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TKSLPGVADLRLGANHPRMWTRRVQGTVVNVGVKVLPWIPTPAKRILSAGRSVIIDGNTLDPTLQLMLST SRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSGGGATPLLVFYH GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRVA VGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSMGLFGNGFLLTKRDIDWFHTQY LRDSDVDPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRYLGSLTHGFLNL FQLGGGSAAGTNELISALRAHLSRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2970c | lipN | - | 100% (376) | PROBABLE LIPASE/ESTERASE LIPN |
| M. tuberculosis H37Rv | Rv1400c | lipI | 2e-54 | 41.75% (297) | lipase LipH |
| M. tuberculosis H37Rv | Rv1399c | lipH | 1e-48 | 40.13% (319) | lipase LipH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2994c | lipN | 0.0 | 100.00% (376) | lipase/esterase LipN |
| M. gilvum PYR-GCK | Mflv_4203 | - | 1e-105 | 53.59% (362) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_00314 | - | 2e-10 | 23.73% (236) | putative esterase |
| M. abscessus ATCC 19977 | MAB_3270c | - | 1e-100 | 55.92% (338) | lipase/esterase LipN |
| M. marinum M | MMAR_1746 | lipN | 1e-158 | 72.15% (377) | lipase/esterase LipN |
| M. avium 104 | MAV_3814 | - | 1e-158 | 73.81% (378) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2409 | - | 1e-103 | 55.43% (350) | alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1220 | lipN | 1e-71 | 66.03% (209) | PROBABLE LIPASE/ESTERASE LIPN |
| M. ulcerans Agy99 | MUL_1989 | lipN | 1e-159 | 72.41% (377) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 1e-110 | 57.55% (351) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2970c|M.tuberculosis_H37Rv ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
Mb2994c|M.bovis_AF2122/97 ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
MMAR_1746|M.marinum_M ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MUL_1989|M.ulcerans_Agy99 ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MAV_3814|M.avium_104 ---MTKPLTDTAPVDPGVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRR
MSMEG_2409|M.smegmatis_MC2_155 ---------------------------MLLAHATRLGLAAIPRMSDRRKH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK MPASRATESHNNWTTPKGSPHAGGAVEKLTNTLAGVTLRALPRIPDPVKR
Mvan_2162|M.vanbaalenii_PYR-1 MTETVAAGES---VQPPVRRKVG-VSDVVANKVAGVTLRGMPRIPHPVKR
MAB_3270c|M.abscessus_ATCC_199 -------------------------MSPFRDFALRASTAATPHIPTPVRR
MLBr_00314|M.leprae_Br4923 -----------------------------MAISAGAPVEIVESGPSIAAR
Rv2970c|M.tuberculosis_H37Rv ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
Mb2994c|M.bovis_AF2122/97 ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
MMAR_1746|M.marinum_M LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MUL_1989|M.ulcerans_Agy99 LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MAV_3814|M.avium_104 GLVRGRSVIIDGNTLDPTLQLMLSGLRAVGIDGLVVDDD----PELSRAQ
MSMEG_2409|M.smegmatis_MC2_155 LLLGGRSVTVDGNTLDTTMQFMLTTQRLAGLPGLVADYDPEHGVAVSRAK
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LLLGRRTITLDGNTLDTTLHLMLAGQRLMGIEGLVADDD----VTVARAQ
Mvan_2162|M.vanbaalenii_PYR-1 VLLGGRSITIDGNTLDTTLHLMLAGQQLLGLDGLVADDD----FVAARTQ
MAB_3270c|M.abscessus_ATCC_199 AMAG-RQVIIDGNILDPTTQLLLRGMELMGEGEISRGED----VAENRAN
MLBr_00314|M.leprae_Br4923 LASLTSRLTIR---------------PILAVGSYVPQLP-------WPFG
Rv2970c|M.tuberculosis_H37Rv MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
Mb2994c|M.bovis_AF2122/97 MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
MMAR_1746|M.marinum_M MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MUL_1989|M.ulcerans_Agy99 MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MAV_3814|M.avium_104 MHESTVGFPGPQIHVDVAELALPGPAGDIPARHYRPAGGETQAPLLVFYH
MSMEG_2409|M.smegmatis_MC2_155 LRETAAMMRMPIHVD-VSDISIPGPAGPLAARRYVPVERGSASALVLYFH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LEVLAAAFKQHIPVAAVTNLTVPGAQGPLDARHYRTDEPD--AALLVFFH
Mvan_2162|M.vanbaalenii_PYR-1 LELLAASFKQRIPIAGVTDLTVSGAEGPVKARHYRTDEPG--APLLVFYH
MAB_3270c|M.abscessus_ATCC_199 MRRQAGLLQFSTPVGQVRNFSIPGPAGPIGVRHYKPVH-DHTGALLVFFH
MLBr_00314|M.leprae_Br4923 LIDHAARVLLPVTNAARAEVNLSNTSAQL-VRAAGVRPADGSGRIVLYLH
Rv2970c|M.tuberculosis_H37Rv GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
Mb2994c|M.bovis_AF2122/97 GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
MMAR_1746|M.marinum_M GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEDRAPAAIDDAFAA
MUL_1989|M.ulcerans_Agy99 GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAA
MAV_3814|M.avium_104 GGGWSIGDLDTHDSLCRLTCRDAGIHVLSIDYRLAPEHPAPAAIDDAYAA
MSMEG_2409|M.smegmatis_MC2_155 GGGFVIGDLEVHDNLCRLICRDGDVQVVSVDYRLAPEHKAPAAAEDAYAA
TH_1220|M.thermoresistible__bu --------------------------VLSVDYRLAPEHKAPAAVEDAYAA
Mflv_4203|M.gilvum_PYR-GCK GGGHVIGSLDSHDDLCREICRAGRIHVLSVDYRLAPEHKAPAGAQDAYSA
Mvan_2162|M.vanbaalenii_PYR-1 GGGHVIGSIDSHDDLCREICRSGGVHVLSVDYRLAPEHPAPAAVEDSYAA
MAB_3270c|M.abscessus_ATCC_199 GGGWVIGDLETHDQPCRQTCRDAGVSVLSVDYRLAPEHKAPAAAQDCLAA
MLBr_00314|M.leprae_Br4923 GGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDG
:: ::*** *:. . :*. .
Rv2970c|M.tuberculosis_H37Rv FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
Mb2994c|M.bovis_AF2122/97 FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
MMAR_1746|M.marinum_M FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MUL_1989|M.ulcerans_Agy99 FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MAV_3814|M.avium_104 FTWAHEHAG-ELGAIPGRVAVGGDSAGGNLAAVVSQLARD----AGGPAP
MSMEG_2409|M.smegmatis_MC2_155 YQWALEHAG-GLGAS--RIVVAGDSAGGNLAAVVSQWARD----DELPLP
TH_1220|M.thermoresistible__bu YRWVLDHPG-DVGADPARIAVGGDSAGGNLAAVVAQRCRD----EGAPAP
Mflv_4203|M.gilvum_PYR-GCK YLWAREHAA-ELGADPERVAVGGDSAGGNLSAVLTQRARD----EGAPLP
Mvan_2162|M.vanbaalenii_PYR-1 YLWACEHAA-ELGADPQRVAVGGDSAGGNLAALVTLRARD----EKAPRP
MAB_3270c|M.abscessus_ATCC_199 YLWAVEHAG-DLGVAPDRIAVGGDSAGGNLAAVVAQQARD----TGAQLP
MLBr_00314|M.leprae_Br4923 YQWLR-----RLGYDPEQIVLAGDSAGGYLALALAQRLQD---VGEEPAA
: * .* ::.:.****** *: : :* .
Rv2970c|M.tuberculosis_H37Rv VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK--RDIDWFHTQYLRDSDVDP
Mb2994c|M.bovis_AF2122/97 VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK--RDIDWFHTQYLRDSDVDP
MMAR_1746|M.marinum_M IFQWLIYPRTDFAGRTRSASLFARGFLLTK--RDIDWFHSQYLKGSGIEP
MUL_1989|M.ulcerans_Agy99 IFQWLIYPRTDFAGRTRSASLFARGFLLTK--RDIDWFHSQYLKGSGIEP
MAV_3814|M.avium_104 VLQWLIYPRTDFTARTRSLSLFSRGFLLTK--RDIDWFESQYLRNSGLDR
MSMEG_2409|M.smegmatis_MC2_155 ALQVLLYPITDWVSETRSRTLFSDGYFLNR--QDMDWFAGHYLDGADVTP
TH_1220|M.thermoresistible__bu ALQLLLYPVTDLRGRYRSRTLFADGFFLTA--EDMDWFTAHYLDGSGVDE
Mflv_4203|M.gilvum_PYR-GCK ALQVLLYPATEVGIQTRSQTLFSDGFFLTK--RDMDWFMDHFLDGADVAD
Mvan_2162|M.vanbaalenii_PYR-1 ALQLLLYPVTHYDAETRSRTLFARGFFLTQ--HDIDWFRARYLGGAQLEG
MAB_3270c|M.abscessus_ATCC_199 LLQFLIYPAVDFTVRRPSRDLFAEGFFLTK--AAMDGFESHYLDGSDVDK
MLBr_00314|M.leprae_Br4923 LVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDD
. . . : :. : :
Rv2970c|M.tuberculosis_H37Rv ADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLR
Mb2994c|M.bovis_AF2122/97 ADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLR
MMAR_1746|M.marinum_M TDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLR
MUL_1989|M.ulcerans_Agy99 TDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLR
MAV_3814|M.avium_104 TDPRVSPALAESLAGLAPALIAVAGFDPLRDEGQSYAEALRAAGTPVDLR
MSMEG_2409|M.smegmatis_MC2_155 EDPAVSPLLAEDLSGLPPALVVTAGFDPLRDEGNRYAAAMRDAGVLVDLR
TH_1220|M.thermoresistible__bu KDPRVSPLLADDLSGLAPALVVTAGFDPLRDEGNEYAEAMRAAGVPVDLR
Mflv_4203|M.gilvum_PYR-GCK TDPRVSPLRTDDMSGLPPALVVTAGFDPLRDEGRLYAEALREAGTPVDYR
Mvan_2162|M.vanbaalenii_PYR-1 SDPRVSPLLAEDHSGLSPALVVTAGFDPLRDEGRHYADALRAAGTPVDYR
MAB_3270c|M.abscessus_ATCC_199 ADPQVSPILAADLAGLPPALITTAGFDPLRDEGNEYAAKLRAAGVPVDLR
MLBr_00314|M.leprae_Br4923 KPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIR
: .**. :*: .:* : * .:.. * : .*. .: *
Rv2970c|M.tuberculosis_H37Rv YLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
Mb2994c|M.bovis_AF2122/97 YLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
MMAR_1746|M.marinum_M AMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 AMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MAV_3814|M.avium_104 YLGSLTHGFANLFQLGGDSMVATSELISALRAHLSRV--------
MSMEG_2409|M.smegmatis_MC2_155 EERSMIHAFANFFPLGGGGAAATTAMISALRAHLRHV--------
TH_1220|M.thermoresistible__bu EYGSLIHAFANFFPLGGGSATATAEVISALRAHLSRV--------
Mflv_4203|M.gilvum_PYR-GCK EYGTVVHGFANFFPLGGDSATAMADVISAIRAHLTRAG-------
Mvan_2162|M.vanbaalenii_PYR-1 EYGSLVHGFANFFPLGGASATATGDVISAMRAHLTRAG-------
MAB_3270c|M.abscessus_ATCC_199 VQGPLIHGFYNMAGLGGAPSEAMNQLTSALRAHLSR---------
MLBr_00314|M.leprae_Br4923 VWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* * : . : . :*