For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLHEEIRTATVNDVDLAYRIIGDGPEPIVLLHGWPQTGQCWRKVARPLAERYTVIVPDLRGYGASGLASS GYDKQTTAADLSALLRHLGLDSAVVVGHDRGARVAHRWALDRPSEISALALLDVLPTRVVMRSFDRQSAT AMWHWFFHLQPDLPELLVAGNTEAYLRYFLRGVLESGAVDEPTFRHYVDAYSDPAHLTATFEDYRAGFTT DLALDDADHARGVRLQCPLLLLWGAEGALASADVLGIWREHHADPAAVTGTPVPGGHYVPEEAPQAVLDA LHHFLEMSPDMSPGKEPNPCG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6708 | - | - | 100% (301) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_1984 | - | 7e-43 | 37.19% (285) | haloacetate dehalogenase H-1 |
| M. smegmatis MC2 155 | MSMEG_6719 | - | 6e-37 | 36.62% (284) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3694 | ephE | 1e-13 | 29.35% (276) | epoxide hydrolase EphE |
| M. gilvum PYR-GCK | Mflv_1960 | - | 2e-19 | 29.24% (277) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 1e-20 | 29.74% (269) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_02297 | - | 2e-15 | 29.67% (273) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 2e-17 | 29.75% (279) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 5e-20 | 27.68% (271) | epoxide hydrolase EphF |
| M. avium 104 | MAV_5163 | - | 7e-20 | 27.50% (280) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_4292 | - | 5e-29 | 35.86% (290) | PUTATIVE putative epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4778 | ephF | 1e-19 | 27.31% (271) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 5e-16 | 27.89% (294) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0134|M.tuberculosis_H37Rv ------------MIALPALEGVEHRHVDVAEGVRIHVADAGPA-------
MAV_5163|M.avium_104 ------------MVTMPELDGVEHRYVDLGDDVTIHVADAGPA-------
MMAR_0342|M.marinum_M ------------MSTLPALDGVEHRFVDLDGGITIHVADAGPA-------
MUL_4778|M.ulcerans_Agy99 ------------MSTLPALDGVEHRFVDLDGGITIHVADAGPA-------
MAB_4522c|M.abscessus_ATCC_199 ----------MTQRSMPVLDGVEHQYVQAG-DVKIHVAVAGPQ-------
Mflv_1960|M.gilvum_PYR-GCK ---------------------------MTVRGVDFHITEAGPE-------
Mvan_4764|M.vanbaalenii_PYR-1 ------------MTDQPPPIDGVRRHFVTARGVNFHVTEAGPE-------
Mb3694|M.bovis_AF2122/97 --------MAAPDPSMTRIAGPWRHLDVHANGIRFHVVEAVPSGQPEGPD
MLBr_02297|M.leprae_Br4923 --------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPT-QPAGQD
TH_4292|M.thermoresistible__bu VVDTGAHAFDSATRDDDEFNRLFRHEFADVDGVRMHYVTGGSG-------
MSMEG_6708|M.smegmatis_MC2_155 -----------------MLHEEIRTATVNDVDLAYRIIGDGPE-------
.: : .
Rv0134|M.tuberculosis_H37Rv ----------DGPAVMLVHGFPQNWWEWRDLIGPLAAD----------GN
MAV_5163|M.avium_104 ----------SGPAVMLVHGFPQNWWEWRALIGPLAAD----------GY
MMAR_0342|M.marinum_M ----------DGPAVMLVHGFPENWWEWHELIGPLAAD----------GY
MUL_4778|M.ulcerans_Agy99 ----------DGPAVMLVHGFPENWWEWHELIGPLAAD----------GY
MAB_4522c|M.abscessus_ATCC_199 ----------DGRAVVLLHGWPENWWMWHKVIPALAAA----------GY
Mflv_1960|M.gilvum_PYR-GCK ----------DGRPVLALHGWPQHHWAYRDLLGDPP-----------PGL
Mvan_4764|M.vanbaalenii_PYR-1 ----------DGRPVLALHGWPQHHWVYRSLLADPPTSAGASSRLPEPGL
Mb3694|M.bovis_AF2122/97 AATPPMQPALARPLVILLHGFGSFWWSWRHQLCGLTGA------------
MLBr_02297|M.leprae_Br4923 CAP----SATARPLVMLLHGFGSFWWSWRHQLRGLTEA------------
TH_4292|M.thermoresistible__bu ------------DPLVLLHGWPQTWYAWRGIIPALAQK-----------Y
MSMEG_6708|M.smegmatis_MC2_155 -------------PIVLLHGWPQTGQCWRKVARPLAER-----------Y
:: :**: . :: .
Rv0134|M.tuberculosis_H37Rv RVLCPDLRGAGWSSAPRSRYTKTEMADDLA-AVLDGLGVAKVKLVAHDWG
MAV_5163|M.avium_104 RVLCPDLRGAGWSSAPRSSYRKDEMADDLA-GVLDRLGVRSVDLVAHDWG
MMAR_0342|M.marinum_M RVLCPDLRGAGWSSAPRSRYTKKEMADDLA-GVLDRLGIASVRLVAHDWG
MUL_4778|M.ulcerans_Agy99 RVLCPDLRGAGWSSAPRSRYTKKEMADDLA-GVLDRLGIASVRLVAHDWG
MAB_4522c|M.abscessus_ATCC_199 RVHAMDLRGAGWSEVAPAGYEKEQFASDVL-AAADALGLESFDLVGHDWG
Mflv_1960|M.gilvum_PYR-GCK RIIAPDLPGYGWSGPPPHRWAKEDVVTDLV-ALVDALGLDRFLLVGHDWG
Mvan_4764|M.vanbaalenii_PYR-1 RIIAPDLPGYGWSGPAPHKWAKEDVVSDLV-ALMDAMGLDRVLLIGHDWG
Mb3694|M.bovis_AF2122/97 RVVAVDLRGYGGSDKPPRGYDGWTLAGDTA-GLIRALGHPSATLVGHADG
MLBr_02297|M.leprae_Br4923 RLVAVDLRGYGGSDKPPRGYDGWTLAGDTA-GLIRALGHSSATLVGHAEG
TH_4292|M.thermoresistible__bu TVYALDLPGLGDSEGAPPSYDKATLARFVHRLLADQLGLRSIRLVAHDLG
MSMEG_6708|M.smegmatis_MC2_155 TVIVPDLRGYGASGLASSGYDKQTTAADLS-ALLRHLGLDSAVVVGHDRG
: ** * * * . : . :* ::.* *
Rv0134|M.tuberculosis_H37Rv GPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMS--
MAV_5163|M.avium_104 GPVAFIMMLRHPEKVTGFFGVNTSAPFVKRSLSTIRNVWRFWYQIPIS--
MMAR_0342|M.marinum_M GPVAFIMMLRYPAKVTGFFGMNTAAPWFPRDLGMVRDIWRFWYQIPIM--
MUL_4778|M.ulcerans_Agy99 GPVAFIMMLRYPAKVTGFFGMNTAAPWFPRDLGMVRDIWRFWYQIPIL--
MAB_4522c|M.abscessus_ATCC_199 GWTAQLVALKAQSRIRRLVVLNIPPVWQQPGR-VARYAHKLAYQLVVG--
Mflv_1960|M.gilvum_PYR-GCK GYIGHLLALRIPERIDAYLALNIAHPWVPPKVMAPHLWRFLLYQPVVA--
Mvan_4764|M.vanbaalenii_PYR-1 GYIGHLLAMRVPERIDGYLALNIAHPWVPPKVMAPHLWRFLQYQPLVA--
Mb3694|M.bovis_AF2122/97 GLACWTTALLHSRLVRAIALISSPHPAALRRSTLTRRDQRHALLPTLLRY
MLBr_02297|M.leprae_Br4923 GLACWATALLHPRLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRY
TH_4292|M.thermoresistible__bu AGVGFQYAAQYPTEVSKYAHLDYPLPG--PALSAARYREFSWHMAFHHQP
MSMEG_6708|M.smegmatis_MC2_155 ARVAHRWALDRPSEISALALLDVLPTRVVMRSFDRQSATAMWHWFFHLQP
. : :. :
Rv0134|M.tuberculosis_H37Rv -LPVIGPRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAE
MAV_5163|M.avium_104 -LPVIGPRVISTPDSRFVRLLGSWVGGGYTLPEEDVRLYLECMRQPGHAE
MMAR_0342|M.marinum_M -LPVIGPRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAV
MUL_4778|M.ulcerans_Agy99 -LPVIGPRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAV
MAB_4522c|M.abscessus_ATCC_199 -APVVGPLSHLSPTLWWFIRRS---G----MPKESVDFFRSCFRDRDRRV
Mflv_1960|M.gilvum_PYR-GCK -SAGVPLQTRTR-----YLEKVVFRAAAPKLDAATVGTYAERFRDPVVAR
Mvan_4764|M.vanbaalenii_PYR-1 -FAGVPLQRHTS-----FLKR-AYKLAAPKLDPQTVRVYSERFRDPVVAR
Mb3694|M.bovis_AF2122/97 QLPIWPERLLTRNNAAEIERLVRARGCAKWLASEDFSQAIDHLRQAIQIP
MLBr_02297|M.leprae_Br4923 QLPIWPERLLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIP
TH_4292|M.thermoresistible__bu RVPEAVVANDVREYLALFYPYVAYGGTSFGGPGAQSPFTDEQVDEFARTY
MSMEG_6708|M.smegmatis_MC2_155 DLPELLVAGNTEAYLRYFLRGVLESG---AVDEPTFRHYVDAYSDPAHLT
. .
Rv0134|M.tuberculosis_H37Rv AGSRWYR-TFQTREMLRWLRGEYNDAR------VDVPVRWLHGTGDPVIT
MAV_5163|M.avium_104 AGSRWYR-SFQTREMLSWMRGEYDGAR------VHVPVRWLSGTEDPVLT
MMAR_0342|M.marinum_M AGSRWYR-TFQSSEALPWMRGEYADAR------VDVPVRWLHGTEDPVLT
MUL_4778|M.ulcerans_Agy99 AGSRWYR-TFQSSEALPWMRGEYADAR------VDVPVRWLHGTDDPVLT
MAB_4522c|M.abscessus_ATCC_199 AGSKIYR-SMVGKEFANLARGPYDDQK------LTMPVRVLFGLDDVAVH
Mflv_1960|M.gilvum_PYR-GCK TARDTYR-TFLTREIPKGVR-DGERRW------STVPTRVLFGRSDTAIH
Mvan_4764|M.vanbaalenii_PYR-1 TARDTYR-TFLLREAPAAIR-NGERRR------SKVPTRALFGRDDAAIH
Mb3694|M.bovis_AF2122/97 AAAHCAL-EYQRWAVRSQLRSEGRRFIRAMTQQLGMPLLHLRGDADPYVL
MLBr_02297|M.leprae_Br4923 AAAHCAL-EYQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLL
TH_4292|M.thermoresistible__bu NRPDVLSGGFDLYRTLDQDEHDNVAAG-------PITTPTLLMTAEGLLE
MSMEG_6708|M.smegmatis_MC2_155 ATFEDYRAGFTTDLALDDADHARGVRL-------QCPLLLLWGAEGALAS
. :
Rv0134|M.tuberculosis_H37Rv PDLLDGYAERASDFEVELVDGV--GHWIVEQRPELVLDRVRAFLAAGTEQ
MAV_5163|M.avium_104 PDLLDGYAERIDDFQLELVDGV--GHWIVDQRPDLVLDRVRAFLRRET--
MMAR_0342|M.marinum_M PQLLRGYEDHISDFEVEFVDGV--GHWIVEQRPDLVLDRLRAFLRIET--
MUL_4778|M.ulcerans_Agy99 PQLLRGYEDHISDFEVEFVDGV--GHWIVEQRPDLVLDRLRAFLRIET--
MAB_4522c|M.abscessus_ATCC_199 PSLLDGFKDHADDLNITEVPNC--GHFIVDEQPELVVKWLSEVLAEPAP-
Mflv_1960|M.gilvum_PYR-GCK PDLAAAETARADDYTIDVVDG---GHFILDEQPDLVRAKLIAVADEFPER
Mvan_4764|M.vanbaalenii_PYR-1 PSLAAAETARADDYTIDVVDG---GHFILDEQPELVRAKLIALAEEFPAR
Mb3694|M.bovis_AF2122/97 ADPVERTQRYAPHGRYISIAGA--GHFSHEEAPEEVNRHLMRFLEQVH--
MLBr_02297|M.leprae_Br4923 ADSVDRTRRYAPHGRYVSVSDA--GHFSHEEAPEEINRYLTRFLKQVHGP
TH_4292|M.thermoresistible__bu STRLTVEPRMANITRAVEVPGA--GHWLVEENPAFVTNELLTFLAD----
MSMEG_6708|M.smegmatis_MC2_155 ADVLGIWREHHADPAAVTGTPVPGGHYVPEEAPQAVLDALHHFLEMSPDM
. **: :: * : : .
Rv0134|M.tuberculosis_H37Rv RD--------
MAV_5163|M.avium_104 ----------
MMAR_0342|M.marinum_M ----------
MUL_4778|M.ulcerans_Agy99 ----------
MAB_4522c|M.abscessus_ATCC_199 ----------
Mflv_1960|M.gilvum_PYR-GCK PVR-------
Mvan_4764|M.vanbaalenii_PYR-1 ----------
Mb3694|M.bovis_AF2122/97 QLS-------
MLBr_02297|M.leprae_Br4923 RLS-------
TH_4292|M.thermoresistible__bu ----------
MSMEG_6708|M.smegmatis_MC2_155 SPGKEPNPCG