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STIAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELAAVGARPLDSVAQAFDSGVVFSVLADDHAVT ETLLTPEVLAAGHGALHVNLATVSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQI DKAQSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAERSGVDSALLVELLTSTLFQG PAYSSYGKLIATSAYEPAGFTTTLGRKDVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSIA DLQRARDAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1043c | - | - | 100% (290) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1186c | - | 4e-19 | 28.72% (296) | 3-hydroxyisobutyrate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4486 | - | 6e-18 | 26.99% (289) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 6e-26 | 28.86% (298) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_5012 | - | 3e-24 | 29.49% (295) | 3-hydroxyisobutyrate dehydrogenase |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 6e-26 | 28.86% (298) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1077 | mmsB | 5e-28 | 29.69% (293) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_4419 | mmsB | 1e-23 | 26.96% (293) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5884 | - | 1e-59 | 45.80% (286) | 3-hydroxyisobutyrate dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_0328 | mmsB | 5e-21 | 30.74% (296) | PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 3e-27 | 29.35% (293) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | 4e-63 | 46.81% (282) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKGATM
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
MAV_4419|M.avium_104 ----MVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTG
Mb0773c|M.bovis_AF2122/97 ---MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Rv0751c|M.tuberculosis_H37Rv ---MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Mflv_5012|M.gilvum_PYR-GCK ---MTTIAFLGLGNMGGPMAANLVAAGHTVHAFDVVPELRDAAEAKGANV
TH_0328|M.thermoresistible__bu --------------MGGPMAANLVAAGHTVRGFDPVAESRAAAADKGVQT
MSMEG_5884|M.smegmatis_MC2_155 ----MRIGFIGLGNMGAAMAANLLAAGHDVVAYNRSPQKVAALAEQGATA
Mvan_5187|M.vanbaalenii_PYR-1 ----MKIGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALAERGATP
MAB_1043c|M.abscessus_ATCC_199 ---MSTIAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELAAVGARP
** .*: **: * * * :: *.
MMAR_1077|M.marinum_M FDSAAEAVAGADVVITMLPNGAVVKRCYA------EVLPAARSGALFIDS
MUL_0835|M.ulcerans_Agy99 FDSAAEAVARADVVITMLPNGAVVKRCYA------EVLPAARSGALFIDS
MAV_4419|M.avium_104 FDTATDAVTGADVVITMLPNGEVVKRCYA------EILPAARPGALFIDS
Mb0773c|M.bovis_AF2122/97 FRSAPEAVAEADVVITMLPTGEVVRRCYT------DVLAAARPATLFIDS
Rv0751c|M.tuberculosis_H37Rv FRSAPEAVAEADVVITMLPTGEVVRRCYT------DVLAAARPATLFIDS
Mflv_5012|M.gilvum_PYR-GCK FDSAAAAVADADVVVTSLPNGAVVKAVYD------EVVPAAKAGALLIDT
TH_0328|M.thermoresistible__bu FDSGAEAVAGAEVVITSLPNGDIVKQCYA------EVLPAATSGALFIDT
MSMEG_5884|M.smegmatis_MC2_155 AESVRDAAQADVVVTMLADDNAVETVAFGGADPAEGLVAAMPADAIHISS
Mvan_5187|M.vanbaalenii_PYR-1 VPTVAAACEGDVVFTMLADDTAVESVTFG----DTGIVAALAPGAIHVSA
MAB_1043c|M.abscessus_ATCC_199 LDSVAQAFDSGVVFSVLADDHAVTETLLT------PEVLAAGHGALHVNL
: * *. : : * :: :.
MMAR_1077|M.marinum_M STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
MUL_0835|M.ulcerans_Agy99 STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
MAV_4419|M.avium_104 STISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGGEPEAL
Mb0773c|M.bovis_AF2122/97 STISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTL
Rv0751c|M.tuberculosis_H37Rv STISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTL
Mflv_5012|M.gilvum_PYR-GCK STISVDDARAIHEQATAGGLAQIDAPVSGGIKGATAGTLAFMVGGDDEAF
TH_0328|M.thermoresistible__bu STISVDDARTVHAQATGRGFAQVDAPVSGGVKGAVAGTLAFMVGGDAEAV
MSMEG_5884|M.smegmatis_MC2_155 STISVDLAKRLAAAHAEARNQFVSAPVFGRPDAAAAAKLFVVASGAPAAV
Mvan_5187|M.vanbaalenii_PYR-1 STISVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGPHDAV
MAB_1043c|M.abscessus_ATCC_199 ATVSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQI
:*:*. : : *** * * *. * .:..* .
MMAR_1077|M.marinum_M AQARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAE
MUL_0835|M.ulcerans_Agy99 AQARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAE
MAV_4419|M.avium_104 ERARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFILAE
Mb0773c|M.bovis_AF2122/97 RRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAE
Rv0751c|M.tuberculosis_H37Rv RRARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAE
Mflv_5012|M.gilvum_PYR-GCK ERAKPVLEPMAGKIIHCG-ASGAGQAAKLCNNMVLAVQQIAIGEAFVLAE
TH_0328|M.thermoresistible__bu ERARPVLEPMAGKIIHCG-ASGTGQAAKLCNNMVLAVQQIAIGEAFVLAE
MSMEG_5884|M.smegmatis_MC2_155 EAATPVFDAIGQRTFVVGDEPSAASLVKISGNFLIASVIESLGEAMALVG
Mvan_5187|M.vanbaalenii_PYR-1 TSLQPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAMALVS
MAB_1043c|M.abscessus_ATCC_199 DKAQSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAE
. :: :. : . . .. .*: .*:::* ::.**. :.
MMAR_1077|M.marinum_M NLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
MUL_0835|M.ulcerans_Agy99 NLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
MAV_4419|M.avium_104 KLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFAAAL
Mb0773c|M.bovis_AF2122/97 KLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
Rv0751c|M.tuberculosis_H37Rv KLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
Mflv_5012|M.gilvum_PYR-GCK KLGLPAQSLFDVITGATGNCWSVHTNCPVPGPVPTSPANNDFKPGFATAL
TH_0328|M.thermoresistible__bu KLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
MSMEG_5884|M.smegmatis_MC2_155 KAGVDKQQYLELLTSTLFDAPVYRTYGGLLVDEQFTPP------GFAAPL
Mvan_5187|M.vanbaalenii_PYR-1 KAGVDRQTYLELLTSTLFAAPAYQTYGGLLARKQFEPA------GFAAHL
MAB_1043c|M.abscessus_ATCC_199 RSGVDSALLVELLTSTLFQGPAYSSYGKLIATSAYEPA------GFTTTL
. *: .:::*.: : : *. **:: *
MMAR_1077|M.marinum_M MNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKFAADHAD---QDFSAVIEM
MUL_0835|M.ulcerans_Agy99 MNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHAD---QDFSAVIEM
MAV_4419|M.avium_104 MNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGD---KDFSAVIEM
Mb0773c|M.bovis_AF2122/97 MNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHAD---LDFSAVIHT
Rv0751c|M.tuberculosis_H37Rv MNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHAD---LDFSAVIHT
Mflv_5012|M.gilvum_PYR-GCK MNKDLGLAMAAVESSGAKAPLGTHAAEIYSDFAKEHAG---KDFSAIIEA
TH_0328|M.thermoresistible__bu MNKDLGLAMDAVKSSGASAPLGSHAAEIYAEFIRAADGNADKDFSAVIEL
MSMEG_5884|M.smegmatis_MC2_155 GLKDVKLALSAGEELRVPLPVGSLLRDRFLTLLATGGG--ELDWSALGAL
Mvan_5187|M.vanbaalenii_PYR-1 GLKDVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGR--DLDWSALGAL
MAB_1043c|M.abscessus_ATCC_199 GRKDVGLALEVAADTGLRLPFGEILRTVFDEALAGGHA--NLDWSSIADL
**: *.: . *.. : *:*::
MMAR_1077|M.marinum_M LRGS---------
MUL_0835|M.ulcerans_Agy99 LRGS---------
MAV_4419|M.avium_104 LRGAC--------
Mb0773c|M.bovis_AF2122/97 LRARADA------
Rv0751c|M.tuberculosis_H37Rv LRARADA------
Mflv_5012|M.gilvum_PYR-GCK LRD----------
TH_0328|M.thermoresistible__bu LRNS---------
MSMEG_5884|M.smegmatis_MC2_155 PAWEAGAPHPA--
Mvan_5187|M.vanbaalenii_PYR-1 ADWEAGGPRPGSG
MAB_1043c|M.abscessus_ATCC_199 QRARDAE------