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RTVDVAVVQEPAVAGDVAANVRRAVAALAKHPGADLVVFPELFLCGYRLDVVADAAIEMIPEPGPVADLC AAAAAHDTAVVTGFAERSGDLVYNSLLCIDRTGAVAGVYRKTHLFGAECEAFATGDRLEVIEVDGLRVGP MICFDVEFPEIARTLALSGVDLFVVSSANMFPYHHDHRVACLSRALENRTPLVYSNLIGAEAGLTFVGGS RVVDAGGELLVECGGEVSVARCRVTPATATSTEDDVDYLRHRRPELYRLK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6733 | - | - | 100% (261) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_5655 | - | 6e-26 | 32.71% (269) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_0566 | - | 1e-20 | 29.75% (279) | aliphatic amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 5e-12 | 29.34% (259) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 4e-10 | 30.40% (273) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 5e-12 | 29.34% (259) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 6e-12 | 27.69% (260) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4348c | - | 9e-33 | 36.19% (257) | putative hydrolase |
| M. marinum M | MMAR_4512 | - | 4e-21 | 36.09% (230) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 2e-15 | 30.56% (252) | carbon-nitrogen hydrolase |
| M. thermoresistible (build 8) | TH_0873 | - | 9e-16 | 34.41% (247) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4683 | - | 2e-20 | 41.04% (173) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_1219 | - | 3e-21 | 31.25% (272) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6733|M.smegmatis_MC2_155 ----------------------------MRTVDVAVVQEPAVAGDVAANV
MAB_4348c|M.abscessus_ATCC_199 ------------------------MTLSTGRLKVAGLQTSGTPGDIAANL
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGT-DPAANL
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSGT-DPAANL
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSGT-DPVANL
MAV_4670|M.avium_104 -------------------------------MRIALAQILSGT-DPAANL
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSST-DPAANL
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSGT-DPSANL
MMAR_4512|M.marinum_M ------------------------MHQVETELVVAVAQPRTEMGAVAANV
MUL_4683|M.ulcerans_Agy99 ------------------------MHQVKTELVVAVAQPRTVMGAVAANV
Mvan_1219|M.vanbaalenii_PYR-1 -------------------------------MKVGAVAAHFGR-DVDRGV
: :. .:
MSMEG_6733|M.smegmatis_MC2_155 RRAVAALAKHP--GADLVVFPELFLCGYRL-DVVADAAIEMIPEPGPVAD
MAB_4348c|M.abscessus_ATCC_199 DELASAACAAAGEGAQLLITPELFVTGYDIGDVIYELAAQDLLSP-----
Mb0490c|M.bovis_AF2122/97 QLVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANG----
Rv0480c|M.tuberculosis_H37Rv QLVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANG----
MLBr_02449|M.leprae_Br4923 RLVREYTGQATDAGATLVVFPEATMCRFGVPLGPVAEPIDGPWANG----
MAV_4670|M.avium_104 ALVGEYTRRAAGAGARLVVFPEATMCRFGVPLAPIAEPVDGPWADG----
Mflv_0095|M.gilvum_PYR-GCK TLVEEYTRRAVDAGASLVLFPEATMVRFGVPLGGVAEPFDGPWANA----
TH_0873|M.thermoresistible__bu NLVEEYTRRAAATGAGLVLFPEATMCRFGVSLKPVAEPLDGPWATA----
MMAR_4512|M.marinum_M DAHAALIRRAN---ARLVVFPELSLTGYQLKVAPVDVAG--PVVDR----
MUL_4683|M.ulcerans_Agy99 DAHAALIQRAN---ARLVVFPELSLTGYQLEVAPVDVAG--PVVDR----
Mvan_1219|M.vanbaalenii_PYR-1 AKVVGIVEAAARDGVQLLVFPDACLGGYIGDLRRPDPSDPPPALDPDGPE
. *:: *: : .
MSMEG_6733|M.smegmatis_MC2_155 LCAAAAAHD-TAVVTGFAERSGD-LVYNSLLCIDR--TGAVAGVYRKTHL
MAB_4348c|M.abscessus_ATCC_199 LKRIAEEHG-IALVVGIPEAVGE-KLYNSAVFVDQ--QGQVRATHRKTHL
Mb0490c|M.bovis_AF2122/97 VRRIATEAG-ITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDAHYHKIHL
Rv0480c|M.tuberculosis_H37Rv VRRIATEAG-ITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDAHYHKIHL
MLBr_02449|M.leprae_Br4923 VRQIATEAG-ITIIAGIFTPADDGRVMNTLIAAGPGTPNQPDTHYHKIHL
MAV_4670|M.avium_104 VRRIATEAN-VTVIAGMFTPSGDGRVKNTLLVAN--SDDQAVTHYDKIHL
Mflv_0095|M.gilvum_PYR-GCK VRDIAARAG-IVVVAGMFVPSDDGRSFNTLLATGP----GVEARYDKIHL
TH_0873|M.thermoresistible__bu VREIAAGAG-VVVVAGMFTPSGDGRVTNTLLATGP----GVAAHYHKIHL
MMAR_4512|M.marinum_M LVLACAATG-CSVLVGAPVEDRGRRYIAMVLVDSS----GAEVVYRKTHL
MUL_4683|M.ulcerans_Agy99 LVLACAATG-CSALVGAPVEDRGRRYIAMVLVDSS----GAEVVYRKTHL
Mvan_1219|M.vanbaalenii_PYR-1 IAAVIAAAGPMTVCVGYAEAAPGGSRYNSAICVSG---DGVLGTHRKVHQ
: . .* : . : * *
MSMEG_6733|M.smegmatis_MC2_155 FGAE--CEAFATG--DRLEVIEVDG----LRVGPMICFDVEFPEIARTLA
MAB_4348c|M.abscessus_ATCC_199 FGPL--DRQYFTAGSDAVTVVDYLG----LKVGMMICYDVEFPENPRMAA
Mb0490c|M.bovis_AF2122/97 YDAFGFTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTELA
Rv0480c|M.tuberculosis_H37Rv YDAFGFTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTELA
MLBr_02449|M.leprae_Br4923 YDAFGFTESRTVTAGHEPVVITVDD----VQVGLTICYDIRFPALYTELA
MAV_4670|M.avium_104 YDAFGFTESRTVAPGREPVVVGVDG----VRVGLSVCYDIRFPELYTELA
Mflv_0095|M.gilvum_PYR-GCK YDAFGFLESKTVAPGREPVVISVDTESGPVTVGLTLCYDIRFPELYVELA
TH_0873|M.thermoresistible__bu YDAYGFTESRTVAPGSEPVTIDVGG----VRVGLTTCYDIRFPELYVELA
MMAR_4512|M.marinum_M ----GAAEKARFRPGPGPRTIDLDG----WRIGLGICRDTGVPEHVRGTA
MUL_4683|M.ulcerans_Agy99 ----DAAEKARFRPGPGPRTIDLDG----WRIGLGICRDTGVPEHVRGTA
Mvan_1219|M.vanbaalenii_PYR-1 PAG----ESLAYLAGDTFAAFDTPVG----RLGMLIDYDKTFPESARALA
. .. :* * .* *
MSMEG_6733|M.smegmatis_MC2_155 LSGVDLFVVSSANMFPYHHDHR----------VACLS--RALENRTPLVY
MAB_4348c|M.abscessus_ATCC_199 LEGVDLLAVPTAQMKPFEFVAD----------SVIRT--RAWENQMYVAY
Mb0490c|M.bovis_AF2122/97 RRGAQLIAVCASWGSGPGKLEQ----------WTLLARARALDSMSYVAA
Rv0480c|M.tuberculosis_H37Rv RRGAQLIAVCASWGSGPGKLEQ----------WTLLARARALDSMSYVAA
MLBr_02449|M.leprae_Br4923 RRGAQLIVVCASWGSGAGKLEQ----------WTLLARARALDSMSYVAA
MAV_4670|M.avium_104 RRGAQLIAVCASWGAGPGKLDQ----------WTLLARARALDSMSYIAA
Mflv_0095|M.gilvum_PYR-GCK DRGAEIITAHASWGTGPGKLEQ----------WTLLARARAIDTSSVVAA
TH_0873|M.thermoresistible__bu RRGAELLTVHASWGSGPGKLEQ----------WTLLARARALDTTCVVAA
MMAR_4512|M.marinum_M RLGVDLYACGVVHHD--WELGE----------QRHRARTIAATCDAPVAM
MUL_4683|M.ulcerans_Agy99 RLGVDLYACGVVHHD--GELGE----------QRHRARTIAATCTAPVAM
Mvan_1219|M.vanbaalenii_PYR-1 LDGAHIIAALSAWPASVTDRASRLPADRQSRLFDLYDCARAAENQVVVVS
*..: . * :.
MSMEG_6733|M.smegmatis_MC2_155 SNLIGAEAGLTFVG----------GSRVVDAGGELLVECGGEVSVARCRV
MAB_4348c|M.abscessus_ATCC_199 INHAGRERQTAYVG----------RSSIVAPDATVLGRILSATGIIYGIV
Mb0490c|M.bovis_AF2122/97 AGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADI
Rv0480c|M.tuberculosis_H37Rv AGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADI
MLBr_02449|M.leprae_Br4923 VGQADPGGALTDSGPSSAAPTGVGGSLVASPLGEVVASAGTESKLVVADI
MAV_4670|M.avium_104 AGQADPGGSLSASG----APTGVGGSLVASPLGEVVASAGAQPQLVLADI
Mflv_0095|M.gilvum_PYR-GCK VGQAYPGDEIAALG-----PTGVGGSLVASALGEVLASAGDDPELLVCDV
TH_0873|M.thermoresistible__bu VGQAYPGDEIAAQG-----PTGVGGSLVASATGEVLAAAGPEPELLVADL
MMAR_4512|M.marinum_M ASFAGPTGGGYLHT--------AGHSAIWSATSTLVAEAGAGPDQIAHTT
MUL_4683|M.ulcerans_Agy99 ASFAGP------------------------------------PEVATYTQ
Mvan_1219|M.vanbaalenii_PYR-1 ANQTGIMGSLRFLG----------QAKVVGPGGDVLATTRSKGGLARVDI
.
MSMEG_6733|M.smegmatis_MC2_155 TPATATS-TEDDVDYLRHRRPELYRLK--------
MAB_4348c|M.abscessus_ATCC_199 DGHAVRS-ARKRNPYLSDTRPELNQRLIRRHEPGD
Mb0490c|M.bovis_AF2122/97 DVDNVAA-ARDRIAVLRNQTDFVQIDKAQSRG---
Rv0480c|M.tuberculosis_H37Rv DVDNVAA-ARDRIAVLRNQTDFVQIDKAQSRG---
MLBr_02449|M.leprae_Br4923 DVDNVTT-ARENIAVLRNRSHFA------------
MAV_4670|M.avium_104 DVDRVAQ-ARKTIAALSNRSDFAQVGRAESVG---
Mflv_0095|M.gilvum_PYR-GCK DLEAARK-ARQTVAVMQNRSGFAHRGKAESRG---
TH_0873|M.thermoresistible__bu DLDAARR-ARDTIAVLRNRSDVAQWGKAESVG---
MMAR_4512|M.marinum_M IGRPPPG-RAGDDHTPKTA----------------
MUL_4683|M.ulcerans_Agy99 RAIRLSG-RRRRRW---------------------
Mvan_1219|M.vanbaalenii_PYR-1 DVEAEIARARRVLDHLAERRVDTYSTTARS-----