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TKPLTDTAPVDPGVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRRGLVRGRSVIIDGNTLDPTLQLMLS GLRAVGIDGLVVDDDPELSRAQMHESTVGFPGPQIHVDVAELALPGPAGDIPARHYRPAGGETQAPLLVF YHGGGWSIGDLDTHDSLCRLTCRDAGIHVLSIDYRLAPEHPAPAAIDDAYAAFTWAHEHAGELGAIPGRV AVGGDSAGGNLAAVVSQLARDAGGPAPVLQWLIYPRTDFTARTRSLSLFSRGFLLTKRDIDWFESQYLRN SGLDRTDPRVSPALAESLAGLAPALIAVAGFDPLRDEGQSYAEALRAAGTPVDLRYLGSLTHGFANLFQL GGDSMVATSELISALRAHLSRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3814 | - | - | 100% (373) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_3025 | - | 5e-54 | 46.95% (262) | esterase |
| M. avium 104 | MAV_3377 | - | 4e-51 | 38.91% (311) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2994c | lipN | 1e-158 | 73.81% (378) | lipase/esterase LipN |
| M. gilvum PYR-GCK | Mflv_4203 | - | 1e-108 | 56.70% (351) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2970c | lipN | 1e-158 | 73.81% (378) | lipase/esterase LipN |
| M. leprae Br4923 | MLBr_00314 | - | 6e-14 | 26.69% (236) | putative esterase |
| M. abscessus ATCC 19977 | MAB_3270c | - | 1e-104 | 58.98% (334) | lipase/esterase LipN |
| M. marinum M | MMAR_1746 | lipN | 1e-164 | 75.07% (373) | lipase/esterase LipN |
| M. smegmatis MC2 155 | MSMEG_2409 | - | 1e-101 | 54.47% (347) | alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1220 | lipN | 2e-77 | 67.65% (204) | PROBABLE LIPASE/ESTERASE LIPN |
| M. ulcerans Agy99 | MUL_1989 | lipN | 1e-165 | 75.34% (373) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 1e-114 | 56.33% (371) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1746|M.marinum_M ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MUL_1989|M.ulcerans_Agy99 ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MAV_3814|M.avium_104 ---MTKPLTDTAPVDPGVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRR
Mb2994c|M.bovis_AF2122/97 ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
Rv2970c|M.tuberculosis_H37Rv ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
MSMEG_2409|M.smegmatis_MC2_155 ---------------------------MLLAHATRLGLAAIPRMSDRRKH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK MPASRATESHNNWTTPKGSPHAGGAVEKLTNTLAGVTLRALPRIPDPVKR
Mvan_2162|M.vanbaalenii_PYR-1 MTETVAAGES---VQPPVRRKVG-VSDVVANKVAGVTLRGMPRIPHPVKR
MAB_3270c|M.abscessus_ATCC_199 -------------------------MSPFRDFALRASTAATPHIPTPVRR
MLBr_00314|M.leprae_Br4923 -----------------------------MAISAGAPVEIVESGPSIAAR
MMAR_1746|M.marinum_M LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MUL_1989|M.ulcerans_Agy99 LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MAV_3814|M.avium_104 GLVRGRSVIIDGNTLDPTLQLMLSGLRAVGIDGLVVDDD----PELSRAQ
Mb2994c|M.bovis_AF2122/97 ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
Rv2970c|M.tuberculosis_H37Rv ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
MSMEG_2409|M.smegmatis_MC2_155 LLLGGRSVTVDGNTLDTTMQFMLTTQRLAGLPGLVADYDPEHGVAVSRAK
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LLLGRRTITLDGNTLDTTLHLMLAGQRLMGIEGLVADDD----VTVARAQ
Mvan_2162|M.vanbaalenii_PYR-1 VLLGGRSITIDGNTLDTTLHLMLAGQQLLGLDGLVADDD----FVAARTQ
MAB_3270c|M.abscessus_ATCC_199 AMAG-RQVIIDGNILDPTTQLLLRGMELMGEGEISRGED----VAENRAN
MLBr_00314|M.leprae_Br4923 LASLTSRLTIR---------------PILAVGSYVPQLP-------WPFG
MMAR_1746|M.marinum_M MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MUL_1989|M.ulcerans_Agy99 MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MAV_3814|M.avium_104 MHESTVGFPGPQIHVDVAELALPGPAGDIPARHYRPAGGETQAPLLVFYH
Mb2994c|M.bovis_AF2122/97 MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
Rv2970c|M.tuberculosis_H37Rv MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
MSMEG_2409|M.smegmatis_MC2_155 LRETAAMMRMPIHVD-VSDISIPGPAGPLAARRYVPVERGSASALVLYFH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LEVLAAAFKQHIPVAAVTNLTVPGAQGPLDARHYRTDEPD--AALLVFFH
Mvan_2162|M.vanbaalenii_PYR-1 LELLAASFKQRIPIAGVTDLTVSGAEGPVKARHYRTDEPG--APLLVFYH
MAB_3270c|M.abscessus_ATCC_199 MRRQAGLLQFSTPVGQVRNFSIPGPAGPIGVRHYKPVH-DHTGALLVFFH
MLBr_00314|M.leprae_Br4923 LIDHAARVLLPVTNAARAEVNLSNTSAQL-VRAAGVRPADGSGRIVLYLH
MMAR_1746|M.marinum_M GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEDRAPAAIDDAFAA
MUL_1989|M.ulcerans_Agy99 GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAA
MAV_3814|M.avium_104 GGGWSIGDLDTHDSLCRLTCRDAGIHVLSIDYRLAPEHPAPAAIDDAYAA
Mb2994c|M.bovis_AF2122/97 GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
Rv2970c|M.tuberculosis_H37Rv GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
MSMEG_2409|M.smegmatis_MC2_155 GGGFVIGDLEVHDNLCRLICRDGDVQVVSVDYRLAPEHKAPAAAEDAYAA
TH_1220|M.thermoresistible__bu --------------------------VLSVDYRLAPEHKAPAAVEDAYAA
Mflv_4203|M.gilvum_PYR-GCK GGGHVIGSLDSHDDLCREICRAGRIHVLSVDYRLAPEHKAPAGAQDAYSA
Mvan_2162|M.vanbaalenii_PYR-1 GGGHVIGSIDSHDDLCREICRSGGVHVLSVDYRLAPEHPAPAAVEDSYAA
MAB_3270c|M.abscessus_ATCC_199 GGGWVIGDLETHDQPCRQTCRDAGVSVLSVDYRLAPEHKAPAAAQDCLAA
MLBr_00314|M.leprae_Br4923 GGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDG
:: ::*** *:. . :*. .
MMAR_1746|M.marinum_M FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MUL_1989|M.ulcerans_Agy99 FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MAV_3814|M.avium_104 FTWAHEHAG-ELGAIPGRVAVGGDSAGGNLAAVVSQLARD----AGGPAP
Mb2994c|M.bovis_AF2122/97 FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
Rv2970c|M.tuberculosis_H37Rv FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
MSMEG_2409|M.smegmatis_MC2_155 YQWALEHAG-GLGAS--RIVVAGDSAGGNLAAVVSQWARD----DELPLP
TH_1220|M.thermoresistible__bu YRWVLDHPG-DVGADPARIAVGGDSAGGNLAAVVAQRCRD----EGAPAP
Mflv_4203|M.gilvum_PYR-GCK YLWAREHAA-ELGADPERVAVGGDSAGGNLSAVLTQRARD----EGAPLP
Mvan_2162|M.vanbaalenii_PYR-1 YLWACEHAA-ELGADPQRVAVGGDSAGGNLAALVTLRARD----EKAPRP
MAB_3270c|M.abscessus_ATCC_199 YLWAVEHAG-DLGVAPDRIAVGGDSAGGNLAAVVAQQARD----TGAQLP
MLBr_00314|M.leprae_Br4923 YQWLR-----RLGYDPEQIVLAGDSAGGYLALALAQRLQD---VGEEPAA
: * .* ::.:.****** *: : :* .
MMAR_1746|M.marinum_M IFQWLIYPRTDFAGRTRSASLFARGFLLTK--RDIDWFHSQYLKGSGIEP
MUL_1989|M.ulcerans_Agy99 IFQWLIYPRTDFAGRTRSASLFARGFLLTK--RDIDWFHSQYLKGSGIEP
MAV_3814|M.avium_104 VLQWLIYPRTDFTARTRSLSLFSRGFLLTK--RDIDWFESQYLRNSGLDR
Mb2994c|M.bovis_AF2122/97 VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK--RDIDWFHTQYLRDSDVDP
Rv2970c|M.tuberculosis_H37Rv VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK--RDIDWFHTQYLRDSDVDP
MSMEG_2409|M.smegmatis_MC2_155 ALQVLLYPITDWVSETRSRTLFSDGYFLNR--QDMDWFAGHYLDGADVTP
TH_1220|M.thermoresistible__bu ALQLLLYPVTDLRGRYRSRTLFADGFFLTA--EDMDWFTAHYLDGSGVDE
Mflv_4203|M.gilvum_PYR-GCK ALQVLLYPATEVGIQTRSQTLFSDGFFLTK--RDMDWFMDHFLDGADVAD
Mvan_2162|M.vanbaalenii_PYR-1 ALQLLLYPVTHYDAETRSRTLFARGFFLTQ--HDIDWFRARYLGGAQLEG
MAB_3270c|M.abscessus_ATCC_199 LLQFLIYPAVDFTVRRPSRDLFAEGFFLTK--AAMDGFESHYLDGSDVDK
MLBr_00314|M.leprae_Br4923 LVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDD
. . . : :. : :
MMAR_1746|M.marinum_M TDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLR
MUL_1989|M.ulcerans_Agy99 TDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLR
MAV_3814|M.avium_104 TDPRVSPALAESLAGLAPALIAVAGFDPLRDEGQSYAEALRAAGTPVDLR
Mb2994c|M.bovis_AF2122/97 ADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLR
Rv2970c|M.tuberculosis_H37Rv ADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLR
MSMEG_2409|M.smegmatis_MC2_155 EDPAVSPLLAEDLSGLPPALVVTAGFDPLRDEGNRYAAAMRDAGVLVDLR
TH_1220|M.thermoresistible__bu KDPRVSPLLADDLSGLAPALVVTAGFDPLRDEGNEYAEAMRAAGVPVDLR
Mflv_4203|M.gilvum_PYR-GCK TDPRVSPLRTDDMSGLPPALVVTAGFDPLRDEGRLYAEALREAGTPVDYR
Mvan_2162|M.vanbaalenii_PYR-1 SDPRVSPLLAEDHSGLSPALVVTAGFDPLRDEGRHYADALRAAGTPVDYR
MAB_3270c|M.abscessus_ATCC_199 ADPQVSPILAADLAGLPPALITTAGFDPLRDEGNEYAAKLRAAGVPVDLR
MLBr_00314|M.leprae_Br4923 KPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIR
: .**. :*: .:* : * .:.. * : .*. .: *
MMAR_1746|M.marinum_M AMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 AMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MAV_3814|M.avium_104 YLGSLTHGFANLFQLGGDSMVATSELISALRAHLSRV--------
Mb2994c|M.bovis_AF2122/97 YLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
Rv2970c|M.tuberculosis_H37Rv YLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
MSMEG_2409|M.smegmatis_MC2_155 EERSMIHAFANFFPLGGGGAAATTAMISALRAHLRHV--------
TH_1220|M.thermoresistible__bu EYGSLIHAFANFFPLGGGSATATAEVISALRAHLSRV--------
Mflv_4203|M.gilvum_PYR-GCK EYGTVVHGFANFFPLGGDSATAMADVISAIRAHLTRAG-------
Mvan_2162|M.vanbaalenii_PYR-1 EYGSLVHGFANFFPLGGASATATGDVISAMRAHLTRAG-------
MAB_3270c|M.abscessus_ATCC_199 VQGPLIHGFYNMAGLGGAPSEAMNQLTSALRAHLSR---------
MLBr_00314|M.leprae_Br4923 VWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* * : . : . :*