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MHQVKTELVVAVAQPRTVMGAVAANVDAHAALIQRANARLVVFPELSLTGYQLEVAPVDVAGPVVDRLVL ACAATGCSALVGAPVEDRGRRYIAMVLVDSSGAEVVYRKTHLDAAEKARFRPGPGPRTIDLDGWRIGLGI CRDTGVPEHVRGTARLGVDLYACGVVHHDGELGEQRHRARTIAATCTAPVAMASFAGPPEVATYTQRAIR LSGRRRRRW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4683 | - | - | 100% (219) | amidohydrolase |
| M. ulcerans Agy99 | MUL_4548 | - | 8e-09 | 29.44% (180) | amidohydrolase |
| M. ulcerans Agy99 | MUL_3705 | nadE | 3e-05 | 25.44% (228) | NAD synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2464c | nadE | 3e-07 | 28.07% (228) | NAD synthetase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2438c | nadE | 4e-07 | 28.07% (228) | NAD synthetase |
| M. leprae Br4923 | MLBr_02449 | - | 9e-05 | 26.67% (135) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4348c | - | 2e-11 | 33.73% (166) | putative hydrolase |
| M. marinum M | MMAR_4512 | - | 1e-106 | 95.96% (198) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 9e-10 | 30.64% (173) | carbon-nitrogen hydrolase |
| M. smegmatis MC2 155 | MSMEG_2902 | - | 7e-62 | 60.31% (194) | hydrolase, putative |
| M. thermoresistible (build 8) | TH_0873 | - | 4e-09 | 27.86% (201) | POSSIBLE AMIDOHYDROLASE |
| M. vanbaalenii PYR-1 | Mvan_3160 | - | 1e-05 | 29.52% (166) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4683|M.ulcerans_Agy99 ----MHQVKTELVVAVAQPRTVMG-AVAANVDAHAALIQRANAR---LVV
MMAR_4512|M.marinum_M ----MHQVETELVVAVAQPRTEMG-AVAANVDAHAALIRRANAR---LVV
MSMEG_2902|M.smegmatis_MC2_155 -------MGENLVVAAVQPRVLDG-DVEANVASHVEAIVSADAR---LVV
Mb2464c|M.bovis_AF2122/97 MNFYSAYQHGFVRVAACTHHTTIG-DPAANAASVLDMARACHDDGAALAV
Rv2438c|M.tuberculosis_H37Rv MNFYSAYQHGFVRVAACTHHTTIG-DPAANAASVLDMARACHDDGAALAV
MLBr_02449|M.leprae_Br4923 -----------MRIALAQILSGT--DPVANLRLVREYTGQATDAGATLVV
MAV_4670|M.avium_104 -----------MRIALAQILSGT--DPAANLALVGEYTRRAAGAGARLVV
TH_0873|M.thermoresistible__bu -----------MRIALAQIRSGT--DPSANLNLVEEYTRRAAATGAGLVL
MAB_4348c|M.abscessus_ATCC_199 ----MTLSTGRLKVAGLQTSGTPG-DIAANLDELASAACAAAGEGAQLLI
Mvan_3160|M.vanbaalenii_PYR-1 ------MAPSTYTLAMAQPRRIAGPDGSANVAHAVRLVEQAAGAD--LVC
:* ** . *
MUL_4683|M.ulcerans_Agy99 FPELSLTGY-----QLEVAPVDVAGPVVDRLVLACAATGCSALVGAPVED
MMAR_4512|M.marinum_M FPELSLTGY-----QLKVAPVDVAGPVVDRLVLACAATGCSVLVGAPVED
MSMEG_2902|M.smegmatis_MC2_155 FPELSLSGY-----RADAQPVDLAGDGLAQLVRACAATHSVALVGAAVET
Mb2464c|M.bovis_AF2122/97 FPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRH
Rv2438c|M.tuberculosis_H37Rv FPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRH
MLBr_02449|M.leprae_Br4923 FPEATMCRFG---VPLGPVAEPIDGPWANGVRQIATEAGITIIAGIFTPA
MAV_4670|M.avium_104 FPEATMCRFG---VPLAPIAEPVDGPWADGVRRIATEANVTVIAGMFTPS
TH_0873|M.thermoresistible__bu FPEATMCRFG---VSLKPVAEPLDGPWATAVREIAAGAGVVVVAGMFTPS
MAB_4348c|M.abscessus_ATCC_199 TPELFVTGYD----IGDVIYELAAQDLLSPLKRIAEEHGIALVVGIPEAV
Mvan_3160|M.vanbaalenii_PYR-1 FPEFSPGPVR---------AHDTFYDAGPALAAAARACDVNVVWSRTERC
** : . : .
MUL_4683|M.ulcerans_Agy99 RGRRYIAMVLVDS----SGAEVVYRKTHLDAA----EKARFRPGPGPR--
MMAR_4512|M.marinum_M RGRRYIAMVLVDS----SGAEVVYRKTHLGAA----EKARFRPGPGPR--
MSMEG_2902|M.smegmatis_MC2_155 SGGRFIAMVQVDG----TGVDVAYRKTFLSGD----ESRHFTAGDGPS--
Mb2464c|M.bovis_AF2122/97 RHRIYNTAVVIHR----GAVLGVVPKSYLPTYREFYERRQMAPGDGERGT
Rv2438c|M.tuberculosis_H37Rv RHRIYNTAVVIHR----GAVLGVVPKSYLPTYREFYERRQMAPGDGERGT
MLBr_02449|M.leprae_Br4923 DDGRVMNTLIAAGPGTPNQPDTHYHKIHLYDAFGFTESRTVTAGHEPV--
MAV_4670|M.avium_104 GDGRVKNTLLVAN--SDDQAVTHYDKIHLYDAFGFTESRTVAPGREPV--
TH_0873|M.thermoresistible__bu GDGRVTNTLLATG----PGVAAHYHKIHLYDAYGFTESRTVAPGSEPV--
MAB_4348c|M.abscessus_ATCC_199 GEKLYNSAVFVDQ---QGQVRATHRKTHLFGP---LDRQYFTAGSDAVT-
Mvan_3160|M.vanbaalenii_PYR-1 DDGRNRLVVYVTG--RDGDPVLRYARTHPATIPPGEDGELVSPADTFG--
: : . : . ..
MUL_4683|M.ulcerans_Agy99 -----------------TIDLDGWRIGLGICRDTGVPEHVRGTARLGVDL
MMAR_4512|M.marinum_M -----------------TIDLDGWRIGLGICRDTGVPEHVRGTARLGVDL
MSMEG_2902|M.smegmatis_MC2_155 -----------------VIEVDGWRVGMGICRDTGIDDHVRGTAALGVDV
Mb2464c|M.bovis_AF2122/97 IRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGAT
Rv2438c|M.tuberculosis_H37Rv IRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGAT
MLBr_02449|M.leprae_Br4923 -----------------VITVDDVQVGLTICYDIRFPALYTELARRGAQL
MAV_4670|M.avium_104 -----------------VVGVDGVRVGLSVCYDIRFPELYTELARRGAQL
TH_0873|M.thermoresistible__bu -----------------TIDVGGVRVGLTTCYDIRFPELYVELARRGAEL
MAB_4348c|M.abscessus_ATCC_199 -----------------VVDYLGLKVGMMICYDVEFPENPRMAALEGVDL
Mvan_3160|M.vanbaalenii_PYR-1 -----------------NFEVDGIPMGIVVCSEMWTPEIARIVALRGAEI
. : : * : * .
MUL_4683|M.ulcerans_Agy99 YACGVVHHDGELGEQRHR---ARTIAATCTAPVAMASFAGP---------
MMAR_4512|M.marinum_M YACGVVHHDWELGEQRHR---ARTIAATCDAPVAMASFAGPTGGGYLHTA
MSMEG_2902|M.smegmatis_MC2_155 YACGVVHHATELAEQQRR---GRNISAVCDAPVVMASFAGATGGGFTKTA
Mb2464c|M.bovis_AF2122/97 VLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWD
Rv2438c|M.tuberculosis_H37Rv VLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWD
MLBr_02449|M.leprae_Br4923 IVVCASWG-SGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALTDSGP
MAV_4670|M.avium_104 IAVCASWG-AGPGKLDQWTLLARARALDSMSYIAAAGQADPGGSLSASG-
TH_0873|M.thermoresistible__bu LTVHASWG-SGPGKLEQWTLLARARALDTTCVVAAVGQAYPGDEIAAQG-
MAB_4348c|M.abscessus_ATCC_199 LAVPTAQMKPFEFVADSV---IRTRAWENQMYVAYINHAGRERQTAYVG-
Mvan_3160|M.vanbaalenii_PYR-1 ILSPAGGGFTSLTRNWQIIVSARAIENLCYIGLTNNLWGDEQGAAMITGP
* . .
MUL_4683|M.ulcerans_Agy99 -------------------PEVATYTQRAIRLSGRRRRRW----------
MMAR_4512|M.marinum_M GHSAIWSATSTLVAEAGAGPDQIAHTTIGRPPPGRAGDDHTPKTA-----
MSMEG_2902|M.smegmatis_MC2_155 GRSAIWAKDGSVLAEADACPGGMAHTTLQRTVIAARRARRASR-------
Mb2464c|M.bovis_AF2122/97 GQTMIWEN-GALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRR
Rv2438c|M.tuberculosis_H37Rv GQTMIWEN-GALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRR
MLBr_02449|M.leprae_Br4923 SSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTTARENIAVL
MAV_4670|M.avium_104 ---APTGVGGSLVASPLGEVVASAGAQPQLVLADIDVDRVAQARKTIAAL
TH_0873|M.thermoresistible__bu ----PTGVGGSLVASATGEVLAAAGPEPELLVADLDLDAARRARDTIAVL
MAB_4348c|M.abscessus_ATCC_199 -RSSIVAPDATVLGRILSATGIIYGIVDGHAVRSARKRNPYLSDTRPELN
Mvan_3160|M.vanbaalenii_PYR-1 EHPLAHAGRSELVTATVDLDRLRWLRAHDDSMAEPKAFDSIPGLLRARRP
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 HHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAY
Rv2438c|M.tuberculosis_H37Rv HHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAY
MLBr_02449|M.leprae_Br4923 RNRSHFA-------------------------------------------
MAV_4670|M.avium_104 SNRSDFAQVGRAESVG----------------------------------
TH_0873|M.thermoresistible__bu RNRSDVAQWGKAESVG----------------------------------
MAB_4348c|M.abscessus_ATCC_199 QRLIRRHEPGD---------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 ELYGELVAPQADAYDYANGQA-----------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 NIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDI
Rv2438c|M.tuberculosis_H37Rv NIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDI
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 LAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYS
Rv2438c|M.tuberculosis_H37Rv LAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYS
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 VGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYG
Rv2438c|M.tuberculosis_H37Rv VGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYG
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 VGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITP
Rv2438c|M.tuberculosis_H37Rv VGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITP
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 ELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWND
Rv2438c|M.tuberculosis_H37Rv ELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWND
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 AERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGPK
Rv2438c|M.tuberculosis_H37Rv AERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGPK
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 -----------------------------------
MMAR_4512|M.marinum_M -----------------------------------
MSMEG_2902|M.smegmatis_MC2_155 -----------------------------------
Mb2464c|M.bovis_AF2122/97 VSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
Rv2438c|M.tuberculosis_H37Rv VSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
MLBr_02449|M.leprae_Br4923 -----------------------------------
MAV_4670|M.avium_104 -----------------------------------
TH_0873|M.thermoresistible__bu -----------------------------------
MAB_4348c|M.abscessus_ATCC_199 -----------------------------------
Mvan_3160|M.vanbaalenii_PYR-1 -----------------------------------