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AAALLVGLTAAPFEVPVAGAAPVSSLDQVLSDAVAADGVPGAIAVVYDGHTLSRHWAGVSDVATGAEFTP NTHVRAGSVSKVFVAAMILQLVAEGRIDLDAPIEVYLPGRVRGEGIDPEAITVRQVLRHQSGLPEYFDSV TDVPTEPVTGEQLLDMALTRPAGFAPGEKTVYTNTNYVVAGLIAEAVTGTPVADEVTRRVIVPLGLRDTY WPAPDDTGLRKPFAHGYENKHGVRTDVTDFNASAAGMSGSLVSTGEDMAVFVSALLAGRVVPPAQLADMM DTVELDSQGQRYGLGLGSIDLSCGVRVWGHSGGIPGFHTLMIAPQGGPALTVTVTQDPETGDPLEQAAEA FYCT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6784 | - | - | 100% (355) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_4455 | - | 1e-36 | 27.48% (393) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 2e-36 | 31.03% (348) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1957 | - | 1e-20 | 28.27% (336) | lipoprotein |
| M. gilvum PYR-GCK | Mflv_0495 | - | 1e-14 | 29.82% (218) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1922 | - | 1e-20 | 28.27% (336) | lipoprotein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0330 | - | 1e-40 | 34.14% (331) | Beta-lactamase |
| M. marinum M | MMAR_2827 | - | 1e-18 | 26.80% (362) | lipoprotein |
| M. avium 104 | MAV_3991 | - | 1e-15 | 28.02% (232) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 2e-38 | 32.58% (353) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_3735 | lipP | 6e-10 | 31.76% (170) | esterase/lipase LipP |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 3e-37 | 31.15% (321) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0495|M.gilvum_PYR-GCK -----------------------MTRSSTRLRRLGAAGAVVLALGACGDR
MAV_3991|M.avium_104 ----------------------------------------MLTLVAASST
Mb1957|M.bovis_AF2122/97 -----------------------------MDST----------VTASIRR
Rv1922|M.tuberculosis_H37Rv -----------------------------MDST----------VTASIRR
MMAR_2827|M.marinum_M MCDSLTRWTVRSDEVYGQHAGVCESLCGEGDSTTVIARDEAEAQTSSAPD
MAB_0330|M.abscessus_ATCC_1997 ------------------------------MPELSTR---CFDESSLMRR
Mvan_3027|M.vanbaalenii_PYR-1 ------------------------------MADENGRRDSAHTLGAMITR
TH_3520|M.thermoresistible__bu -----------------------------------------MRAVRTLAA
MSMEG_6784|M.smegmatis_MC2_155 -------------------------------------------MAAALLV
MUL_3735|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0495|M.gilvum_PYR-GCK PEP---------------------PGTSAVRPPATPT-------RVLPSP
MAV_3991|M.avium_104 GRV---------------------VHTS---PSEAPP-------ASMTPH
Mb1957|M.bovis_AF2122/97 MLG---------------------LLAATLLLGGCTG----------QHT
Rv1922|M.tuberculosis_H37Rv MLG---------------------LLAATLLLGGCTG----------QHT
MMAR_2827|M.marinum_M QVGSVRWKPVSSTHRCGWRSKWAPLLVIAVMLGACGG----------LPP
MAB_0330|M.abscessus_ATCC_1997 ILA--------------------VVLTIALLVSACGK----------HSA
Mvan_3027|M.vanbaalenii_PYR-1 ALP--------------------IVFAMVLALTACGESVDTTQTTGSRNP
TH_3520|M.thermoresistible__bu LLL--------------------AVFAVSAGPSAAGQ-------------
MSMEG_6784|M.smegmatis_MC2_155 G-----------------------LTAAPFEVPVAG--------------
MUL_3735|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0495|M.gilvum_PYR-GCK PPPVPEVT-PTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFG
MAV_3991|M.avium_104 ASLVPESTSPAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYG
Mb1957|M.bovis_AF2122/97 TRTAASTTYTPHIKASSQDVLDGAINAD-EPGCSAAVGVEGKVIWSGVRG
Rv1922|M.tuberculosis_H37Rv TRTAASTTYTPHIKASSQDVLDGAINAD-EPGCSAAVGVEGKVIWSGVRG
MMAR_2827|M.marinum_M AVTPPGTTDNSDLKTRSQRVLDGAVNPD-EPGCSAAVGVEGVVMWTGVLG
MAB_0330|M.abscessus_ATCC_1997 IVVA---ELDPQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVRTFG
Mvan_3027|M.vanbaalenii_PYR-1 AVTAPATTMAAEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVRAFG
TH_3520|M.thermoresistible__bu ---------PPDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTRAFG
MSMEG_6784|M.smegmatis_MC2_155 ----------AAPVSSLDQVLSDAVAADGVPGAIAVVYDG-HTLSRHWAG
MUL_3735|M.ulcerans_Agy99 ----------------------------MEVGAAVAVWVDGDLVVNLWGG
*. . : *
Mflv_0495|M.gilvum_PYR-GCK VRKLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRV
MAV_3991|M.avium_104 SRKLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKV
Mb1957|M.bovis_AF2122/97 IADLASG----------AKITTDTVFDIASVSKQFT-ATAILLLVEAGKL
Rv1922|M.tuberculosis_H37Rv IADLASG----------AKITTDTVFDIASVSKQFT-ATAILLLVEAGKL
MMAR_2827|M.marinum_M IADLATN----------KKVTKDTVFDIGSVSKQFT-ATAVLLLINEGRL
MAB_0330|M.abscessus_ATCC_1997 VANTATR----------APLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKV
Mvan_3027|M.vanbaalenii_PYR-1 VADTKTR----------APMKTDFYSRIGSLTKTFT-VTAVLLLADQGRL
TH_3520|M.thermoresistible__bu VGDTATG----------TPMLVDNHHRIGSVTKTFI-GTAILQLADQGRI
MSMEG_6784|M.smegmatis_MC2_155 VSDVATG----------AEFTPNTHVRAGSVSKVFV-AAMILQLVAEGRI
MUL_3735|M.ulcerans_Agy99 SADAAGT----------RPWRQDTLTTVLSGSKALT-ATCVHQLADRGEL
. : * :* : . : * *.:
Mflv_0495|M.gilvum_PYR-GCK RIDEPVQTYLPGFNPAGDPRRAAVTVRMLLTHTSGIAGDLSLDGPWGLAG
MAV_3991|M.avium_104 AFDDPVQKYLPAFNTTNDPQRAKVTIRMLLTNTSGEGIDVSLRDPWGLAG
Mb1957|M.bovis_AF2122/97 TLDDPISQYVPELPDW----AQTVTVEQLMHQTSGIPDYVALLAARGYQV
Rv1922|M.tuberculosis_H37Rv TLDDPISQYVPELPDW----AQTVTVEQLMHQTSGIPDYVALLAARGYQV
MMAR_2827|M.marinum_M TLDDPLAHYVPDLPDW----SSAVTVAQLMHHTSGIPDYTGLLEAQGYQM
MAB_0330|M.abscessus_ATCC_1997 ELDDPIAKYVDKVPN-----GNKITLRELARMQSGLFNYSMSLAFSRDLE
Mvan_3027|M.vanbaalenii_PYR-1 GLDDPIAGYVDGVPG-----GDAITLRQLARMQSGLPDYTANPEFVPTVI
TH_3520|M.thermoresistible__bu RLSDPISRYVEGVPS-----GDVITLDMLARMRSGLADYTETDEFVERLY
MSMEG_6784|M.smegmatis_MC2_155 DLDAPIEVYLPGRVRGEGIDPEAITVRQVLRHQSGLPEYFDSVTDVPTEP
MUL_3735|M.ulcerans_Agy99 NLHAPVARYWPEFRQAG---KEAITVAMVLSHRSGVIGPNARMSWQQVTD
: *: * :*: : **
Mflv_0495|M.gilvum_PYR-GCK PDKADG-----------VRRALGAWVVSDPGEGFHYSDINF-IILGALVE
MAV_3991|M.avium_104 PDKAEG-----------IHRALTTPLQSAPAGEFRYSDINY-LLLGALLE
Mb1957|M.bovis_AF2122/97 SDRTI-------EAEARQALAAAPELQFKPGTRFDYSNSNY-LLLGEIVH
Rv1922|M.tuberculosis_H37Rv SDRTI-------EAEARQALAAAPELQFKPGTRFDYSNSNY-LLLGEIVH
MMAR_2827|M.marinum_M SDRTT-------QAQALAAIQGAPELEFKPGTRFEYSNSNY-LLLAEIVR
MAB_0330|M.abscessus_ATCC_1997 ADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYSNTNA-VLLGQVVE
Mvan_3027|M.vanbaalenii_PYR-1 ADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYSNTNT-VLLGLVVE
TH_3520|M.thermoresistible__bu RESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYSNTNT-VLLGMVVE
MSMEG_6784|M.smegmatis_MC2_155 VTGEQ-----------LLDMALTRPAGFAPGEKTVYTNTNY-VVAGLIAE
MUL_3735|M.ulcerans_Agy99 WDFVC------------EQLALAEP-RWEPGSAQGYHMTTFGFILGEVFR
*. * . .: . : .
Mflv_0495|M.gilvum_PYR-GCK KITGEPEDSYVDRNVFAPLKMSETRYLPVT-------KVCGPHRVRGTAI
MAV_3991|M.avium_104 KITGEDEDDYVQHHVFGPLGMHDTRYLPPA-------KACGPHIIRGAAI
Mb1957|M.bovis_AF2122/97 RASGQPLPEFLSAEIFQPLGLAMVVDPVG----------KVPNKAVSYEK
Rv1922|M.tuberculosis_H37Rv RASGQPLPEFLSAEIFQPLGLAMVVDPVG----------KVPNKAVSYEK
MMAR_2827|M.marinum_M LVSGKSLPDFLSIEIFRPLDLAMVVDPIS----------ADPDEAVSYGE
MAB_0330|M.abscessus_ATCC_1997 KVSGQTLPAFVQEHITGPLGMRRTSFPETS-------AIADPHARGYTQL
Mvan_3027|M.vanbaalenii_PYR-1 KVSGQSLGDYIRRHISAPLGMAETSFPTDA-------TFPGPHATGYTVQ
TH_3520|M.thermoresistible__bu RVSGVPLARYLQDNIFGPVGLTQTSYPADG-------RLPAPYTHGYNQ-
MSMEG_6784|M.smegmatis_MC2_155 AVTGTPVADEVTRRVIVPLGLRDTYWPAPD-------DTGLRKPFAHGYE
MUL_3735|M.ulcerans_Agy99 RITGRTVGQYLRTEIAEPIGADVHIGLSPFDQSRCAERVNKPHARDLLAD
:* : .: *:
Mflv_0495|M.gilvum_PYR-GCK AADPHGQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYGYPLRG
MAV_3991|M.avium_104 AWAPNGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRG
Mb1957|M.bovis_AF2122/97 GTGGN---------------------------------------------
Rv1922|M.tuberculosis_H37Rv GTGGN---------------------------------------------
MMAR_2827|M.marinum_M GDTGN---------------------------------------------
MAB_0330|M.abscessus_ATCC_1997 TPTGS---------------------------------------------
Mvan_3027|M.vanbaalenii_PYR-1 PPDDR---------------------------------------------
TH_3520|M.thermoresistible__bu GPDGA---------------------------------------------
MSMEG_6784|M.smegmatis_MC2_155 NKHGVR--------------------------------------------
MUL_3735|M.ulcerans_Agy99 VQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSND-----------LHLWR
Mflv_0495|M.gilvum_PYR-GCK TVHDPTARRMGGVAGSAGVFTTVHDMGRFAQALLDRVAGRPSPFP-LSQA
MAV_3991|M.avium_104 TVHDPTARRMGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFP-LQQG
Mb1957|M.bovis_AF2122/97 RSEYRVGNPAWEQIGDGGIQTTPSQLARWADNYRTGSVGGLKLLE-AQLA
Rv1922|M.tuberculosis_H37Rv RSEYRVGNPAWEQIGDGGIQTTPSQLARWADNYRTGSVGGLKLLE-AQLA
MMAR_2827|M.marinum_M PPQFPVLHSGWEQVGDGAIQTTPSQLVLWADNYRTGKVGGQKLLD-EQLA
MAB_0330|M.abscessus_ATCC_1997 LVDSTDWNPSWASWA-GAMISTLDDLRIWVPALATGVLLKPDSQQ-QRLQ
Mvan_3027|M.vanbaalenii_PYR-1 EMTATDWNLSWSWAA-GNMVSTLHDLRIWAPALVTGTLLSRQMQQ-QRLQ
TH_3520|M.thermoresistible__bu IVDTTLWNPAWADAA-GKIVSNVHDMRTWARALGSGALLRPDTHA-ERIH
MSMEG_6784|M.smegmatis_MC2_155 -TDVTDFNASAAGMS-GSLVSTGEDMAVFVSALLAGRVVPPAQLA-DMMD
MUL_3735|M.ulcerans_Agy99 QLEFPGTNAQVSALGLATFYNALAQEKLLSREHMDLVRVSQGGFDTDLVL
. . . . . :
Mflv_0495|M.gilvum_PYR-GCK GARMMTTPQQP-----------------AP------GRDLRGFGWDIDTA
MAV_3991|M.avium_104 TVELMTTPQQPGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWDIDTG
Mb1957|M.bovis_AF2122/97 GAVETEPGGGDRYGAG---------------------------------I
Rv1922|M.tuberculosis_H37Rv GAVETEPGGGDRYGAG---------------------------------I
MMAR_2827|M.marinum_M GAVETEPGSGDRYGAG---------------------------------I
MAB_0330|M.abscessus_ATCC_1997 TVAMPPVPDDIRYGLG---------------------------------I
Mvan_3027|M.vanbaalenii_PYR-1 MVESSGQPAPEEYGLG---------------------------------M
TH_3520|M.thermoresistible__bu GG-SSVVPG-VDYSFA---------------------------------I
MSMEG_6784|M.smegmatis_MC2_155 TVELDSQGQRYGLGLG-------------------------------SID
MUL_3735|M.ulcerans_Agy99 GPRVADHGWGLGYMLN-------------------------------QRA
Mflv_0495|M.gilvum_PYR-GCK HSGPRGSVFPVGSFGHTGFTGVSVWLDPESDTYVVILGNVIHQRGGPPIT
MAV_3991|M.avium_104 YSRPRGRVFPIGSFGNTGFTGTTLWMDPGSDTYVILLSNSIHLRGSPPIS
Mb1957|M.bovis_AF2122/97 VSRADGTLDHAGAWA--GFVTAFHIS-SDRRTSVAISCNTDKPDPVAMAD
Rv1922|M.tuberculosis_H37Rv VSRADGTLDHAGAWA--GFVTAFHIS-SDRRTSVAISCNTDKPDPVAMAD
MMAR_2827|M.marinum_M FSRANGTLDHDGSWA--GFVTDFRIS-SDRRTSVAVSCNMEGQDPESLAD
MAB_0330|M.abscessus_ATCC_1997 FD-ARGWIGHSGSIP--GYQTLAIYS-PAEQTTVVALLNTDVAKQPAQPS
Mvan_3027|M.vanbaalenii_PYR-1 FN-VAGWIGHNGSVP--GYQTVSVYL-PERQTALVILTNTDIAFRGAEPG
TH_3520|M.thermoresistible__bu FN-AQGWLGHNGDIP--GYATVVVYL-PERDATLVVFVNSDVPEP--HSA
MSMEG_6784|M.smegmatis_MC2_155 LSCGVRVWGHSGGIP--GFHTLMIAPQGGPALTVTVTQDPETGDPLEQAA
MUL_3735|M.ulcerans_Agy99 VNGPNQKIFGHGGLG--GSFGFVDLEHRIGYAYVMNRFDASKANADPRSV
. * * : :
Mflv_0495|M.gilvum_PYR-GCK PLSGAVATEAARALHLYGS-------------
MAV_3991|M.avium_104 NLRGDVATAAARALHLYGAAPP----------
Mb1957|M.bovis_AF2122/97 ALGRLWM-------------------------
Rv1922|M.tuberculosis_H37Rv ALGRLWM-------------------------
MMAR_2827|M.marinum_M AIGRLWM-------------------------
MAB_0330|M.abscessus_ATCC_1997 TLFGTAITKVISPDHVFLLENAIPQPR-----
Mvan_3027|M.vanbaalenii_PYR-1 TLLARAVTTELTPDHVYTLS------------
TH_3520|M.thermoresistible__bu GQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA
MSMEG_6784|M.smegmatis_MC2_155 EAFYCT--------------------------
MUL_3735|M.ulcerans_Agy99 ALSNEVYAALDVAAD-----------------