For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARHEAEVGGYVAAEAAAAVLDA GRAAVAALSGLPDAEVVFTTGSLHALDLLLGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDG RVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVDAAQGLGHVDCAVGADVTYA SSRKWIAGPRGVGVLAVRPELMERLRARLPAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHLACGPQ AIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRIVTTYAGVERAP LELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3700c | - | - | 100% (390) | hypothetical protein Rv3700c |
| M. tuberculosis H37Rv | Rv1464 | csd | 1e-11 | 26.95% (308) | cysteine desulfurase |
| M. tuberculosis H37Rv | Rv3025c | iscS | 5e-06 | 25.79% (221) | cysteine desulfurase IscS |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3726c | - | 0.0 | 100.00% (390) | hypothetical protein Mb3726c |
| M. gilvum PYR-GCK | Mflv_1319 | - | 1e-121 | 60.65% (371) | aminotransferase, class V |
| M. leprae Br4923 | MLBr_00842 | - | 8e-11 | 25.00% (328) | hypothetical protein MLBr_00842 |
| M. abscessus ATCC 19977 | MAB_0373 | - | 1e-106 | 55.26% (371) | aminotransferase |
| M. marinum M | MMAR_5211 | csdB | 1e-168 | 77.84% (379) | selenocysteine lyase, CsdB |
| M. avium 104 | MAV_0403 | - | 1e-164 | 76.13% (377) | pyridoxal-phosphate-dependent transferase |
| M. smegmatis MC2 155 | MSMEG_6246 | - | 1e-138 | 65.85% (366) | pyridoxal-phosphate-dependent transferase |
| M. thermoresistible (build 8) | TH_1723 | - | 1e-112 | 65.62% (320) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4284 | csdB | 1e-167 | 77.31% (379) | selenocysteine lyase, CsdB |
| M. vanbaalenii PYR-1 | Mvan_5482 | - | 1e-117 | 59.14% (372) | aminotransferase, class V |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1319|M.gilvum_PYR-GCK -MDGDAHDLEDTPLAQRWREARPPAAG---VHVDSAACSRQSVAVIEATA
Mvan_5482|M.vanbaalenii_PYR-1 -----------MTLAEQWRAARPPVAG---VHVDSAACSRQSFAVIEAAA
Rv3700c|M.tuberculosis_H37Rv MRRSGANSPAGDSLADRWRAARPPVAG---LHLDSAACSRQSFAALDAAA
Mb3726c|M.bovis_AF2122/97 MRRSGANSPAGDSLADRWRAARPPVAG---LHLDSAACSRQSFAALDAAA
MAV_0403|M.avium_104 -------MSGGTPLADTWRSARPPAAG---LHLDSAACSRQSFAVIEATA
MMAR_5211|M.marinum_M ---------MTDTLADRWRAARPPAAG---LHLDSAACSRQSLEVLQAVA
MUL_4284|M.ulcerans_Agy99 ---------MTDTLADRWRAARPPATG---LHLDSAACSRQSLEVLRAVA
MSMEG_6246|M.smegmatis_MC2_155 -----------MMLAQQWRDARPKVAG---LHLDSGACSRQSFAVIDATT
TH_1723|M.thermoresistible__bu --------------------------------------------------
MAB_0373|M.abscessus_ATCC_1997 -----------MSLRDRWRHARPPVLG---VHLDSAACSRQSIETLRAVA
MLBr_00842|M.leprae_Br4923 ----MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRLS
Mflv_1319|M.gilvum_PYR-GCK QHARHEA----EVGGYVAAEAAAPVLDAGRAAVRVLAGMPDAEVVFTTGS
Mvan_5482|M.vanbaalenii_PYR-1 QHARHEA----EVGGYVAAEAAAPALDAGRTAVRALTGMSDAVVHFTTGS
Rv3700c|M.tuberculosis_H37Rv QHARHEA----EVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGS
Mb3726c|M.bovis_AF2122/97 QHARHEA----EVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGS
MAV_0403|M.avium_104 QHARNEA----ELGGYVAAEAAAPVLDAGRFAFTALTGMTDAEAVFTTGS
MMAR_5211|M.marinum_M AHGLHEA----EVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGS
MUL_4284|M.ulcerans_Agy99 AHGLHEA----EVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGS
MSMEG_6246|M.smegmatis_MC2_155 AHARHEA----EVGGYVAAEAATPALDAGRAAVASLIGFAASDVVYTSGS
TH_1723|M.thermoresistible__bu ------------------------VLHAGRAAVAHLVGMDAADVVFTTGS
MAB_0373|M.abscessus_ATCC_1997 QHAEHEA----QIGGYVAQEAATPVLEAGRAAVRQLTGMPEAHVQFTTGA
MLBr_00842|M.leprae_Br4923 YFYAHENSNIHRAAHELAARATDAYEEARETARRFIGAAKAQEIIFVRGT
.* . * : . :. *:
Mflv_1319|M.gilvum_PYR-GCK NNALDILLADWPGE---------RTLACLQGEFGPNLAIMARHGFEVRTL
Mvan_5482|M.vanbaalenii_PYR-1 NHALDILLGDWTGA---------RTLACLPGEFGPNLAIMARHGFSIKVL
Rv3700c|M.tuberculosis_H37Rv LHALDLLLGSWPGEN--------RTLACLPGEYGPNLAVMAAHGFDVRPL
Mb3726c|M.bovis_AF2122/97 LHALDLLLGSWPGEN--------RTLACLPGEYGPNLAVMAAHGFDVRPL
MAV_0403|M.avium_104 LHALDLLLGSWPAER--------RTLACLPGEYGPNLAVMAAHGFDRWLL
MMAR_5211|M.marinum_M LHALDLLLGSWPRES--------RTLACLPGEYGPNLAVMAAHGFEVRLL
MUL_4284|M.ulcerans_Agy99 LHALDLLLGSWPRES--------RTLACLPGEYGPNLAVMAAHGFEVRLL
MSMEG_6246|M.smegmatis_MC2_155 NHAIDLLLSSWPGK---------RTLACLPGEYGPNLSAMAANGFQVRAL
TH_1723|M.thermoresistible__bu NHALDLLLSSWPQP---------RSLACLPGEFGPNLAIMAANGFEVRAL
MAB_0373|M.abscessus_ATCC_1997 ADALRTLLQAWPADSG-------RVVACLPGEFGPNLMIMNHFGFTPVWL
MLBr_00842|M.leprae_Br4923 TEAINLVAYAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTGAILKVA
.*: : * .: * *
Mflv_1319|M.gilvum_PYR-GCK PLEESGRLDVNAIGAALAHDPPALVHFTVLGSHSGVVQPARAMASACHGH
Mvan_5482|M.vanbaalenii_PYR-1 PVDEFGRLDVNAVGAALSSHQPALVHFTVLGSHSGIVQPVRDMASACRGH
Rv3700c|M.tuberculosis_H37Rv PTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTEL
Mb3726c|M.bovis_AF2122/97 PTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTEL
MAV_0403|M.avium_104 PTLADGRVALDDAALALQTDPPDLVHLTTIGSHSGVVQPVSMIARLCREL
MMAR_5211|M.marinum_M PTLDDGRLALDDAAYELEEDPPELVHLTPVASHRGTVQPLAMMAELCREL
MUL_4284|M.ulcerans_Agy99 PTLDDGRLALDDAAYELEEDPPELVHLTPVASHRGTVQPLAMMAELCREL
MSMEG_6246|M.smegmatis_MC2_155 PVDDDGRVLVDEASHELSAHPVALVHLTALASHRGIAQPAAELVEACHNA
TH_1723|M.thermoresistible__bu PVDEIGRVRPDRAEHLLRTDPPALVHLTALASHRGIAQPAARIAELCRAY
MAB_0373|M.abscessus_ATCC_1997 PVDGDGRADVDGIEVFLRHEKIDLLHLTVVGSHRGTVQPAAEVVALARAA
MLBr_00842|M.leprae_Br4923 PVDDAGNLLMSEFEDLLG-PRTKLVAATQVSNALGTVTQGEKIVELGHRY
* *. . * *: * :.. * . :.
Mflv_1319|M.gilvum_PYR-GCK GIPLIVDAAQGFAHIDVAG--IGADALYSSSRKWTAGPRGVGVLATKPGF
Mvan_5482|M.vanbaalenii_PYR-1 GIPLIVDAAQGFAHLDVAG--IGADALYSSSRKWTAGPRGVGVLASRPGL
Rv3700c|M.tuberculosis_H37Rv KLPLVVDAAQGLGHVDCA---VGADVTYASSRKWIAGPRGVGVLAVRPEL
Mb3726c|M.bovis_AF2122/97 KLPLVVDAAQGLGHVDCA---VGADVTYASSRKWIAGPRGVGVLAVRPEL
MAV_0403|M.avium_104 GLPLVVDAAQALGQVDCT---AGADVTYSSSRKWIAGPRGVGMLAVRREL
MMAR_5211|M.marinum_M GLPLVVDAAQGMGQIDCA---VGADVTYSSSRKWLAGPRGVGVLAMRPEV
MUL_4284|M.ulcerans_Agy99 GLPLVVDAAQGMGQIDCA---VGADVTYSSSRKWLAGPRGVGVLAMRPEV
MSMEG_6246|M.smegmatis_MC2_155 GIPVVIDAAQALGHLDCN---VGADAVYSSSRKWLAGPRGVGVLAVRPEL
TH_1723|M.thermoresistible__bu RVPLVIDAAQALGHLDCA---VGADAVYSSSRKWLAGPRGVGVLAIRPEL
MAB_0373|M.abscessus_ATCC_1997 GVPVVVDAAQALGHIDCT---YGADAMYAPSRKWLAGPRGVGVLAVNP-V
MLBr_00842|M.leprae_Br4923 GARVLIDGAQSIPHLPINVSELGADFFVFSG-HKIYGPTGIGVLYGCEDV
:::*.**.: :: *** .. : ** *:*:* .
Mflv_1319|M.gilvum_PYR-GCK LSEATR----------------------QRISHTEANVGMHVGFSVALGE
Mvan_5482|M.vanbaalenii_PYR-1 LADDTR----------------------IRLNHAETNVGLQVGFSVAVGE
Rv3700c|M.tuberculosis_H37Rv MERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARVGFSVALGE
Mb3726c|M.bovis_AF2122/97 MERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARVGFSVALGE
MAV_0403|M.avium_104 MENLHPRLAAPDWAP--------GSTVAQQLEFGEANIAARVGFSLALGE
MMAR_5211|M.marinum_M LDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARVGFSLAVGE
MUL_4284|M.ulcerans_Agy99 LDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARVGFSLAVGE
MSMEG_6246|M.smegmatis_MC2_155 AERLQPRIPPSDWPIP--------MSVLEKLELGEHNAAARVGFSVAVGE
TH_1723|M.thermoresistible__bu AERLCPRLPPPDWPVAR------TLRVLDRLAHGEANIAARVGFSVAVGE
MAB_0373|M.abscessus_ATCC_1997 LEHLLP----------------------QWAGHVEAHVAGWVGLSVAVGQ
MLBr_00842|M.leprae_Br4923 LTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIADAVGLGEALRY
: . **:. *:
Mflv_1319|M.gilvum_PYR-GCK HVAAGVEAVQARLREVGAATRRALADVRGWRVLEALDEPSAITTLRPPDG
Mvan_5482|M.vanbaalenii_PYR-1 YVAAGPDAVQSRLREVGAATRTALADVPGWRVVEHVTEPSAITTLQSTDG
Rv3700c|M.tuberculosis_H37Rv HLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDG
Mb3726c|M.bovis_AF2122/97 HLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDG
MAV_0403|M.avium_104 YLGYGPAAVCARLAELGGLSRGVLTDVTGWAVVEEAEEPSAITTLAPTDG
MMAR_5211|M.marinum_M HLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAITTLAPIDG
MUL_4284|M.ulcerans_Agy99 HLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAITTLAPIDG
MSMEG_6246|M.smegmatis_MC2_155 HLAAGPTAVRERLAEVGRLSRQVLAEVDGWRVVEPVDQPTAITTLESTDG
TH_1723|M.thermoresistible__bu HLAAGPAAVRARLAEVGRQTHAVLAQVPGWRVVEPPDEPTAITTLEPTAG
MAB_0373|M.abscessus_ATCC_1997 HLAAGPGQIQGALAERGRAARKILGELKDWRVIESVDEPSAITTLEPVGD
MLBr_00842|M.leprae_Br4923 VERVGVQRIASHEQALLDYATPRLADIPGVRLVGTATEKASVLSFVLAG-
* : : * :: . :: : ::: ::
Mflv_1319|M.gilvum_PYR-GCK VDAQDVRARLIAEHSIVATYLGTERAPREMN--RPALRVSPHVDVTAADL
Mvan_5482|M.vanbaalenii_PYR-1 IDPLDVRTRLIAEHQIVTTYLGLERAPREMS--HPALRVSPHVDVTDADL
Rv3700c|M.tuberculosis_H37Rv ADPAAVRAWLLSQRRIVTTYAGVERAPLELP--APVLRISPHVDNTADDL
Mb3726c|M.bovis_AF2122/97 ADPAAVRAWLLSQRRIVTTYAGVERAPLELP--APVLRISPHVDNTADDL
MAV_0403|M.avium_104 ADPRAVRDWLLAERRILTTFVGVQRAPLRLT--APVLRISPHLDTTAEDL
MMAR_5211|M.marinum_M ADPAAVREWLLEQRRILTTYAGIARAPQELT--APVLRVAPHVDTTAEDL
MUL_4284|M.ulcerans_Agy99 ADPAAEREWLLEQRRILTTYAGIARAPQELT--APVLRVAPHVDTTAEDL
MSMEG_6246|M.smegmatis_MC2_155 ADPASVRSWLIAERGIVTTACELARAPFEMR--TPVLRISPHVDVTVDEL
TH_1723|M.thermoresistible__bu ADPAAVR-RTLIERGIVTTAAEPARAPFELR--TPVLRLSPHIDTTTAEL
MAB_0373|M.abscessus_ATCC_1997 IDVIAVRARLIEEHAIVTTGAEMVRAPFEMT--KPVLRVSPHVDGTDEEL
MLBr_00842|M.leprae_Br4923 HEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEI
: : : : :. . ..:* : . * ::
Mflv_1319|M.gilvum_PYR-GCK GRVAEALAEVTPG-----
Mvan_5482|M.vanbaalenii_PYR-1 AALADALATVTR------
Rv3700c|M.tuberculosis_H37Rv DAFAEALVAATAATSGER
Mb3726c|M.bovis_AF2122/97 DAFAEALVAATAATSGER
MAV_0403|M.avium_104 ETFAEALIAATAATSA--
MMAR_5211|M.marinum_M ENFAEALIEATAATTAT-
MUL_4284|M.ulcerans_Agy99 ENFAEALIEATAATTAT-
MSMEG_6246|M.smegmatis_MC2_155 EQFAAALREAP-------
TH_1723|M.thermoresistible__bu EQFAAALADVTAALR---
MAB_0373|M.abscessus_ATCC_1997 ELLAGVLASARRV-----
MLBr_00842|M.leprae_Br4923 DVFINVVRRIAEGGTNIG
. .: