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M. leprae Br4923 MLBr_02449 (-)

annotation: putative hydrolase
coordinates: 2924539 - 2925354
length: 271

MRIALAQILSGTDPVANLRLVREYTGQATDAGATLVVFPEATMCRFGVPLGPVAEPIDGPWANGVRQIAT
EAGITIIAGIFTPADDGRVMNTLIAAGPGTPNQPDTHYHKIHLYDAFGFTESRTVTAGHEPVVITVDDVQ
VGLTICYDIRFPALYTELARRGAQLIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALT
DSGPSSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTTARENIAVLRNRSHFA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02449--100% (271)putative hydrolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0490c-1e-12681.85% (270) hypothetical protein Mb0490c
M. gilvum PYR-GCKMflv_0095-9e-9665.09% (275) Nitrilase/cyanide hydratase and apolipoprotein
M. tuberculosis H37RvRv0480c-1e-12681.85% (270) amidohydrolase
M. abscessus ATCC 19977MAB_4076-2e-9162.69% (268) putative nitrilase/cyanide hydratase
M. marinum MMMAR_0805-1e-12480.00% (270) amidohydrolase
M. avium 104MAV_4670-1e-11375.28% (271) carbon-nitrogen hydrolase
M. smegmatis MC2 155MSMEG_0924-1e-10066.79% (271) hydrolase, carbon-nitrogen family protein
M. thermoresistible (build 8)TH_0873-5e-9967.90% (271) POSSIBLE AMIDOHYDROLASE
M. ulcerans Agy99MUL_4548-1e-12378.89% (270) amidohydrolase
M. vanbaalenii PYR-1Mvan_0813-3e-8960.44% (273) Nitrilase/cyanide hydratase and apolipoprotein

CLUSTAL 2.0.9 multiple sequence alignment


Mb0490c|M.bovis_AF2122/97           MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGTDPAANLQ
Rv0480c|M.tuberculosis_H37Rv        -------------------------------MRIALAQIRSGTDPAANLQ
MLBr_02449|M.leprae_Br4923          -------------------------------MRIALAQILSGTDPVANLR
MMAR_0805|M.marinum_M               -------------------------------MRIALAQILSGTDPTANLE
MUL_4548|M.ulcerans_Agy99           -------------------------------MRIALAQILSGTDPTANLE
MAV_4670|M.avium_104                -------------------------------MRIALAQILSGTDPAANLA
MAB_4076|M.abscessus_ATCC_1997      -------------------------------MRIVLAQITSGADPTENLA
Mflv_0095|M.gilvum_PYR-GCK          ---------------------------MRSGMRIALAQIQSSTDPAANLT
Mvan_0813|M.vanbaalenii_PYR-1       -------------------------------MRIALAQIRGSTDPAENLD
TH_0873|M.thermoresistible__bu      -------------------------------MRIALAQIRSGTDPSANLN
MSMEG_0924|M.smegmatis_MC2_155      ------------------------------MMRIALAQITTGTDPSSNLE
                                                                   ***.****  .:**  ** 

Mb0490c|M.bovis_AF2122/97           LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANGVRRIA
Rv0480c|M.tuberculosis_H37Rv        LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANGVRRIA
MLBr_02449|M.leprae_Br4923          LVREYTGQATDAGATLVVFPEATMCRFGVPLGPVAEPIDGPWANGVRQIA
MMAR_0805|M.marinum_M               LVRDYAERAADAGARLVVFPEATMCRFGVPLGPVAQPLDGPWANGVRRIA
MUL_4548|M.ulcerans_Agy99           LVRDYAERAADAGARLVVFPEATMCRFGVPLGPVAQPLDGPWANGVRRIA
MAV_4670|M.avium_104                LVGEYTRRAAGAGARLVVFPEATMCRFGVPLAPIAEPVDGPWADGVRRIA
MAB_4076|M.abscessus_ATCC_1997      TVAATVRDAAAQGATLIVFPEATMCRFGVPLGPVAQPVNGRWADGVRAIA
Mflv_0095|M.gilvum_PYR-GCK          LVEEYTRRAVDAGASLVLFPEATMVRFGVPLGGVAEPFDGPWANAVRDIA
Mvan_0813|M.vanbaalenii_PYR-1       LVEEYTGRAAEAGASLVLFPEATICRFGVPPAEIAEPFDGPWASAVRGIA
TH_0873|M.thermoresistible__bu      LVEEYTRRAAATGAGLVLFPEATMCRFGVSLKPVAEPLDGPWATAVREIA
MSMEG_0924|M.smegmatis_MC2_155      LVESCTRRAADDGARLVLFPEATMCRFGVPLGPVAQPLDGPWARAVRDIA
                                     *   .  *.  ** *::*****: *:**.   :*:*.:* ** .** **

Mb0490c|M.bovis_AF2122/97           TEAGITVIAGMFTPTGDG-RVTNTLIAAGPGTPNQPDAHYHKIHLYDAFG
Rv0480c|M.tuberculosis_H37Rv        TEAGITVIAGMFTPTGDG-RVTNTLIAAGPGTPNQPDAHYHKIHLYDAFG
MLBr_02449|M.leprae_Br4923          TEAGITIIAGIFTPADDG-RVMNTLIAAGPGTPNQPDTHYHKIHLYDAFG
MMAR_0805|M.marinum_M               AQTGITVVAGMFTPADAG-RVSNTLFAAGPGAPNQPDDHYHKIHLYDAFG
MUL_4548|M.ulcerans_Agy99           AQTGITVVAGMFTPADAG-RVSNTLFAAGPGAPNQPDDHYHKIHLYDAFG
MAV_4670|M.avium_104                TEANVTVIAGMFTPSGDG-RVKNTLLVAN--SDDQAVTHYDKIHLYDAFG
MAB_4076|M.abscessus_ATCC_1997      DEAGLTVVVGMFTPAGDG-RVHNTLLATGP----GVDTHYNKIHLYDAFG
Mflv_0095|M.gilvum_PYR-GCK          ARAGIVVVAGMFVPSDDG-RSFNTLLATGP----GVEARYDKIHLYDAFG
Mvan_0813|M.vanbaalenii_PYR-1       ARAGVVVVAGMYVPSDDDDRVTNTLIATGP----GVDARYDKIHLYDAFG
TH_0873|M.thermoresistible__bu      AGAGVVVVAGMFTPSGDG-RVTNTLLATGP----GVAAHYHKIHLYDAYG
MSMEG_0924|M.smegmatis_MC2_155      ARAGVVVVAGMFSPSDDG-RVTNTLIAAGA----GVDTHYHKIHLYDAFG
                                      :.:.::.*:: *:. . *  ***:.:.         :*.*******:*

Mb0490c|M.bovis_AF2122/97           FTESRTVAPGREPVVVVVD----GVRVGLTVCYDIRFPALYTELARRGAQ
Rv0480c|M.tuberculosis_H37Rv        FTESRTVAPGREPVVVVVD----GVRVGLTVCYDIRFPALYTELARRGAQ
MLBr_02449|M.leprae_Br4923          FTESRTVTAGHEPVVITVD----DVQVGLTICYDIRFPALYTELARRGAQ
MMAR_0805|M.marinum_M               FAESRTVAPGHEPVVITVD----DVQVGLTVCYDIRFPALYTELARRGAE
MUL_4548|M.ulcerans_Agy99           FAESRTVAPGHEPVVITVD----DFQVGLTVCYDIRFPALYTELARRGAE
MAV_4670|M.avium_104                FTESRTVAPGREPVVVGVD----GVRVGLSVCYDIRFPELYTELARRGAQ
MAB_4076|M.abscessus_ATCC_1997      FRESATVAPGHEPVLITVD----GVAVGLTTCYDIRFPGLYTDLARRGAQ
Mflv_0095|M.gilvum_PYR-GCK          FLESKTVAPGREPVVISVDTESGPVTVGLTLCYDIRFPELYVELADRGAE
Mvan_0813|M.vanbaalenii_PYR-1       FSESKTVAPGRDPVVITVESESGPVKVGLTLCYDIRFPELYVELAERGAE
TH_0873|M.thermoresistible__bu      FTESRTVAPGSEPVTIDV----GGVRVGLTTCYDIRFPELYVELARRGAE
MSMEG_0924|M.smegmatis_MC2_155      FTESRTVAPGFTPTTITVD----GTPVGITTCYDIRFPELYVELARRGAQ
                                    * ** **:.*  *. : *        **:: ******* **.:** ***:

Mb0490c|M.bovis_AF2122/97           LIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGA
Rv0480c|M.tuberculosis_H37Rv        LIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGA
MLBr_02449|M.leprae_Br4923          LIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALTDSGP
MMAR_0805|M.marinum_M               LIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGDTASDPGG
MUL_4548|M.ulcerans_Agy99           LIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGDTASDPGG
MAV_4670|M.avium_104                LIAVCASWGAGPGKLDQWTLLARARALDSMSYIAAAGQADPGGSLS----
MAB_4076|M.abscessus_ATCC_1997      VITVSASWAAGTGKWDQWTLLARARAADSTCFVAAADQALPALEAP----
Mflv_0095|M.gilvum_PYR-GCK          IITAHASWGTGPGKLEQWTLLARARAIDTSSVVAAVGQAYPGDEIA----
Mvan_0813|M.vanbaalenii_PYR-1       IITAHASWGNGPGKIDQWTLLARARAIDTSTVVAAVGQAYPGDEIA----
TH_0873|M.thermoresistible__bu      LLTVHASWGSGPGKLEQWTLLARARALDTTCVVAAVGQAYPGDEIA----
MSMEG_0924|M.smegmatis_MC2_155      LITVHASWGSGPGKLDQWTLLARARALDTTGYIAAVDQAYPGDEIA----
                                    ::.. ***. *.** :********** *:   :**..** *.   .    

Mb0490c|M.bovis_AF2122/97           SSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVL
Rv0480c|M.tuberculosis_H37Rv        SSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVL
MLBr_02449|M.leprae_Br4923          SSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTTARENIAVL
MMAR_0805|M.marinum_M               GSGAPRGVGGSLVASPLGEVVASAGSDPQLVVADIDLAKVGAARDNIGVL
MUL_4548|M.ulcerans_Agy99           GSGAPRGVGGSLVTSPLGEVVASAGSDPQLVVADIDLAKVGAARDNIGML
MAV_4670|M.avium_104                ASGAPTGVGGSLVASPLGEVVASAGAQPQLVLADIDVDRVAQARKTIAAL
MAB_4076|M.abscessus_ATCC_1997      AHGSPTGIGGSLLASPTGELIAQAGPDPELIVADLNLGAVAETRKILPVL
Mflv_0095|M.gilvum_PYR-GCK          -ALGPTGVGGSLVASALGEVLASAGDDPELLVCDVDLEAARKARQTVAVM
Mvan_0813|M.vanbaalenii_PYR-1       -ALGPTGVGHSVVASALGEVLASAGADPQLLMCDIDLEAARAARQTVAVM
TH_0873|M.thermoresistible__bu      -AQGPTGVGGSLVASATGEVLAAAGPEPELLVADLDLDAARRARDTIAVL
MSMEG_0924|M.smegmatis_MC2_155      -KAGPTGVGGSLVASPTGDVLASAGAEPELLTVDIDLDAATRVRDTVAIL
                                       .* *:* *:::*. *:::. ** :.:*:  *:::  .  .*. :  :

Mb0490c|M.bovis_AF2122/97           RNQTDFVQIDKAQSRG-------------------
Rv0480c|M.tuberculosis_H37Rv        RNQTDFVQIDKAQSRG-------------------
MLBr_02449|M.leprae_Br4923          RNRSHFA----------------------------
MMAR_0805|M.marinum_M               RNQSRFTQTDKAQSRR-------------------
MUL_4548|M.ulcerans_Agy99           RNQSRFTQTDKAQSRR-------------------
MAV_4670|M.avium_104                SNRSDFAQVGRAESVG-------------------
MAB_4076|M.abscessus_ATCC_1997      NSSS-------AE----------------------
Mflv_0095|M.gilvum_PYR-GCK          QNRSGFAHRGKAESRG-------------------
Mvan_0813|M.vanbaalenii_PYR-1       HNRSEAVRSSRERSSPAVRSSRERSSPAVRSSRER
TH_0873|M.thermoresistible__bu      RNRSDVAQWGKAESVG-------------------
MSMEG_0924|M.smegmatis_MC2_155      DNRSALAGLS-------------------------
                                     . :