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TTTPTVTVLGLGPMGQALSRALLDAGHTVTVWNRTESKAQALRDRGALSAPTPAAAIAASDLALVNVVDH DAVDAILTAAGDAPAGRTVIGLSSDTPDRARRTAKLVGNVGGRYLDGAIMTPIDTIGTRGASILFAGPQA LFDEHRGVLDTLGQLTWVGEDHGRAAAFDMALLDLFWTSVGGFGHALMVARANGIEPSELMPHAHGIVGI LSPIFTEVAQRVEDDRHSDASASVSSVASSVRHLIAASREAGVDAGLLEAFRGYVDATVAAGHGDDEISR IASEMTTLTRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6341 | - | - | 100% (292) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. smegmatis MC2 155 | MSMEG_6342 | - | 5e-38 | 32.51% (283) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5884 | - | 1e-12 | 21.48% (284) | 3-hydroxyisobutyrate dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1911 | - | 8e-08 | 21.24% (193) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1043c | - | 3e-15 | 23.67% (283) | putative oxidoreductase |
| M. marinum M | MMAR_1077 | mmsB | 5e-07 | 24.06% (212) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_0917 | - | 9e-08 | 23.38% (201) | 6-phosphogluconate dehydrogenase |
| M. thermoresistible (build 8) | TH_2512 | - | 4e-07 | 33.33% (105) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 4e-07 | 24.06% (212) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | 7e-10 | 25.77% (163) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0917|M.avium_104 ----MRVGFIGLGSQGGPMARRIVEGGYPTTLWARRPATLEVFADTDAKV
TH_2512|M.thermoresistible__bu ----MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTPAKT
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKGATM
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
Mflv_1911|M.gilvum_PYR-GCK --MDTALGFLGLGNMGFPMMGRLLSAGHPVVVFDTDPAAVSRATALGADA
MAB_1043c|M.abscessus_ATCC_199 ---MSTIAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELAAVGARP
Mvan_5187|M.vanbaalenii_PYR-1 ----MKIGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALAERGATP
MSMEG_6341|M.smegmatis_MC2_155 MTTTPTVTVLGLGPMGQALSRALLDAGHTVTVWNRTESKAQALRDRGALS
: .:*** * .: : *: . : *
MAV_0917|M.avium_104 AGSPAELAAASDLVCLCVIGDADIDELTDGEHGLLSAMQPGGVIAVHSTV
TH_2512|M.thermoresistible__bu AGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIHSTV
MMAR_1077|M.marinum_M FDSAAEAVAG-ADVVITMLPNGAVVKRCY--AEVLPAARSGALFIDSSTI
MUL_0835|M.ulcerans_Agy99 FDSAAEAVAR-ADVVITMLPNGAVVKRCY--AEVLPAARSGALFIDSSTI
Mflv_1911|M.gilvum_PYR-GCK AASVREVADR-AGTVLASLPTPQVSNSVA--EEVAGGSR-VRRFVDLSTV
MAB_1043c|M.abscessus_ATCC_199 LDSVAQAFDS-GVVFSVLADDHAVTETLL--TPEVLAAGHGALHVNLATV
Mvan_5187|M.vanbaalenii_PYR-1 VPTVAAACEG-DVVFTMLADDTAVESVTFGDTGIVAALAPGAIHVSASTI
MSMEG_6341|M.smegmatis_MC2_155 APTPAAAIAASDLALVNVVDHDAVDAILT----AAGDAPAGRTVIGLSSD
: . : ::
MAV_0917|M.avium_104 HPDTCRKLAKRAAALGVSVVDAPVSGGGGAAAEGRLLVMAGGDADVVERC
TH_2512|M.thermoresistible__bu HPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVVERC
MMAR_1077|M.marinum_M SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
MUL_0835|M.ulcerans_Agy99 SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
Mflv_1911|M.gilvum_PYR-GCK GQHAAQRNSELLGPHGIAALDSPVSGGVHGAEAGTLAVMVSGPRHEFDAL
MAB_1043c|M.abscessus_ATCC_199 SARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQIDKA
Mvan_5187|M.vanbaalenii_PYR-1 SVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGPHDAVTSL
MSMEG_6341|M.smegmatis_MC2_155 TPDRARRTAKLVGNVGGRYLDGAIMTPIDTIGTRGASILFAGPQALFDEH
. . : ..: .: .* .
MAV_0917|M.avium_104 RPVFETYADPVVHLGELG-SGQTTKLLNNLLFTANLATAATALSLAEQLG
TH_2512|M.thermoresistible__bu RPVFASYADPIVHLGPLG-SGQVTKILNNLLFTANLGSALSTLELGESLG
MMAR_1077|M.marinum_M RPVLEPMAGKIIHCGAAG-AGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
MUL_0835|M.ulcerans_Agy99 RPVLEPMAGKIIHCGAAG-AGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
Mflv_1911|M.gilvum_PYR-GCK EPVWSAIGRATFVSEKAG-AAQTMKLINNLIAATTLAVTAEAMVMGAKAG
MAB_1043c|M.abscessus_ATCC_199 QSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAERSG
Mvan_5187|M.vanbaalenii_PYR-1 QPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAMALVSKAG
MSMEG_6341|M.smegmatis_MC2_155 RGVLDTLGQLTWVGEDHG-RAAAFDMALLDLFWTSVGGFGHALMVARANG
. . . .: : :. : *
MAV_0917|M.avium_104 VRPERLTEVVSRSSGNSFALNA--------LGGIGG-LDQLAGVAGALLR
TH_2512|M.thermoresistible__bu IPRVKLAEVLNGGSATSKALGS--------ISVFGGTVEGLAPIAGALLQ
MMAR_1077|M.marinum_M LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATALMN
MUL_0835|M.ulcerans_Agy99 LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATALMN
Mflv_1911|M.gilvum_PYR-GCK LDSQVMLDVLNAGSGGTHASRD------KFPRAVLPRTFDYG-FATGLMT
MAB_1043c|M.abscessus_ATCC_199 VDSALLVELLTSTLFQGPAYSS-------YGKLIATSAYEPAGFTTTLGR
Mvan_5187|M.vanbaalenii_PYR-1 VDRQTYLELLTSTLFAAPAYQT-------YGGLLARKQFEPAGFAAHLGL
MSMEG_6341|M.smegmatis_MC2_155 IEPSELMPHAHGIVGILSPIFT------EVAQRVEDDRHSDASASVSSVA
: . . :
MAV_0917|M.avium_104 KDVRLVVDLAEQAGAAGGAVLDAADAALALMGHPR---------------
TH_2512|M.thermoresistible__bu KDVRHAANIAASASVPEGTVFTVADTALTAMGHARR--------------
MMAR_1077|M.marinum_M KDLGLAMDAVTSTGSAAPLGSHAAEIYAKFAADH-ADQDFSAVIEMLRGS
MUL_0835|M.ulcerans_Agy99 KDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDH-ADQDFSAVIEMLRGS
Mflv_1911|M.gilvum_PYR-GCK KDVLLYLSETQAMGSPSALAEVVARVWRDTQDEEGPASDFTSVVKPMERR
MAB_1043c|M.abscessus_ATCC_199 KDVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSIADLQRAR
Mvan_5187|M.vanbaalenii_PYR-1 KDVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSALGALADWE
MSMEG_6341|M.smegmatis_MC2_155 SSVRHLIAASREAGVDAGLLEAFRGYVDATVAAGHGDDEISRIASEMTTL
..:
MAV_0917|M.avium_104 ---------
TH_2512|M.thermoresistible__bu ---------
MMAR_1077|M.marinum_M ---------
MUL_0835|M.ulcerans_Agy99 ---------
Mflv_1911|M.gilvum_PYR-GCK AGVTLGPQ-
MAB_1043c|M.abscessus_ATCC_199 DAE------
Mvan_5187|M.vanbaalenii_PYR-1 AGGPRPGSG
MSMEG_6341|M.smegmatis_MC2_155 TRG------