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AAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHRGAHQLMEESTDAYEQGRA DIAAFVGADPDELVFTKNATEALNLVSYVVGDNRFERAVGPGDVIVTTELEHHANLVPWQELARRTGASL RWYGVTDDGRIDLDSLQLDERVKVVAFSHHSNVTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFH ALDVDFAAFSGHKMLGPNGIGVLYGRREVLSQLPPFLTGGSMIETVTMESSSYAPVPQRFEAGTPMASQV VGLAAAARYLGALGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVL DDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDRLVAGVRRALDFFGGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3315 | - | - | 100% (408) | cysteine desulfurase |
| M. avium 104 | MAV_2055 | - | 8e-93 | 45.01% (411) | cysteine desulphurases, SufS |
| M. avium 104 | MAV_3872 | - | 4e-24 | 28.64% (398) | cysteine desulfurase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1499 | csd | 0.0 | 87.25% (408) | cysteine desulfurase |
| M. gilvum PYR-GCK | Mflv_3674 | - | 0.0 | 82.88% (403) | SufS subfamily cysteine desulfurase |
| M. tuberculosis H37Rv | Rv1464 | csd | 0.0 | 87.25% (408) | cysteine desulfurase |
| M. leprae Br4923 | MLBr_00596 | - | 0.0 | 86.24% (407) | putative aminotransferase |
| M. abscessus ATCC 19977 | MAB_2746c | - | 1e-179 | 76.05% (405) | cysteine desulfurase/aminotransferase |
| M. marinum M | MMAR_2269 | csd | 0.0 | 87.19% (406) | cysteine desulfurase Csd |
| M. smegmatis MC2 155 | MSMEG_3125 | - | 0.0 | 86.67% (405) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_3033 | - | 0.0 | 85.96% (406) | PUTATIVE cysteine desulfurases, SufS subfamily |
| M. ulcerans Agy99 | MUL_1865 | csd | 0.0 | 86.95% (406) | cysteine desulfurase Csd |
| M. vanbaalenii PYR-1 | Mvan_2736 | - | 0.0 | 81.03% (406) | SufS subfamily cysteine desulfurase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3674|M.gilvum_PYR-GCK MTTART-LDLTVLNRVRADFPILSRVMRGGQQLAYLDSGATSQKPLAVLD
MSMEG_3125|M.smegmatis_MC2_155 MTAAKT-LDVTAI---RADFPILSRVMRGGNQLAYLDSGATSQKPLQVLD
Mb1499|M.bovis_AF2122/97 MTASVNSLDLAAI---RADFPILKRIMRGGNPLAYLDSGATSQRPLQVLD
Rv1464|M.tuberculosis_H37Rv MTASVNSLDLAAI---RADFPILKRIMRGGNPLAYLDSGATSQRPLQVLD
MAV_3315|M.avium_104 ---------MAAI---RADFPILKRIMRSGNQLAYLDSGATSQRPLQVLD
MLBr_00596|M.leprae_Br4923 MTISLTPLDLSAI---RADFPILKRVMRGGNQLAYLDSGATSQRPVQVLD
MMAR_2269|M.marinum_M MTVSVARLDLAAI---RADFPILQRVMRSGNQLAYLDSGATSQRPLQVLD
MUL_1865|M.ulcerans_Agy99 MTVSVARLDLAAI---RADFPILQRVMRSGNQLAYLDSGATSQRPLQVLD
TH_3033|M.thermoresistible__bu MTVAPNRLDLGAI---RADFPILQRVMRGGSQLAYLDSGATAQRPVQVLD
Mvan_2736|M.vanbaalenii_PYR-1 MTASVD-LDVAAI---RADFPILKRVMRGGNTLAYLDSGATSQKPLQVLD
MAB_2746c|M.abscessus_ATCC_199 MTATVP-LDITAI---RNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLD
: .: * *****.* :*.*. *********:*:*: ***
Mflv_3674|M.gilvum_PYR-GCK AERDFLLHSNGAVHRGAHQLMEESTDAYEHGREAIASFVGADSDELVFTK
MSMEG_3125|M.smegmatis_MC2_155 AEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADIAAFVGADPDELVFTK
Mb1499|M.bovis_AF2122/97 AEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTK
Rv1464|M.tuberculosis_H37Rv AEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTK
MAV_3315|M.avium_104 AEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADIAAFVGADPDELVFTK
MLBr_00596|M.leprae_Br4923 AEREFLVTSNGAVHRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTK
MMAR_2269|M.marinum_M AEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAEPDELVFTK
MUL_1865|M.ulcerans_Agy99 AEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAEPDELVFTK
TH_3033|M.thermoresistible__bu AEREFLTTSYGAVHRGAHQLMEEATDAYEEGRADIAAFVGADPDELVFTK
Mvan_2736|M.vanbaalenii_PYR-1 AERQFLTTSYGAVHRGAHQLMEESTDAYEQGRADIAAFVGAAPGELVFTK
MAB_2746c|M.abscessus_ATCC_199 AERRFLTERNAAVHRGAHQLAEEATDAYEGARNAIARFVGVDDGEIVFTK
*** ** .********* **:***** .* ** *:*. .*:****
Mflv_3674|M.gilvum_PYR-GCK NATEAINLVAYALGDKRFENAIGPG-DVIVTTELEHHANLVPWQELVLRT
MSMEG_3125|M.smegmatis_MC2_155 NATEAINLVAYVLGDKRFERAVGPG-DVIVTTEVEHHANLVPWQELAERT
Mb1499|M.bovis_AF2122/97 NATEALNLVSYVLGDSRFERAVGPG-DVIVTTELEHHANLIPWQELARRT
Rv1464|M.tuberculosis_H37Rv NATEALNLVSYVLGDSRFERAVGPG-DVIVTTELEHHANLIPWQELARRT
MAV_3315|M.avium_104 NATEALNLVSYVVGDNRFERAVGPG-DVIVTTELEHHANLVPWQELARRT
MLBr_00596|M.leprae_Br4923 NATESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRI
MMAR_2269|M.marinum_M NATESLNLVSYVLGDSRFDRAIGPG-DVIVTTELEHHANLIPWQELARRT
MUL_1865|M.ulcerans_Agy99 NATESLNLVSYVLGDSRFDRAIGPG-DVIVTTELEHHANLIPWQELARRT
TH_3033|M.thermoresistible__bu NATEALNLVAYVLGDDRFDRAVGPG-DVIVTTELEHHANLIPWQELARRT
Mvan_2736|M.vanbaalenii_PYR-1 NATEALNLVSYVLGDDRSGFAVGPG-DVIVVTEMEHHANLIPWQELARRT
MAB_2746c|M.abscessus_ATCC_199 NATESLNLVAYTLGDNRFDRAVGPG-DEIVVTELEHHANLVPWQELCRRT
****::***:*..**.* : * * * **.**:******:***** *
Mflv_3674|M.gilvum_PYR-GCK GATLKWYGVTAEGRIDLDSLVLDERVKVVAFSHHSNVTGAIAPVSELVAR
MSMEG_3125|M.smegmatis_MC2_155 GATLKWYGVTDSGRIDLDSLELDERVKVVAFSHHSNVTGAVAPVAELVSR
Mb1499|M.bovis_AF2122/97 GATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSR
Rv1464|M.tuberculosis_H37Rv GATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSR
MAV_3315|M.avium_104 GASLRWYGVTDDGRIDLDSLQLDERVKVVAFSHHSNVTGAVAPVAELVGR
MLBr_00596|M.leprae_Br4923 GATLRWYGVTDDGQIDLDSLQLDERVKVVAFSHHSNVTGAVAPVRELVAR
MMAR_2269|M.marinum_M GATLRWYSVTDEGRIDLDSLQLDERVKVVTFTHHSNVTGALAPVAELVSR
MUL_1865|M.ulcerans_Agy99 GATLRWYSVTDEGRIDLDSLQLDERVKVVTFTHHSNVTGALAPVAELVSR
TH_3033|M.thermoresistible__bu GAELRWYSVTDDGRIDLDSLELDERVKVVAFTHHSNVTGAIAPVEELVSR
Mvan_2736|M.vanbaalenii_PYR-1 GATLRWFGLTDDGEVDLDSLKLDERVKVVSFSHHSNVTGVGVPVADMVAR
MAB_2746c|M.abscessus_ATCC_199 GATLRWFGVTDDGRIDVDSLELTEAVKVVAFTHQSNVTGAVAPVAELVRR
** *:*:.:* .*.:*:*** * : ****:*:*:*****. .** ::* *
Mflv_3674|M.gilvum_PYR-GCK ARAVGALVVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPTGIGVLYGR
MSMEG_3125|M.smegmatis_MC2_155 AKAVGALTVLDACQSAPHQPVDLHALDVDYAAFSGHKMLGPTGIGVLYGR
Mb1499|M.bovis_AF2122/97 AHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGIGVLYGR
Rv1464|M.tuberculosis_H37Rv AHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGIGVLYGR
MAV_3315|M.avium_104 ARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGVLYGR
MLBr_00596|M.leprae_Br4923 AKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNGIGVLYAR
MMAR_2269|M.marinum_M AKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPNGIGVLYGR
MUL_1865|M.ulcerans_Agy99 AKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPNGIGELYGR
TH_3033|M.thermoresistible__bu ARAVGALTVLDACQSVPHQPVDLHALGVDYAAWSGHKMLGPNGIGALYGR
Mvan_2736|M.vanbaalenii_PYR-1 AKAVGALTVLDSCQAVPHQPVDFHALDVDFAAFSGHKMLGPTGIGALYGR
MAB_2746c|M.abscessus_ATCC_199 AKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVGVLYGR
*: ***.***:**:.** .*::: *.**:**:********.*:* **.*
Mflv_3674|M.gilvum_PYR-GCK RALLNALPPFLTGGSMIETVTMEATTFAPAPQRFEAGTPMTSQVVGLGAA
MSMEG_3125|M.smegmatis_MC2_155 RGLLDAMPPFITGGSMIETVTMEKTTFAPAPQRFEAGTPMTSQVVGLAAA
Mb1499|M.bovis_AF2122/97 RELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAA
Rv1464|M.tuberculosis_H37Rv RELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAA
MAV_3315|M.avium_104 REVLSQLPPFLTGGSMIETVTMESSSYAPVPQRFEAGTPMASQVVGLAAA
MLBr_00596|M.leprae_Br4923 RELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAA
MMAR_2269|M.marinum_M RELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTSQVVGLAAA
MUL_1865|M.ulcerans_Agy99 RELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTSQVVGLAAA
TH_3033|M.thermoresistible__bu RELLEAMPPFLTGGSMIETVSMEGATYAPAPQRFEAGTPMTSQVVGLAAA
Mvan_2736|M.vanbaalenii_PYR-1 ARLLEQLPPFLTGGSMIETVTMEGATYAPPPQRFEAGTQMISQVVGLGAA
MAB_2746c|M.abscessus_ATCC_199 RALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAA
:* :***:*********:** :::** *******. * ******.**
Mflv_3674|M.gilvum_PYR-GCK ARYLDALGMPAVEEHERELVAAALAGLSEVPGVRVIGPASMDDRGSPVSF
MSMEG_3125|M.smegmatis_MC2_155 ARYLTALGMPAVEAHEAELVAAALEGLAGVPGVRIIGPTAMENRGSPVSF
Mb1499|M.bovis_AF2122/97 ARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAF
Rv1464|M.tuberculosis_H37Rv ARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAF
MAV_3315|M.avium_104 ARYLGALGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRGSPVSF
MLBr_00596|M.leprae_Br4923 ARYLDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMENRGSPVSF
MMAR_2269|M.marinum_M SRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPTSMENRGSPVSF
MUL_1865|M.ulcerans_Agy99 SRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPTSMENRGSPVSF
TH_3033|M.thermoresistible__bu ARYLSAIGMDAVQAHEAELVAAALEGLSGIEQVRIIGPTSMELRGSPVSF
Mvan_2736|M.vanbaalenii_PYR-1 TRYLGGIGMSAVEEHEHRLVTATLEGLAAIPGVRIIGPATAERR-SPVAF
MAB_2746c|M.abscessus_ATCC_199 VDYLNAVGMEAVAAHEHQLVSAALAGLAGIEGVRIIGPTDNLDRGGAVSF
** .:** .: ** **:*:: **: : **::** * ..*:*
Mflv_3674|M.gilvum_PYR-GCK VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHRRFGIAATARASFAVYNT
MSMEG_3125|M.smegmatis_MC2_155 VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHRRFGIAATARASFAVYNT
Mb1499|M.bovis_AF2122/97 VVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
Rv1464|M.tuberculosis_H37Rv VVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
MAV_3315|M.avium_104 VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
MLBr_00596|M.leprae_Br4923 VVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNT
MMAR_2269|M.marinum_M VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGVAATARASFAVYNT
MUL_1865|M.ulcerans_Agy99 VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGVAATARASFAVYNT
TH_3033|M.thermoresistible__bu VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHQRFGIAATARASFAVYNT
Mvan_2736|M.vanbaalenii_PYR-1 VVDGVHAHDVGQVLDDDGVAVRVGHHCAAPLHRRFGIAATVRASFAVYNT
MAB_2746c|M.abscessus_ATCC_199 VVDGIHAHDLGQVLDDEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNT
**:*:****:****** *********** ***::*.:**:.*********
Mflv_3674|M.gilvum_PYR-GCK VDEVDRLVAGVRRAVEFFGRE
MSMEG_3125|M.smegmatis_MC2_155 LDEVDRLVAGVKRAVEFFA--
Mb1499|M.bovis_AF2122/97 ADEVDRLVAGVRRSRHFFGRA
Rv1464|M.tuberculosis_H37Rv ADEVDRLVAGVRRSRHFFGRA
MAV_3315|M.avium_104 AEEVDRLVAGVRRALDFFGGA
MLBr_00596|M.leprae_Br4923 VDEVDRLVAGVLRALDFFGRE
MMAR_2269|M.marinum_M RDEVNRLLAGVQRSLNFFGRG
MUL_1865|M.ulcerans_Agy99 RDEVNRLLAGVQRSLNFFGRG
TH_3033|M.thermoresistible__bu LDEVDRLVAGVRRAVEFFGDR
Mvan_2736|M.vanbaalenii_PYR-1 LDEVDRLIAGVQRAIEFFGRD
MAB_2746c|M.abscessus_ATCC_199 LDEVDRLTAGVRRAQEFFS--
:**:** *** *: .**.