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FSLSRLSCFIAVAEELHFGRAAERLHMTQPPLSRQIQQLENELGVHLIDRTTRSVTLTPAGVAFLPDARR ILQLAEGAALNVKRVPAGDLGTVVIGFTAASAHAVLPRLLDAAREQLPDVTLDLREMVTAAQIEGLMTGE LDLGMARPPLKRPGLVSRPLLHEQLIAALPASHPLVDVGRQLTLNDLDGQDMIMYSPVQARYFNELLIST FTIAGATPRYVQYVTQVHTMLVLVRSGIGIALVPASAATLHPEGVVFRSIGAFRERPVELDAVWRGDSTN PALLRLLRDVLPPREWTTDELVGEQIAY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6125 | - | - | 100% (309) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 8e-50 | 39.37% (287) | HTH-type transcriptional regulator AlsR |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 8e-48 | 39.50% (281) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 3e-13 | 30.20% (202) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 2e-49 | 40.34% (290) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 3e-13 | 30.20% (202) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 5e-21 | 31.30% (262) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0023 | - | 3e-31 | 31.06% (293) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 7e-22 | 28.00% (250) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 8e-23 | 28.98% (283) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-24 | 29.80% (245) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 3e-22 | 28.00% (250) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 1e-153 | 89.63% (299) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6125|M.smegmatis_MC2_155 --------------MFSLSRLSCFIAVAEELHFGRAAERLHMTQPPLSRQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
MAB_0023|M.abscessus_ATCC_1997 -------------MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQ
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: . ::.: . ** * : * .::
MSMEG_6125|M.smegmatis_MC2_155 IQQLENELGVHLIDRTTRSVTLTPAGVAFLPDARRILQLAEGAALNVKRV
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
MAB_0023|M.abscessus_ATCC_1997 IRELERRLGTSLFTR--RPVSLTAAGAVFVEHAREVLSSVDNLVTATRST
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :. * .
MSMEG_6125|M.smegmatis_MC2_155 PAGDLGTVVIGFTAASAHAVLPRLLDAAREQLP----DVTLDLR-EMVTA
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLP----DVKLDLR-EMVTA
MAB_0023|M.abscessus_ATCC_1997 ATGEAGELAVGYILSGAYDTIPRLREASTAAYP----GLRLDSR-ELWPA
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALP----AVDLRVRGEMLAP
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP----TLTLRVV-EDQTE
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSP----RVTFTLE-EGAAE
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP----STSFTLR-QLYPD
. : .
MSMEG_6125|M.smegmatis_MC2_155 AQIEGLMTGELDLGMARPPLKRPGLVSRPLLHEQLIAALPASHPLVDVGR
Mvan_1027|M.vanbaalenii_PYR-1 AQIEGLMTGELDLGMARPPLKRPGLVSRPLLHEQLLAALPEGHPLADMTR
MAB_0023|M.abscessus_ATCC_1997 QLDAGLLDGELDLVIAHTMPVRPEFRRERLRTDPLVAVTRPKNPAASGAG
Mflv_1346|M.gilvum_PYR-GCK EQLAALHAKDIDLALMRPPVDDPALTAVSLRRDRLLVALPAGHRCADRD-
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRHG
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRHG
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVETAGIAEIPIYDEDFVLALPPGHPLSGKRR
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
MAV_1538|M.avium_104 SIADRVRSGGVDIGVVSPRPVERTLAWRSLFRQRLGVAVPDGHRFARGAA
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDSHPLAARES
: : . : : . . . :
MSMEG_6125|M.smegmatis_MC2_155 QLTL-NDLDGQDMIMYSPVQ--ARYFNELLISTFTIAGATPRYVQYVTQV
Mvan_1027|M.vanbaalenii_PYR-1 ELTL-IDLDGQDFVMYSPVQ--ARYFNELLISTFTIAGTTPRYVQYVTQV
MAB_0023|M.abscessus_ATCC_1997 PVRLGEAFDGQTFVFYDPKY--APEHYAVLTKALDAGGGSHAVRLDMTPG
Mflv_1346|M.gilvum_PYR-GCK EVSL-ADLRDEDFISHAGGG--RSRMSALLAALCADAGFSPRIRDEVDET
MMAR_2756|M.marinum_M VPVA--ALSELPLLLLDEG---HCLRDQALDVCQNAGVRAELADTRAASL
MUL_2998|M.ulcerans_Agy99 VPVA--ALSELPLLLLDEG---HCLRDQALDVCQNAGVRAEHADTRADSL
MLBr_02041|M.leprae_Br4923 VPTT--ALAQLPLLLLDEG---HCLRDQTLDICRKSGVQAELANTRAASL
Mb2303c|M.bovis_AF2122/97 VVSA-RELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVLELSSA
Rv2282c|M.tuberculosis_H37Rv VVSA-RELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVLELSSA
MAV_1538|M.avium_104 VSMV--DLADEPFVTMHPGFG----MRRLLDELCAAAQFRPRVALQAPNL
TH_3504|M.thermoresistible__bu VDIT--ELAREQVALWAPPG--TSYYSDFLMGACRRAGFEPDYVVSRVQG
: . *
MSMEG_6125|M.smegmatis_MC2_155 HTMLVLVRSGIGIALVPASAATLHPEGVVFRSIGAFRERP-VELDAVWRG
Mvan_1027|M.vanbaalenii_PYR-1 HTMLVLVRSGIGIALVPASAATLHPEGVVFRTIGAFRERP-VELDAVWRG
MAB_0023|M.abscessus_ATCC_1997 LRNIVLP-DDYSFTLIPESMKPFLPRTVREVPLDTSALPA-LEVELVWHR
Mflv_1346|M.gilvum_PYR-GCK STLVTLVAGGLGVALVPEPTAALEIGGVTYRPLAAKAGAT-IELLAVYRS
MMAR_2756|M.marinum_M ATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIGLVYRA
MUL_2998|M.ulcerans_Agy99 ATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLVYRA
MLBr_02041|M.leprae_Br4923 ATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRS
Mb2303c|M.bovis_AF2122/97 AAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWVG
Rv2282c|M.tuberculosis_H37Rv AAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWVG
MAV_1538|M.avium_104 TTAASLVAAGLGISLVPIDGSSYPSG---VSVKPLADADAYRDVGMIWDS
TH_3504|M.thermoresistible__bu AATVAAPLTTGGIAFVTAAAGPTMNGRVQVVDLTPPLLVP---VQALWQR
. : :. . : :
MSMEG_6125|M.smegmatis_MC2_155 DSTNPALLR---LLRDVLPPREWTTDELVGEQIAY
Mvan_1027|M.vanbaalenii_PYR-1 DSTNPALLR---VLKDVLPQQEWTT----------
MAB_0023|M.abscessus_ATCC_1997 ERESPGLLRFLAIAREVSAGRDWLTASYT------
Mflv_1346|M.gilvum_PYR-GCK ADASPLTAKVVDVLRATV-----------------
MMAR_2756|M.marinum_M SSGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 SSGRDEAYRQLAAIMGESISNEQQVRLVN------
MLBr_02041|M.leprae_Br4923 ASGRSASYRQIAKIIGELISTEHHVRLVA------
Mb2303c|M.bovis_AF2122/97 GRTPPAGAIRDLLSHITSRST--------------
Rv2282c|M.tuberculosis_H37Rv GRTPPAGAIRDLLSHITSRST--------------
MAV_1538|M.avium_104 GRPLPRSARDFIAGAAAVGHGGW------------
TH_3504|M.thermoresistible__bu HTLSAIRDRILEGLG--------------------