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MNTTPFGDVAGFRVSRRQFGRISAITAGAATLAACGSPSAPPAPTPPSTPAHVLGQVNQLTAGDLDVGYV EAGPATGQPVILLHGWPYDIHSYADVSALLAAQGFRVIVPYARGFGSTRFLSKDTLRNGQQAALAHDVLA LMDALDIQDAILAGYDWGGRTANVMAALWPQRCSGLVAVSGYIVVNLASNLQPLAPQAEHGWHQHRVLDG IGHNVPQEAPEAFAAAVVDVHAQRGSHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6850 | - | - | 100% (238) | alpha/beta hydrolase |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 3e-13 | 37.82% (119) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1998 | - | 7e-13 | 36.15% (130) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 7e-12 | 34.29% (105) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1960 | - | 1e-14 | 31.08% (148) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 2e-12 | 35.14% (111) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_01899 | lipG | 7e-06 | 30.63% (160) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2499c | - | 3e-60 | 58.65% (208) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2866 | ephB | 5e-14 | 37.98% (129) | epoxide hydrolase EphB |
| M. avium 104 | MAV_0357 | - | 6e-13 | 32.08% (159) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_2421 | - | 2e-14 | 35.61% (132) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_2888 | ephB | 5e-13 | 36.43% (129) | epoxide hydrolase EphB |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | 1e-77 | 71.13% (194) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6850|M.smegmatis_MC2_155 MNTTPFGDVAGFRVSRRQFGRISAITAG-AATLAACGSPSAPPAPTPPST
Mvan_0326|M.vanbaalenii_PYR-1 MN--------GF--SRRDFGLLATAAAG-AVTLTACTS--TPATAGPPPA
MAB_2499c|M.abscessus_ATCC_199 ------------MISRRGFSKVALLTAVGATALGACSN----GASVDPTR
MMAR_2866|M.marinum_M --------------------------------------------------
MUL_2888|M.ulcerans_Agy99 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv ---------------------------------------------MIALP
MAV_0357|M.avium_104 --------------------------------MHTLRTPDDRFHTVPDFP
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
MSMEG_6850|M.smegmatis_MC2_155 PAHVLGQVNQLTAGDLDVGYVEAGP--ATGQPVILLHGWPYDIHSYADVS
Mvan_0326|M.vanbaalenii_PYR-1 PRNQLGPIKQIDAGDLNVGYAEAGP--PDGQPVILLHGWPYDIHSYADVT
MAB_2499c|M.abscessus_ATCC_199 PRTEFPPLKQVDAGLLNVGYVDEGP--SDGPPVILLHGWPYDIHSYLDVV
MMAR_2866|M.marinum_M ---MAQAHRILNCRGTRIHAVEDG----EGPLVILLHGFPESWYSWRHQI
MUL_2888|M.ulcerans_Agy99 ---MAQAHRILNCRGTRIHAVEDG----EGPLVILLHGFPESWYSWRHQI
Mb1973|M.bovis_AF2122/97 ---MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQI
Mflv_1960|M.gilvum_PYR-GCK ----------MTVRGVDFHITEAGP--EDGRPVLALHGWPQHHWAYRDLL
TH_2421|M.thermoresistible__bu -----VRRSFVEARGVRFHVTESGP--ADGRPVLALHGWPQHHWAYRDLL
Rv0134|M.tuberculosis_H37Rv ALEGVEHRHVDVAEGVRIHVADAGP--ADGPAVMLVHGFPQNWWEWRDLI
MAV_0357|M.avium_104 YPPRYCEVSDDDGGALRVAWVEDGP--AGADPVLMLHGEPSWSYLYRKMI
MLBr_01899|M.leprae_Br4923 ---MEVRSGYATSGDLKLYYEDMGN--VDDPPVLLIMGLGAQLVLWRTAF
. . *: : * :
MSMEG_6850|M.smegmatis_MC2_155 AL-LAAQGFRVIVPYARGFGSTRFLS---------------------KDT
Mvan_0326|M.vanbaalenii_PYR-1 AI-LAAQGFRVIVPHLRGFGTTRFRS---------------------ANT
MAB_2499c|M.abscessus_ATCC_199 PL-LTTKGFRVLVPYLRGYGSTRFRS---------------------GDT
MMAR_2866|M.marinum_M PA-LAAAGYRVVAVDQRGYGRSSKY-----------------------RV
MUL_2888|M.ulcerans_Agy99 PA-LAAADYRVVAVDQRGYGRSSKY-----------------------RV
Mb1973|M.bovis_AF2122/97 PA-LAGAGYRVVAIDQRGYGRSSKY-----------------------RV
Mflv_1960|M.gilvum_PYR-GCK GD-PPP-GLRIIAPDLPGYGWSG-------------------------PP
TH_2421|M.thermoresistible__bu AD-PPA-GLRIIAPDLPGYGWSG-------------------------PA
Rv0134|M.tuberculosis_H37Rv GP-LAADGNRVLCPDLRGAGWSS-------------------------AP
MAV_0357|M.avium_104 PV-LAGAGHRVVCPDLVGFGRSDKP----------------------TRR
MLBr_01899|M.leprae_Br4923 CEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPSQPLTARLIRFWLGQRN
. *:: . * :
MSMEG_6850|M.smegmatis_MC2_155 LRNGQQAALAHDVLALMDALDIQDAILAGYDWGGRTANVMAALWPQRCSG
Mvan_0326|M.vanbaalenii_PYR-1 VRNGQQAALAHDAISLMDALNIPDAILGGYDWGGRTANAVAALWPQRCTG
MAB_2499c|M.abscessus_ATCC_199 FHNGQQAALATDVIDFMDALKIPSAILGGFDWGARNADIVAAIWPDRVTA
MMAR_2866|M.marinum_M QKAYRIKELVGDVLGLVDAYGADKAFVIGHDWGAPVAWTFAWLYPQRCAG
MUL_2888|M.ulcerans_Agy99 QKAYRIKELVGDVLGVVDAYGADKAFVIGHDWGAPVAWTFAWLYPQRCAG
Mb1973|M.bovis_AF2122/97 QKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAG
Mflv_1960|M.gilvum_PYR-GCK PHRWAKEDVVTDLVALVDALGLDRFLLVGHDWGGYIGHLLALRIPERIDA
TH_2421|M.thermoresistible__bu PHRWAKEDVASDLLALMDELGLGRTLLIGHDWGGYIGFLMILRAPERFDG
Rv0134|M.tuberculosis_H37Rv RSRYTKTEMADDLAAVLDGLGVAKVKLVAHDWGGPVAFIMMLRHPEKVTG
MAV_0357|M.avium_104 EDHSYARHVEWMRAVAFDVLDLHNVTLVGQDWGGLIGLRLAAEHPERFAR
MLBr_01899|M.leprae_Br4923 ACAYTLEDMTDDAVALLDHLSIERAHIVGASMGGMIAQIFAARFPTRTRS
: .* : . . *. . . * :
MSMEG_6850|M.smegmatis_MC2_155 LVAVSGYIVVNLASNLQPLAPQAEHGWH----------------------
Mvan_0326|M.vanbaalenii_PYR-1 LVAVSGYIVVNLATNLEPLAPQSEYGWWYQYYFATP------------RG
MAB_2499c|M.abscessus_ATCC_199 LVAVSGYIIVNLEANQQPLSPQAEWGWWYQYYFATE------------RG
MMAR_2866|M.marinum_M VVGISVPFAGRGVIGLPGSPFGEHRPNDYHLELAGEGRVWYQDYFSAQDG
MUL_2888|M.ulcerans_Agy99 VVGISVPFAGRGVIGLPGSPFGEHRPNDYHLELAGEGRVWYQD-FSAQDG
Mb1973|M.bovis_AF2122/97 VVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDG
Mflv_1960|M.gilvum_PYR-GCK YLALNIAHP--WVPPKV-MAPHLWRFLLYQPVVAS-------------AG
TH_2421|M.thermoresistible__bu YIPLNIAHP--WVSTGT-VLKHIWRFS-YQPPMAA-------------FG
Rv0134|M.tuberculosis_H37Rv FFGVNTVAP--WVKRDLGMLRNMWRFW-YQIPMSLP-----------VIG
MAV_0357|M.avium_104 MVVANTGLP----NGDQPMADVWWRFR-----------------------
MLBr_01899|M.leprae_Br4923 LAVFFSSNN---RPFLPPPAPRALLALLTGPPTGSR--------------
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 ELGYRRNTKDFNRLIWTNASPLWHFDDAAYDMAARAFD------------
MAB_2499c|M.abscessus_ATCC_199 LHGYRHNTRDFNKLIWHNASPTWKFDDDTYARSAAAFD------------
MMAR_2866|M.marinum_M IIAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLASMDPIDVIRA
MUL_2888|M.ulcerans_Agy99 IIAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLASMDPIDVIRA
Mb1973|M.bovis_AF2122/97 IITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRA
Mflv_1960|M.gilvum_PYR-GCK --VPLQTRTRYLEKVV-FRAAAPKLDAATVGTYAERFR------------
TH_2421|M.thermoresistible__bu --VPLQQRTRVLERVV-FGKGS-ALDAETAKVYADRFR------------
Rv0134|M.tuberculosis_H37Rv PRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMR------------
MAV_0357|M.avium_104 --EAITSAPQLNIGAFVQGGCRRRLSDAERAGYDAPFP-----------S
MLBr_01899|M.leprae_Br4923 ---RDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIY-----------D
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 NPDHADIVIHNYRWRLSLAPGESRYD------------------------
MAB_2499c|M.abscessus_ATCC_199 NPDHVDIVIHNYRWRLGLARGESRYD------------------------
MMAR_2866|M.marinum_M GPLCMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLSFYH
MUL_2888|M.ulcerans_Agy99 GPLCMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLSFYH
Mb1973|M.bovis_AF2122/97 GPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYH
Mflv_1960|M.gilvum_PYR-GCK DPVVARTARDTYRTFLTREIPKGVR-------------------------
TH_2421|M.thermoresistible__bu DPVCARAGRDTYRTFLVREMPAAAR-------------------------
Rv0134|M.tuberculosis_H37Rv EPGHAEAGSRWYRTFQTREMLRWLRG------------------------
MAV_0357|M.avium_104 DEYCAGPRAMPTLVPTSPEDPAAAAN------------------------
MLBr_01899|M.leprae_Br4923 RSFYPLGVSRQFSAILGSGSLLHYN-------------------------
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 ---------ADEQRLAAKPPIEVPTITIGSDFDGPAKDGSTYRALYTGPY
MAB_2499c|M.abscessus_ATCC_199 ---------AVEAKLATKPTIAVPTITIGSDFDGPTKDGTAYRKMFTGKY
MMAR_2866|M.marinum_M NIDNDWHDLADQEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMSDYR
MUL_2888|M.ulcerans_Agy99 NIDNDWHDLADQEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMSDYR
Mb1973|M.bovis_AF2122/97 NIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYR
Mflv_1960|M.gilvum_PYR-GCK ----------DGERRWSTVPTRVLFGRSDTAIHP---DLAAAETARADDY
TH_2421|M.thermoresistible__bu ----------NPEKRRATVPIRALFGTRDLAIHP---SLAAPETALADDY
Rv0134|M.tuberculosis_H37Rv ----------EYNDARVDVPVRWLHGTGDPVITP---DLLDGYAERASDF
MAV_0357|M.avium_104 --------KAAWAKLAVSPTPMLVAFSDSDPITGPMAAIFQREMRGAQGI
MLBr_01899|M.leprae_Br4923 --------------QRIIAPTVVIHGRADKLVRP---SSGRAVARAITGA
MSMEG_6850|M.smegmatis_MC2_155 QHRVLDGIGHNVPQEAPEAFAAAVVDVHAQRGSHR--
Mvan_0326|M.vanbaalenii_PYR-1 QHRVLDGIGHNVPQEAPQEFASAITDVTRQ-------
MAB_2499c|M.abscessus_ATCC_199 AHRVLDGIGHNVPQEAPQEFANAIIAAHAL-------
MMAR_2866|M.marinum_M GTHMVADVGHWIQQEAPDETNRLLLEFLGGLRQ----
MUL_2888|M.ulcerans_Agy99 GTHMVADVGHWIQQEAPDETNRLLLEFLGGLRQ----
Mb1973|M.bovis_AF2122/97 GTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
Mflv_1960|M.gilvum_PYR-GCK TIDVVDGG-HFILDEQPDLVRAKLIAVADEFPERPVR
TH_2421|M.thermoresistible__bu TLETVDCS-HFIVDERPDLVRARLVALAEETA-----
Rv0134|M.tuberculosis_H37Rv EVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-
MAV_0357|M.avium_104 DHPLIRGAGHFLQEDAGAELAGHIVEFLRR-------
MLBr_01899|M.leprae_Br4923 RLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS-----
. * : :: :