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MHQVETELVVAVAQPRTEMGAVAANVDAHAALIRRANARLVVFPELSLTGYQLKVAPVDVAGPVVDRLVL ACAATGCSVLVGAPVEDRGRRYIAMVLVDSSGAEVVYRKTHLGAAEKARFRPGPGPRTIDLDGWRIGLGI CRDTGVPEHVRGTARLGVDLYACGVVHHDWELGEQRHRARTIAATCDAPVAMASFAGPTGGGYLHTAGHS AIWSATSTLVAEAGAGPDQIAHTTIGRPPPGRAGDDHTPKTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4512 | - | - | 100% (252) | amidohydrolase |
| M. marinum M | MMAR_0805 | - | 1e-10 | 29.49% (234) | amidohydrolase |
| M. marinum M | MMAR_3759 | nadE | 3e-05 | 25.40% (252) | glutamine-dependent NAD(+) synthetase NadE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 2e-09 | 28.81% (243) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 8e-08 | 25.31% (245) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 2e-09 | 28.81% (243) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 7e-07 | 26.84% (190) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4076 | - | 5e-13 | 29.11% (237) | putative nitrilase/cyanide hydratase |
| M. avium 104 | MAV_4670 | - | 2e-13 | 30.42% (240) | carbon-nitrogen hydrolase |
| M. smegmatis MC2 155 | MSMEG_2902 | - | 1e-73 | 58.97% (234) | hydrolase, putative |
| M. thermoresistible (build 8) | TH_0873 | - | 2e-14 | 30.99% (242) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4683 | - | 1e-107 | 95.96% (198) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_0813 | - | 3e-09 | 27.94% (247) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGTDPAANLQ
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSGTDPAANLQ
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSGTDPVANLR
MAV_4670|M.avium_104 -------------------------------MRIALAQILSGTDPAANLA
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSSTDPAANLT
Mvan_0813|M.vanbaalenii_PYR-1 -------------------------------MRIALAQIRGSTDPAENLD
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSGTDPSANLN
MAB_4076|M.abscessus_ATCC_1997 -------------------------------MRIVLAQITSGADPTENLA
MMAR_4512|M.marinum_M --------------------------MHQVETELVVAVAQPRTEMGAVAA
MUL_4683|M.ulcerans_Agy99 --------------------------MHQVKTELVVAVAQPRTVMGAVAA
MSMEG_2902|M.smegmatis_MC2_155 -----------------------------MGENLVVAAVQPRVLDGDVEA
.:.:* .
Mb0490c|M.bovis_AF2122/97 LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANGVRRIA
Rv0480c|M.tuberculosis_H37Rv LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANGVRRIA
MLBr_02449|M.leprae_Br4923 LVREYTGQATDAGATLVVFPEATMCRFGVPLGPVAEPIDGPWANGVRQIA
MAV_4670|M.avium_104 LVGEYTRRAAGAGARLVVFPEATMCRFGVPLAPIAEPVDGPWADGVRRIA
Mflv_0095|M.gilvum_PYR-GCK LVEEYTRRAVDAGASLVLFPEATMVRFGVPLGGVAEPFDGPWANAVRDIA
Mvan_0813|M.vanbaalenii_PYR-1 LVEEYTGRAAEAGASLVLFPEATICRFGVPPAEIAEPFDGPWASAVRGIA
TH_0873|M.thermoresistible__bu LVEEYTRRAAATGAGLVLFPEATMCRFGVSLKPVAEPLDGPWATAVREIA
MAB_4076|M.abscessus_ATCC_1997 TVAATVRDAAAQGATLIVFPEATMCRFGVPLGPVAQPVNGRWADGVRAIA
MMAR_4512|M.marinum_M NVDAHAALIRRANARLVVFPELSLTGYQLKVAPVD--VAGPVVDRLVLAC
MUL_4683|M.ulcerans_Agy99 NVDAHAALIQRANARLVVFPELSLTGYQLEVAPVD--VAGPVVDRLVLAC
MSMEG_2902|M.smegmatis_MC2_155 NVASHVEAIVSADARLVVFPELSLSGYRADAQPVD--LAGDGLAQLVRAC
* . .* *::*** :: : . * : .
Mb0490c|M.bovis_AF2122/97 TEAGITVIAGMFTPTGDG-RVTNTLIAAGPGTPNQPDAHYHKIHLYDAFG
Rv0480c|M.tuberculosis_H37Rv TEAGITVIAGMFTPTGDG-RVTNTLIAAGPGTPNQPDAHYHKIHLYDAFG
MLBr_02449|M.leprae_Br4923 TEAGITIIAGIFTPADDG-RVMNTLIAAGPGTPNQPDTHYHKIHLYDAFG
MAV_4670|M.avium_104 TEANVTVIAGMFTPSGDG-RVKNTLLVAN--SDDQAVTHYDKIHLYDAFG
Mflv_0095|M.gilvum_PYR-GCK ARAGIVVVAGMFVPSDDG-RSFNTLLATGP----GVEARYDKIHLYDAFG
Mvan_0813|M.vanbaalenii_PYR-1 ARAGVVVVAGMYVPSDDDDRVTNTLIATGP----GVDARYDKIHLYDAFG
TH_0873|M.thermoresistible__bu AGAGVVVVAGMFTPSGDG-RVTNTLLATGP----GVAAHYHKIHLYDAYG
MAB_4076|M.abscessus_ATCC_1997 DEAGLTVVVGMFTPAGDG-RVHNTLLATGP----GVDTHYNKIHLYDAFG
MMAR_4512|M.marinum_M AATGCSVLVGAPVEDRGR-RYIAMVLVDSS----GAEVVYRKTHLGAA--
MUL_4683|M.ulcerans_Agy99 AATGCSALVGAPVEDRGR-RYIAMVLVDSS----GAEVVYRKTHLDAA--
MSMEG_2902|M.smegmatis_MC2_155 AATHSVALVGAAVETSGG-RFIAMVQVDGT----GVDVAYRKTFLSGD--
: :.* . . * : . . . * * .*
Mb0490c|M.bovis_AF2122/97 FTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTELARRGAQ
Rv0480c|M.tuberculosis_H37Rv FTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTELARRGAQ
MLBr_02449|M.leprae_Br4923 FTESRTVTAGHEPVVITVDD----VQVGLTICYDIRFPALYTELARRGAQ
MAV_4670|M.avium_104 FTESRTVAPGREPVVVGVDG----VRVGLSVCYDIRFPELYTELARRGAQ
Mflv_0095|M.gilvum_PYR-GCK FLESKTVAPGREPVVISVDTESGPVTVGLTLCYDIRFPELYVELADRGAE
Mvan_0813|M.vanbaalenii_PYR-1 FSESKTVAPGRDPVVITVESESGPVKVGLTLCYDIRFPELYVELAERGAE
TH_0873|M.thermoresistible__bu FTESRTVAPGSEPVTIDV----GGVRVGLTTCYDIRFPELYVELARRGAE
MAB_4076|M.abscessus_ATCC_1997 FRESATVAPGHEPVLITVDG----VAVGLTTCYDIRFPGLYTDLARRGAQ
MMAR_4512|M.marinum_M --EKARFRPGPGPRTIDLDG----WRIGLGICRDTGVPEHVRGTARLGVD
MUL_4683|M.ulcerans_Agy99 --EKARFRPGPGPRTIDLDG----WRIGLGICRDTGVPEHVRGTARLGVD
MSMEG_2902|M.smegmatis_MC2_155 --ESRHFTAGDGPSVIEVDG----WRVGMGICRDTGIDDHVRGTAALGVD
*. . .* * : : :*: * * . * *.:
Mb0490c|M.bovis_AF2122/97 LIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGA
Rv0480c|M.tuberculosis_H37Rv LIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGA
MLBr_02449|M.leprae_Br4923 LIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALTDSGP
MAV_4670|M.avium_104 LIAVCASWGAGPGKLDQWTLLARARALDSMSYIAAAGQADPGGSLSASG-
Mflv_0095|M.gilvum_PYR-GCK IITAHASWGTGPGKLEQWTLLARARAIDTSSVVAAVGQAYPGDEIAALG-
Mvan_0813|M.vanbaalenii_PYR-1 IITAHASWGNGPGKIDQWTLLARARAIDTSTVVAAVGQAYPGDEIAALG-
TH_0873|M.thermoresistible__bu LLTVHASWGSGPGKLEQWTLLARARALDTTCVVAAVGQAYPGDEIAAQG-
MAB_4076|M.abscessus_ATCC_1997 VITVSASWAAGTGKWDQWTLLARARAADSTCFVAAADQALPALEAPAHG-
MMAR_4512|M.marinum_M LYACGVVHHDW----ELGEQRHRARTIAATCDAPVAMASFAGPTGGGYL-
MUL_4683|M.ulcerans_Agy99 LYACGVVHHDG----ELGEQRHRARTIAATCTAPVAMASFAGP-------
MSMEG_2902|M.smegmatis_MC2_155 VYACGVVHHAT----ELAEQQRRGRNISAVCDAPVVMASFAGATGGGFT-
: . . : *.* : ... : ..
Mb0490c|M.bovis_AF2122/97 SSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVL
Rv0480c|M.tuberculosis_H37Rv SSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVL
MLBr_02449|M.leprae_Br4923 SSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTTARENIAVL
MAV_4670|M.avium_104 ---APTGVGGSLVASPLGEVVASAGAQPQLVLADIDVDRVAQARKTIAAL
Mflv_0095|M.gilvum_PYR-GCK ----PTGVGGSLVASALGEVLASAGDDPELLVCDVDLEAARKARQTVAVM
Mvan_0813|M.vanbaalenii_PYR-1 ----PTGVGHSVVASALGEVLASAGADPQLLMCDIDLEAARAARQTVAVM
TH_0873|M.thermoresistible__bu ----PTGVGGSLVASATGEVLAAAGPEPELLVADLDLDAARRARDTIAVL
MAB_4076|M.abscessus_ATCC_1997 ---SPTGIGGSLLASPTGELIAQAGPDPELIVADLNLGAVAETRKILPVL
MMAR_4512|M.marinum_M -----HTAGHSAIWSATSTLVAEAGAGPDQIAHTTIGRPPPGRAGDDHTP
MUL_4683|M.ulcerans_Agy99 ---------------------------PEVATYTQRAIRLSGRRRRRW--
MSMEG_2902|M.smegmatis_MC2_155 -----KTAGRSAIWAKDGSVLAEADACPGGMAHTTLQRTVIAARRARRAS
.
Mb0490c|M.bovis_AF2122/97 RNQTDFVQIDKAQSRG-------------------
Rv0480c|M.tuberculosis_H37Rv RNQTDFVQIDKAQSRG-------------------
MLBr_02449|M.leprae_Br4923 RNRSHFA----------------------------
MAV_4670|M.avium_104 SNRSDFAQVGRAESVG-------------------
Mflv_0095|M.gilvum_PYR-GCK QNRSGFAHRGKAESRG-------------------
Mvan_0813|M.vanbaalenii_PYR-1 HNRSEAVRSSRERSSPAVRSSRERSSPAVRSSRER
TH_0873|M.thermoresistible__bu RNRSDVAQWGKAESVG-------------------
MAB_4076|M.abscessus_ATCC_1997 NSSSAE-----------------------------
MMAR_4512|M.marinum_M KTA--------------------------------
MUL_4683|M.ulcerans_Agy99 -----------------------------------
MSMEG_2902|M.smegmatis_MC2_155 R----------------------------------