For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHTLRTPDDRFHTVPDFPYPPRYCEVSDDDGGALRVAWVEDGPAGADPVLMLHGEPSWSYLYRKMIPVLA GAGHRVVCPDLVGFGRSDKPTRREDHSYARHVEWMRAVAFDVLDLHNVTLVGQDWGGLIGLRLAAEHPER FARMVVANTGLPNGDQPMADVWWRFREAITSAPQLNIGAFVQGGCRRRLSDAERAGYDAPFPSDEYCAGP RAMPTLVPTSPEDPAAAANKAAWAKLAVSPTPMLVAFSDSDPITGPMAAIFQREMRGAQGIDHPLIRGAG HFLQEDAGAELAGHIVEFLRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0357 | - | - | 100% (301) | haloalkane dehalogenase |
| M. avium 104 | MAV_2130 | - | 6e-76 | 48.66% (298) | haloalkane dehalogenase |
| M. avium 104 | MAV_5163 | - | 7e-14 | 31.51% (146) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2318 | - | 7e-79 | 50.67% (300) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4004 | - | 4e-33 | 56.45% (124) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv2296 | - | 7e-79 | 50.67% (300) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0528c | - | 4e-14 | 26.03% (315) | epoxide hydrolase EphA |
| M. marinum M | MMAR_3472 | - | 2e-74 | 48.67% (300) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6314 | - | 1e-137 | 73.67% (300) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 3e-20 | 29.51% (305) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3052 | - | 8e-19 | 30.00% (300) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 1e-88 | 56.08% (296) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0357|M.avium_104 MHTLRTPDDRFHTVPDFPYPPRYCEVSDDDGGALRVAWVEDGPAGADPVL
MSMEG_6314|M.smegmatis_MC2_155 MQTLRTPDERFAQLPEFPYAPMYCDIDDGEGGRLRVAWVEDGPAHAEPVL
Mb2318|M.bovis_AF2122/97 MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIV
Rv2296|M.tuberculosis_H37Rv MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIV
MMAR_3472|M.marinum_M MDVVRTPDARFQNLVGYPFAAHYVDVAATDTPHLRMHYIDEGPADGPPIV
Mflv_4004|M.gilvum_PYR-GCK MDVLRTPYERFTDLPGFPFDPHYVEVGG-----LRMHYLDEGPAGGDVVL
Mvan_2384|M.vanbaalenii_PYR-1 MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDEGPADGPVVL
MUL_3052|M.ulcerans_Agy99 MGRQFTP-DFTPDPKLYPFASRWFDSSRG-----RLHYIDE--SDGPPIL
TH_1615|M.thermoresistible__bu -----MPGSKPYG------EPRFREIKNK-----RMAYIDEG--EGDAIV
MAB_0528c|M.abscessus_ATCC_199 -------------MTDAAVDIRERDIATNG---VHLRIVEAGEPGQPAVI
: :: :: ::
MAV_0357|M.avium_104 MLHGEPSWSYLYRKMIPVLAGAGHRVVCPDLVGFGRSD--KPTRREDHSY
MSMEG_6314|M.smegmatis_MC2_155 LLHGEPSWSFLYRKMIPILVAAGHRVICPDLVGFGRSD--KPTRIEDHTY
Mb2318|M.bovis_AF2122/97 LLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--KPTRIEDYTY
Rv2296|M.tuberculosis_H37Rv LLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--KPTRIEDYTY
MMAR_3472|M.marinum_M LLHGEPTWSYLYRTMIPPLAAGGYRVLAPDLIGFGRSD--KPTRIADYTY
Mflv_4004|M.gilvum_PYR-GCK LLHGEPSWSYLYRTMIPVLVDAGLRAVAIDLVGFGRSD--KPADRADYTY
Mvan_2384|M.vanbaalenii_PYR-1 LLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSD--KPTRREDYTY
MUL_3052|M.ulcerans_Agy99 LCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSE--HPGTFG-YKV
TH_1615|M.thermoresistible__bu FQHGNPTSSYLWRNVLPHLEGLGRLVAC-DLIGMGGSEKLSPSGPDRYHY
MAB_0528c|M.abscessus_ATCC_199 LSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSS--MPAHIDDYNI
: ** * :: :* : * . * * * *. * :
MAV_0357|M.avium_104 ARHVEWMRAVAFDVLDLHNVTLVGQDWGGLIGLRLAAEHPERFARMVVAN
MSMEG_6314|M.smegmatis_MC2_155 ARHVEWMRSLVFDALDLRKVTLVGQDWGGLIGLRLAAEHPDRFANIVVAN
Mb2318|M.bovis_AF2122/97 LRHVEWVTS-WFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVAN
Rv2296|M.tuberculosis_H37Rv LRHVEWVTS-WFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVAN
MMAR_3472|M.marinum_M LRHVEWVKS-WFEELRLAEATLFVQDWGSLIGLRVAAEHGDAIARLVVAN
Mflv_4004|M.gilvum_PYR-GCK QAHVDWTWG-AVAALGLADITLVCQD------------------------
Mvan_2384|M.vanbaalenii_PYR-1 QAHVDWTWA-AIEAIGLTGITLVCQDWGGLIGLRLVGEHPDRFARVVAAN
MUL_3052|M.ulcerans_Agy99 DEHAQVVGE-FVDHLGLDNYLTMGQDWGGPISMAVAVERAERVRGIVLGN
TH_1615|M.thermoresistible__bu GEHRDYLFALWEELELGDRVVLVLHDWGSVLGFDWANHHRDRVQGIAHME
MAB_0528c|M.abscessus_ATCC_199 EALSDDLLG-ILDDVGAGKATFVGHDWGAVVTWHTALAVPERVSGVVGLS
: . :*
MAV_0357|M.avium_104 TGLPNG-----DQPMADVW-------WRFR-----EAITSAPQLNIGAFV
MSMEG_6314|M.smegmatis_MC2_155 TGLPTG-----DIPMPDIW-------WQFR-----NAIQKAPKVDVGRFV
Mb2318|M.bovis_AF2122/97 GFLPAA-----QGRTPLPF-------YVWR-----AFARYSPVLPAGRLV
Rv2296|M.tuberculosis_H37Rv GFLPAA-----QGRTPLPF-------YVWR-----AFARYSPVLPAGRLV
MMAR_3472|M.marinum_M GFLPTA-----RGRTPTAF-------HIWR-----AFARYSPVLPAGRLV
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 TTLPTG-----DQRPGEAF-------LAWQ-----RFSQETPDFAVGHIV
MUL_3052|M.ulcerans_Agy99 TWFWPA-----DTLTMKAF-------STVMSSLPMQYAILHHNFFVERLI
TH_1615|M.thermoresistible__bu SIVTPLTWADWEDPARSVF-------QGLRTP-EGERMVLEENIFVEAML
MAB_0528c|M.abscessus_ATCC_199 VPFTRRSQVPPTQAWNKLFGDNFFYILYFQEPGVADADLNRDPATTMRRM
MAV_0357|M.avium_104 QGGCRRRLSDAERAGYDAPFPSD-EYCAGPRAMPTLVPTSPEDPAAAAN-
MSMEG_6314|M.smegmatis_MC2_155 ASGCRRPLSDGVIAAYDAPFPDD-SYCAGPRAMPGLVPTSPDDPAAEAN-
Mb2318|M.bovis_AF2122/97 NFGTVHRVPAGVRAGYDAPFPDK-TYQAGARAFPRLVPTSPDDPAVPAN-
Rv2296|M.tuberculosis_H37Rv NFGTVHRVPAGVRAGYDAPFPDK-TYQAGARAFPRLVPTSPDDPAVPAN-
MMAR_3472|M.marinum_M AAGTVRKVPPAVRAGYDAPFPDK-SYQAGARAFPQLVPISPDDPAVAAN-
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 NGGCVSTLAPEVIAAYDAPFPDD-SYKAGARQFPTLVPTSPDDPAAPAN-
MUL_3052|M.ulcerans_Agy99 PAGTTHRPSSAVMEHYRGVQPTA-SARVGVAEMPKQILAARPLLARLAS-
TH_1615|M.thermoresistible__bu PRGVHRTLSDEEMAHYREPFRDRGEGRRPTLTWPRNVPIDGEPADVAAI-
MAB_0528c|M.abscessus_ATCC_199 MAGMARIDGATMIAPGPAGFVERMPDPGELPEWLSQDELDHYITEFARTG
MAV_0357|M.avium_104 ---------------KAAWAKLAVS-PTPMLVAFSDSDPITGPMAAIFQR
MSMEG_6314|M.smegmatis_MC2_155 ---------------RAAWKVLRAS-KTPMLVAFSDGDPITGGMAPIFKK
Mb2318|M.bovis_AF2122/97 ---------------RAAWEALGRW-DKPFLAIFGYRDPILGQADGPLIK
Rv2296|M.tuberculosis_H37Rv ---------------RAAWEALGRW-DKPFLAIFGYRDPILGQADGPLIK
MMAR_3472|M.marinum_M ---------------RAAWDALGRW-EKPFLAIFGERDPLLGRADRPLIK
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ---------------RAAWEVLRTF-DRPFLCAFSDSDPITRGADAPLRK
MUL_3052|M.ulcerans_Agy99 ---------------EVPAQLG----TKPALLVWGMKDFAFR-PEPMLAR
TH_1615|M.thermoresistible__bu ---------------VADYAVWLAEGDVPKLFVNAEPGAIVRGRVRDFVR
MAB_0528c|M.abscessus_ATCC_199 FTGGLNWYRNFDRNWALTERLAGANVVVPSLFIAGAADPVLGFTDHAGSA
MAV_0357|M.avium_104 EMRGAQGIDHPLIRGAGHFLQEDAGAELAGHIVEFLRR---
MSMEG_6314|M.smegmatis_MC2_155 EMRGAHGIEHPVISGAGHFLQEDAGEDLASAVVEFLRDR--
Mb2318|M.bovis_AF2122/97 HIPGAAGQPHARIKAS-HFIQEDSGTELAERMLSWQQAT--
Rv2296|M.tuberculosis_H37Rv HIPGAAGQPHARIKAS-HFIQEDSGTELAERMLSWQQAT--
MMAR_3472|M.marinum_M HIPGAAGQPHARINAN-HFIQEDSGPELAERIISWQ-----
Mflv_4004|M.gilvum_PYR-GCK -----------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 FIPGAQGRPEVTIAGGGHFLQEDKGPELAAVVVDFIAANPV
MUL_3052|M.ulcerans_Agy99 MRAVFADHILVELPEAKHLIQEDAPDEIAAAIIARFG----
TH_1615|M.thermoresistible__bu SWP----NQTEITVAGRHYIQEDSPDEIGAAIADFVRKLRG
MAB_0528c|M.abscessus_ATCC_199 KYR-TDNRGDLLIDGAGHWIQQERPLEVNAALLAFLREVVH