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VMRAAFGAEFVGAEGFLNSATYGLPPQFLVDALDTHIRQWQSGTLDAASFDEPVRRARAGYAALTGVPTE SVVLAGSTSAALGLVAASVPDGSRVAVVTGEFTSTSFPFAAQAGRGVTVTEVAPDRLPDAAVEHDVVVGS LVQSADGALLDLAGVREAVAGTETRVVLDVTQAAGWKHLDLGWVDVTVASAYKWLLAPRGTAWMSLSDSV AERMTPHAANWYAGDRPWDSIYGLPLRLSGEARRFDVSPAWFAALGAGLTLPWLASLDPVAVEAHAVGLA NRLRHELELAPQDSAIVSIPITGAEERLRQAGIRAAVRAGAVRVGFHLYNTEDDLERLLHALGDNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0978 | - | - | 100% (346) | aminotransferase, class V superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6591 | - | 1e-20 | 29.75% (363) | aminotransferase, class V family protein |
| M. smegmatis MC2 155 | MSMEG_6246 | - | 3e-09 | 27.98% (243) | pyridoxal-phosphate-dependent transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3726c | - | 2e-11 | 26.58% (365) | hypothetical protein Mb3726c |
| M. gilvum PYR-GCK | Mflv_1319 | - | 5e-07 | 25.96% (208) | aminotransferase, class V |
| M. tuberculosis H37Rv | Rv3700c | - | 3e-11 | 26.58% (365) | hypothetical protein Rv3700c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5211 | csdB | 3e-12 | 28.96% (366) | selenocysteine lyase, CsdB |
| M. avium 104 | MAV_0403 | - | 3e-10 | 26.03% (365) | pyridoxal-phosphate-dependent transferase |
| M. thermoresistible (build 8) | TH_1723 | - | 3e-09 | 25.62% (324) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4284 | csdB | 2e-12 | 28.42% (366) | selenocysteine lyase, CsdB |
| M. vanbaalenii PYR-1 | Mvan_2142 | - | 9e-07 | 29.10% (189) | cystathionine gamma-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3726c|M.bovis_AF2122/97 MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHA
Rv3700c|M.tuberculosis_H37Rv MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHA
MAV_0403|M.avium_104 -------MSGGTPLADTWRSARPPAAGLHLDSAACSRQSFAVIEATAQHA
MMAR_5211|M.marinum_M ---------MTDTLADRWRAARPPAAGLHLDSAACSRQSLEVLQAVAAHG
MUL_4284|M.ulcerans_Agy99 ---------MTDTLADRWRAARPPATGLHLDSAACSRQSLEVLRAVAAHG
TH_1723|M.thermoresistible__bu --------------------------------------------------
Mflv_1319|M.gilvum_PYR-GCK -MDGDAHDLEDTPLAQRWREARPPAAGVHVDSAACSRQSVAVIEATAQHA
MSMEG_0978|M.smegmatis_MC2_155 -------------MMRAAFGAEFVGAEGFLNSATYGLPPQFLVDALDTHI
Mvan_2142|M.vanbaalenii_PYR-1 -------------MAGTYGDSTRSVKAVGAEAIPGLPVSSPPVPAAAYHL
Mb3726c|M.bovis_AF2122/97 RHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLL
Rv3700c|M.tuberculosis_H37Rv RHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLL
MAV_0403|M.avium_104 RNEAELGGYVAAEAAAPVLDAGRFAFTALTGMTDAEAVFTTGSLHALDLL
MMAR_5211|M.marinum_M LHEAEVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGSLHALDLL
MUL_4284|M.ulcerans_Agy99 LHEAEVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGSLHALDLL
TH_1723|M.thermoresistible__bu -----------------VLHAGRAAVAHLVGMDAADVVFTTGSNHALDLL
Mflv_1319|M.gilvum_PYR-GCK RHEAEVGGYVAAEAAAPVLDAGRAAVRVLAGMPDAEVVFTTGSNNALDIL
MSMEG_0978|M.smegmatis_MC2_155 R--QWQSGTLDAASFDEPVRRARAGYAALTGVPTESVVLAGSTSAALGLV
Mvan_2142|M.vanbaalenii_PYR-1 APDEDGSLDSYGRSSNPTWRQLESALARLEGAATALVFGSG--MAALTSV
. . * * .. : ** :
Mb3726c|M.bovis_AF2122/97 LGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAF
Rv3700c|M.tuberculosis_H37Rv LGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAF
MAV_0403|M.avium_104 LGSWPAERRTLACLPGEYGPNLAVMAAHGFDRWLLPTLADGRVALDDAAL
MMAR_5211|M.marinum_M LGSWPRESRTLACLPGEYGPNLAVMAAHGFEVRLLPTLDDGRLALDDAAY
MUL_4284|M.ulcerans_Agy99 LGSWPRESRTLACLPGEYGPNLAVMAAHGFEVRLLPTLDDGRLALDDAAY
TH_1723|M.thermoresistible__bu LSSWP-QPRSLACLPGEFGPNLAIMAANGFEVRALPVDEIGRVRPDRAEH
Mflv_1319|M.gilvum_PYR-GCK LADWP-GERTLACLQGEFGPNLAIMARHGFEVRTLPLEESGRLDVNAIGA
MSMEG_0978|M.smegmatis_MC2_155 AASVP-DGSRVAVVTGEFTSTSFPFAAQAGRGVTVTEVAPDRLPDAAVEH
Mvan_2142|M.vanbaalenii_PYR-1 LRVVAEPGHTLVVPADGY------YQVRAYAKEYLAPRGVTVVEARCAEM
. :. . : .. :. :
Mb3726c|M.bovis_AF2122/97 MLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVD--AAQGLG
Rv3700c|M.tuberculosis_H37Rv MLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVD--AAQGLG
MAV_0403|M.avium_104 ALQTDPPDLVHLTTIGSHSGVVQPVSMIARLCRELGLPLVVD--AAQALG
MMAR_5211|M.marinum_M ELEEDPPELVHLTPVASHRGTVQPLAMMAELCRELGLPLVVD--AAQGMG
MUL_4284|M.ulcerans_Agy99 ELEEDPPELVHLTPVASHRGTVQPLAMMAELCRELGLPLVVD--AAQGMG
TH_1723|M.thermoresistible__bu LLRTDPPALVHLTALASHRGIAQPAARIAELCRAYRVPLVID--AAQALG
Mflv_1319|M.gilvum_PYR-GCK ALAHDPPALVHFTVLGSHSGVVQPARAMASACHGHGIPLIVD--AAQGFA
MSMEG_0978|M.smegmatis_MC2_155 DVVVG-------SLVQSADGALLDLAGVREAVAGTETRVVLD--VTQAAG
Mvan_2142|M.vanbaalenii_PYR-1 CDAARDADVVLAETPSNPGLDVVDLHRLAMTCRAQRTLLVVDNTTATPFG
. : :::* .: .
Mb3726c|M.bovis_AF2122/97 HVDCA-VGADVTYASSRKWIAGPRGVG---VLAVRPELMERLRAR-LPAP
Rv3700c|M.tuberculosis_H37Rv HVDCA-VGADVTYASSRKWIAGPRGVG---VLAVRPELMERLRAR-LPAP
MAV_0403|M.avium_104 QVDCT-AGADVTYSSSRKWIAGPRGVG---MLAVRRELMENLHPR-LAAP
MMAR_5211|M.marinum_M QIDCA-VGADVTYSSSRKWLAGPRGVG---VLAMRPEVLDRLTPR-LAPP
MUL_4284|M.ulcerans_Agy99 QIDCA-VGADVTYSSSRKWLAGPRGVG---VLAMRPEVLDRLTPR-LAPP
TH_1723|M.thermoresistible__bu HLDCA-VGADAVYSSSRKWLAGPRGVG---VLAIRPELAERLCPR-LPPP
Mflv_1319|M.gilvum_PYR-GCK HIDVAGIGADALYSSSRKWTAGPRGVG---VLATKPGFLSEATR------
MSMEG_0978|M.smegmatis_MC2_155 WKHLDLGWVDVTVASAYKWLLAPRGTA---WMSLSDSVAERMTP---HAA
Mvan_2142|M.vanbaalenii_PYR-1 QQPLS-LGADLVVASATKALAGHHDVLAGYVAGSQPELMERVQRERLHAG
.* :*: * . :.. . . ..
Mb3726c|M.bovis_AF2122/97 DWMP---PLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAEL
Rv3700c|M.tuberculosis_H37Rv DWMP---PLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAEL
MAV_0403|M.avium_104 DWAP---GSTVAQQLEFGEANIAARVGFSLALGEYLGYGPAAVCARLAEL
MMAR_5211|M.marinum_M DWSPDSPSTSVAQILEFGEANIAARVGFSLAVGEHLEYGPALIRARLAEL
MUL_4284|M.ulcerans_Agy99 DWSPDSPSTSVAQILEFGEANIAARVGFSLAVGEHLEYGPALIRARLAEL
TH_1723|M.thermoresistible__bu DWPVAR-TLRVLDRLAHGEANIAARVGFSVAVGEHLAAGPAAVRARLAEV
Mflv_1319|M.gilvum_PYR-GCK ------------QRISHTEANVGMHVGFSVALGEHVAAGVEAVQARLREV
MSMEG_0978|M.smegmatis_MC2_155 NWYAGDRPWDSIYGLPLRLSGEARRFDVSPAWFAALGAGLTLPWLASLDP
Mvan_2142|M.vanbaalenii_PYR-1 PILGAFEAWLVLRSLGSAGLRFERQCQNAAALALMLRSHPAVHTVRYPGL
: : : * :
Mb3726c|M.bovis_AF2122/97 GDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRI
Rv3700c|M.tuberculosis_H37Rv GDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRI
MAV_0403|M.avium_104 GGLSRGVLTDVTGWAVVEEAEEPSAITTLAPTDGADPRAVRDWLLAERRI
MMAR_5211|M.marinum_M GAAARRVLADVDGWLVVEEVDEPSAITTLAPIDGADPAAVREWLLEQRRI
MUL_4284|M.ulcerans_Agy99 GAAARRVLADVDGWLVVEEVDEPSAITTLAPIDGADPAAEREWLLEQRRI
TH_1723|M.thermoresistible__bu GRQTHAVLAQVPGWRVVEPPDEPTAITTLEPTAGADPAAVRRTLI-ERGI
Mflv_1319|M.gilvum_PYR-GCK GAATRRALADVRGWRVLEALDEPSAITTLRPPDGVDAQDVRARLIAEHSI
MSMEG_0978|M.smegmatis_MC2_155 VAVEAHAVGLANRLRHELELAPQDSAIVSIPITGAEERLR----------
Mvan_2142|M.vanbaalenii_PYR-1 PEDPSHAVASMQMRRFG-GIVAAELGDAQAVHDLVRRSALLIASTSFGGI
.: . .
Mb3726c|M.bovis_AF2122/97 VTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER
Rv3700c|M.tuberculosis_H37Rv VTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER
MAV_0403|M.avium_104 LTTFVGVQRAPLRLTAPVLRISPHLDTTAEDLETFAEALIAATAATSA--
MMAR_5211|M.marinum_M LTTYAGIARAPQELTAPVLRVAPHVDTTAEDLENFAEALIEATAATTAT-
MUL_4284|M.ulcerans_Agy99 LTTYAGIARAPQELTAPVLRVAPHVDTTAEDLENFAEALIEATAATTAT-
TH_1723|M.thermoresistible__bu VTTAAEPARAPFELRTPVLRLSPHIDTTTAELEQFAAALADVTAALR---
Mflv_1319|M.gilvum_PYR-GCK VATYLGTERAPREMNRPALRVSPHVDVTAADLGRVAEALAEVTPG-----
MSMEG_0978|M.smegmatis_MC2_155 ------QAGIRAAVRAGAVRVGFHLYNTEDDLERLLHALGDNR-------
Mvan_2142|M.vanbaalenii_PYR-1 HTSVDRRARWGDHVSDGFARISLGIEDTDDLVDDVRQALGAG--------
: *:. : * : . **