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PSTQHVTFLGVGEMGSALAHSALAAGHRVTVWNRTPSKTAPLVEAGARAVADVADALDDADGPIVVCLFD QASVHDVLDPVAHRLAGRRVVNLTTTSPEGARELGRWATGHGAEHLDGGILATPDMIGTPGSRILYSGSP GLFEDVHPLLETWGTPEYLGDDAGIASLYDLALLAGMYAMFAGFFHGAAMVAAQGVSAKDFAFRAADWLT AMAPAVTGYAEIIDGGDYSVPGQQSLEFSDISDIVEASRAQGISTELVDVVQRFIHRQIDAGHGSDGFPR IIESIRSAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6342 | - | - | 100% (290) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6341 | - | 5e-38 | 32.51% (283) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. smegmatis MC2 155 | MSMEG_5884 | - | 5e-14 | 27.54% (236) | 3-hydroxyisobutyrate dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 9e-06 | 21.92% (146) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_2480 | - | 3e-11 | 28.99% (169) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 1e-05 | 21.92% (146) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1043c | - | 2e-12 | 23.10% (277) | putative oxidoreductase |
| M. marinum M | MMAR_1077 | mmsB | 1e-06 | 26.40% (125) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_1928 | - | 2e-08 | 29.09% (165) | 6-phosphogluconate dehydrogenase |
| M. thermoresistible (build 8) | TH_2512 | - | 2e-05 | 21.29% (155) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 9e-07 | 26.40% (125) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | 5e-09 | 23.66% (279) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1043c|M.abscessus_ATCC_199 ---MSTIAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELAAVGARP
Mvan_5187|M.vanbaalenii_PYR-1 ----MKIGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALAERGATP
Mb0773c|M.bovis_AF2122/97 MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Rv0751c|M.tuberculosis_H37Rv MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKGATM
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
Mflv_2480|M.gilvum_PYR-GCK --MS-AVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIAGLGATA
MAV_1928|M.avium_104 --MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARREEARHRLESKGANL
TH_2512|M.thermoresistible__bu ----MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTPAKT
MSMEG_6342|M.smegmatis_MC2_155 MPSTQHVTFLGVGEMGSALAHSALAAGHRVTVWNRTPSKTAPLVEAGARA
: .:* * * .: *: . .
MAB_1043c|M.abscessus_ATCC_199 LDSVAQAFDS-GVVFSVLADDHAVTETLL--TPEVLAAGHGALHVNLATV
Mvan_5187|M.vanbaalenii_PYR-1 VPTVAAACEG-DVVFTMLADDTAVESVTFGDTGIVAALAPGAIHVSASTI
Mb0773c|M.bovis_AF2122/97 FRSAPEAVAEADVVITMLPTGEVVRR---CYTDVLAAARPATLFIDSSTI
Rv0751c|M.tuberculosis_H37Rv FRSAPEAVAEADVVITMLPTGEVVRR---CYTDVLAAARPATLFIDSSTI
MMAR_1077|M.marinum_M FDSAAEAVAGADVVITMLPNGAVVKR---CYAEVLPAARSGALFIDSSTI
MUL_0835|M.ulcerans_Agy99 FDSAAEAVARADVVITMLPNGAVVKR---CYAEVLPAARSGALFIDSSTI
Mflv_2480|M.gilvum_PYR-GCK VATTAEVSGGADVVIVCVFTDDQVAELCLDGD-LVTSMSAGATLVLHTTG
MAV_1928|M.avium_104 AASVADLARGSDVLISCLFSDAQLRETGLGPDGFVANAKPGAVLVSHTTG
TH_2512|M.thermoresistible__bu AGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIHSTV
MSMEG_6342|M.smegmatis_MC2_155 VADVADALDDADGPIVVCLFDQASVH---DVLDPVAHRLAGRRVVNLTTT
. . . : . :*
MAB_1043c|M.abscessus_ATCC_199 SARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQIDKA
Mvan_5187|M.vanbaalenii_PYR-1 SVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGPHDAVTSL
Mb0773c|M.bovis_AF2122/97 SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
Rv0751c|M.tuberculosis_H37Rv SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
MMAR_1077|M.marinum_M SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
MUL_0835|M.ulcerans_Agy99 SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
Mflv_2480|M.gilvum_PYR-GCK SPRTAQSVAEK--FPHVAVVDAPVSGGPHDIAAGNVTLFVGGAQDVLARI
MAV_1928|M.avium_104 NLSTLEALRDSS-ATPPVILDGPVSGTADDIAAGKLTVLLGGPTDAVAAV
TH_2512|M.thermoresistible__bu HPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVVERC
MSMEG_6342|M.smegmatis_MC2_155 SPEGARELGRWATGHGAEHLDGGILATPDMIGTPGSRILYSGSPGLFEDV
: . : . .. .* .
MAB_1043c|M.abscessus_ATCC_199 QSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAERSG
Mvan_5187|M.vanbaalenii_PYR-1 QPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAMALVSKAG
Mb0773c|M.bovis_AF2122/97 RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
Rv0751c|M.tuberculosis_H37Rv RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
MMAR_1077|M.marinum_M RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
MUL_0835|M.ulcerans_Agy99 RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
Mflv_2480|M.gilvum_PYR-GCK RPVLGAYGDPILHAG-DTGAGQLVKLVNNTMFAAQIGLVAEGVRLGARFG
MAV_1928|M.avium_104 TPILAAYADPVVATG-ELGTALALKLINNLLFAANAQLLASAAQLGTQLG
TH_2512|M.thermoresistible__bu RPVFASYADPIVHLG-PLGSGQVTKILNNLLFTANLGSALSTLELGESLG
MSMEG_6342|M.smegmatis_MC2_155 HPLLETWGTPEYLGDDAGIASLYDLALLAGMYAMFAGFFHGAAMVAAQGV
. : . . . : : :
MAB_1043c|M.abscessus_ATCC_199 VDSALLVELLTSTLFQGPAYSSYGKLIATSAYEPAG------FTTTLGRK
Mvan_5187|M.vanbaalenii_PYR-1 VDRQTYLELLTSTLFAAPAYQTYGGLLARKQFEPAG------FAAHLGLK
Mb0773c|M.bovis_AF2122/97 LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNK
Rv0751c|M.tuberculosis_H37Rv LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNK
MMAR_1077|M.marinum_M LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNK
MUL_0835|M.ulcerans_Agy99 LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNK
Mflv_2480|M.gilvum_PYR-GCK VDEGALLNALTHGSAQSRALSMIASAG-SAETFIS-------RVGEFIGK
MAV_1928|M.avium_104 IDPDVLLSTLQVCSANSNAAAHAHRIG-GMDRFTE-------LAGPFLRK
TH_2512|M.thermoresistible__bu IPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAP-------IAGALLQK
MSMEG_6342|M.smegmatis_MC2_155 SAKDFAFRAADWLTAMAPAVTGYAEIIDGGDYSVPG-------QQSLEFS
* : .
MAB_1043c|M.abscessus_ATCC_199 DVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSIADLQRARD
Mvan_5187|M.vanbaalenii_PYR-1 DVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSALGALADWEA
Mb0773c|M.bovis_AF2122/97 DLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARAD
Rv0751c|M.tuberculosis_H37Rv DLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARAD
MMAR_1077|M.marinum_M DLGLAMDAVTSTGSAAPLGSHAAEIYAKFAADHADQDFSAVIEMLRGS--
MUL_0835|M.ulcerans_Agy99 DLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHADQDFSAVIEMLRGS--
Mflv_2480|M.gilvum_PYR-GCK DVAVVRRTVADLGGTLGDLEPLVN---------AVAP-------------
MAV_1928|M.avium_104 DIAACREAAAEAGVDLGLLGTAVREGPLTLDDRAAGQN------------
TH_2512|M.thermoresistible__bu DVRHAANIAASASVPEGTVFTVADTALT-----AMGHARR----------
MSMEG_6342|M.smegmatis_MC2_155 DISDIVEASRAQGISTELVDVVQRFIHRQIDAGHGSDGFPRIIESIRSAA
*:
MAB_1043c|M.abscessus_ATCC_199 AE------
Mvan_5187|M.vanbaalenii_PYR-1 GGPRPGSG
Mb0773c|M.bovis_AF2122/97 A-------
Rv0751c|M.tuberculosis_H37Rv A-------
MMAR_1077|M.marinum_M --------
MUL_0835|M.ulcerans_Agy99 --------
Mflv_2480|M.gilvum_PYR-GCK --------
MAV_1928|M.avium_104 --------
TH_2512|M.thermoresistible__bu --------
MSMEG_6342|M.smegmatis_MC2_155 --------