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NGFSRRDFGLLATAAAGAVTLTACTSTPATAGPPPAPRNQLGPIKQIDAGDLNVGYAEAGPPDGQPVILL HGWPYDIHSYADVTAILAAQGFRVIVPHLRGFGTTRFRSANTVRNGQQAALAHDAISLMDALNIPDAILG GYDWGGRTANAVAALWPQRCTGLVAVSGYIVVNLATNLEPLAPQSEYGWWYQYYFATPRGELGYRRNTKD FNRLIWTNASPLWHFDDAAYDMAARAFDNPDHADIVIHNYRWRLSLAPGESRYDADEQRLAAKPPIEVPT ITIGSDFDGPAKDGSTYRALYTGPYQHRVLDGIGHNVPQEAPQEFASAITDVTRQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | - | 100% (336) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0714 | - | 6e-16 | 29.76% (289) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 4e-15 | 29.75% (158) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 4e-13 | 32.26% (155) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_0191 | - | 5e-20 | 30.25% (281) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1938 | ephB | 4e-13 | 32.26% (155) | epoxide hydrolase EphB |
| M. leprae Br4923 | MLBr_01899 | lipG | 2e-05 | 25.67% (300) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2499c | - | 1e-132 | 67.89% (327) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2866 | ephB | 6e-14 | 34.44% (151) | epoxide hydrolase EphB |
| M. avium 104 | MAV_5163 | - | 5e-13 | 25.17% (290) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6850 | - | 2e-77 | 71.13% (194) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_2421 | - | 1e-14 | 28.41% (176) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4193 | ephA | 2e-13 | 24.12% (311) | epoxide hydrolase EphA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0326|M.vanbaalenii_PYR-1 MN--------GF--SRRDFGLLATAAAG-AVTLTACTS--TPATAGPPPA
MSMEG_6850|M.smegmatis_MC2_155 MNTTPFGDVAGFRVSRRQFGRISAITAG-AATLAACGSPSAPPAPTPPST
MAB_2499c|M.abscessus_ATCC_199 ------------MISRRGFSKVALLTAVGATALGACSN----GASVDPTR
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
Rv1938|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2866|M.marinum_M --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 ------------------------------------------------MV
MAV_5163|M.avium_104 -------------------------------------------MVTMPEL
TH_2421|M.thermoresistible__bu --------------------------------------------------
Mflv_0191|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 PRNQLGPIKQIDAGDLNVGYAEAGPPDGQPVILLHGWPYDIHSYA-DVTA
MSMEG_6850|M.smegmatis_MC2_155 PAHVLGQVNQLTAGDLDVGYVEAGPATGQPVILLHGWPYDIHSYA-DVSA
MAB_2499c|M.abscessus_ATCC_199 PRTEFPPLKQVDAGLLNVGYVDEGPSDGPPVILLHGWPYDIHSYL-DVVP
Mb1973|M.bovis_AF2122/97 MSQVHRILNCRG-TRIHAVADSPPDQQGPLVVLLHGFPESWYSWR-HQIP
Rv1938|M.tuberculosis_H37Rv MSQVHRILNCRG-TRIHAVADSPPDQQGPLVVLLHGFPESWYSWR-HQIP
MMAR_2866|M.marinum_M MAQAHRILNCRG-TRIHAVEDG----EGPLVILLHGFPESWYSWR-HQIP
MUL_4193|M.ulcerans_Agy99 ATSTERLVDTNG-VRLRVTEAG--ERGAPVVILAHGFPELAYSWR-HQIP
MAV_5163|M.avium_104 DGVEHRYVDLGDDVTIHVADAG--PASGPAVMLVHGFPQNWWEWR-ALIG
TH_2421|M.thermoresistible__bu --VRRSFVEARG-VRFHVTESG--PADGRPVLALHGWPQHHWAYR-DLLA
Mflv_0191|M.gilvum_PYR-GCK --MTDPQTLTLTLPHLTVTALSWGPPDGRLVLCLHGFPDSAWGWR-KFAP
MLBr_01899|M.leprae_Br4923 ---MEVRSGYATSGDLKLYYEDMGNVDDPPVLLIMGLGAQLVLWRTAFCE
: *: * :
Mvan_0326|M.vanbaalenii_PYR-1 ILAAQGFRVIVPHLRGFGTTRFRSANTVRNGQ------------------
MSMEG_6850|M.smegmatis_MC2_155 LLAAQGFRVIVPYARGFGSTRFLSKDTLRNGQ------------------
MAB_2499c|M.abscessus_ATCC_199 LLTTKGFRVLVPYLRGYGSTRFRSGDTFHNGQ------------------
Mb1973|M.bovis_AF2122/97 ALAGAGYRVVAIDQRGYGRSSKYRVQKAYR--------------------
Rv1938|M.tuberculosis_H37Rv ALAGAGYRVVAIDQRGYGRSSKYRVQKAYR--------------------
MMAR_2866|M.marinum_M ALAAAGYRVVAVDQRGYGRSSKYRVQKAYR--------------------
MUL_4193|M.ulcerans_Agy99 VLAEAGYHVLAPDQRGYGGSSRPEAIEDYD--------------------
MAV_5163|M.avium_104 PLAADGYRVLCPDLRGAGWSS--APRSSYR--------------------
TH_2421|M.thermoresistible__bu DPPAG-LRIIAPDLPGYGWSG--PAPHRWA--------------------
Mflv_0191|M.gilvum_PYR-GCK ILAEHGFRVVAPFSRGYAPTGPAPDGDYHIG-------------------
MLBr_01899|M.leprae_Br4923 KLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPSQPLTARLIRFWLGQRNAC
::: . . :
Mvan_0326|M.vanbaalenii_PYR-1 ---QAALAHDAISLMDALNIPD-AILGGYDWGGRTANAVAALWPQRCTGL
MSMEG_6850|M.smegmatis_MC2_155 ---QAALAHDVLALMDALDIQD-AILAGYDWGGRTANVMAALWPQRCSGL
MAB_2499c|M.abscessus_ATCC_199 ---QAALATDVIDFMDALKIPS-AILGGFDWGARNADIVAAIWPDRVTAL
Mb1973|M.bovis_AF2122/97 ---IKELVGDVVGVLDSYGAEQ-AFVVGHDWGAPVAWTFAWLHPDRCAGV
Rv1938|M.tuberculosis_H37Rv ---IKELVGDVVGVLDSYGAEQ-AFVVGHDWGAPVAWTFAWLHPDRCAGV
MMAR_2866|M.marinum_M ---IKELVGDVLGLVDAYGADK-AFVIGHDWGAPVAWTFAWLYPQRCAGV
MUL_4193|M.ulcerans_Agy99 ---IHQLTADLVGLLDDVGAER-AAWVGHDWGAVVVWNAPLLHPDRVAAV
MAV_5163|M.avium_104 ---KDEMADDLAGVLDRLGVRS-VDLVAHDWGGPVAFIMMLRHPEKVTGF
TH_2421|M.thermoresistible__bu ---KEDVASDLLALMDELGLGR-TLLIGHDWGGYIGFLMILRAPERFDGY
Mflv_0191|M.gilvum_PYR-GCK -----ALMYDALAVHRELGAPDDAVLIGHDWGGFTAAGIAAYPDSPFAEH
MLBr_01899|M.leprae_Br4923 AYTLEDMTDDAVALLDHLSIER-AHIVGASMGGMIAQIFAARFPTRTRSL
: * . . . . *.
Mvan_0326|M.vanbaalenii_PYR-1 VAVSGYIVVNLATNLEPLAPQ------------SEYGWWYQYYFATPRGE
MSMEG_6850|M.smegmatis_MC2_155 VAVSGYIVVNLASNLQPLAPQ------------AEHGWH-----------
MAB_2499c|M.abscessus_ATCC_199 VAVSGYIIVNLEANQQPLSPQ------------AEWGWWYQYYFATERGL
Mb1973|M.bovis_AF2122/97 VGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGI
Rv1938|M.tuberculosis_H37Rv VGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGI
MMAR_2866|M.marinum_M VGISVPFAGRGVIGLPGSPFGEHRPNDYHLELAGEGRVWYQDYFSAQDGI
MUL_4193|M.ulcerans_Agy99 AGLSVPVLPRAQV-PPIQAFRQR---------FG-EHFFYILYFQQPGVA
MAV_5163|M.avium_104 FGVNTSAP---FVKRSLSTIR------------NVWRFWYQIPISLPVIG
TH_2421|M.thermoresistible__bu IPLNIAHP---WVS-TGTVLK------------HIWRFSYQPPMAA----
Mflv_0191|M.gilvum_PYR-GCK ITMAVAPIGAVNRTRGPLTRQLALLP------KQLRNSWYIMFFQLPELP
MLBr_01899|M.leprae_Br4923 AVFFSSNNRPFLPPPAPRALLALLTG-------PPTGSRRDVVVDNVVRV
.
Mvan_0326|M.vanbaalenii_PYR-1 LGYRRNTKD-------FNRLIWTNASPLWHFDDA-----------AYDMA
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2499c|M.abscessus_ATCC_199 HGYRHNTRD-------FNKLIWHNASPTWKFDDD-----------TYARS
Mb1973|M.bovis_AF2122/97 ITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAG
Rv1938|M.tuberculosis_H37Rv ITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAG
MMAR_2866|M.marinum_M IAEIEEDVRTWLLGLTYTVSGDGMIAATKAAADAGVDLASMDPIDVIRAG
MUL_4193|M.ulcerans_Agy99 DAELNGDP---------ARTMRRMIGGQRSPTDQGAALR------MVAPG
MAV_5163|M.avium_104 PRVISTPDS------RFVRLLGSWVGG-GYTLPE----------EDVRLY
TH_2421|M.thermoresistible__bu ---FGVPLQ------QRTRVLERVVFGKGSALDA----------ETAKVY
Mflv_0191|M.gilvum_PYR-GCK ERLLPRVIP------RLWRDWGPQGYDTGAELAD-----------ALAAL
MLBr_01899|M.leprae_Br4923 TKITGSPLY---------RMPEEQVRTNAAEIYDR---------------
Mvan_0326|M.vanbaalenii_PYR-1 ARAFDN-------------------PDHADIVIHNYRWRLSLA-------
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2499c|M.abscessus_ATCC_199 AAAFDN-------------------PDHVDIVIHNYRWRLGLA-------
Mb1973|M.bovis_AF2122/97 PL----CMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLS
Rv1938|M.tuberculosis_H37Rv PL----CMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLS
MMAR_2866|M.marinum_M PL----CMADGARLKDAFVYPETMPAWFTDADLDFYTGEFERSGFGGPLS
MUL_4193|M.ulcerans_Agy99 PE----GFID--RLPE----PDAPPSWISRDELDHYISEFTRTGFTGGLN
MAV_5163|M.avium_104 LE----CMRQ---------------PGHAEAGSRWYRSFQTR--------
TH_2421|M.thermoresistible__bu AD----RFRD---------------PVCARAGRDTYRTFLVR--------
Mflv_0191|M.gilvum_PYR-GCK PS-----------------------PAHRRAAVAYYRAMVRPS-------
MLBr_01899|M.leprae_Br4923 -------------------------SFYPLGVSRQFSAILGSG-------
Mvan_0326|M.vanbaalenii_PYR-1 -----PGESRYDADEQRLAAKPPIEVPTITIGSDFDGPAKDGSTYRALYT
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2499c|M.abscessus_ATCC_199 -----RGESRYDAVEAKLATKPTIAVPTITIGSDFDGPTKDGTAYRKMFT
Mb1973|M.bovis_AF2122/97 FYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMP
Rv1938|M.tuberculosis_H37Rv FYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMP
MMAR_2866|M.marinum_M FYHNIDNDWHDLADQEGKPLSAPALFIGGQYDVGTTWGAEAIARAHEVMS
MUL_4193|M.ulcerans_Agy99 WYRNFDRNWETTADLEGATITVPSLFMAGTKDP--VLSFARSDRASEVIT
MAV_5163|M.avium_104 -----EMLSWMRGEYDGARVHVPVRWLSGTEDPVLTPDLLDG---YAERI
TH_2421|M.thermoresistible__bu -----EMPAAAR-NPEKRRATVPIRALFGTRDLAIHPSLAAP---ETALA
Mflv_0191|M.gilvum_PYR-GCK -----EPSGRYADLHRWCFDVPRVPILHLQGELDGAMEAEYAAPIATALP
MLBr_01899|M.leprae_Br4923 -----------SLLHYNQRIIAPTVVIHGRADKLVRPSSGR---AVARAI
Mvan_0326|M.vanbaalenii_PYR-1 GPYQHRVLDGIGHNVPQEAPQEFASAITDVTRQ-----
MSMEG_6850|M.smegmatis_MC2_155 ---QHRVLDGIGHNVPQEAPEAFAAAVVDVHAQRGSHR
MAB_2499c|M.abscessus_ATCC_199 GKYAHRVLDGIGHNVPQEAPQEFANAIIAAHAL-----
Mb1973|M.bovis_AF2122/97 NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP--
Rv1938|M.tuberculosis_H37Rv NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP--
MMAR_2866|M.marinum_M DYRGTHMVADVGHWIQQEAPDETNRLLLEFLGGLRQ--
MUL_4193|M.ulcerans_Agy99 GPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW--
MAV_5163|M.avium_104 DDFQLELVDGVGHWIVDQRPDLVLDRVRAFLRRET---
TH_2421|M.thermoresistible__bu DDYTLETVD-CSHFIVDERPDLVRARLVALAEETA---
Mflv_0191|M.gilvum_PYR-GCK AGSRVRIIDEAGHFLQIERPQVTADTVLDYLGDRRGPR
MLBr_01899|M.leprae_Br4923 TGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS---
. .* : : : :