGGGGGTGGFGFAAGGQGGVGGSAGMLSGSGGSGGAGGSGGPAG
MUL_3062|M.ulcerans_Agy99 AGLMFSSGGSGGVGGAGSIDGGAGGAGGDAGWLGG-GGAGGAGGFGTISD
MMAR_0755|M.marinum_M AGALFGAGGAGGAGGFGQVSGGAGGAGGNSGMVYGDGGAGGAGGIGGAAA
Mflv_5091|M.gilvum_PYR-GCK AGGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGG
MSMEG_0868|M.smegmatis_MC2_155 TGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGG
TH_3810|M.thermoresistible__bu AGGWGGSGVDG---------------------VDVVGGNP----------
MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPV
Rv1759c|M.tuberculosis_H37Rv TA-----AGGAGG-------------------------------------
Mb1789c|M.bovis_AF2122/97 TA-----AGGAGG-------------------------------------
MUL_3062|M.ulcerans_Agy99 GG-----AGGRGG-------------------------------------
MMAR_0755|M.marinum_M GG-----KGGDGGDAATLFGSGGTGGHGAAGAVAGGDGGRGGTGGGLAGS
Mflv_5091|M.gilvum_PYR-GCK KG----IQGGQG--------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 KG----IQGGQG--------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 RGGTSWVQAGYGPTTGG---------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AG------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 DP------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv ------------------AGGAPGLIGNGGNGGNGGES------------
Mb1789c|M.bovis_AF2122/97 ------------------AGGAPGLIGNGGNGGNGGES------------
MUL_3062|M.ulcerans_Agy99 ------------------GGGQ--LLGNGGAGGAGGQG------------
MMAR_0755|M.marinum_M GGTGGNGAVGTVSGVGGDGGNAAGLFGDGGTGGNGGLAT-----------
Mflv_5091|M.gilvum_PYR-GCK --------------------LQGGKGGDGGAGGKGGDADSMGS-------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------LQGGQGGDGGTGGTGGDATSMGE-------
MSMEG_0868|M.smegmatis_MC2_155 ------------KASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVAT
TH_3810|M.thermoresistible__bu ---------------------------DGGTPG-----------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------GSAAVGGNAGLAG--------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------------------EPGDDELAY--------------
Rv1759c|M.tuberculosis_H37Rv ---------------GGTGGVGGAGGNAVLIG---------------NGG
Mb1789c|M.bovis_AF2122/97 ---------------GGTGGVGGAGGNAVLIG---------------NGG
MUL_3062|M.ulcerans_Agy99 ---------------GNDGGAGGLGGNGVLIG---------------NGG
MMAR_0755|M.marinum_M --------------AGGAGGDGGAGGKAALIG---------------SGG
Mflv_5091|M.gilvum_PYR-GCK -----------AGATGGKGGNGGNGGRGGLFG---------------KGG
Mvan_1264|M.vanbaalenii_PYR-1 -----------AGATGGKGGNGGNGGRGSLFG---------------RGG
MSMEG_0868|M.smegmatis_MC2_155 GNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGG
TH_3810|M.thermoresistible__bu -------------AHGESHTPGVYTDRQ----------------------
MAB_4284c|M.abscessus_ATCC_199 --------------NAGLAGNAGLAGNAGLAG------------------
MLBr_01183|M.leprae_Br4923 --------------------------MPLFLN------------------
MAV_4827|M.avium_104 ---------------SAVGEEDAESPTVVIEK------------------
Rv1759c|M.tuberculosis_H37Rv EGGIG-------------------------ALAGKSGFGGFGGLLLGADG
Mb1789c|M.bovis_AF2122/97 EGGIG-------------------------ALAGKSGFGGFGGLLLGADG
MUL_3062|M.ulcerans_Agy99 NGGVGGV----------------------GETPGGDGGGGISGLLLGADG
MMAR_0755|M.marinum_M NGGAGGSG---------------------TVDPGGNGGRGGDAQLFGTGG
Mflv_5091|M.gilvum_PYR-GCK NAGNGAD----------------------GGTGGAGGAGGTGG-TGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 NAGNGGN----------------------GGTGGNGGNGGTGG-TGGNGG
MSMEG_0868|M.smegmatis_MC2_155 NGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGG
TH_3810|M.thermoresistible__bu ---------------------------------GEDGEDGTGTGIGGRGG
MAB_4284c|M.abscessus_ATCC_199 -------------------------------NAGLAGNAGLAGNAGLAGN
MLBr_01183|M.leprae_Br4923 --------------------------------AEPQALTAAANTLEG---
MAV_4827|M.avium_104 ------------------------------LFLPEDSEPRRRPVLLVGSG
.
Rv1759c|M.tuberculosis_H37Rv ------YNAPESTS------PWHNLQQDILSFINEPTEALTGRPLIGNGD
Mb1789c|M.bovis_AF2122/97 ------YNAPESTS------PWHNLQQDILSFINEPTEALTGRPLIGNGD
MUL_3062|M.ulcerans_Agy99 ------FNAPAGSS------PVHALQQQALAAINAPVQELTGRPLIGNGL
MMAR_0755|M.marinum_M NGGNPGLGVPAGTAGEAGAPGLATSNQALLDVINAPTQALLDRPLIGNGA
Mflv_5091|M.gilvum_PYR-GCK ------TGG----------------------TGGTGGIGGAGSTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 ------TGG----------------------TGGTGGIGGAGSTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155 ------DGAGASVW-----KANGQHSTGQTDTGGNGGRGGDGGTFVNAGA
TH_3810|M.thermoresistible__bu ------NGG---------------------SSSGTHPMAEDG--------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------AGLAGNAGLAGNAGLAGNAGL
MLBr_01183|M.leprae_Br4923 -------------------------------LSAATVASNAAAAQLTTEI
MAV_4827|M.avium_104 ----------------------------LAVVGISAVLALEIALAIGIRT
Rv1759c|M.tuberculosis_H37Rv SGTPGTGDDGGAGGWLFGNGGNGGAGAAGTN--GSAGGAGGAGGILFGTG
Mb1789c|M.bovis_AF2122/97 SGTPGTGDDGGAGGWLFGNGGNGGAGAAGTN--GSAGGAGGAGGILFGTG
MUL_3062|M.ulcerans_Agy99 PGSAGSGAAGAPGGWLLGDGGAGGS-AAATP--GAAGGAGGAAG-LVGAG
MMAR_0755|M.marinum_M NGAAGTGANGGDGGILFGNGGAGGSGAVNGLGTGQAGGNGGAAGLLSGGA
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGGTG-GTGGTGGTGGTGGKGGT--GGTGGAGGTG----GDG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGTG-GTGGTGGTGGTGGKGGT--GGTGGDGGTG----GTG
MSMEG_0868|M.smegmatis_MC2_155 NGNGGAGGAGGVSEGEGGTGGHGGDGGRGGD--GALGGNGGTGGVGLGNG
TH_3810|M.thermoresistible__bu EHVKALDGRPGLD---GGNGSHGGNGGHGGR--GGFLGIGGSG-------
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG-NAGLA
MLBr_01183|M.leprae_Br4923 APPAADDVSILLAHFFSGHG--RQYQAHASQ--GATNHQDLIQSLLTSSS
MAV_4827|M.avium_104 TGTVALQPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSP
.
Rv1759c|M.tuberculosis_H37Rv GAGGAGGVGTAGAG-------GAGGAGGSAFLIGSGGTGGVGGA-----A
Mb1789c|M.bovis_AF2122/97 GAGGAGGVGTAGAG-------GAGGAGGSAFLIGSGGTGGVGGA-----A
MUL_3062|M.ulcerans_Agy99 GAGGAGANTGISNP-------GFGGAG------GAGGAG----------A
MMAR_0755|M.marinum_M GVGGTGGIGAVLG--------GAGGTGGMAGLFGAGGAGGEGG------G
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG---------GTGGTG------GTGGAG-----------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG---------GTGGTG------GTGGAG-----------
MSMEG_0868|M.smegmatis_MC2_155 GKGGNGGNGGNGGTYVDPSHTGAGGNG------GNGGAGRIRVNNGTATG
TH_3810|M.thermoresistible__bu GWGGHGGNGGD-----------TDADG------GNGGDG-----------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGN--------AAVAG------NAAVAG----------N
MLBr_01183|M.leprae_Br4923 AYAGTETANHDSL-------------------------------------
MAV_4827|M.avium_104 PVAAPLPAAPPPAAP---------------------------------PL
..
Rv1759c|M.tuberculosis_H37Rv TTTGGVGGAGGNAGLLIGAAGLGGCGGGAFTAGVT-TGGAG---------
Mb1789c|M.bovis_AF2122/97 TTTGGVGGAGGNAGLLIGAAGLGGCGGGAFTAGVT-TGGAG---------
MUL_3062|M.ulcerans_Agy99 GAGGGVGEAGG-AGGLLGAGGTGGGGGVAPSLVDGGTGGAG---------
MMAR_0755|M.marinum_M GQSGGAGGAGG--VGLFGAGGNGGTGG--FSLVTGGAGGAGGASLLSGNG
Mflv_5091|M.gilvum_PYR-GCK DGTGGTGGTGG----TGGQGGQGGQGG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1 DGLGGTGGTGG----TGGFGGQGGQGG-----------------------
MSMEG_0868|M.smegmatis_MC2_155 TATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGT-------
TH_3810|M.thermoresistible__bu ----GNGGSAG---------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AAVAGNAAVGG----VLNTGVSGAIGG-----------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDP---------------
Rv1759c|M.tuberculosis_H37Rv GTGGAAGLFAN--GGAGGAGG----------------TGSTAGGAGGAGG
Mb1789c|M.bovis_AF2122/97 GTGGAAGLFAN--GGAGGAGG----------------TGSTAGGAGGAGG
MUL_3062|M.ulcerans_Agy99 GAGGAGGLFGGIFGAGGGDGG----------------AGGFTGGIDGAGG
MMAR_0755|M.marinum_M GAGGAGGIGGTGAGGAGGDGG----------------AAGAFSGNGGAGG
Mflv_5091|M.gilvum_PYR-GCK -TGGTGGQGG--LGGGGGTG-----------------------GQGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 -TGGTGGQGG--LGGVGGTG-----------------------GTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGNGGT-LGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGI
TH_3810|M.thermoresistible__bu -RGGTGGLRGV-FGINGGNG------------------------RAGLGG
MAB_4284c|M.abscessus_ATCC_199 -SSHVGGAINESLGGSGSVGG-----------------STAVGGGAHTGV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -VSPPQLLAPPRLSVPQPVQP-----------------PVRVPQPPSPPQ
Rv1759c|M.tuberculosis_H37Rv AGGLYAHGGTGGPGGNG--------GSTGAGGTGGAGGPGG---------
Mb1789c|M.bovis_AF2122/97 AGGLYAHGGTGGPGGNG--------GSTGAGGTGGAGGPGG---------
MUL_3062|M.ulcerans_Agy99 VGG--AGGNTGLLGGPG--------GSGGSGGDGIAK--LG---------
MMAR_0755|M.marinum_M AGGIAPAGTEGGAGGAGGNAGVFS-GTGGAGGAGGAGQTVGGAGGTGGGA
Mflv_5091|M.gilvum_PYR-GCK TGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGG---------
Mvan_1264|M.vanbaalenii_PYR-1 TGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGG---------
MSMEG_0868|M.smegmatis_MC2_155 NGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGG---------
TH_3810|M.thermoresistible__bu RGXXXXGGGVGAAVRSG---------------NGVFSGGGG---------
MAB_4284c|M.abscessus_ATCC_199 GGGVSTGVGVGSHVGGG-----ISESLGGSGSVGGSTAVGG---------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 VGGTVPQSPPQHQTPPG---------EGTPPKPDGPGNYGGG--------
Rv1759c|M.tuberculosis_H37Rv --LYGAGGSGGAGGHGGMAGGGGGVGGNAGSLT-LNASGGAGGSGGSSLS
Mb1789c|M.bovis_AF2122/97 --LYGAGGSGGAGGHGGMAGGGGGVGGNAGSLT-LNASGGAGGSGGSSLS
MUL_3062|M.ulcerans_Agy99 --FNVDGGAGGAGVNGGFLFGSGGTGG----------FGGVGGVGTS--T
MMAR_0755|M.marinum_M ATLFGAGGAGGAGAIGLDTGGAGGAGGSAGALSGTGGAGGAGGIGVGGGG
Mflv_5091|M.gilvum_PYR-GCK --FGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GS
Mvan_1264|M.vanbaalenii_PYR-1 --FGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GS
MSMEG_0868|M.smegmatis_MC2_155 --NGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQS
TH_3810|M.thermoresistible__bu --TPSAGFGVPTTIQFPAGSCTSRAVSREG--------------------
MAB_4284c|M.abscessus_ATCC_199 ----GAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --HVPTPGAGGSGGSGGGHVPTPGAGGSGG--------SGGGHVPTPGTG
Rv1759c|M.tuberculosis_H37Rv GKAGAGGAGGSAGLFYGSGGAGGNGGYS-LNGTG------------GDGG
Mb1789c|M.bovis_AF2122/97 GKAGAGGAGGSAGLFYGSGGAGGNGGYS-LNGTG------------GDGG
MUL_3062|M.ulcerans_Agy99 GIGGAGGRGGNAGLLFSDAGVGGFGGFGGTGGNAG---------WLGSGG
MMAR_0755|M.marinum_M GGGGVGGAGGNAGVVYGDGGAGGAGGGGTVAAGAAGGSGGNAAMLFGNGG
Mflv_5091|M.gilvum_PYR-GCK GSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAG
Mvan_1264|M.vanbaalenii_PYR-1 GSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASG
MSMEG_0868|M.smegmatis_MC2_155 GYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTA
TH_3810|M.thermoresistible__bu ----IMPSSRAASARAG---------------------------AACASS
MAB_4284c|M.abscessus_ATCC_199 GVGGGVNTGVGVGSHVGGGISESLGGSGSVG---------------GSTA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 GPGGTGGSGGGHVPTPGAGTPGGSGGGHLPFPG-------------AGST
Rv1759c|M.tuberculosis_H37Rv TGGAGQITGLRSGFGGAGG-----------AGG--ASDTGAGGNGGAGGK
Mb1789c|M.bovis_AF2122/97 TGGAGQITGLRSGFGGAGG-----------AGG--ASDTGAGGNGGAGGK
MUL_3062|M.ulcerans_Agy99 SGGAGGGSNGDGGAGGTGG-----------SGGQIVGDGGAGGAGGQGDL
MMAR_0755|M.marinum_M AGGTGAVGAAVGGNGGTGG-----------DGGGLSGSGGAGGNGAGGGT
Mflv_5091|M.gilvum_PYR-GCK KAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQ
Mvan_1264|M.vanbaalenii_PYR-1 AQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQ
MSMEG_0868|M.smegmatis_MC2_155 TGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGK
TH_3810|M.thermoresistible__bu TSRSRRSFCCSRA-------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VGGGAHTSAINDALGGSGS-----------VGGSTAVGGGAHTSAINESM
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PGGSGGGHLPTPGAGTPGG--------------------GLGGFGGGHAP
Rv1759c|M.tuberculosis_H37Rv AGLYGNGG-----------------------DGGAGGDGATSGKGGAGGN
Mb1789c|M.bovis_AF2122/97 AGLYGNGG-----------------------DGGAGGDGATSGKGGAGGN
MUL_3062|M.ulcerans_Agy99 LAAGGSGG-----------------------DGGQGGDAVLIGTGGNGGN
MMAR_0755|M.marinum_M GGTGGDGGRARGLLGDGGTGGDGGFGGITSGDGGNGGTGALIGDGGNGGA
Mflv_5091|M.gilvum_PYR-GCK GAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-
Mvan_1264|M.vanbaalenii_PYR-1 GAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-
MSMEG_0868|M.smegmatis_MC2_155 GADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGN
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NSSINASHS----------------------SSMNESFGSSMGSHGAAGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 APGGGLGG------------------------GGGHAPAPGGGLGGFGGG
Rv1759c|M.tuberculosis_H37Rv ------------------AVVIGNGGNGGNA----------GKAGGTAGA
Mb1789c|M.bovis_AF2122/97 ------------------AVVIGNGGNGGNA----------GKAGGTAGA
MUL_3062|M.ulcerans_Agy99 G---------------ASGVLAGIGGDGGSR----------GLLLGEDGV
MMAR_0755|M.marinum_M GGIGLGAAPGGDGGKGGDAQLVGTGGNGGILGL--------GLPPGTAGT
Mflv_5091|M.gilvum_PYR-GCK --------------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGA
Mvan_1264|M.vanbaalenii_PYR-1 --------------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGA
MSMEG_0868|M.smegmatis_MC2_155 TSVW----KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 G-------------------------------------------FEAQGH
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -----------------------------------------HSGGGLGGL
Rv1759c|M.tuberculosis_H37Rv GGAGG------LVLGRDGQHGLT--------------
Mb1789c|M.bovis_AF2122/97 GGAGG------LVLGRDGQHGLT--------------
MUL_3062|M.ulcerans_Agy99 NGEAAPPMTHIVLLGGDFPAAAS--------------
MMAR_0755|M.marinum_M GGTGG------TLIGENGHDGA---------------
Mflv_5091|M.gilvum_PYR-GCK GGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 GGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu -------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AQGHASETAHTTLPGAEHH------------------
MLBr_01183|M.leprae_Br4923 -------------------------------------
MAV_4827|M.avium_104 GGGHK--------------------------------