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PEHRFQVAVVTGGGGGIGRAVARGLASAGYCVAILGRCMEDLAEAARDHAHIAPFCLDVGDAARSAAVFA EVERRMGPVDILVANAAVYPKVHFLDQSPADFEETFRTNVHGVANAVRAVLPGMLSRNAGRVIVLGSLAD QSPLAGACSYSASKGALHALVRGIAAEIDRVRYPNVLVNEFNPGQTRTAMSDGGQPPEAVYPLIQALIDL PPGGAHGRMFVMDREVRSNERLSRAILRRAGIGPRLTRLERHG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5966 | - | - | 100% (254) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6753 | - | 4e-23 | 39.56% (182) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_1689 | - | 4e-21 | 39.56% (182) | 3-oxoacyl- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 7e-18 | 34.16% (202) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2469 | - | 7e-23 | 33.02% (212) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 7e-18 | 34.16% (202) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-18 | 31.38% (188) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_1408c | - | 9e-20 | 32.18% (202) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2289 | fabG1 | 2e-16 | 30.60% (183) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 9e-22 | 39.76% (166) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2488 | - | 9e-21 | 35.05% (194) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1491 | fabG1 | 1e-16 | 30.60% (183) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 9e-22 | 32.08% (212) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 --MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID-------
Rv1941|M.tuberculosis_H37Rv --MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID-------
TH_2488|M.thermoresistible__bu -----MEFQGLHVLVTGGTGGIGLACARAFAEAGAEVTVTGRD-------
Mflv_2469|M.gilvum_PYR-GCK -------MSSRVAVVTGGASGMGESTCHELGRRGHKVAVLDLN-------
Mvan_4185|M.vanbaalenii_PYR-1 --------MTRVAVVTGGASGMGEATCHELGRRGCKVAVLDLD-------
MAV_1395|M.avium_104 -----------MAVVTGGGSGIGRAIVERLAHDGHRVAVLDVN-------
MMAR_2289|M.marinum_M MTDTATEQNTESAADGGKPAFVSRSVLVTGGNRGIGLAIAQRL-------
MUL_1491|M.ulcerans_Agy99 MTDTATEQNTESAADGGKPAFVSRSVLVTGGNRGIGLAIAQRL-------
MLBr_01807|M.leprae_Br4923 MTDAAAKVS--AAPGRGKPAFVSRSILVTGGNRGIGLAVARRL-------
MAB_1408c|M.abscessus_ATCC_199 ----MADFEGKTALITGGARGMGRSHAVALAEAGADIAICDRCENSDVVG
MSMEG_5966|M.smegmatis_MC2_155 ----MPEHRFQVAVVTGGGGGIGRAVARGLASAGYCVAILGRC-------
. * :. : . * :
Mb1976|M.bovis_AF2122/97 ---GDAADAAATKIGCGAAAC-----RVDVSDEQQIIAMVDACVAAFGGV
Rv1941|M.tuberculosis_H37Rv ---GDAADAAATKIGCGAAAC-----RVDVSDEQQIIAMVDACVAAFGGV
TH_2488|M.thermoresistible__bu ---AGRGAAAA-----GAHPR-----LRFIRGDLADLASVQNLIRYADAV
Mflv_2469|M.gilvum_PYR-GCK ---GEAAQRVAEELRADGVTA--LGIAADVTDRAAVEDAFAKVRTELGPV
Mvan_4185|M.vanbaalenii_PYR-1 ---GQAAQRVAEELRGDGVPA--LGVAADVTDRAAVEDAFAKVRTELGPV
MAV_1395|M.avium_104 ---EEAAEKVAARVAADGAHA--IAVPTDVAESASVAAAFESVRRALGSV
MMAR_2289|M.marinum_M ---AADGHRVAVTHRGSGAPEGLFGVECDVTDNDAVDRAFKEVEEHQGPV
MUL_1491|M.ulcerans_Agy99 ---ATDGHRVAVTHRGSGAPEGLFGVECDVTDNDAVDRAFKEVEEHQGPV
MLBr_01807|M.leprae_Br4923 ---VADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
MAB_1408c|M.abscessus_ATCC_199 YPLATADDLAETVALVEKTGRRCISAKVDVKDRAALESFVAEAEDTLGGI
MSMEG_5966|M.smegmatis_MC2_155 -----MEDLAEAARDHAHIAP----FCLDVGDAARSAAVFAEVERRMGPV
. : . . :
Mb1976|M.bovis_AF2122/97 DKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGG
Rv1941|M.tuberculosis_H37Rv DKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGG
TH_2488|M.thermoresistible__bu DVLVNNAASFPGALTVEQDAESFTRTFATNVTGTYFLTAGLIPGMLARGR
Mflv_2469|M.gilvum_PYR-GCK HILVTSAGLVDFAPFLDISPQLWQRLIDVNLNGTFHCAQAAIPDMLAAGW
Mvan_4185|M.vanbaalenii_PYR-1 HILVTSAGLVDFAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLAAGW
MAV_1395|M.avium_104 QVLVTSAAITGFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVEAGW
MMAR_2289|M.marinum_M EVLVSNAGLSADAFLIRMTEERFEKVIDANLTGAFRVAQRASRSMQRKKF
MUL_1491|M.ulcerans_Agy99 EVLVSNAGLSADAFLIRMTEERFEKVIDANLTGAFRVAQRASRSMQRKKF
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRF
MAB_1408c|M.abscessus_ATCC_199 DIAITNAGISTIALLPEVESAQWDEVIGTNLTGTFNTIAAVAPGMIKRNY
MSMEG_5966|M.smegmatis_MC2_155 DILVANAAVYPKVHFLDQSPADFEETFRTNVHGVANAVRAVLPGMLSRNA
. : .*. : . : *: *. *
Mb1976|M.bovis_AF2122/97 GAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSS---GIRSN
Rv1941|M.tuberculosis_H37Rv GAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSS---GIRSN
TH_2488|M.thermoresistible__bu GSIVNITSMVATKAVPGASVYSSSKAAVESLTRSWAVEFAAH---GIRVN
Mflv_2469|M.gilvum_PYR-GCK GRIVMISSSSAQRGSPGMAHYAASKGALISLTRSLAREYGAA---GITVN
Mvan_4185|M.vanbaalenii_PYR-1 GRIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPA---GITVN
MAV_1395|M.avium_104 GRVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYAAH---GITAN
MMAR_2289|M.marinum_M GRLIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKV---NVTAN
MUL_1491|M.ulcerans_Agy99 GRLIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKV---NVTAN
MLBr_01807|M.leprae_Br4923 GRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSR---SITAN
MAB_1408c|M.abscessus_ATCC_199 GRIVTVSSMLGHSANFAQASYVSSKWGVIGLTKCAAHDLVGY---GITVN
MSMEG_5966|M.smegmatis_MC2_155 GRVIVLGSLADQSPLAGACSYSASKGALHALVRGIAAEIDRVRYPNVLVN
* : : * * ** .: : : * : .: *
Mb1976|M.bovis_AF2122/97 TLLPAFVDTPMQQTAMAMFDGALGAGGARSM--------IARLQGRMAAP
Rv1941|M.tuberculosis_H37Rv TLLPAFVDTPMQQTAMAMFDGALGAGGARSM--------IARLQGRMAAP
TH_2488|M.thermoresistible__bu AVAPGPTSTDGVATEWGETNEALGR---------------ALPIGRTADP
Mflv_2469|M.gilvum_PYR-GCK NIPPSGIETPMQLQSQAAGFLPPNEQMAA-----------SIPVGHLGTG
Mvan_4185|M.vanbaalenii_PYR-1 NVPPSGIETPMQHQSQAAGFLPPNEQMAA-----------SIPVGHLGTG
MAV_1395|M.avium_104 TVPPFSVDTPMLRAAQEAGNLPPVKYLAK-----------ASPVGRLGTG
MMAR_2289|M.marinum_M VVAPGYIDTDMTRALDER----IQEGALQ-----------FIPAKRVGTA
MUL_1491|M.ulcerans_Agy99 VVAPGYIDTDMTRALDER----IQEGALQ-----------FIPAKRVGTA
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSK----YQEAALQ-----------AIPLGRIGAV
MAB_1408c|M.abscessus_ATCC_199 AVAPGNIETPMTHNDFVFGTMRPDLEKPTLKDVESVFASLHLQYAPFLKP
MSMEG_5966|M.smegmatis_MC2_155 EFNPGQTRTAMSDGGQPPEAVYPLIQALID----------LPPGGAHGRM
. * *
Mb1976|M.bovis_AF2122/97 EEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
Rv1941|M.tuberculosis_H37Rv EEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
TH_2488|M.thermoresistible__bu DEIAQAVVFLASSRASFITGAVLHVDGGGIAV--
Mflv_2469|M.gilvum_PYR-GCK DDIAAAVGFLCSEQAGFITGQTLGVNGGSVMA--
Mvan_4185|M.vanbaalenii_PYR-1 DDIAAAVGFLCSEEAGFITGQTLGVNGGSVMA--
MAV_1395|M.avium_104 EDIAAACAFLCSDEAGYITGQIIGVNGGEVI---
MMAR_2289|M.marinum_M AEVAGVVSFLASEDASYISGAVIPVDGGMGMGH-
MUL_1491|M.ulcerans_Agy99 AEVAGVVSFLASEDASYISGAVIPVDGGMGMGH-
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-
MAB_1408c|M.abscessus_ATCC_199 EEVTRAVLFLVDEASSHITGTVLPIDAGATARMI
MSMEG_5966|M.smegmatis_MC2_155 FVMDREVRSNERLSRAILRRAGIGPRLTRLERHG
: . :