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MKIGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALAERGATPVPTVAAACEGDVVFTMLADDTAVE SVTFGDTGIVAALAPGAIHVSASTISVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGPHD AVTSLQPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAMALVSKAGVDRQTYLELLTSTLF AAPAYQTYGGLLARKQFEPAGFAAHLGLKDVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSA LGALADWEAGGPRPGSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | - | 100% (297) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_1360 | - | 8e-20 | 30.83% (253) | 3-hydroxyisobutyrate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4822 | - | 2e-19 | 28.63% (262) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 4e-21 | 28.22% (287) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_5012 | - | 8e-21 | 30.19% (265) | 3-hydroxyisobutyrate dehydrogenase |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 4e-21 | 28.22% (287) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | MLBr_02430 | proC | 4e-09 | 28.05% (221) | pyrroline-5-carboxylate reductase |
| M. abscessus ATCC 19977 | MAB_1043c | - | 3e-63 | 46.81% (282) | putative oxidoreductase |
| M. marinum M | MMAR_4926 | - | 2e-23 | 30.04% (273) | dehydrogenase/reductase |
| M. avium 104 | MAV_0931 | - | 2e-25 | 29.33% (283) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5884 | - | 1e-112 | 70.13% (298) | 3-hydroxyisobutyrate dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_1259 | - | 6e-19 | 27.57% (272) | putative oxidoreductase |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-20 | 28.12% (288) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5187|M.vanbaalenii_PYR-1 -----MKIGFIGLGNMGSAMAANLLSAG---HEVLAYNRSRDRVVALAER
MSMEG_5884|M.smegmatis_MC2_155 -----MRIGFIGLGNMGAAMAANLLAAG---HDVVAYNRSPQKVAALAEQ
MAB_1043c|M.abscessus_ATCC_199 ----MSTIAVIGLGAMGKAMADNLVQAG---HQVSVWNRSPAPVAELAAV
Mb0773c|M.bovis_AF2122/97 -MTT---IAFLGLGNMGAPMSANLVGAG---HVVRGFDPAPTAASGAAAH
Rv0751c|M.tuberculosis_H37Rv -MTT---IAFLGLGNMGAPMSANLVGAG---HVVRGFDPAPTAASGAAAH
MUL_0835|M.ulcerans_Agy99 -MTKSCQIAFLGLGHMGAPMSANLIGAG---HTVRGFDPVPAAASATAAK
Mflv_5012|M.gilvum_PYR-GCK -MTT---IAFLGLGNMGGPMAANLVAAG---HTVHAFDVVPELRDAAEAK
MMAR_4926|M.marinum_M -MSEHPKLGYIGLGNQGAPMAKRLLDWP---GGLVVYDVRAEAMTPLAEA
TH_1259|M.thermoresistible__bu -MSDL-KLGYIGLGNMGAPMAKRLVDWP---GGLIVYDVRTEAMTPLAEV
MAV_0931|M.avium_104 -----MTIGFIGLGNMGFPMASRLIREQ---HDVVAFDSRREALERLVAA
MLBr_02430|M.leprae_Br4923 MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRARYLADT
:. :* * * .: *: : :
Mvan_5187|M.vanbaalenii_PYR-1 GATPVPTVAAACEGDVVFTMLADDTAVESVTFG----DTGIVAALAPGAI
MSMEG_5884|M.smegmatis_MC2_155 GATAAESVRDAAQADVVVTMLADDNAVETVAFGGADPAEGLVAAMPADAI
MAB_1043c|M.abscessus_ATCC_199 GARPLDSVAQAFDSGVVFSVLADDHAVTETLLT------PEVLAAGHGAL
Mb0773c|M.bovis_AF2122/97 GVAVFRSAPEAVAEADVVITMLPTGEVVRRCY------TDVLAAARPATL
Rv0751c|M.tuberculosis_H37Rv GVAVFRSAPEAVAEADVVITMLPTGEVVRRCY------TDVLAAARPATL
MUL_0835|M.ulcerans_Agy99 GATMFDSAAEAVARADVVITMLPNGAVVKRCY------AEVLPAARSGAL
Mflv_5012|M.gilvum_PYR-GCK GANVFDSAAAAVADADVVVTSLPNGAVVKAVY------DEVVPAAKAGAL
MMAR_4926|M.marinum_M GASAAASVAEVAGADIISVTVLNDAQVREVITG----ANGLAAHARAGTI
TH_1259|M.thermoresistible__bu GANLADSVADVAKADIISVTVLDDEQVRAVVD-------ELAAGAGPGTV
MAV_0931|M.avium_104 GARPASSPKEVADGAETVLASLPTPGASLEVATG----TAGVIEGARVKR
MLBr_02430|M.leprae_Br4923 YSVLVTSVTDAVENAMFVVVAVKPTDVESVMG-------DLVQAAAVAND
: . .
Mvan_5187|M.vanbaalenii_PYR-1 HVSASTISVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGP
MSMEG_5884|M.smegmatis_MC2_155 HISSSTISVDLAKRLAAAHAEARNQFVSAPVFGRPDAAAAAKLFVVASGA
MAB_1043c|M.abscessus_ATCC_199 HVNLATVSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGA
Mb0773c|M.bovis_AF2122/97 FIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGD
Rv0751c|M.tuberculosis_H37Rv FIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGD
MUL_0835|M.ulcerans_Agy99 FIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGD
Mflv_5012|M.gilvum_PYR-GCK LIDTSTISVDDARAIHEQATAGGLAQIDAPVSGGIKGATAGTLAFMVGGD
MMAR_4926|M.marinum_M IAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAG
TH_1259|M.thermoresistible__bu IAIHSTIRPETAVELAEQLRPKDIHLVDAPVSGGGGAAEKGELAVMVGAD
MAV_0931|M.avium_104 YVDLSTVGSRTAMRIHDLLARRNIVAIDSPVSGGVGGAEQGTLALMVSGP
MLBr_02430|M.leprae_Br4923 SAEQVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVGAGVTVLAKGR
: . . . : :. .
Mvan_5187|M.vanbaalenii_PYR-1 HDAVTSLQPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAM
MSMEG_5884|M.smegmatis_MC2_155 PAAVEAATPVFDAIGQRTFVVGDEPSAASLVKISGNFLIASVIESLGEAM
MAB_1043c|M.abscessus_ATCC_199 AAQIDKAQSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAV
Mb0773c|M.bovis_AF2122/97 ESTLRRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAF
Rv0751c|M.tuberculosis_H37Rv ESTLRRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAF
MUL_0835|M.ulcerans_Agy99 QSALAQARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAF
Mflv_5012|M.gilvum_PYR-GCK DEAFERAKPVLEPMAGKIIHCG-ASGAGQAAKLCNNMVLAVQQIAIGEAF
MMAR_4926|M.marinum_M DDVFARVKEPFSCWASLVVHAG-PPGAGTRMKLARNMLTFTIYAAVGEAW
TH_1259|M.thermoresistible__bu RDVYERIKPAFKRFASLVVHAG-EPGAGTRMKLARNMLTFTSYVAACEAM
MAV_0931|M.avium_104 RGEFDVIRTTLEALG-RPFYVGDKPGAAQTMKLANNILAANVLAATAEVV
MLBr_02430|M.leprae_Br4923 FVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPAYFFLLVEALV
: . .
Mvan_5187|M.vanbaalenii_PYR-1 ALVSKAGVDRQTYLELLTSTLFAAPAYQTYGGLLARKQFEPAG-------
MSMEG_5884|M.smegmatis_MC2_155 ALVGKAGVDKQQYLELLTSTLFDAPVYRTYGGLLVDEQFTPPG-------
MAB_1043c|M.abscessus_ATCC_199 SMAERSGVDSALLVELLTSTLFQGPAYSSYGKLIATSAYEPAG-------
Mb0773c|M.bovis_AF2122/97 VLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-
Rv0751c|M.tuberculosis_H37Rv VLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-
MUL_0835|M.ulcerans_Agy99 VLAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-
Mflv_5012|M.gilvum_PYR-GCK VLAEKLGLPAQSLFDVITGATGNCWSVHTNCPVPGPVPTSPANNDFKPG-
MMAR_4926|M.marinum_M KLAEASGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFV
TH_1259|M.thermoresistible__bu ELAEAAGLSLQALGRVVRHSDAQSGGPGAIIVREDMRDLEPDHWLYEAFT
MAV_0931|M.avium_104 VMGVKAGLDPAVMIEVLNAGSGATSASRDKFPRAILPRSFDYG-------
MLBr_02430|M.leprae_Br4923 DAGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAEVAP-------
*: :
Mvan_5187|M.vanbaalenii_PYR-1 FAAHLGLKDVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSAL
MSMEG_5884|M.smegmatis_MC2_155 FAAPLGLKDVKLALSAGEELRVPLPVGSLLRDRFLTLLATGGGELDWSAL
MAB_1043c|M.abscessus_ATCC_199 FTTTLGRKDVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSI
Mb0773c|M.bovis_AF2122/97 FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVI
Rv0751c|M.tuberculosis_H37Rv FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVI
MUL_0835|M.ulcerans_Agy99 FATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHADQDFSAVI
Mflv_5012|M.gilvum_PYR-GCK FATALMNKDLGLAMAAVESSGAKAPLGTHAAEIYSDFAKEHAGKDFSAII
MMAR_4926|M.marinum_M HARDLGEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA---
TH_1259|M.thermoresistible__bu HTRGLGEKDLSLALDLGRQTGVDLPLARIALQNLAAALGVPHTKE-----
MAV_0931|M.avium_104 FATGLMVKDVRLYLDEAKALGVPAEVAETIARLWETAAREEGPEADFTTV
MLBr_02430|M.leprae_Br4923 LGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAKIRS
: *
Mvan_5187|M.vanbaalenii_PYR-1 GALADWEAGGPRPGSG-
MSMEG_5884|M.smegmatis_MC2_155 GALPAWEAGAPHPA---
MAB_1043c|M.abscessus_ATCC_199 ADLQRARDAE-------
Mb0773c|M.bovis_AF2122/97 HTLRARADA--------
Rv0751c|M.tuberculosis_H37Rv HTLRARADA--------
MUL_0835|M.ulcerans_Agy99 EMLRGS-----------
Mflv_5012|M.gilvum_PYR-GCK EALRD------------
MMAR_4926|M.marinum_M -----------------
TH_1259|M.thermoresistible__bu -----------------
MAV_0931|M.avium_104 IKPLERAAGVTVGRSAR
MLBr_02430|M.leprae_Br4923 EQLRITSE---------