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MALLSNRVVADALARTFAATVNPAPKPGVRFSDITCRTSDAAIPTRHGTVFARIYHPPAAGATSAVYVNV HGGGFVVGHPEQDDPWCRYLATHAEVVVVNPDYVLAPRHRFPAAPQQIYDVVCWAAAPDRDWDGSRICVG GQSAGGNLSAAAARLALRHGTPRISLQVLHYAPLDLVTPTRDKPSTIGRRAVMKPWMGEVFDTAYIPDPA QRRDPLASPAWDQATDDLSGIAPAVVVTAEFDRLRNEARTYAERLRSFGALREYIEVPDVDHGYNIMTNA TDVTRGVYDRVAHHVRRATDDGGQGRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6852 | - | - | 100% (307) | putative carboxylesterase/lipase |
| M. smegmatis MC2 155 | MSMEG_2409 | - | 2e-33 | 38.33% (240) | alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_2875 | - | 3e-27 | 34.15% (287) | esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2994c | lipN | 4e-29 | 35.66% (244) | lipase/esterase LipN |
| M. gilvum PYR-GCK | Mflv_4203 | - | 2e-32 | 37.19% (242) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2970c | lipN | 4e-29 | 35.66% (244) | lipase/esterase LipN |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0078 | - | 1e-30 | 37.14% (245) | putative lipase/esterase |
| M. marinum M | MMAR_0576 | - | 1e-28 | 34.72% (265) | monooxygenase |
| M. avium 104 | MAV_3814 | - | 1e-28 | 34.31% (239) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_2562 | - | 7e-28 | 34.33% (300) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1794 | lipH | 1e-25 | 35.94% (217) | lipase LipH |
| M. vanbaalenii PYR-1 | Mvan_0324 | - | 1e-124 | 72.58% (299) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M MSDAHHTDVDVVVAGAGFAGLYAAYRLRRAGHSMRIFEAGDDIGGTWYWN
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M RYPGARVDIPSVDYMYSFDPDWSRDWQWSEKYATQPEILRYLNHVADKHD
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M LRRDIQFGTRVTHAHWDDDAGRYRVRTDRGDEIICRYLIMATGCLSVPKD
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M LDIDGIENFTGELYFTSRWPHEPVDFTGKRVGVVGTGSSGIQSIPLIAAQ
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M AAQVVVFQRTPCFSIPAHNGPISPDKLAQLADDDAYRRAARYSFGGVPME
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M RSLTPTFSVSAEERRQRYERAWQLGELLEALNLYADEMINPLANSEFAEF
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M IRDKIRATVHDPQTAEALCPSGYPVGSKRLCLDSNYYATFNLPQVRLVDL
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M RNQPLLGVTKTGIDTVGESFEFDAIVFATGFDAVTGALAAIDIVGRNGLA
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 --------------------------------------------------
Rv2970c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3814|M.avium_104 --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M LGDKWAPGPSTYLGLTTEGFPNLFLIAGPNSPSVLSNMAVSIEQHVDFVA
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 ---------------------------------MTKSLPGVAD----LRL
Rv2970c|M.tuberculosis_H37Rv ---------------------------------MTKSLPGVAD----LRL
MAV_3814|M.avium_104 ---------------------------------MTKPLTDTAP----VDP
Mflv_4203|M.gilvum_PYR-GCK ---------------------------------MPASRATESHNNWTTPK
MUL_1794|M.ulcerans_Agy99 ---------------------------------MTEQISTRPG-------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0576|M.marinum_M DALSYLREHGFDRIEPTELAEAGWMQHSDDAASITLFPQANSWYVGANIP
TH_2562|M.thermoresistible__bu --------------------------------------------------
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 GANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKRILSAGRSVIIDGNTLD
Rv2970c|M.tuberculosis_H37Rv GANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKRILSAGRSVIIDGNTLD
MAV_3814|M.avium_104 GVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRRGLVRGRSVIIDGNTLD
Mflv_4203|M.gilvum_PYR-GCK GSPHAGG-AVEKLTNTLAGVTLRALPRIPDPVKRLLLGRRTITLDGNTLD
MUL_1794|M.ulcerans_Agy99 ------------------------------------------------ID
MAB_0078|M.abscessus_ATCC_1997 ----------------------------------------------MTLD
MMAR_0576|M.marinum_M GKPRTFMAYTAGVDVYRVACEEVVARDYLGFRLSGPNGSQCNDGVVRRLQ
TH_2562|M.thermoresistible__bu ---------------------------------------VNPPEAGQRLA
MSMEG_6852|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0324|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2994c|M.bovis_AF2122/97 PTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQIHVDVTDL
Rv2970c|M.tuberculosis_H37Rv PTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQIHVDVTDL
MAV_3814|M.avium_104 PTLQLMLSGLRAVGIDGLVVDDDPELSRAQMHESTVGFPGPQIHVDVAEL
Mflv_4203|M.gilvum_PYR-GCK TTLHLMLAGQRLMGIEGLVADDDVTVARAQLEVLAAAFKQHIPVAAVTNL
MUL_1794|M.ulcerans_Agy99 PILKMLLDAVPMT----FCAADGVELARERLAALKAPPELLPDLRTEDRK
MAB_0078|M.abscessus_ATCC_1997 PQLAALLPALNA-GFPRVEKMTG-AQARAAIRARYVPPARPLPMRSVTDE
MMAR_0576|M.marinum_M PDIQMVLEQLEALGLPPLESLPA-DQARALMNEMNLARPPGPDVGEIVDG
TH_2562|M.thermoresistible__bu PELRHLWGTRTDLTADLLPTVRAVLDDRRRATAAAVDTGG----VHIDDR
MSMEG_6852|M.smegmatis_MC2_155 ---------MALLSNRVVADALARTFAATVNPAPKPGVRFSDITCRTSDA
Mvan_0324|M.vanbaalenii_PYR-1 ---------MSILPVPVVADTVARVFAAAVNPAPKAAVRFADIPGRTAQV
.
Mb2994c|M.bovis_AF2122/97 SIPGPAGEIPARHYRP-SGGG-ATPLLVFYHGGGWTLGDLDTHDALCRLT
Rv2970c|M.tuberculosis_H37Rv SIPGPAGEIPARHYRP-SGGG-ATPLLVFYHGGGWTLGDLDTHDALCRLT
MAV_3814|M.avium_104 ALPGPAGDIPARHYRP-AGGETQAPLLVFYHGGGWSIGDLDTHDSLCRLT
Mflv_4203|M.gilvum_PYR-GCK TVPGAQGPLDARHYRT-DEPD--AALLVFFHGGGHVIGSLDSHDDLCREI
MUL_1794|M.ulcerans_Agy99 IGYGELTDIPVRTYWPTVEPDWVLPVVVYYHGGGWALGSLDTHDHVARAH
MAB_0078|M.abscessus_ATCC_1997 CVYAFGGELPIRVYRPAVPGP--LPTVVFAHGGGFVFCDLDSHDGLCRRL
MMAR_0576|M.marinum_M TLPGAAGPLAYRLYRPASPGP--HPVVVYFHGGGWVLGDHTSDDPLCRDL
TH_2562|M.thermoresistible__bu EIHCGTGPIEIRIYRG---RRGVAPAVLYCHAGAFVLGNLDTDHRQCVEL
MSMEG_6852|M.smegmatis_MC2_155 AIPTRHGTVFARIYHPPAAGA-TSAVYVNVHGGGFVVGHPEQDDPWCRYL
Mvan_0324|M.vanbaalenii_PYR-1 TIPTRHGPVTATIYHPPSEVQ-SPPVYANVHGGGFVVGHPEQDDPWCRYL
: * . *.*. . .. .
Mb2994c|M.bovis_AF2122/97 CRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRV
Rv2970c|M.tuberculosis_H37Rv CRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRV
MAV_3814|M.avium_104 CRDAGIHVLSIDYRLAPEHPAPAAIDDAYAAFTWAHEHAG-ELGAIPGRV
Mflv_4203|M.gilvum_PYR-GCK CRAGRIHVLSVDYRLAPEHKAPAGAQDAYSAYLWAREHAA-ELGADPERV
MUL_1794|M.ulcerans_Agy99 AVGAEAIVVSVDYRLAPEHPYPAGIEDSWAALRWVGEHAH-ELGGDPNRI
MAB_0078|M.abscessus_ATCC_1997 AAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRNAP-TLGGDPARV
MMAR_0576|M.marinum_M CVLSDTLIVSVDYRHAPEHRFPAALDDGWAAVQWIAEHAG-ELGGIPGQL
TH_2562|M.thermoresistible__bu ARRAECTVVSVDYRLAPEHPWPAAVDDATAVLSWLAGNAT-ALDVDPARL
MSMEG_6852|M.smegmatis_MC2_155 ATHAEVVVVNPDYVLAPRHRFPAAPQQIYDVVCWAAAPDR---DWDGSRI
Mvan_0324|M.vanbaalenii_PYR-1 AANAGVVVVNPDYALAPRRRFPAAPQQIYDIVCWAADEAR---DWDGTRL
. ::. ** **.: *:. :: * . ::
Mb2994c|M.bovis_AF2122/97 AVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSM
Rv2970c|M.tuberculosis_H37Rv AVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSM
MAV_3814|M.avium_104 AVGGDSAGGNLAAVVSQLARD----AGGPAPVLQWLIYPRTDFTARTRSL
Mflv_4203|M.gilvum_PYR-GCK AVGGDSAGGNLSAVLTQRARD----EGAPLPALQVLLYPATEVGIQTRSQ
MUL_1794|M.ulcerans_Agy99 AVAGDSAGGNISAIMAQLARDHAG-NGAPNLVFQLLWYPSCVGDLALPSF
MAB_0078|M.abscessus_ATCC_1997 LVCGDSAGGNLAAVTTLMARD----LGGPVLAGQILIYPVLDADFDTPSY
MMAR_0576|M.marinum_M VVSGWSAGAGIAAVVCHLARD----AGAPSIVGQALLTPVTDFDPTRGSY
TH_2562|M.thermoresistible__bu AVAGSSAGGALAAGLAQRSGR----NGLPQLVFQLLHQPALDDRVTP-SK
MSMEG_6852|M.smegmatis_MC2_155 CVGGQSAGGNLSAAAARLALR----HGTPRISLQVLHYAPLDLVTPTRDK
Mvan_0324|M.vanbaalenii_PYR-1 CVGGQSAGGNLSAAAARLALE----NRTPIISLQVLHYAPLDLVTPTRDK
* * ***. ::* : * * * . .
Mb2994c|M.bovis_AF2122/97 GLFGNGFLLTKRDI-DWFHTQYLRDSDVDPADPRLSPLLAES--LSGLAP
Rv2970c|M.tuberculosis_H37Rv GLFGNGFLLTKRDI-DWFHTQYLRDSDVDPADPRLSPLLAES--LSGLAP
MAV_3814|M.avium_104 SLFSRGFLLTKRDI-DWFESQYLRNSGLDRTDPRVSPALAES--LAGLAP
Mflv_4203|M.gilvum_PYR-GCK TLFSDGFFLTKRDM-DWFMDHFLDGADVADTDPRVSPLRTDD--MSGLPP
MUL_1794|M.ulcerans_Agy99 SENATAPILDLEVI-DAFLSWYVPDLDVSDHTALPATLAPGNGDLTGLPP
MAB_0078|M.abscessus_ATCC_1997 RSCGSGYYNTRAAM-QWYWDQYLPDPALRDHPYAAP---LRA-DLSGLPP
MMAR_0576|M.marinum_M LENADGYGLTAPLM-QWFFDHYA-DPDVRTDPRIAP---LRAPDLSALPP
TH_2562|M.thermoresistible__bu AEFCTTPGFDGPAC-DQMWRHYLAGAAPTAAAAPGR-----ADDLTGAPP
MSMEG_6852|M.smegmatis_MC2_155 PSTIGRRAVMKPWMGEVFDTAYIPDPAQRRDPLASPAWDQATDDLSGIAP
Mvan_0324|M.vanbaalenii_PYR-1 PSAFGARAVLKPWMGEVFDTAYIPDPAQRSDRLASPAWGANAEDIVGIAP
: : . : . .*
Mb2994c|M.bovis_AF2122/97 ALIAVAGFDPLRDEGESYAKALRAAGTAVDLRYLGSLTHGFLNLFQLGGG
Rv2970c|M.tuberculosis_H37Rv ALIAVAGFDPLRDEGESYAKALRAAGTAVDLRYLGSLTHGFLNLFQLGGG
MAV_3814|M.avium_104 ALIAVAGFDPLRDEGQSYAEALRAAGTPVDLRYLGSLTHGFANLFQLGGD
Mflv_4203|M.gilvum_PYR-GCK ALVVTAGFDPLRDEGRLYAEALREAGTPVDYREYGTVVHGFANFFPLGGD
MUL_1794|M.ulcerans_Agy99 AFIGTAEHDPLRDDGARYAELLTAAGIAAEWCNEPNLVHGYVSFAVVVPS
MAB_0078|M.abscessus_ATCC_1997 AVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELA
MMAR_0576|M.marinum_M AIVVAAEFDPLRDEGIEYAEALAAAGVPTELVRARGHTHLSLTMVDVVVS
TH_2562|M.thermoresistible__bu AFISCSELDPLRDEALDYAARLLRCGVPTELHLFPGTCHGFDSLLPEWEL
MSMEG_6852|M.smegmatis_MC2_155 AVVVTAEFDRLRNEARTYAERLRSFGALREYIEVPDVDHGYNIMTNATDV
Mvan_0324|M.vanbaalenii_PYR-1 AVVVTAEHDRLRNEGHRYAKKLDAAGSLVEYHEVAGVDHGYNIMGGALGA
*.: : * .:. ** * * * :
Mb2994c|M.bovis_AF2122/97 SAAGTNELISALRAHLSRV--------
Rv2970c|M.tuberculosis_H37Rv SAAGTNELISALRAHLSRV--------
MAV_3814|M.avium_104 SMVATSELISALRAHLSRV--------
Mflv_4203|M.gilvum_PYR-GCK SATAMADVISAIRAHLTRAG-------
MUL_1794|M.ulcerans_Agy99 AAEATSRGLATLRKVLHY---------
MAB_0078|M.abscessus_ATCC_1997 DAGIQRLCR-------DVGEMLG----
MMAR_0576|M.marinum_M GAPIRAQLAGALRGFFAIGAAVPA---
TH_2562|M.thermoresistible__bu SRQLFALQAAAVRRAFTTAEYPAGQVN
MSMEG_6852|M.smegmatis_MC2_155 TRGVYDRVAHHVRRATDDGGQGRS---
Mvan_0324|M.vanbaalenii_PYR-1 TEQVYSRIAGHVARATGSA--------