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ISRRGFSKVALLTAVGATALGACSNGASVDPTRPRTEFPPLKQVDAGLLNVGYVDEGPSDGPPVILLHGW PYDIHSYLDVVPLLTTKGFRVLVPYLRGYGSTRFRSGDTFHNGQQAALATDVIDFMDALKIPSAILGGFD WGARNADIVAAIWPDRVTALVAVSGYIIVNLEANQQPLSPQAEWGWWYQYYFATERGLHGYRHNTRDFNK LIWHNASPTWKFDDDTYARSAAAFDNPDHVDIVIHNYRWRLGLARGESRYDAVEAKLATKPTIAVPTITI GSDFDGPTKDGTAYRKMFTGKYAHRVLDGIGHNVPQEAPQEFANAIIAAHAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2499c | - | - | 100% (333) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3556 | - | 8e-32 | 30.15% (272) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_0679c | - | 3e-15 | 28.47% (288) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 7e-13 | 31.87% (160) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1960 | - | 3e-15 | 27.38% (252) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1938 | ephB | 8e-13 | 31.87% (160) | epoxide hydrolase EphB |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5114 | ephA | 2e-14 | 25.32% (308) | epoxide hydrolase EphA |
| M. avium 104 | MAV_2130 | - | 1e-13 | 33.80% (142) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6850 | - | 6e-60 | 58.65% (208) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_2421 | - | 2e-11 | 32.03% (128) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4193 | ephA | 1e-14 | 25.32% (308) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | 1e-132 | 67.89% (327) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
Rv1938|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5114|M.marinum_M --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6850|M.smegmatis_MC2_155 MNTTPFGDVAGFRVSRRQFGRISAITAG-AATLAACGSPSAPPAPTPPST
Mvan_0326|M.vanbaalenii_PYR-1 MN--------GF--SRRDFGLLATAAAG-AVTLTACTS--TPATAGPPPA
MAB_2499c|M.abscessus_ATCC_199 ------------MISRRGFSKVALLTAVGATALGACSN----GASVDPTR
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAV_2130|M.avium_104 -----------------------MPVHAEELNMHVLRTPDSRFENLEDYP
Mb1973|M.bovis_AF2122/97 ---MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQI
Rv1938|M.tuberculosis_H37Rv ---MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQI
MMAR_5114|M.marinum_M -MVATSTERLVDTNGVRLRVTEAG--ERGAPVVILAHGFPELAYSWRHQI
MUL_4193|M.ulcerans_Agy99 -MVATSTERLVDTNGVRLRVTEAG--ERGAPVVILAHGFPELAYSWRHQI
MSMEG_6850|M.smegmatis_MC2_155 PAHVLGQVNQLTAGDLDVGYVEAGP--ATGQPVILLHGWPYDIHSYADVS
Mvan_0326|M.vanbaalenii_PYR-1 PRNQLGPIKQIDAGDLNVGYAEAGP--PDGQPVILLHGWPYDIHSYADVT
MAB_2499c|M.abscessus_ATCC_199 PRTEFPPLKQVDAGLLNVGYVDEGP--SDGPPVILLHGWPYDIHSYLDVV
Mflv_1960|M.gilvum_PYR-GCK ----------MTVRGVDFHITEAGP--EDGRPVLALHGWPQHHWAYRDLL
TH_2421|M.thermoresistible__bu -----VRRSFVEARGVRFHVTESGP--ADGRPVLALHGWPQHHWAYRDLL
MAV_2130|M.avium_104 FVAHYLDVTARDTRPLRMHYLDEGP--IDGPPIVLLHGEPTWSYLYRTMI
. . . :: ** * :
Mb1973|M.bovis_AF2122/97 PALAGAGYRVVAIDQRGYGRS--SKYRVQKAYRIKELVGDVVGVLDSYGA
Rv1938|M.tuberculosis_H37Rv PALAGAGYRVVAIDQRGYGRS--SKYRVQKAYRIKELVGDVVGVLDSYGA
MMAR_5114|M.marinum_M PVLAEAGYHVLAPDQRGYGGS--SRPEAIEDYDIHQLTADLVGLLDDVGA
MUL_4193|M.ulcerans_Agy99 PVLAEAGYHVLAPDQRGYGGS--SRPEAIEDYDIHQLTADLVGLLDDVGA
MSMEG_6850|M.smegmatis_MC2_155 ALLAAQGFRVIVPYARGFGSTRFLSKDTLRNGQQAALAHDVLALMDALDI
Mvan_0326|M.vanbaalenii_PYR-1 AILAAQGFRVIVPHLRGFGTTRFRSANTVRNGQQAALAHDAISLMDALNI
MAB_2499c|M.abscessus_ATCC_199 PLLTTKGFRVLVPYLRGYGSTRFRSGDTFHNGQQAALATDVIDFMDALKI
Mflv_1960|M.gilvum_PYR-GCK GDPPP-GLRIIAPDLPGYG----WSGPPPHRWAKEDVVTDLVALVDALGL
TH_2421|M.thermoresistible__bu ADPPA-GLRIIAPDLPGYG----WSGPAPHRWAKEDVASDLLALMDELGL
MAV_2130|M.avium_104 TPLTDAGNRVLAPDLIGFGRS--DKPSRIEDYSYQRHVDWVVSWFEHLNL
. * :::. *:* . . : .:
Mb1973|M.bovis_AF2122/97 EQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFG
Rv1938|M.tuberculosis_H37Rv EQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFG
MMAR_5114|M.marinum_M ERAAWVGHDWGAVVVWNAPLLHPDRVAAVAGLSVPVLPRAQV-PPIQAFR
MUL_4193|M.ulcerans_Agy99 ERAAWVGHDWGAVVVWNAPLLHPDRVAAVAGLSVPVLPRAQV-PPIQAFR
MSMEG_6850|M.smegmatis_MC2_155 QDAILAGYDWGGRTANVMAALWPQRCSGLVAVSGYIVVNLASNLQPLAPQ
Mvan_0326|M.vanbaalenii_PYR-1 PDAILGGYDWGGRTANAVAALWPQRCTGLVAVSGYIVVNLATNLEPLAPQ
MAB_2499c|M.abscessus_ATCC_199 PSAILGGFDWGARNADIVAAIWPDRVTALVAVSGYIIVNLEANQQPLSPQ
Mflv_1960|M.gilvum_PYR-GCK DRFLLVGHDWGGYIGHLLALRIPER------IDAYLALNIAHPWVPPKVM
TH_2421|M.thermoresistible__bu GRTLLIGHDWGGYIGFLMILRAPER------FDGYIPLNIAHPWVSTGTV
MAV_2130|M.avium_104 SDVTLFVQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPAFYAW
***. *:* . .
Mb1973|M.bovis_AF2122/97 ERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSG
Rv1938|M.tuberculosis_H37Rv ERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSG
MMAR_5114|M.marinum_M QR---------FG-EHFFYILYFQQPGVADAELNGDP---------ARTM
MUL_4193|M.ulcerans_Agy99 QR---------FG-EHFFYILYFQQPGVADAELNGDP---------ARTM
MSMEG_6850|M.smegmatis_MC2_155 AE------------HGWH--------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 SE------------YGWWYQYYFATPRGE-LGYRRNTK------------
MAB_2499c|M.abscessus_ATCC_199 AE------------WGWWYQYYFATERGL-HGYRHNTR------------
Mflv_1960|M.gilvum_PYR-GCK AP------------HLWRFLLYQPVVASAGVPLQTRTR------------
TH_2421|M.thermoresistible__bu LK------------HIWRFS-YQPPMAAFGVPLQQRTR------------
MAV_2130|M.avium_104 RA----------------FARYSPVLPAGRIVSVGTVR------------
Mb1973|M.bovis_AF2122/97 EGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMP
Rv1938|M.tuberculosis_H37Rv EGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMP
MMAR_5114|M.marinum_M RRMIGGQRSPTDQGAALR------MVAPGPEGFID--RLPE----PDTPP
MUL_4193|M.ulcerans_Agy99 RRMIGGQRSPTDQGAALR------MVAPGPEGFID--RLPE----PDAPP
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 --------------------------------DFNRLIWTNASPLWHFDD
MAB_2499c|M.abscessus_ATCC_199 --------------------------------DFNKLIWHNASPTWKFDD
Mflv_1960|M.gilvum_PYR-GCK --------------------------------YLEKVVFRAAAP--KLDA
TH_2421|M.thermoresistible__bu --------------------------------VLERVVFGKGS---ALDA
MAV_2130|M.avium_104 ----------------------------------------------RVSS
Mb1973|M.bovis_AF2122/97 AWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPAL
Rv1938|M.tuberculosis_H37Rv AWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPAL
MMAR_5114|M.marinum_M SWISRDELDHYISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSL
MUL_4193|M.ulcerans_Agy99 SWISRDELDHYISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSL
MSMEG_6850|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0326|M.vanbaalenii_PYR-1 AAYDMAARAFDNPDHADIVIHNYRWRLSLAPGESRYDADEQRLAAKPPIE
MAB_2499c|M.abscessus_ATCC_199 DTYARSAAAFDNPDHVDIVIHNYRWRLGLARGESRYDAVEAKLATKPTIA
Mflv_1960|M.gilvum_PYR-GCK ATVGTYAERFRDPVVARTARDTYRTFLTREIPKGVRDGERRWSTVPTR--
TH_2421|M.thermoresistible__bu ETAKVYADRFRDPVCARAGRDTYRTFLVREMPAAARNPEKRRATVPIR--
MAV_2130|M.avium_104 KVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
Mb1973|M.bovis_AF2122/97 FIGGQYDVGT-IWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETN
Rv1938|M.tuberculosis_H37Rv FIGGQYDVGT-IWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETN
MMAR_5114|M.marinum_M FMAGTKDP---VLSFARSDRASEVITGPYREVMVEGAGHWLQQERPDEVN
MUL_4193|M.ulcerans_Agy99 FMAGTKDP---VLSFARSDRASEVITGPYREVMVEGAGHWLQQERPDEVN
MSMEG_6850|M.smegmatis_MC2_155 -----------------------------QHRVLDGIGHNVPQEAPEAFA
Mvan_0326|M.vanbaalenii_PYR-1 VPTITIGSDF-DGPAKDGSTYRALYTGPYQHRVLDGIGHNVPQEAPQEFA
MAB_2499c|M.abscessus_ATCC_199 VPTITIGSDF-DGPTKDGTAYRKMFTGKYAHRVLDGIGHNVPQEAPQEFA
Mflv_1960|M.gilvum_PYR-GCK ---VLFGRSD-TAIHPDLAAAETARADDYTIDVVDGG-HFILDEQPDLVR
TH_2421|M.thermoresistible__bu ---ALFGTRD-LAIHPSLAAPETALADDYTLETVDCS-HFIVDERPDLVR
MAV_2130|M.avium_104 PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELA
* : ::
Mb1973|M.bovis_AF2122/97 RLLLDFLGGLRP----
Rv1938|M.tuberculosis_H37Rv RLLLDFLGGLRP----
MMAR_5114|M.marinum_M ATLLDFLKGVQW----
MUL_4193|M.ulcerans_Agy99 ATLLDFLKGVQW----
MSMEG_6850|M.smegmatis_MC2_155 AAVVDVHAQRGSHR--
Mvan_0326|M.vanbaalenii_PYR-1 SAITDVTRQ-------
MAB_2499c|M.abscessus_ATCC_199 NAIIAAHAL-------
Mflv_1960|M.gilvum_PYR-GCK AKLIAVADEFPERPVR
TH_2421|M.thermoresistible__bu ARLVALAEETA-----
MAV_2130|M.avium_104 ERILSWQQALL-----
: