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MAQAHRILNCRGTRIHAVEDGEGPLVILLHGFPESWYSWRHQIPALAAAGYRVVAVDQRGYGRSSKYRVQ KAYRIKELVGDVLGLVDAYGADKAFVIGHDWGAPVAWTFAWLYPQRCAGVVGISVPFAGRGVIGLPGSPF GEHRPNDYHLELAGEGRVWYQDYFSAQDGIIAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLAS MDPIDVIRAGPLCMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLAD QEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMSDYRGTHMVADVGHWIQQEAPDETNRLLLEFLGGL RQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2866 | ephB | - | 100% (352) | epoxide hydrolase EphB |
| M. marinum M | MMAR_5114 | ephA | 5e-57 | 39.20% (352) | epoxide hydrolase EphA |
| M. marinum M | MMAR_0342 | ephF | 1e-20 | 41.74% (115) | epoxide hydrolase EphF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 0.0 | 86.76% (355) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1415 | - | 3e-49 | 35.63% (348) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1938 | ephB | 0.0 | 86.76% (355) | epoxide hydrolase EphB |
| M. leprae Br4923 | MLBr_02297 | - | 5e-17 | 38.24% (136) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 3e-52 | 38.95% (344) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 3e-51 | 36.20% (337) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 2e-53 | 37.75% (347) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2582 | - | 3e-77 | 41.21% (347) | PUTATIVE putative alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_2888 | ephB | 0.0 | 99.15% (352) | epoxide hydrolase EphB |
| M. vanbaalenii PYR-1 | Mvan_4002 | - | 0.0 | 86.29% (350) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2866|M.marinum_M MA----------------QAHRILNCRGTRIHAVEDG-------------
MUL_2888|M.ulcerans_Agy99 MA----------------QAHRILNCRGTRIHAVEDG-------------
Mb1973|M.bovis_AF2122/97 MS----------------QVHRILNCRGTRIHAVADSP----------PD
Rv1938|M.tuberculosis_H37Rv MS----------------QVHRILNCRGTRIHAVADSP----------PD
Mvan_4002|M.vanbaalenii_PYR-1 MS----------------QIHRMLNCRGTRIHAVEEG-------------
TH_2582|M.thermoresistible__bu MSNTVAAPRCEIVTEADGYDHATIFAGDQRLHVVVKG-------------
MAV_0539|M.avium_104 ----------------------------MRLRVTEAG------------D
MSMEG_6106|M.smegmatis_MC2_155 ---------------MITPTERSVETNGVTLRVTEAG------------E
MAB_0528c|M.abscessus_ATCC_199 MT-----------DAAVDIRERDIATNGVHLRIVEAG------------E
Mflv_1415|M.gilvum_PYR-GCK ------------------MQSRMVHTNGITLRVFEAG------------E
MLBr_02297|M.leprae_Br4923 ----MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSA
::
MMAR_2866|M.marinum_M -EGPLVILLHGFPESWYSWRHQIPALAAAGYRVVAVDQRGYGRSSKYRVQ
MUL_2888|M.ulcerans_Agy99 -EGPLVILLHGFPESWYSWRHQIPALAAADYRVVAVDQRGYGRSSKYRVQ
Mb1973|M.bovis_AF2122/97 QQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQ
Rv1938|M.tuberculosis_H37Rv QQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQ
Mvan_4002|M.vanbaalenii_PYR-1 -EGPLVVLIHGFPESWYSWRHQIPALAAAGYRVVAIDQRGYGRSSKYRVQ
TH_2582|M.thermoresistible__bu -SGPLVLLVHGFPESWFCWREQIDAIAARGYRVAAPDMRGYGRSGKPAAV
MAV_0539|M.avium_104 RGAPVVILAHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDRPDAV
MSMEG_6106|M.smegmatis_MC2_155 RGNPVVVLAHGFPELAYSWRHQIPALAAAGYHVLAPDQRGYGGSSRPESI
MAB_0528c|M.abscessus_ATCC_199 PGQPAVILSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSSMPAHI
Mflv_1415|M.gilvum_PYR-GCK RSAPVVVLCHGFPELAFTWRHQISALAAAGFHVLAPDQRGYGGSDKPGDA
MLBr_02297|M.leprae_Br4923 TARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDKPP--
* *:* *** . : **.*: :: :: * * **** *.
MMAR_2866|M.marinum_M KAYRIKELVGDVLGLVDAYGADKAFVIGHDWGAPVAWTFAWLYPQRCAGV
MUL_2888|M.ulcerans_Agy99 KAYRIKELVGDVLGVVDAYGADKAFVIGHDWGAPVAWTFAWLYPQRCAGV
Mb1973|M.bovis_AF2122/97 KAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGV
Rv1938|M.tuberculosis_H37Rv KAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGV
Mvan_4002|M.vanbaalenii_PYR-1 KAYRIKELVGDIVGVIDAYGVERAVVVGHDWGAPVAWTFAWLHPQRCAGV
TH_2582|M.thermoresistible__bu EDYSILKLVDDCVAIVTALGAEEATIVGHDWGSMVAWTAAWTRPEVFTAV
MAV_0539|M.avium_104 EAYDIHQLTADLVGLLDDVGAQRAVWVGHDWGAAVVWNAPLLHPDRVAAV
MSMEG_6106|M.smegmatis_MC2_155 DDYDITKLTGDVVGLLDDIGAEHAAVIGHDWGAVVAWNAAQLHPDRVAAV
MAB_0528c|M.abscessus_ATCC_199 DDYNIEALSDDLLGILDDVGAGKATFVGHDWGAVVTWHTALAVPERVSGV
Mflv_1415|M.gilvum_PYR-GCK GVYNVAELTADVVGLLDDVGAERAALVGHDFGAVVAWGAPLLEPDRFSAV
MLBr_02297|M.leprae_Br4923 RGYDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHPRLVRAI
* * * .:: * * :** *. . * . * .:
MMAR_2866|M.marinum_M VGISVPFAGRGVIGLPGSP-FGEHRPNDYHLELAGEGRVWYQDYFSAQDG
MUL_2888|M.ulcerans_Agy99 VGISVPFAGRGVIGLPGSP-FGEHRPNDYHLELAGEGRVWYQD-FSAQDG
Mb1973|M.bovis_AF2122/97 VGISVPFAGRGVIGLPGSP-FGERRPSDYHLELAGPGRVWYQDYFAVQDG
Rv1938|M.tuberculosis_H37Rv VGISVPFAGRGVIGLPGSP-FGERRPSDYHLELAGPGRVWYQDYFAVQDG
Mvan_4002|M.vanbaalenii_PYR-1 AGISVPFAGRGVIGLPGSP-FGEHRPDDYHLELAGPGRVWYQDYFSAQDG
TH_2582|M.thermoresistible__bu IGMSVAFGGRGLIPIAGVDSFGTRRPSEVQREIAGPDKVFYQEYWVQKGA
MAV_0539|M.avium_104 AAMSVPVTPR-----------PRLAPTQAWRKMFGEN-FFYILYFQEPGV
MSMEG_6106|M.smegmatis_MC2_155 GGLSVPPTPR-----------STRPPTQAFRELVGEGKFFYILHFQEPGV
MAB_0528c|M.abscessus_ATCC_199 VGLSVPFTRR-----------SQVPPTQAWNKLFGDN-FFYILYFQEPGV
Mflv_1415|M.gilvum_PYR-GCK AGLSLPPVPR-----------PQVPTTQAFRRVFGDR-FMYILYFQEPGP
MLBr_02297|M.leprae_Br4923 ALINSPHPAA-------------LRRSMLTHRNQGYALLPTLLRYQLPIW
:. . . * . :
MMAR_2866|M.marinum_M IIAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLASMDPIDVIRA
MUL_2888|M.ulcerans_Agy99 IIAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLASMDPIDVIRA
Mb1973|M.bovis_AF2122/97 IITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRA
Rv1938|M.tuberculosis_H37Rv IITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRA
Mvan_4002|M.vanbaalenii_PYR-1 IIAEIEEDLRGWLWGLTYTVSGDGMIAATKAAVAAGVDLESMDPIDVIRA
TH_2582|M.thermoresistible__bu LESEFEADPRGFLRDQYYSFS-AGPFPPDYQAPNP-LEADPAEVAEQTRS
MAV_0539|M.avium_104 ADAELNADPAQVMRRMMGSLRTDGDKAAGLRMVA----------------
MSMEG_6106|M.smegmatis_MC2_155 ADAEFDGDPARALRRMFGGLLPPENEEAAMRMLR----------------
MAB_0528c|M.abscessus_ATCC_199 ADADLNRDPATTMRRMMAGMAR----IDGATMIA----------------
Mflv_1415|M.gilvum_PYR-GCK ADAELARDPATTFRRLFALTTG------GAEMVGD---------------
MLBr_02297|M.leprae_Br4923 PERLLTRNNAAEIERLVRSRSS----------------------------
: : :
MMAR_2866|M.marinum_M GPLCMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLSFYH
MUL_2888|M.ulcerans_Agy99 GPLCMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLSFYH
Mb1973|M.bovis_AF2122/97 GPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYH
Rv1938|M.tuberculosis_H37Rv GPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYH
Mvan_4002|M.vanbaalenii_PYR-1 GPLCMAEGARLKDAFSYPETMPDWFTEDDLDFYTAEFERSGFGGPLSFYH
TH_2582|M.thermoresistible__bu GGACLDPGAKMRDGLLTPDPVPDWL-AADLDEYVAEFERTGLEAPLNWYR
MAV_0539|M.avium_104 -----PGPEGFLERLPEPDGLPEWISQDELDHYIAEFSRTGFTGGLNWYR
MSMEG_6106|M.smegmatis_MC2_155 -----PGPEGLIDRLPEPSALPDWISTGEFDHYVDAFTRTGFTGGLNWYR
MAB_0528c|M.abscessus_ATCC_199 -----PGPAGFVERMPDPGELPEWLSQDELDHYITEFARTGFTGGLNWYR
Mflv_1415|M.gilvum_PYR-GCK -----AGPQGFLDRIPEPGGLPDWISQADFDVYVDEFTRGGFTGPLNWYR
MLBr_02297|M.leprae_Br4923 -----AKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAVR------S
: : : : * ..
MMAR_2866|M.marinum_M NIDNDWHDLADQEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMSDYR
MUL_2888|M.ulcerans_Agy99 NIDNDWHDLADQEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMSDYR
Mb1973|M.bovis_AF2122/97 NIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYR
Rv1938|M.tuberculosis_H37Rv NIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYR
Mvan_4002|M.vanbaalenii_PYR-1 NIDNDWHDLAEQAGTPLTPPAVFIGGQYDVGTTWGAEALERAPEVMPNYC
TH_2582|M.thermoresistible__bu AMDLSWEELEPYADRPIEVPALFIGADLDVATQWSVEAVAAFDRTVPKHR
MAV_0539|M.avium_104 NFDRNWETTPELDGAKIAVPCLFIGGTADP--VLSFTRADRAAEVISGPY
MSMEG_6106|M.smegmatis_MC2_155 NFDRNWELTAHLADAKITVPALFLAGAADP--VLGFARPDRARDLIAGPY
MAB_0528c|M.abscessus_ATCC_199 NFDRNWALTERLAGANVVVPSLFIAGAADP--VLGFTDHAGSAKYRTDNR
Mflv_1415|M.gilvum_PYR-GCK CFDRNWELTAETPAPTIEVPALFVGGTEDA--TLAYTPRDRVREVVTGDY
MLBr_02297|M.leprae_Br4923 QLRNEGRKFMKSMSRPFSVPLLHVRGDADP--YLLADSVDRTRRYAPHG-
: . . * :.: . * .
MMAR_2866|M.marinum_M GTHMVADVGHWIQQEAPDETNRLLLEFLGGLRQ----
MUL_2888|M.ulcerans_Agy99 GTHMVADVGHWIQQEAPDETNRLLLEFLGGLRQ----
Mb1973|M.bovis_AF2122/97 GTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
Rv1938|M.tuberculosis_H37Rv GTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
Mvan_4002|M.vanbaalenii_PYR-1 GTHMVPDVGHWIQQEAPEETNRLLLDFLRGLG-----
TH_2582|M.thermoresistible__bu PSVILQNCGHWFTRERPAETTAAILEFLEGLGHGR--
MAV_0539|M.avium_104 RHVMIDGAGHWLQQERPAEVNAALLDFLNGLELR---
MSMEG_6106|M.smegmatis_MC2_155 TEILLDGAGHWVQQERAEEVNAALIGFLHGLELQ---
MAB_0528c|M.abscessus_ATCC_199 GDLLIDGAGHWIQQERPLEVNAALLAFLREVVH----
Mflv_1415|M.gilvum_PYR-GCK REVMIDGAGHWLTEERPDEVSRVLVDFLTTVR-----
MLBr_02297|M.leprae_Br4923 RYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
: . **: .* . * . : ** :