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VTLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGELPIRVYRPAV PGPLPTVVFAHGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRNAP TLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGPVLAGQILIYPVLDADFDTPSYRSCGSGYYNTRAAMQ WYWDQYLPDPALRDHPYAAPLRADLSGLPPAVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHG FMTMPGLELADAGIQRLCRDVGEMLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0078 | - | - | 100% (306) | putative lipase/esterase |
| M. abscessus ATCC 19977 | MAB_2039 | - | 7e-48 | 43.48% (230) | lipase LipH (carboxylesterase) |
| M. abscessus ATCC 19977 | MAB_3270c | - | 4e-47 | 43.67% (245) | lipase/esterase LipN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 5e-50 | 40.91% (286) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4552 | - | 1e-107 | 60.66% (305) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1399c | lipH | 5e-50 | 40.91% (286) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 7e-12 | 26.96% (230) | putative esterase |
| M. marinum M | MMAR_0576 | - | 1e-55 | 42.71% (295) | monooxygenase |
| M. avium 104 | MAV_3025 | - | 1e-105 | 62.41% (290) | esterase |
| M. smegmatis MC2 155 | MSMEG_2888 | - | 1e-102 | 59.67% (305) | lipase |
| M. thermoresistible (build 8) | TH_2802 | - | 6e-46 | 40.85% (284) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1989 | lipN | 1e-46 | 39.38% (292) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2888 | - | 7e-99 | 57.10% (310) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M MSDAHHTDVDVVVAGAGFAGLYAAYRLRRAGHSMRIFEAGDDIGGTWYWN
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M RYPGARVDIPSVDYMYSFDPDWSRDWQWSEKYATQPEILRYLNHVADKHD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M LRRDIQFGTRVTHAHWDDDAGRYRVRTDRGDEIICRYLIMATGCLSVPKD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M LDIDGIENFTGELYFTSRWPHEPVDFTGKRVGVVGTGSSGIQSIPLIAAQ
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M AAQVVVFQRTPCFSIPAHNGPISPDKLAQLADDDAYRRAARYSFGGVPME
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M RSLTPTFSVSAEERRQRYERAWQLGELLEALNLYADEMINPLANSEFAEF
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M IRDKIRATVHDPQTAEALCPSGYPVGSKRLCLDSNYYATFNLPQVRLVDL
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M RNQPLLGVTKTGIDTVGESFEFDAIVFATGFDAVTGALAAIDIVGRNGLA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M LGDKWAPGPSTYLGLTTEGFPNLFLIAGPNSPSVLSNMAVSIEQHVDFVA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3025|M.avium_104 --------------------------------------------------
MSMEG_2888|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2888|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0078|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0576|M.marinum_M DALSYLREHGFDRIEPTELAEAGWMQHSDDAASITLFPQANSWYVGANIP
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK ---------------------------------------------MR-LD
MAV_3025|M.avium_104 ---------------------------------------------MS-LE
MSMEG_2888|M.smegmatis_MC2_155 ---------------------------------------------MSGLD
Mvan_2888|M.vanbaalenii_PYR-1 ---------------------------------------------MS-LD
MAB_0078|M.abscessus_ATCC_1997 ---------------------------------------------MT-LD
TH_2802|M.thermoresistible__bu -------------------------------------------MNHPVPP
MUL_1989|M.ulcerans_Agy99 -----------MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIP
Mb1434c|M.bovis_AF2122/97 ------------------------------------------MTEPTVAR
Rv1399c|M.tuberculosis_H37Rv ------------------------------------------MTEPTVAR
MMAR_0576|M.marinum_M GKPRTFMAYTAGVDVYRVACEEVVARDYLGFRLSGPNGSQCNDGVVRRLQ
MLBr_00314|M.leprae_Br4923 -------------------------------MAISAGAPVEIVESGPSIA
Mflv_4552|M.gilvum_PYR-GCK PQIAALIDALDG-GFPAVHT--------------------------MTGA
MAV_3025|M.avium_104 PQIAAIIEQLDS-GFPPVQQ--------------------------MSGA
MSMEG_2888|M.smegmatis_MC2_155 PQIADIIEALDS-GFPPVHT--------------------------MTGA
Mvan_2888|M.vanbaalenii_PYR-1 PQIATIIETLDS-GFPAVHT--------------------------MTGE
MAB_0078|M.abscessus_ATCC_1997 PQLAALLPALNA-GFPRVEK--------------------------MTGA
TH_2802|M.thermoresistible__bu LDPDAAARIASL-GPPAPMR-------------------------RRGLQ
MUL_1989|M.ulcerans_Agy99 WVPDVAKRLITR-GRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLA
Mb1434c|M.bovis_AF2122/97 PDIDPVLKMLLD-TFPVTFT------------------------AADGVE
Rv1399c|M.tuberculosis_H37Rv PDIDPVLKMLLD-TFPVTFT------------------------AADGVE
MMAR_0576|M.marinum_M PDIQMVLEQLEALGLPPLES--------------------------LPAD
MLBr_00314|M.leprae_Br4923 ARLASLTSRLTIRPILAVGS---------------------------YVP
Mflv_4552|M.gilvum_PYR-GCK QARATIRSRFTPAAEPEPVHSVHDMAVPVDDGEVPVRVYRPAGPAP--LP
MAV_3025|M.avium_104 EARALIRSRLVPPAQPEPVAEVADRLVEGPGGPLRIRVYRPEAAAP--LP
MSMEG_2888|M.smegmatis_MC2_155 QARAAIKARFRPAAHPQPMAAVEDATATGSSGDVAVRIYRPATPAR-PLP
Mvan_2888|M.vanbaalenii_PYR-1 QARAAIRSRFVPAAEPEPVASVEDRTVPGPDGPVTVRIYRPAAATDGPVP
MAB_0078|M.abscessus_ATCC_1997 QARAAIRARYVPPARPLPMRSVTDECVYAFGGELPIRVYRPAVPGP--LP
TH_2802|M.thermoresistible__bu AVRDAIESAPLPTDMP-AMASIVDRAVPGPGGDIPVRIHRPERGCGDPAP
MUL_1989|M.ulcerans_Agy99 ASRAHMREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG--DAAAP
Mb1434c|M.bovis_AF2122/97 VARARLRQLKTPPELLPELRIEERTVGYDGLTDIPVRVYWPPV-VRDNLP
Rv1399c|M.tuberculosis_H37Rv VARARLRQLKTPPELLPELRIEERTVGYDGLTDIPVRVYWPPV-VRDNLP
MMAR_0576|M.marinum_M QARALMNEMNLARPPGPDVGEIVDGTLPGAAGPLAYRLYRPASPGP--HP
MLBr_00314|M.leprae_Br4923 QLPWPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGR
:
Mflv_4552|M.gilvum_PYR-GCK ALVFAHGGGFVFCDLDSHDGLCRNLSNRLGAVVISVGYRLAP-EHRWPTA
MAV_3025|M.avium_104 ALVYAHGGGFVFCDLDSHDGLCRNLANLVPAVVVSVDYRLAP-ENAWPAA
MSMEG_2888|M.smegmatis_MC2_155 TLVWAHGGGWVFCDLDSHDELCRDIATRVPAVIVSVDYRRAPDEGQWPAA
Mvan_2888|M.vanbaalenii_PYR-1 TMVYAHGGGWVFCDLDSHDGLCRAFANGMSAVVVSVHYRRASEEGRWPAA
MAB_0078|M.abscessus_ATCC_1997 TVVFAHGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAP-EHRWPTA
TH_2802|M.thermoresistible__bu AVLYFHGGGLVMGSNHSFEPLARGLAAASGAVVVAVDYRLAP-EHPPPAQ
MUL_1989|M.ulcerans_Agy99 LLVFYHGGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSP-EHRAPAA
Mb1434c|M.bovis_AF2122/97 VVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAP-EHPYPAG
Rv1399c|M.tuberculosis_H37Rv VVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAP-EHPYPAG
MMAR_0576|M.marinum_M VVVYFHGGGWVLGDHTSDDPLCRDLCVLSDTLIVSVDYRHAP-EHRFPAA
MLBr_00314|M.leprae_Br4923 IVLYLHGGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLP-KHSIGMA
::: ***. . : : . . :: : ** . :
Mflv_4552|M.gilvum_PYR-GCK AEDMYAVTRWVSGDADALGVDPARIAVGGDSAGGNLAAVTALMARDRGGP
MAV_3025|M.avium_104 AEDVYAATCWARDHADALGADPARLVVGGDSAGGNLAAVTTVMCRDRGGP
MSMEG_2888|M.smegmatis_MC2_155 ADDMFTATRWAAAHAADLGGAENLLLVGGDSAGGNLAAVTALMARDRGGP
Mvan_2888|M.vanbaalenii_PYR-1 AEDVYAVAAWAAETIGELGGDLSALLVGGDSAGGNLAAVTALMARDRRGP
MAB_0078|M.abscessus_ATCC_1997 AQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGP
TH_2802|M.thermoresistible__bu FDDAWATTRWVAAHADELGLDTSRLAVAGDSAGGALAAAVALAARDRGGP
MUL_1989|M.ulcerans_Agy99 IDDAFAAFEWAHAHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGP
Mb1434c|M.bovis_AF2122/97 IDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGP
Rv1399c|M.tuberculosis_H37Rv IDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGP
MMAR_0576|M.marinum_M LDDGWAAVQWIAEHAGELGGIPGQLVVSGWSAGAGIAAVVCHLARDAGAP
MLBr_00314|M.leprae_Br4923 LDDCHDGYQWLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEE
:* * ** : : * ***. :: . :*
Mflv_4552|M.gilvum_PYR-GCK ALRAQLLLYPVIAADFDTESYRLFGHGFYNPEPALRWYWDQYVPALS-DR
MAV_3025|M.avium_104 APAAQLLIYPVIAADFDTESYRLFGQGYYNPAPALRWYWDCYVPSTR-DR
MSMEG_2888|M.smegmatis_MC2_155 DLAGQVLLYPVIAADFDNESYRRFGAGHYNPRPALQWYWDQYVPAAA-DR
Mvan_2888|M.vanbaalenii_PYR-1 ALAGQLLLYPVIAANFDTESYRRFGEGFYNPLAALQWYWDQYVPNLA-DR
MAB_0078|M.abscessus_ATCC_1997 VLAGQILIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPA-LR
TH_2802|M.thermoresistible__bu ELLAQLLMYPGLDRDLAAPSIVAMPEAPMLSRDDIVYLHELADLGAG-TP
MUL_1989|M.ulcerans_Agy99 APIFQWLIYPRTDFAGRTRSASLFARGFLLTKRDIDWFHSQYLKGSGIEP
Mb1434c|M.bovis_AF2122/97 PLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISD
Rv1399c|M.tuberculosis_H37Rv PLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISD
MMAR_0576|M.marinum_M SIVGQALLTPVTDFDPTRGSYLENADGYGLTAPLMQWFFDHYADPDV--R
MLBr_00314|M.leprae_Br4923 PAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNK
: : :
Mflv_4552|M.gilvum_PYR-GCK QHPYASPLH---GE-LTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPV
MAV_3025|M.avium_104 AHPYATPLN---AD-LRGLPPAVVVVAGHDPLRDEGLAFGAALEAAGVPT
MSMEG_2888|M.smegmatis_MC2_155 VHPYASPLH---AD-LSGLPPAITVVAGHDPLRDEGLAYAEALELAGVPT
Mvan_2888|M.vanbaalenii_PYR-1 VNPYASPLH---ADDLSGLPPAITVVAGHDPLRDEGLAYTEALEAAGVET
MAB_0078|M.abscessus_ATCC_1997 DHPYAAPLR---AD-LSGLPPAVVVTARYDPPCSEGEAYAAALREAGVPV
TH_2802|M.thermoresistible__bu HDPYRVPAY---ATDLGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQT
MUL_1989|M.ulcerans_Agy99 TDPRVSPLR---AESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPV
Mb1434c|M.bovis_AF2122/97 HTMLPTTLAP-GNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSV
Rv1399c|M.tuberculosis_H37Rv HTMLPTTLAP-GNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSV
MMAR_0576|M.marinum_M TDPRIAPLR---APDLSALPPAIVVAAEFDPLRDEGIEYAEALAAAGVPT
MLBr_00314|M.leprae_Br4923 VDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPA
.*. :. : . * .*. .
Mflv_4552|M.gilvum_PYR-GCK VRCEFDGAVHGFMT-MPMLDIAHEARRRSCQELTALLHG---------
MAV_3025|M.avium_104 VQLRYEGGIHGFMT-MPMLDIAHRARNEAAAALADLLRR---------
MSMEG_2888|M.smegmatis_MC2_155 VTRYFEGGIHGFMT-MPSLDLCRQARAQACSDISALVESIGIAAP---
Mvan_2888|M.vanbaalenii_PYR-1 ICRYFDGGVHGFMT-MPTFDICGRARARVCADIAELVGRPVTN-----
MAB_0078|M.abscessus_ATCC_1997 RYRRYDNAIHGFMT-MPGLELADAGIQRLCRDVGEMLG----------
TH_2802|M.thermoresistible__bu TVTRYPGMYHGFLMRYESTARGRLALAEIGALLRAKFANPLPF-----
MUL_1989|M.ulcerans_Agy99 DLRAMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
Mb1434c|M.bovis_AF2122/97 ELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA---------
Rv1399c|M.tuberculosis_H37Rv ELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA---------
MMAR_0576|M.marinum_M ELVRARGHTHLSLTMVDVVVSGAPIRAQLAGALRGFFAIGAAVPA---
MLBr_00314|M.leprae_Br4923 EIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* . :