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NRKLRVSAVTPDIVIGDLDGNLARLHNALRAIEWTGPYLAVLPELATSGYVFTDIDEARALSLRADDARL TALADDVPADCVAVVGFAEVDGDTLYNSAIVIGDGKVVGTYRKAHLWAAEPEIFATGVEAGTVIDTAICR LGVAICYDNEFPELPRRLALRGAEVLALPVNWPLVDRPEGEHAPETIQAMAAARSSQLATVIADRRGTER GVRWTGGTAVIGPDGWIKATPQGDETIATAVLDLTDSKAIGDRNDALADRRPDLYRDLVESGEAATDIPD *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5655 | - | - | 100% (281) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_2988 | - | 3e-32 | 32.49% (277) | carbon-nitrogen hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0571 | - | 2e-27 | 31.39% (274) | hydrolase, carbon-nitrogen family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2464c | nadE | 1e-09 | 35.40% (113) | NAD synthetase |
| M. gilvum PYR-GCK | Mflv_0095 | - | 6e-08 | 27.83% (212) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv2438c | nadE | 1e-09 | 35.40% (113) | NAD synthetase |
| M. leprae Br4923 | MLBr_02449 | - | 8e-07 | 25.29% (174) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4348c | - | 2e-25 | 29.82% (275) | putative hydrolase |
| M. marinum M | MMAR_0805 | - | 6e-09 | 26.73% (202) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 2e-09 | 28.02% (232) | carbon-nitrogen hydrolase |
| M. thermoresistible (build 8) | TH_0873 | - | 2e-10 | 29.18% (257) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4548 | - | 7e-09 | 26.73% (202) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_1224 | - | 1e-26 | 32.38% (281) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0805|M.marinum_M -----------MRIALAQILSGT-DPTANLELVRDYAERAADAGARLVVF
MUL_4548|M.ulcerans_Agy99 -----------MRIALAQILSGT-DPTANLELVRDYAERAADAGARLVVF
MLBr_02449|M.leprae_Br4923 -----------MRIALAQILSGT-DPVANLRLVREYTGQATDAGATLVVF
MAV_4670|M.avium_104 -----------MRIALAQILSGT-DPAANLALVGEYTRRAAGAGARLVVF
Mflv_0095|M.gilvum_PYR-GCK -------MRSGMRIALAQIQSST-DPAANLTLVEEYTRRAVDAGASLVLF
TH_0873|M.thermoresistible__bu -----------MRIALAQIRSGT-DPSANLNLVEEYTRRAAATGAGLVLF
Mb2464c|M.bovis_AF2122/97 MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVF
Rv2438c|M.tuberculosis_H37Rv MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVF
Mvan_1224|M.vanbaalenii_PYR-1 -----------MTTLAAVSANFTRDLEQNYALIASLADEARHRGVDFLTL
MSMEG_5655|M.smegmatis_MC2_155 -------MNRKLRVSAVTPDIVIGDLDGNLARLHNALRAIEWTGPYLAVL
MAB_4348c|M.abscessus_ATCC_199 ----MTLSTGRLKVAGLQTSGTPGDIAANLDELASAACAAAGEGAQLLIT
: * * : . * :
MMAR_0805|M.marinum_M PEATMCRFGVPLGPVAQPLDG---PWANGVRRIAAQTG--ITVVAGMFTP
MUL_4548|M.ulcerans_Agy99 PEATMCRFGVPLGPVAQPLDG---PWANGVRRIAAQTG--ITVVAGMFTP
MLBr_02449|M.leprae_Br4923 PEATMCRFGVPLGPVAEPIDG---PWANGVRQIATEAG--ITIIAGIFTP
MAV_4670|M.avium_104 PEATMCRFGVPLAPIAEPVDG---PWADGVRRIATEAN--VTVIAGMFTP
Mflv_0095|M.gilvum_PYR-GCK PEATMVRFGVPLGGVAEPFDG---PWANAVRDIAARAG--IVVVAGMFVP
TH_0873|M.thermoresistible__bu PEATMCRFGVSLKPVAEPLDG---PWATAVREIAAGAG--VVVVAGMFTP
Mb2464c|M.bovis_AF2122/97 PELTLSGYSIEDVLLQDSLLD---AVEDALLDLVTESADLLPVLVVGAPL
Rv2438c|M.tuberculosis_H37Rv PELTLSGYSIEDVLLQDSLLD---AVEDALLDLVTESADLLPVLVVGAPL
Mvan_1224|M.vanbaalenii_PYR-1 PEAAIGGYLSSLGNHGDTVRTTARSLPPAIRLDGPEIARVQQIVGDLVVA
MSMEG_5655|M.smegmatis_MC2_155 PELATSGYVFTDIDEARALSLR---ADDARLTALADDVPADCVAVVGFAE
MAB_4348c|M.abscessus_ATCC_199 PELFVTGYDIGDVIYELAAQD----LLSPLKRIAEEHG---IALVVGIPE
** : .
MMAR_0805|M.marinum_M ADAGRVSNTLFAAGPGAPNQPDDHYHKIHLYDAFGFAESRTVAPGH-EPV
MUL_4548|M.ulcerans_Agy99 ADAGRVSNTLFAAGPGAPNQPDDHYHKIHLYDAFGFAESRTVAPGH-EPV
MLBr_02449|M.leprae_Br4923 ADDGRVMNTLIAAGPGTPNQPDTHYHKIHLYDAFGFTESRTVTAGH-EPV
MAV_4670|M.avium_104 SGDGRVKNTLLVAN--SDDQAVTHYDKIHLYDAFGFTESRTVAPGR-EPV
Mflv_0095|M.gilvum_PYR-GCK SDDGRSFNTLLATGPGVEAR----YDKIHLYDAFGFLESKTVAPGR-EPV
TH_0873|M.thermoresistible__bu SGDGRVTNTLLATGPGVAAH----YHKIHLYDAYGFTESRTVAPGS-EPV
Mb2464c|M.bovis_AF2122/97 RHRHRIYNTAVVIHRGAVLG---VVPKSYLPTYREFYERRQMAPGDGERG
Rv2438c|M.tuberculosis_H37Rv RHRHRIYNTAVVIHRGAVLG---VVPKSYLPTYREFYERRQMAPGDGERG
Mvan_1224|M.vanbaalenii_PYR-1 IGFCELADDGHTRYNAAAVLDGSTVYGSYRKVHQPLGEGMSYSAGSGYGV
MSMEG_5655|M.smegmatis_MC2_155 VDGDTLYNSAIVIGDGKVVG---TYRKAHLWAAEPEIFATGVEAGTVIDT
MAB_4348c|M.abscessus_ATCC_199 AVGEKLYNSAVFVDQQGQVR--ATHRKTHLFGP---LDRQYFTAGSDAVT
: : .*
MMAR_0805|M.marinum_M VITVDD------------------VQVGLTVCYDIRFPALY-TELARRGA
MUL_4548|M.ulcerans_Agy99 VITVDD------------------FQVGLTVCYDIRFPALY-TELARRGA
MLBr_02449|M.leprae_Br4923 VITVDD------------------VQVGLTICYDIRFPALY-TELARRGA
MAV_4670|M.avium_104 VVGVDG------------------VRVGLSVCYDIRFPELY-TELARRGA
Mflv_0095|M.gilvum_PYR-GCK VISVDTE--------------SGPVTVGLTLCYDIRFPELY-VELADRGA
TH_0873|M.thermoresistible__bu TIDVGG------------------VRVGLTTCYDIRFPELY-VELARRGA
Mb2464c|M.bovis_AF2122/97 TIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGA
Rv2438c|M.tuberculosis_H37Rv TIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGA
Mvan_1224|M.vanbaalenii_PYR-1 FDTPIG-------------------RVGLQICYDKAFPEAA-RIMALRGA
MSMEG_5655|M.smegmatis_MC2_155 AIC----------------------RLGVAICYDNEFPELP-RRLALRGA
MAB_4348c|M.abscessus_ATCC_199 VVDYLG------------------LKVGMMICYDVEFPENP-RMAALEGV
: : * * .* * *.
MMAR_0805|M.marinum_M ELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGDTASDPG
MUL_4548|M.ulcerans_Agy99 ELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGDTASDPG
MLBr_02449|M.leprae_Br4923 QLIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALTDSG
MAV_4670|M.avium_104 QLIAVCASWGAGPGKLDQWTLLARARALDSMSYIAAAGQADPGGSLS---
Mflv_0095|M.gilvum_PYR-GCK EIITAHASWGTGPGKLEQWTLLARARAIDTSSVVAAVGQAYPGDEIA---
TH_0873|M.thermoresistible__bu ELLTVHASWGSGPGKLEQWTLLARARALDTTCVVAAVGQAYPGDEIA---
Mb2464c|M.bovis_AF2122/97 TVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGE-GESTTDLA
Rv2438c|M.tuberculosis_H37Rv TVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGE-GESTTDLA
Mvan_1224|M.vanbaalenii_PYR-1 QVIASLSAWPAARTATAENLQDDRWTYRFNLFDTARALDNQVFWVASNQS
MSMEG_5655|M.smegmatis_MC2_155 EVLALPVNWPLVDRPEGE-------HAPETIQAMAAARSSQLATVIADRR
MAB_4348c|M.abscessus_ATCC_199 DLLAVPTAQMKP------------FEFVADSVIRTRAWENQMYVAYINHA
::. . .
MMAR_0805|M.marinum_M GGSGAPRGVGGSLVAS----PLGEVVASAGSDPQLVVAD----IDLAKVG
MUL_4548|M.ulcerans_Agy99 GGSGAPRGVGGSLVTS----PLGEVVASAGSDPQLVVAD----IDLAKVG
MLBr_02449|M.leprae_Br4923 PSSAAPTGVGGSLVAS----PLGEVVASAGTESKLVVAD----IDVDNVT
MAV_4670|M.avium_104 -ASGAPTGVGGSLVAS----PLGEVVASAGAQPQLVLAD----IDVDRVA
Mflv_0095|M.gilvum_PYR-GCK --ALGPTGVGGSLVAS----ALGEVLASAGDDPELLVCD----VDLEAAR
TH_0873|M.thermoresistible__bu --AQGPTGVGGSLVAS----ATGEVLAAAGPEPELLVAD----LDLDAAR
Mb2464c|M.bovis_AF2122/97 WDGQTMIWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNR
Rv2438c|M.tuberculosis_H37Rv WDGQTMIWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNR
Mvan_1224|M.vanbaalenii_PYR-1 GTFGSLRYVGNAKVVD----PGGNILATTLLGSGMAVAE----VDIDETF
MSMEG_5655|M.smegmatis_MC2_155 GTERGVRWTGGTAVIG----PDGWIKATPQGDETIATAV----LDLTDSK
MAB_4348c|M.abscessus_ATCC_199 GRERQTAYVGRSSIVA----PDATVLGRILSATGIIYGI----VDGHAVR
. : : . . . :
MMAR_0805|M.marinum_M AARDNIGVLRNQSRFTQTDKAQSRR-------------------------
MUL_4548|M.ulcerans_Agy99 AARDNIGMLRNQSRFTQTDKAQSRR-------------------------
MLBr_02449|M.leprae_Br4923 TARENIAVLRNRSHFA----------------------------------
MAV_4670|M.avium_104 QARKTIAALSNRSDFAQVGRAESVG-------------------------
Mflv_0095|M.gilvum_PYR-GCK KARQTVAVMQNRSGFAHRGKAESRG-------------------------
TH_0873|M.thermoresistible__bu RARDTIAVLRNRSDVAQWGKAESVG-------------------------
Mb2464c|M.bovis_AF2122/97 RHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEA
Rv2438c|M.tuberculosis_H37Rv RHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEA
Mvan_1224|M.vanbaalenii_PYR-1 RTMRAGMFHLRDRRPDVYGPITEVGAGSDLAHA-----------------
MSMEG_5655|M.smegmatis_MC2_155 AIGDRNDALADRRPDLYRDLVESGEAATDIPD------------------
MAB_4348c|M.abscessus_ATCC_199 SARKRNPYLSDTRPELNQRLIRRHEPGD----------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 YNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSD
Rv2438c|M.tuberculosis_H37Rv YNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSD
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 ILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPY
Rv2438c|M.tuberculosis_H37Rv ILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPY
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 SVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTY
Rv2438c|M.tuberculosis_H37Rv SVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTY
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 GVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEIT
Rv2438c|M.tuberculosis_H37Rv GVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEIT
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 PELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWN
Rv2438c|M.tuberculosis_H37Rv PELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWN
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M --------------------------------------------------
MUL_4548|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
Mflv_0095|M.gilvum_PYR-GCK --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 DAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGP
Rv2438c|M.tuberculosis_H37Rv DAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGP
Mvan_1224|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0805|M.marinum_M ------------------------------------
MUL_4548|M.ulcerans_Agy99 ------------------------------------
MLBr_02449|M.leprae_Br4923 ------------------------------------
MAV_4670|M.avium_104 ------------------------------------
Mflv_0095|M.gilvum_PYR-GCK ------------------------------------
TH_0873|M.thermoresistible__bu ------------------------------------
Mb2464c|M.bovis_AF2122/97 KVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
Rv2438c|M.tuberculosis_H37Rv KVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
Mvan_1224|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_5655|M.smegmatis_MC2_155 ------------------------------------
MAB_4348c|M.abscessus_ATCC_199 ------------------------------------