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MRIGFIGLGNMGAAMAANLLAAGHDVVAYNRSPQKVAALAEQGATAAESVRDAAQADVVVTMLADDNAVE TVAFGGADPAEGLVAAMPADAIHISSSTISVDLAKRLAAAHAEARNQFVSAPVFGRPDAAAAAKLFVVAS GAPAAVEAATPVFDAIGQRTFVVGDEPSAASLVKISGNFLIASVIESLGEAMALVGKAGVDKQQYLELLT STLFDAPVYRTYGGLLVDEQFTPPGFAAPLGLKDVKLALSAGEELRVPLPVGSLLRDRFLTLLATGGGEL DWSALGALPAWEAGAPHPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5884 | - | - | 100% (299) | 3-hydroxyisobutyrate dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2170 | - | 5e-35 | 34.56% (298) | 3-hydroxyisobutyrate dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_5477 | - | 7e-32 | 33.33% (294) | 2-hydroxy-3-oxopropionate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 2e-24 | 31.03% (290) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_5012 | - | 4e-25 | 32.30% (291) | 3-hydroxyisobutyrate dehydrogenase |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 2e-24 | 31.03% (290) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | MLBr_02430 | proC | 7e-09 | 27.73% (220) | pyrroline-5-carboxylate reductase |
| M. abscessus ATCC 19977 | MAB_1043c | - | 8e-60 | 45.80% (286) | putative oxidoreductase |
| M. marinum M | MMAR_1077 | mmsB | 7e-25 | 33.46% (272) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_4419 | mmsB | 4e-27 | 33.11% (293) | 3-hydroxyisobutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_0328 | mmsB | 5e-21 | 30.63% (284) | PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 4e-26 | 32.65% (294) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | 1e-112 | 70.13% (298) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5884|M.smegmatis_MC2_155 -----MRIGFIGLGNMGAAMAANLLAAG---HDVVAYNRSPQKVAALAEQ
Mvan_5187|M.vanbaalenii_PYR-1 -----MKIGFIGLGNMGSAMAANLLSAG---HEVLAYNRSRDRVVALAER
MAB_1043c|M.abscessus_ATCC_199 ----MSTIAVIGLGAMGKAMADNLVQAG---HQVSVWNRSPAPVAELAAV
Mb0773c|M.bovis_AF2122/97 -MTT---IAFLGLGNMGAPMSANLVGAG---HVVRGFDPAPTAASGAAAH
Rv0751c|M.tuberculosis_H37Rv -MTT---IAFLGLGNMGAPMSANLVGAG---HVVRGFDPAPTAASGAAAH
MMAR_1077|M.marinum_M -MTKSCQIAFLGLGHMGAPMSANLIGAG---HTVRGFDPVPAAASAAAAK
MUL_0835|M.ulcerans_Agy99 -MTKSCQIAFLGLGHMGAPMSANLIGAG---HTVRGFDPVPAAASATAAK
MAV_4419|M.avium_104 -----MVVAFLGLGNMGAPMAANLVAAQ---HAVRGFDPVPAALSAATAS
TH_0328|M.thermoresistible__bu ---------------MGGPMAANLVAAG---HTVRGFDPVAESRAAAADK
Mflv_5012|M.gilvum_PYR-GCK -MTT---IAFLGLGNMGGPMAANLVAAG---HTVHAFDVVPELRDAAEAK
MLBr_02430|M.leprae_Br4923 MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRARYLADT
:* .: .*: * : : :
MSMEG_5884|M.smegmatis_MC2_155 GATAAESVRDAAQADVVVTMLADDNAVETVAFGGADPAEGLVAAMPADAI
Mvan_5187|M.vanbaalenii_PYR-1 GATPVPTVAAACEGDVVFTMLADDTAVESVTFG----DTGIVAALAPGAI
MAB_1043c|M.abscessus_ATCC_199 GARPLDSVAQAFDSGVVFSVLADDHAVTETLLT------PEVLAAGHGAL
Mb0773c|M.bovis_AF2122/97 GVAVFRSAPEAVAEADVVITMLPTGEVVRRCYT------DVLAAARPATL
Rv0751c|M.tuberculosis_H37Rv GVAVFRSAPEAVAEADVVITMLPTGEVVRRCYT------DVLAAARPATL
MMAR_1077|M.marinum_M GATMFDSAAEAVAGADVVITMLPNGAVVKRCYA------EVLPAARSGAL
MUL_0835|M.ulcerans_Agy99 GATMFDSAAEAVARADVVITMLPNGAVVKRCYA------EVLPAARSGAL
MAV_4419|M.avium_104 GVTGFDTATDAVTGADVVITMLPNGEVVKRCYA------EILPAARPGAL
TH_0328|M.thermoresistible__bu GVQTFDSGAEAVAGAEVVITSLPNGDIVKQCYA------EVLPAATSGAL
Mflv_5012|M.gilvum_PYR-GCK GANVFDSAAAAVADADVVVTSLPNGAVVKAVYD------EVVPAAKAGAL
MLBr_02430|M.leprae_Br4923 YSVLVTSVTDAVENAMFVVVAVKPTDVESVMGD-------LVQAAAVAND
: * .. : : *
MSMEG_5884|M.smegmatis_MC2_155 HISSSTISVDLAKRLAAAHAEARNQFVSAPVFGRPDAAAAAKLFVVASG-
Mvan_5187|M.vanbaalenii_PYR-1 HVSASTISVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAG-
MAB_1043c|M.abscessus_ATCC_199 HVNLATVSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAG-
Mb0773c|M.bovis_AF2122/97 FIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGG-
Rv0751c|M.tuberculosis_H37Rv FIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGG-
MMAR_1077|M.marinum_M FIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGG-
MUL_0835|M.ulcerans_Agy99 FIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGG-
MAV_4419|M.avium_104 FIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGG-
TH_0328|M.thermoresistible__bu FIDTSTISVDDARTVHAQATGRGFAQVDAPVSGGVKGAVAGTLAFMVGG-
Mflv_5012|M.gilvum_PYR-GCK LIDTSTISVDDARAIHEQATAGGLAQIDAPVSGGIKGATAGTLAFMVGG-
MLBr_02430|M.leprae_Br4923 SAEQVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVGAGVTVLAKGR
. ::. . . . .. : .:. *
MSMEG_5884|M.smegmatis_MC2_155 --APAAVEAATPVFDAIGQRTFVVGDEPSAASLVKISGNFLIASVIESLG
Mvan_5187|M.vanbaalenii_PYR-1 --PHDAVTSLQPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLG
MAB_1043c|M.abscessus_ATCC_199 --AAAQIDKAQSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLS
Mb0773c|M.bovis_AF2122/97 --DESTLRRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIA
Rv0751c|M.tuberculosis_H37Rv --DESTLRRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIA
MMAR_1077|M.marinum_M --DQSALAQARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIG
MUL_0835|M.ulcerans_Agy99 --DQSALAQARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIG
MAV_4419|M.avium_104 --EPEALERARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIG
TH_0328|M.thermoresistible__bu --DAEAVERARPVLEPMAGKIIHCG-ASGTGQAAKLCNNMVLAVQQIAIG
Mflv_5012|M.gilvum_PYR-GCK --DDEAFERAKPVLEPMAGKIIHCG-ASGAGQAAKLCNNMVLAVQQIAIG
MLBr_02430|M.leprae_Br4923 FVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPAYFFLLVEALV
. . :: :. .. . : ::
MSMEG_5884|M.smegmatis_MC2_155 EAMALVGKAGVDKQQYLELLTSTLFDAPVYRTYGGLLVDEQFTPP-----
Mvan_5187|M.vanbaalenii_PYR-1 EAMALVSKAGVDRQTYLELLTSTLFAAPAYQTYGGLLARKQFEPA-----
MAB_1043c|M.abscessus_ATCC_199 EAVSMAERSGVDSALLVELLTSTLFQGPAYSSYGKLIATSAYEPA-----
Mb0773c|M.bovis_AF2122/97 EAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
Rv0751c|M.tuberculosis_H37Rv EAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
MMAR_1077|M.marinum_M EAFVLAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
MUL_0835|M.ulcerans_Agy99 EAFVLAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
MAV_4419|M.avium_104 EAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
TH_0328|M.thermoresistible__bu EAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFK
Mflv_5012|M.gilvum_PYR-GCK EAFVLAEKLGLPAQSLFDVITGATGNCWSVHTNCPVPGPVPTSPANNDFK
MLBr_02430|M.leprae_Br4923 DAGVAVG---LTRQVATELAAQTMAGSAAMLLERMDQDRHSAEVAP----
:* . : :: : : .
MSMEG_5884|M.smegmatis_MC2_155 -GFAAPLGLKDVKLALSAGEELRVPLPVGSLLRDRFLTL--LATGGGELD
Mvan_5187|M.vanbaalenii_PYR-1 -GFAAHLGLKDVRLVLAAGEQLEVPLPVASLIRDRFLTL--LAGGGRDLD
MAB_1043c|M.abscessus_ATCC_199 -GFTTTLGRKDVGLALEVAADTGLRLPFGEILRTVFDEA--LAGGHANLD
Mb0773c|M.bovis_AF2122/97 PGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKF--AAD-HADLD
Rv0751c|M.tuberculosis_H37Rv PGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKF--AAD-HADLD
MMAR_1077|M.marinum_M PGFATALMNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKF--AAD-HADQD
MUL_0835|M.ulcerans_Agy99 PGFATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKF--ATD-HADQD
MAV_4419|M.avium_104 PGFAAALMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKF--AAS-HGDKD
TH_0328|M.thermoresistible__bu PGFATALMNKDLGLAMDAVKSSGASAPLGSHAAEIYAEFIRAADGNADKD
Mflv_5012|M.gilvum_PYR-GCK PGFATALMNKDLGLAMAAVESSGAKAPLGTHAAEIYSDF---AKEHAGKD
MLBr_02430|M.leprae_Br4923 --LGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAKI
: : : * . :
MSMEG_5884|M.smegmatis_MC2_155 WSALGALPAWEAGAPHPA--
Mvan_5187|M.vanbaalenii_PYR-1 WSALGALADWEAGGPRPGSG
MAB_1043c|M.abscessus_ATCC_199 WSSIADLQRARDAE------
Mb0773c|M.bovis_AF2122/97 FSAVIHTLRARADA------
Rv0751c|M.tuberculosis_H37Rv FSAVIHTLRARADA------
MMAR_1077|M.marinum_M FSAVIEMLRGS---------
MUL_0835|M.ulcerans_Agy99 FSAVIEMLRGS---------
MAV_4419|M.avium_104 FSAVIEMLRGAC--------
TH_0328|M.thermoresistible__bu FSAVIELLRNS---------
Mflv_5012|M.gilvum_PYR-GCK FSAIIEALRD----------
MLBr_02430|M.leprae_Br4923 RSEQLRITSE----------
*