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RPISPRYLLQFTESAGYLDFARFGPPSYAVLDATARLSEQSAHAGPATVDELMRQEVRAKAAAARLCGSD TDHIVLQPHTSMGLLQAAFSVPGGTVLVSEAEFPANTYPWARAEQTGRVTVRRLRAGHVTPDAVAEALTD DVTVVSVSAVDFRTGYRADLAALRDVIGDRLFVVDGIQGFGVIEAPWEVADVLVVGGQKWLRAGWGTGFT KLSDRMLERMDPVLSGWTGARDPGLFDNTIHPPESTAAAWSISNLSPVTSGAFAEALELVEDAGVAAIAA RIAERVDALQDMLESLGATIVSATDRRAGILAFTLPGQPAEQVGIALNSAGIAATVRPEHVRLSPHASTS LDVVDEVRSALTALARARTATPAPPSASGPATHELLTSLVPAVHGLAAMLGPGNEVLLQDLSRLPDSIVA IAGDLTGRTVGGPMTDLLLGLIRRGTTQDLINYRTNSPDGRPIRSSTLFLRDADGVAVGCLCVNSAMAET VAADAPEQPETFPRDIDSLQRFLIDRAIAKVGVPPAEMKKQHKAAVVRELDEAGFFLIRDSVEHVAGQLD VTRYTIYNYLTEVRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6591 | - | - | 100% (576) | aminotransferase, class V family protein |
| M. smegmatis MC2 155 | MSMEG_0978 | - | 2e-20 | 29.75% (363) | aminotransferase, class V superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3125 | - | 7e-08 | 25.57% (395) | cysteine desulfurase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3726c | - | 7e-10 | 26.08% (372) | hypothetical protein Mb3726c |
| M. gilvum PYR-GCK | Mflv_3674 | - | 5e-08 | 24.10% (390) | SufS subfamily cysteine desulfurase |
| M. tuberculosis H37Rv | Rv3700c | - | 7e-10 | 26.08% (372) | hypothetical protein Rv3700c |
| M. leprae Br4923 | MLBr_00842 | - | 2e-07 | 27.31% (260) | hypothetical protein MLBr_00842 |
| M. abscessus ATCC 19977 | MAB_2746c | - | 3e-12 | 27.13% (387) | cysteine desulfurase/aminotransferase |
| M. marinum M | MMAR_5211 | csdB | 7e-09 | 25.20% (373) | selenocysteine lyase, CsdB |
| M. avium 104 | MAV_3315 | - | 1e-07 | 25.19% (397) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_3033 | - | 5e-08 | 24.81% (395) | PUTATIVE cysteine desulfurases, SufS subfamily |
| M. ulcerans Agy99 | MUL_4284 | csdB | 7e-09 | 25.20% (373) | selenocysteine lyase, CsdB |
| M. vanbaalenii PYR-1 | Mvan_2736 | - | 5e-09 | 25.91% (386) | SufS subfamily cysteine desulfurase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3315|M.avium_104 ----------------------------------------------MAAI
TH_3033|M.thermoresistible__bu -----------------------------------MTVAP--NRLDLGAI
Mflv_3674|M.gilvum_PYR-GCK -----------------------------------MTTARTLDLTVLNRV
Mvan_2736|M.vanbaalenii_PYR-1 -----------------------------------MTASVD---LDVAAI
MAB_2746c|M.abscessus_ATCC_199 -----------------------------------MTATVP---LDITAI
MLBr_00842|M.leprae_Br4923 -----------------------------------MVDVFD-----IQAV
Mb3726c|M.bovis_AF2122/97 -----------------------------------MRRSGA-----NSPA
Rv3700c|M.tuberculosis_H37Rv -----------------------------------MRRSGA-----NSPA
MMAR_5211|M.marinum_M -------------------------------------------------M
MUL_4284|M.ulcerans_Agy99 -------------------------------------------------M
MSMEG_6591|M.smegmatis_MC2_155 MRPISPRYLLQFTESAGYLDFARFGPPSYAVLDATARLSEQSAHAGPATV
MAV_3315|M.avium_104 RADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHRG
TH_3033|M.thermoresistible__bu RADFPILQRVMRGGSQLAYLDSGATAQRPVQVLDAEREFLTTSYGAVHRG
Mflv_3674|M.gilvum_PYR-GCK RADFPILSRVMRGGQQLAYLDSGATSQKPLAVLDAERDFLLHSNGAVHRG
Mvan_2736|M.vanbaalenii_PYR-1 RADFPILKRVMRGGNTLAYLDSGATSQKPLQVLDAERQFLTTSYGAVHRG
MAB_2746c|M.abscessus_ATCC_199 RNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVHRG
MLBr_00842|M.leprae_Br4923 RADFPILQETVN-GKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRA
Mb3726c|M.bovis_AF2122/97 GDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARH---EAEVG
Rv3700c|M.tuberculosis_H37Rv GDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARH---EAEVG
MMAR_5211|M.marinum_M TDTLADRWRAARPPAAGLHLDSAACSRQSLEVLQAVAAHGLH---EAEVG
MUL_4284|M.ulcerans_Agy99 TDTLADRWRAARPPATGLHLDSAACSRQSLEVLRAVAAHGLH---EAEVG
MSMEG_6591|M.smegmatis_MC2_155 DELMRQEVRAKAAAARLCGSDTDHIVLQPHTSMGLLQAAFSVPGGTVLVS
: . *. :. : .
MAV_3315|M.avium_104 AHQLMEES---TDAYEQGRADIAAFVGAD------------------PDE
TH_3033|M.thermoresistible__bu AHQLMEEA---TDAYEEGRADIAAFVGAD------------------PDE
Mflv_3674|M.gilvum_PYR-GCK AHQLMEES---TDAYEHGREAIASFVGAD------------------SDE
Mvan_2736|M.vanbaalenii_PYR-1 AHQLMEES---TDAYEQGRADIAAFVGAA------------------PGE
MAB_2746c|M.abscessus_ATCC_199 AHQLAEEA---TDAYEGARNAIARFVGVD------------------DGE
MLBr_00842|M.leprae_Br4923 AHELAARA---TDAYEEARETARRFIGAAK-----------------AQE
Mb3726c|M.bovis_AF2122/97 GYVAAEAA---AAVLDAGRAAVAALSGLP------------------DAE
Rv3700c|M.tuberculosis_H37Rv GYVAAEAA---AAVLDAGRAAVAALSGLP------------------DAE
MMAR_5211|M.marinum_M GYVAAEAA---APVLDAGRAAVATLCGVP------------------DAR
MUL_4284|M.ulcerans_Agy99 GYVAAEAA---APVLDAGRAAVATLCGVP------------------DAR
MSMEG_6591|M.smegmatis_MC2_155 EAEFPANTYPWARAEQTGRVTVRRLRAGHVTPDAVAEALTDDVTVVSVSA
: : . : .* : .
MAV_3315|M.avium_104 LVFTKNATEALNLVSYVVGDNRFERAVGPGDVIVTTELEHHANLVPWQEL
TH_3033|M.thermoresistible__bu LVFTKNATEALNLVAYVLGDDRFDRAVGPGDVIVTTELEHHANLIPWQEL
Mflv_3674|M.gilvum_PYR-GCK LVFTKNATEAINLVAYALGDKRFENAIGPGDVIVTTELEHHANLVPWQEL
Mvan_2736|M.vanbaalenii_PYR-1 LVFTKNATEALNLVSYVLGDDRSGFAVGPGDVIVVTEMEHHANLIPWQEL
MAB_2746c|M.abscessus_ATCC_199 IVFTKNATESLNLVAYTLGDNRFDRAVGPGDEIVVTELEHHANLVPWQEL
MLBr_00842|M.leprae_Br4923 IIFVRGTTEAINLVAYAWGGKHLQ----PGDEVVITHLEHHANIVPWQLL
Mb3726c|M.bovis_AF2122/97 VVFTTGSLHALDLLLGSWPGENRTLACLPGEYG------------PNLAV
Rv3700c|M.tuberculosis_H37Rv VVFTTGSLHALDLLLGSWPGENRTLACLPGEYG------------PNLAV
MMAR_5211|M.marinum_M VVFTTGSLHALDLLLGSWPRESRTLACLPGEYG------------PNLAV
MUL_4284|M.ulcerans_Agy99 VVFTTGSLHALDLLLGSWPRESRTLACLPGEYG------------PNLAV
MSMEG_6591|M.smegmatis_MC2_155 VDFRTGYRADLAALRDVIGDRLFVVDGIQGFGVIEAPWEVADVLVVGGQK
: * . : : *
MAV_3315|M.avium_104 ARRTGASLRWYGVTD--------------------------------DGR
TH_3033|M.thermoresistible__bu ARRTGAELRWYSVTD--------------------------------DGR
Mflv_3674|M.gilvum_PYR-GCK VLRTGATLKWYGVTA--------------------------------EGR
Mvan_2736|M.vanbaalenii_PYR-1 ARRTGATLRWFGLTD--------------------------------DGE
MAB_2746c|M.abscessus_ATCC_199 CRRTGATLRWFGVTD--------------------------------DGR
MLBr_00842|M.leprae_Br4923 SSQTGAILKVAPVDD--------------------------------AGN
Mb3726c|M.bovis_AF2122/97 MAAHGFDVRPLPTLQ--------------------------------DGR
Rv3700c|M.tuberculosis_H37Rv MAAHGFDVRPLPTLQ--------------------------------DGR
MMAR_5211|M.marinum_M MAAHGFEVRLLPTLD--------------------------------DGR
MUL_4284|M.ulcerans_Agy99 MAAHGFEVRLLPTLD--------------------------------DGR
MSMEG_6591|M.smegmatis_MC2_155 WLRAGWGTGFTKLSDRMLERMDPVLSGWTGARDPGLFDNTIHPPESTAAA
* .
MAV_3315|M.avium_104 IDLDSLQ--LDERVK-VVAFSHHSNVTGAVAPVAE---------------
TH_3033|M.thermoresistible__bu IDLDSLE--LDERVK-VVAFTHHSNVTGAIAPVEE---------------
Mflv_3674|M.gilvum_PYR-GCK IDLDSLV--LDERVK-VVAFSHHSNVTGAIAPVSE---------------
Mvan_2736|M.vanbaalenii_PYR-1 VDLDSLK--LDERVK-VVSFSHHSNVTGVGVPVAD---------------
MAB_2746c|M.abscessus_ATCC_199 IDVDSLE--LTEAVK-VVAFTHQSNVTGAVAPVAE---------------
MLBr_00842|M.leprae_Br4923 LLMSEFEDLLGPRTK-LVAATQVSNALGTVTQGEK---------------
Mb3726c|M.bovis_AF2122/97 VALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAM---------------
Rv3700c|M.tuberculosis_H37Rv VALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAM---------------
MMAR_5211|M.marinum_M LALDDAAYELEEDPPELVHLTPVASHRGTVQPLAM---------------
MUL_4284|M.ulcerans_Agy99 LALDDAAYELEEDPPELVHLTPVASHRGTVQPLAM---------------
MSMEG_6591|M.smegmatis_MC2_155 WSISNLSPVTSGAFAEALELVEDAGVAAIAARIAERVDALQDMLESLGAT
:.. : :. .
MAV_3315|M.avium_104 -LVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIG
TH_3033|M.thermoresistible__bu -LVSRARAVGALTVLDACQSVPHQPVDLHALGVDYAAWSGHKMLGPNGIG
Mflv_3674|M.gilvum_PYR-GCK -LVARARAVGALVVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPTGIG
Mvan_2736|M.vanbaalenii_PYR-1 -MVARAKAVGALTVLDSCQAVPHQPVDFHALDVDFAAFSGHKMLGPTGIG
MAB_2746c|M.abscessus_ATCC_199 -LVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVG
MLBr_00842|M.leprae_Br4923 -IVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPTGIG
Mb3726c|M.bovis_AF2122/97 -VAQLCTELKLPLVVDAAQGLGHVDCAVG-ADVTYASSR-KWIAGPRGVG
Rv3700c|M.tuberculosis_H37Rv -VAQLCTELKLPLVVDAAQGLGHVDCAVG-ADVTYASSR-KWIAGPRGVG
MMAR_5211|M.marinum_M -MAELCRELGLPLVVDAAQGMGQIDCAVG-ADVTYSSSR-KWLAGPRGVG
MUL_4284|M.ulcerans_Agy99 -MAELCRELGLPLVVDAAQGMGQIDCAVG-ADVTYSSSR-KWLAGPRGVG
MSMEG_6591|M.smegmatis_MC2_155 IVSATDRRAGILAFTLPGQPAEQVGIALNSAGIAATVRPEHVRLSPHAST
: . * : . . : .* .
MAV_3315|M.avium_104 VLYGRREVLSQLPPFLTGGSMIETVTMESSSYAPVPQRFEAGTPMASQVV
TH_3033|M.thermoresistible__bu ALYGRRELLEAMPPFLTGGSMIETVSMEGATYAPAPQRFEAGTPMTSQVV
Mflv_3674|M.gilvum_PYR-GCK VLYGRRALLNALPPFLTGGSMIETVTMEATTFAPAPQRFEAGTPMTSQVV
Mvan_2736|M.vanbaalenii_PYR-1 ALYGRARLLEQLPPFLTGGSMIETVTMEGATYAPPPQRFEAGTQMISQVV
MAB_2746c|M.abscessus_ATCC_199 VLYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVV
MLBr_00842|M.leprae_Br4923 VLYGCEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAV
Mb3726c|M.bovis_AF2122/97 VLAVRPELMERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARV
Rv3700c|M.tuberculosis_H37Rv VLAVRPELMERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARV
MMAR_5211|M.marinum_M VLAMRPEVLDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARV
MUL_4284|M.ulcerans_Agy99 VLAMRPEVLDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARV
MSMEG_6591|M.smegmatis_MC2_155 SLDVVDEVRSALTALARARTATPAP-----PSASGPATHELLTSLVPAVH
* : : . . .
MAV_3315|M.avium_104 GLAAAARYLGALGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRG
TH_3033|M.thermoresistible__bu GLAAAARYLSAIGMDAVQAHEAELVAAALEGLSGIEQVRIIGPTSMELRG
Mflv_3674|M.gilvum_PYR-GCK GLGAAARYLDALGMPAVEEHERELVAAALAGLSEVPGVRVIGPASMDDRG
Mvan_2736|M.vanbaalenii_PYR-1 GLGAATRYLGGIGMSAVEEHEHRLVTATLEGLAAIPGVRIIGPATAERR-
MAB_2746c|M.abscessus_ATCC_199 GLGAAVDYLNAVGMEAVAAHEHQLVSAALAGLAGIEGVRIIGPTDNLDRG
MLBr_00842|M.leprae_Br4923 GLGEALRYVERVGVQRIASHEQALLDYATPRLADIPGVRLVG--TATEKA
Mb3726c|M.bovis_AF2122/97 GFSVALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAI
Rv3700c|M.tuberculosis_H37Rv GFSVALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAI
MMAR_5211|M.marinum_M GFSLAVGEHLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAI
MUL_4284|M.ulcerans_Agy99 GFSLAVGEHLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAI
MSMEG_6591|M.smegmatis_MC2_155 GLAAMLGPGNEVLLQDLSRLPDSIVAIAGDLTGRTVGGPMTDLLLGLIRR
*:. : : : . :
MAV_3315|M.avium_104 SPVSFVVDGVHAHDVGQVLDDEGVAVR------VGHHCALPLHRRFGLAA
TH_3033|M.thermoresistible__bu SPVSFVVDGVHAHDVGQVLDDDGVAVR------VGHHCAWPLHQRFGIAA
Mflv_3674|M.gilvum_PYR-GCK SPVSFVVDGVHAHDVGQVLDDDGVAVR------VGHHCAWPLHRRFGIAA
Mvan_2736|M.vanbaalenii_PYR-1 SPVAFVVDGVHAHDVGQVLDDDGVAVR------VGHHCAAPLHRRFGIAA
MAB_2746c|M.abscessus_ATCC_199 GAVSFVVDGIHAHDLGQVLDDEGVAVR------VGHHCAWPLHRRFGIAA
MLBr_00842|M.leprae_Br4923 SVLSFVLAGHEPLEVGKALNAEGIAVR------AGHHCAQPVLRRLGLEA
Mb3726c|M.bovis_AF2122/97 TTLAPIDGADPAAVRAWLLSQRRIVTT------YAGVERAPLEL---PAP
Rv3700c|M.tuberculosis_H37Rv TTLAPIDGADPAAVRAWLLSQRRIVTT------YAGVERAPLEL---PAP
MMAR_5211|M.marinum_M TTLAPIDGADPAAVREWLLEQRRILTT------YAGIARAPQEL---TAP
MUL_4284|M.ulcerans_Agy99 TTLAPIDGADPAAEREWLLEQRRILTT------YAGIARAPQEL---TAP
MSMEG_6591|M.smegmatis_MC2_155 GTTQDLINYRTNSPDGRPIRSSTLFLRDADGVAVGCLCVNSAMAETVAAD
: : : . .
MAV_3315|M.avium_104 TARASFAVYNTAEEVDRLVAGVRRALDFFGGA------------------
TH_3033|M.thermoresistible__bu TARASFAVYNTLDEVDRLVAGVRRAVEFFGDR------------------
Mflv_3674|M.gilvum_PYR-GCK TARASFAVYNTVDEVDRLVAGVRRAVEFFGRE------------------
Mvan_2736|M.vanbaalenii_PYR-1 TVRASFAVYNTLDEVDRLIAGVQRAIEFFGRD------------------
MAB_2746c|M.abscessus_ATCC_199 SARASFAVYNTLDEVDRLTAGVRRAQEFFS--------------------
MLBr_00842|M.leprae_Br4923 TVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG-----------------
Mb3726c|M.bovis_AF2122/97 VLRISPHVDNTADDLDAFAEALVAATAATSGER-----------------
Rv3700c|M.tuberculosis_H37Rv VLRISPHVDNTADDLDAFAEALVAATAATSGER-----------------
MMAR_5211|M.marinum_M VLRVAPHVDTTAEDLENFAEALIEATAATTAT------------------
MUL_4284|M.ulcerans_Agy99 VLRVAPHVDTTAEDLENFAEALIEATAATTAT------------------
MSMEG_6591|M.smegmatis_MC2_155 APEQPETFPRDIDSLQRFLIDRAIAKVGVPPAEMKKQHKAAVVRELDEAG
. . . :.:: :
MAV_3315|M.avium_104 -------------------------------
TH_3033|M.thermoresistible__bu -------------------------------
Mflv_3674|M.gilvum_PYR-GCK -------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 -------------------------------
MAB_2746c|M.abscessus_ATCC_199 -------------------------------
MLBr_00842|M.leprae_Br4923 -------------------------------
Mb3726c|M.bovis_AF2122/97 -------------------------------
Rv3700c|M.tuberculosis_H37Rv -------------------------------
MMAR_5211|M.marinum_M -------------------------------
MUL_4284|M.ulcerans_Agy99 -------------------------------
MSMEG_6591|M.smegmatis_MC2_155 FFLIRDSVEHVAGQLDVTRYTIYNYLTEVRG