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MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLSYFYAHENSNIHRAAHELAARATDA YEEARETARRFIGAAKAQEIIFVRGTTEAINLVAYAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTG AILKVAPVDDAGNLLMSEFEDLLGPRTKLVAATQVSNALGTVTQGEKIVELGHRYGARVLIDGAQSIPHL PINVSELGADFFVFSGHKIYGPTGIGVLYGCEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTG NIADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLADIPGVRLVGTATEKASVLSFVLAGHEPLEVG KALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00842 | - | - | 100% (411) | hypothetical protein MLBr_00842 |
| M. leprae Br4923 | MLBr_00596 | - | 2e-88 | 41.98% (405) | putative aminotransferase |
| M. leprae Br4923 | MLBr_00117 | - | 3e-19 | 25.67% (409) | hypothetical protein MLBr_00117 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1499 | csd | 1e-93 | 43.63% (408) | cysteine desulfurase |
| M. gilvum PYR-GCK | Mflv_3674 | - | 5e-94 | 44.04% (411) | SufS subfamily cysteine desulfurase |
| M. tuberculosis H37Rv | Rv1464 | csd | 1e-93 | 43.63% (408) | cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_0217c | - | 0.0 | 81.39% (403) | cysteine desulfurase |
| M. marinum M | MMAR_2269 | csd | 4e-88 | 42.33% (404) | cysteine desulfurase Csd |
| M. avium 104 | MAV_2055 | - | 0.0 | 85.09% (409) | cysteine desulphurases, SufS |
| M. smegmatis MC2 155 | MSMEG_4538 | - | 0.0 | 88.12% (404) | cysteine desulphurase, SufS |
| M. thermoresistible (build 8) | TH_3033 | - | 2e-88 | 42.75% (407) | PUTATIVE cysteine desulfurases, SufS subfamily |
| M. ulcerans Agy99 | MUL_1865 | csd | 1e-87 | 42.08% (404) | cysteine desulfurase Csd |
| M. vanbaalenii PYR-1 | Mvan_2736 | - | 2e-90 | 43.10% (406) | SufS subfamily cysteine desulfurase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MAV_2055|M.avium_104 MSTSEYRAVDAESDLPISAAELAALASQLYAASIR---PGPDSPPQQAPV
MSMEG_4538|M.smegmatis_MC2_155 MSTSEYRSLNAESDLPISADELSALATQLFAAGIR---PGPDTPPQTAPV
MAB_0217c|M.abscessus_ATCC_199 MPTSDEIPVADSPPGFPSSAELAALATQLFWEATPSGAPGIDTPGPAVPV
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MAV_2055|M.avium_104 APRGSVPDATAAISAGRTAAGTADVYPGPVPQVGGRDVYLPPPASPAPEA
MSMEG_4538|M.smegmatis_MC2_155 APRGNVPGTAHPVAP-----------PTEFVAVPSAVWSVPAHTSPVPEP
MAB_0217c|M.abscessus_ATCC_199 APRGTVPDATAGSSAAATTGSWASPYVPAPLADALSTATVAPPVAAFSSA
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MAV_2055|M.avium_104 PPQAAPPAPRGSAPDATAATSAGRAAAGTSDVYSSWVPQLGVADIYLGAP
MSMEG_4538|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0217c|M.abscessus_ATCC_199 TPDGIPG-------------------------------------------
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MAV_2055|M.avium_104 TPAGPEAPPQSAPPAPRGQVPDTTAAATAYGADLSAFAVPTGIVSTAPGV
MSMEG_4538|M.smegmatis_MC2_155 ------VAPQTDPLVPPG------------VADLTAFTVPGGIVPTLPGV
MAB_0217c|M.abscessus_ATCC_199 --AVPVAPRGGGGDLSSGTSAAHTAATGYPTTGLADFAVPSGLVPTIPGV
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MAV_2055|M.avium_104 QAGTVPPVPVVPRAATAPSWLPEAPSVADLGWSDAPAPDAP--AGDEHDY
MSMEG_4538|M.smegmatis_MC2_155 LAG--------------------------------ARTAVP--AAESPDY
MAB_0217c|M.abscessus_ATCC_199 LAS---PATAPVTASPRTAPYSEGLSVPDLGWAPPAAPSGGDRAGDEANY
Mb1499|M.bovis_AF2122/97 ------------MTAS--VNSLDLAAIRADFPILKRIMRGGNPLAYLDSG
Rv1464|M.tuberculosis_H37Rv ------------MTAS--VNSLDLAAIRADFPILKRIMRGGNPLAYLDSG
MMAR_2269|M.marinum_M ------------MTVS--VARLDLAAIRADFPILQRVMRSGNQLAYLDSG
MUL_1865|M.ulcerans_Agy99 ------------MTVS--VARLDLAAIRADFPILQRVMRSGNQLAYLDSG
TH_3033|M.thermoresistible__bu ------------MTVA--PNRLDLGAIRADFPILQRVMRGGSQLAYLDSG
Mflv_3674|M.gilvum_PYR-GCK ------------MTTARTLDLTVLNRVRADFPILSRVMRGGQQLAYLDSG
Mvan_2736|M.vanbaalenii_PYR-1 ------------MTAS---VDLDVAAIRADFPILKRVMRGGNTLAYLDSG
MLBr_00842|M.leprae_Br4923 -----------------MVDVFDIQAVRADFPILQETVN-GKPLIWFDNA
MAV_2055|M.avium_104 HFLTKT---DPVPQFRDEHEVFDVAAIRSDFPILKETVN-GKPLIWFDNA
MSMEG_4538|M.smegmatis_MC2_155 YFLRDTRAHQPVPQFPDRHEIFDVNAIRADFPILRETVN-GKPLIWFDNA
MAB_0217c|M.abscessus_ATCC_199 YFLGGAP---AAAPTHEDARAFDVTAIRADFPILSETVN-GKPLIWFDNA
: :*:***** . :. *. * ::*..
Mb1499|M.bovis_AF2122/97 ATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFV
Rv1464|M.tuberculosis_H37Rv ATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFV
MMAR_2269|M.marinum_M ATSQRPLQVLDAEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFV
MUL_1865|M.ulcerans_Agy99 ATSQRPLQVLDAEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFV
TH_3033|M.thermoresistible__bu ATAQRPVQVLDAEREFLTTSYGAVHRGAHQLMEEATDAYEEGRADIAAFV
Mflv_3674|M.gilvum_PYR-GCK ATSQKPLAVLDAERDFLLHSNGAVHRGAHQLMEESTDAYEHGREAIASFV
Mvan_2736|M.vanbaalenii_PYR-1 ATSQKPLQVLDAERQFLTTSYGAVHRGAHQLMEESTDAYEQGRADIAAFV
MLBr_00842|M.leprae_Br4923 ATTQKPQVVIDRLSYFYAHENSNIHRAAHELAARATDAYEEARETARRFI
MAV_2055|M.avium_104 ATTQKPQVVIDRLSHFYAHENSNIHRAAHELAARATDAYEEARDTVAEFI
MSMEG_4538|M.smegmatis_MC2_155 ATTQKPQAVIDRLSHFYAHENSNIHRAAHELAARATDAYEDAREAVRRFI
MAB_0217c|M.abscessus_ATCC_199 ATTQKPQSVIDRLVHFYQHENSNIHRAAHELAARATDAYEDARGAARKFL
**:*:* *:* * . :**.**:* .:*****..* *:
Mb1499|M.bovis_AF2122/97 GADTDE-LVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHAN
Rv1464|M.tuberculosis_H37Rv GADTDE-LVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHAN
MMAR_2269|M.marinum_M GAEPDE-LVFTKNATESLNLVSYVLGDSRFDRAIGPGDVIVTTELEHHAN
MUL_1865|M.ulcerans_Agy99 GAEPDE-LVFTKNATESLNLVSYVLGDSRFDRAIGPGDVIVTTELEHHAN
TH_3033|M.thermoresistible__bu GADPDE-LVFTKNATEALNLVAYVLGDDRFDRAVGPGDVIVTTELEHHAN
Mflv_3674|M.gilvum_PYR-GCK GADSDE-LVFTKNATEAINLVAYALGDKRFENAIGPGDVIVTTELEHHAN
Mvan_2736|M.vanbaalenii_PYR-1 GAAPGE-LVFTKNATEALNLVSYVLGDDRSGFAVGPGDVIVVTEMEHHAN
MLBr_00842|M.leprae_Br4923 GAAKAQEIIFVRGTTEAINLVAYAWGGKH----LQPGDEVVITHLEHHAN
MAV_2055|M.avium_104 GAPSSENIVFVRGTTEAINLVAHAWGAKH----LQPGDEIVITHLEHHAN
MSMEG_4538|M.smegmatis_MC2_155 GAAKAEEIIFLRGTTEAINLVAHAWGGKH----LGPGDEIVITHLEHHAN
MAB_0217c|M.abscessus_ATCC_199 GAEADENIIFVRGATEAINLVAYAWGGKN----LGHGDEIVITHLEHHAN
** : ::* :.:**::***::. * .. : ** :* *.:*****
Mb1499|M.bovis_AF2122/97 LIPWQELARRTGATLRWYGVTDDGRIDLDSLY--LDDRVKVVAFTHHSNV
Rv1464|M.tuberculosis_H37Rv LIPWQELARRTGATLRWYGVTDDGRIDLDSLY--LDDRVKVVAFTHHSNV
MMAR_2269|M.marinum_M LIPWQELARRTGATLRWYSVTDEGRIDLDSLQ--LDERVKVVTFTHHSNV
MUL_1865|M.ulcerans_Agy99 LIPWQELARRTGATLRWYSVTDEGRIDLDSLQ--LDERVKVVTFTHHSNV
TH_3033|M.thermoresistible__bu LIPWQELARRTGAELRWYSVTDDGRIDLDSLE--LDERVKVVAFTHHSNV
Mflv_3674|M.gilvum_PYR-GCK LVPWQELVLRTGATLKWYGVTAEGRIDLDSLV--LDERVKVVAFSHHSNV
Mvan_2736|M.vanbaalenii_PYR-1 LIPWQELARRTGATLRWFGLTDDGEVDLDSLK--LDERVKVVSFSHHSNV
MLBr_00842|M.leprae_Br4923 IVPWQLLSSQTGAILKVAPVDDAGNLLMSEFEDLLGPRTKLVAATQVSNA
MAV_2055|M.avium_104 IVPWQLISQKTGAILKVAPIDDAGNLLLSEFEGLLGPRTKLVAASHVSNA
MSMEG_4538|M.smegmatis_MC2_155 IVPWQLLSRQTGAVLKVAPVDDAGNLLLGEFEDLLGPRTKLVAATQVSNA
MAB_0217c|M.abscessus_ATCC_199 IVPWQLIAQKTGAVIKVAPVDDAGNLLLSELEDLVGPRTKLVAATQVSNA
::*** : :*** :: : *.: :..: :. *.*:*: :: **.
Mb1499|M.bovis_AF2122/97 TGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHK
Rv1464|M.tuberculosis_H37Rv TGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHK
MMAR_2269|M.marinum_M TGALAPVAELVSRAKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHK
MUL_1865|M.ulcerans_Agy99 TGALAPVAELVSRAKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHK
TH_3033|M.thermoresistible__bu TGAIAPVEELVSRARAVGALTVLDACQSVPHQPVDLHALGVDYAAWSGHK
Mflv_3674|M.gilvum_PYR-GCK TGAIAPVSELVARARAVGALVVLDACQSVPHQPVDFHALDVDFAAFSGHK
Mvan_2736|M.vanbaalenii_PYR-1 TGVGVPVADMVARAKAVGALTVLDSCQAVPHQPVDFHALDVDFAAFSGHK
MLBr_00842|M.leprae_Br4923 LGTVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHK
MAV_2055|M.avium_104 LGTVVPVDKIVELGHRYGARVLIDGAQSIQHIPIDVAELGADFFVFSGHK
MSMEG_4538|M.smegmatis_MC2_155 LGTVTPVETIVELGHRYGARVLIDGAQSIPHMPIDVAALGADFFVFSGHK
MAB_0217c|M.abscessus_ATCC_199 LGTVTPAKQIVEIAHRYGARVLIDGAQSVPHLAVNLQELGADFFVFSGHK
*. . :* .: ** .::*..*:: * .::. *..*: .:****
Mb1499|M.bovis_AF2122/97 MLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAG
Rv1464|M.tuberculosis_H37Rv MLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAG
MMAR_2269|M.marinum_M MLGPNGIGVLYGRRELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAG
MUL_1865|M.ulcerans_Agy99 MLGPNGIGELYGRRELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAG
TH_3033|M.thermoresistible__bu MLGPNGIGALYGRRELLEAMPPFLTGGSMIETVSMEGATYAPAPQRFEAG
Mflv_3674|M.gilvum_PYR-GCK MLGPTGIGVLYGRRALLNALPPFLTGGSMIETVTMEATTFAPAPQRFEAG
Mvan_2736|M.vanbaalenii_PYR-1 MLGPTGIGALYGRARLLEQLPPFLTGGSMIETVTMEGATYAPPPQRFEAG
MLBr_00842|M.leprae_Br4923 IYGPTGIGVLYGCEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAG
MAV_2055|M.avium_104 IYGPTGIGALYGTEEALTETPPWQGGGHMIADVTLERSLYQGPPTKFEAG
MSMEG_4538|M.smegmatis_MC2_155 IYGPTGIGVLYGREDALAETPPWQGGGNMIADVTLERSLYQGPPNKFEAG
MAB_0217c|M.abscessus_ATCC_199 IYGPTGIGVLYGSEDALAETPPWQGGGNMIADVTLQRAVFQGPPNKFEAG
: **.*** *** * **: ** ** *::: : : .* :****
Mb1499|M.bovis_AF2122/97 TPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILG
Rv1464|M.tuberculosis_H37Rv TPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILG
MMAR_2269|M.marinum_M TPMTSQVVGLAAASRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIG
MUL_1865|M.ulcerans_Agy99 TPMTSQVVGLAAASRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIG
TH_3033|M.thermoresistible__bu TPMTSQVVGLAAAARYLSAIGMDAVQAHEAELVAAALEGLSGIEQVRIIG
Mflv_3674|M.gilvum_PYR-GCK TPMTSQVVGLGAAARYLDALGMPAVEEHERELVAAALAGLSEVPGVRVIG
Mvan_2736|M.vanbaalenii_PYR-1 TQMISQVVGLGAATRYLGGIGMSAVEEHEHRLVTATLEGLAAIPGVRIIG
MLBr_00842|M.leprae_Br4923 TGNIADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLADIPGVRLVG
MAV_2055|M.avium_104 TGNIADAVGLTEALRYVQRLGVERIAAYEHALLEYATPRLADIPGVRLIG
MSMEG_4538|M.smegmatis_MC2_155 TGNIADAVGLGEAIRYVERVGIERIAAYEHALLEYATPRLAAIPGVRIVG
MAB_0217c|M.abscessus_ATCC_199 TGNIADAVGLGEALRYVERIGIDRIAEYEHALLEYATPRLAAIPGVTLVG
* ::.*** * **: :*: : :* *: : *: : * ::*
Mb1499|M.bovis_AF2122/97 PTSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGL
Rv1464|M.tuberculosis_H37Rv PTSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGL
MMAR_2269|M.marinum_M PTSMENRGSPVSFVVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGV
MUL_1865|M.ulcerans_Agy99 PTSMENRGSPVSFVVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGV
TH_3033|M.thermoresistible__bu PTSMELRGSPVSFVVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHQRFGI
Mflv_3674|M.gilvum_PYR-GCK PASMDDRGSPVSFVVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHRRFGI
Mvan_2736|M.vanbaalenii_PYR-1 PATAERR-SPVAFVVDGVHAHDVGQVLDDDGVAVRVGHHCAAPLHRRFGI
MLBr_00842|M.leprae_Br4923 --TATEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGL
MAV_2055|M.avium_104 --TAQEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPALRRLGL
MSMEG_4538|M.smegmatis_MC2_155 --TAQEKASVLSFVLAGHEPLEVGKALNAEGIAVRAGHHCAQPILRRMGL
MAB_0217c|M.abscessus_ATCC_199 --TADHKASVLSFVLDGHDPVEVGKALNADGIAVRAGHHCAQPILRRLGL
: : * ::**: * .. :**:.*: *:***.***** * :::*:
Mb1499|M.bovis_AF2122/97 AATARASFAVYNTADEVDRLVAGVRRSRHFFGRA-
Rv1464|M.tuberculosis_H37Rv AATARASFAVYNTADEVDRLVAGVRRSRHFFGRA-
MMAR_2269|M.marinum_M AATARASFAVYNTRDEVNRLLAGVQRSLNFFGRG-
MUL_1865|M.ulcerans_Agy99 AATARASFAVYNTRDEVNRLLAGVQRSLNFFGRG-
TH_3033|M.thermoresistible__bu AATARASFAVYNTLDEVDRLVAGVRRAVEFFGDR-
Mflv_3674|M.gilvum_PYR-GCK AATARASFAVYNTVDEVDRLVAGVRRAVEFFGRE-
Mvan_2736|M.vanbaalenii_PYR-1 AATVRASFAVYNTLDEVDRLIAGVQRAIEFFGRD-
MLBr_00842|M.leprae_Br4923 EATVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG
MAV_2055|M.avium_104 EATVRPSFAFYNTFEEIDVFLRAVRRIAEGGANVG
MSMEG_4538|M.smegmatis_MC2_155 EATVRPSFAFYNTFDEIDVFIDAVRRIAEGSV---
MAB_0217c|M.abscessus_ATCC_199 EQTVRPSFAFYNTFDEIDVFIDAVRRLAESGGPKA
*.*.***.*** :*:: :: *:* .