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MNTPVVIITGASQGIGAGLVSGYRKLGYAVVANSRSIGPSDDPMVLTVAGDVGVPGVGQRLVDAALERFG RVDTVVNNAGIFIAKPFTEYTDADYDAITGVNLRGFFELTRAALGALPAGGHIVNISTSLVDVANSRVPS ALASLTKGGLNAATRALAVENASCRIRVNAVALGSIKTPMHDPSSYDALASLNPMRQLGDIDDAVDAVLY LEQAKFVTGEILRVDGGQSAGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5714 | - | - | 100% (232) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_5632 | - | 5e-27 | 34.85% (241) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4117 | - | 8e-27 | 33.88% (245) | 2-deoxy-D-gluconate 3-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 1e-18 | 29.63% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_1783 | - | 5e-28 | 34.02% (241) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1350 | fabG | 1e-18 | 29.63% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 2e-15 | 29.60% (250) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_2032 | - | 1e-23 | 31.69% (243) | 3-oxoacyl- |
| M. marinum M | MMAR_0302 | - | 7e-26 | 34.02% (241) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5213 | - | 3e-29 | 34.85% (241) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4328 | - | 4e-28 | 33.86% (251) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4820 | - | 1e-22 | 32.77% (238) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | 1e-28 | 35.44% (237) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5714|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2032|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5714|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2032|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5714|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2032|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5714|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2032|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 ---------------------------MASLLNAR---------------
Rv1350|M.tuberculosis_H37Rv ---------------------------MASLLNAR---------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mflv_1783|M.gilvum_PYR-GCK ---------MQTAQVAIVTGASSGIGFGCATALADRGMVVLGTGRDAGRL
Mvan_4967|M.vanbaalenii_PYR-1 ------------MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDPGRL
TH_4328|M.thermoresistible__bu ----------VNMQVAIVTGASSGIGFGCATKLAEQGMAVLGTGRDSGRL
MAV_5213|M.avium_104 ------------MQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRL
MMAR_0302|M.marinum_M ------------MQVAIITGATGGIGFGCAAKLAEMGMAVLGTGRDERRL
MUL_4820|M.ulcerans_Agy99 ------------MQVAIITAATGGIGFGCAAKFAEMSMAVVGTARDERRL
MSMEG_5714|M.smegmatis_MC2_155 ----------MNTPVVIITGASQGIGAGLVSGYRKLGYAVVANSRSIG--
MAB_2032|M.abscessus_ATCC_1997 -----MSGKEFEGQVALVTGASRGIGRSIALALAEHGADIALHYGNSKPA
Mb1385|M.bovis_AF2122/97 --------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVN--LE
Rv1350|M.tuberculosis_H37Rv --------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVN--LE
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
..::*..: *:* . . : .
Mflv_1783|M.gilvum_PYR-GCK AELE----KAAPEPGRIATLAVDLTDDDAPQRIVSAALDRWGR-IDFLVN
Mvan_4967|M.vanbaalenii_PYR-1 AALE----KSS---DRIATLAVDLTDDDAPQRIVSAALERWGR-IDFLVN
TH_4328|M.thermoresistible__bu AGLEKTLRKAGVPADRIATLAVDLTADEAPQRIVDAAVSRWGH-IDFLIN
MAV_5213|M.avium_104 AELE----TAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWGH-IDFLIN
MMAR_0302|M.marinum_M AELT----QLPGGPDRIATHPVDLTDDDAPGQLTRAALERWGR-IDFLIN
MUL_4820|M.ulcerans_Agy99 AELT----QLPGGPDRIATHPVDPTDDDAPGQLTRAALDRWGR-IDFLIN
MSMEG_5714|M.smegmatis_MC2_155 ----------PSDDPMVLTVAGDVGVPGVGQRLVDAALERFGR-VDTVVN
MAB_2032|M.abscessus_ATCC_1997 AEEVA--EKISALGRRVLLCQGDIADPAVPELLADTVHAEFGR-IDVLVN
Mb1385|M.bovis_AF2122/97 ATEVA--AKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGG-LDVMVN
Rv1350|M.tuberculosis_H37Rv ATEVA--AKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGG-LDVMVN
MLBr_02565|M.leprae_Br4923 ALDET--ANRVGGTTLSL----DVTADDAVDKITEHLHDYQGGHADILVN
* : * * ::*
Mflv_1783|M.gilvum_PYR-GCK NAGIGSPKPLHETDDETLDHFLGVMLRAPFRLARDVIVHMQPG--SAIIN
Mvan_4967|M.vanbaalenii_PYR-1 NAGIGSPKPLHETDDETLDRFLDIMLRAPFRLARDVIVHMQPG--SAIIN
TH_4328|M.thermoresistible__bu NAGVGSPKPLGETDDDTLDHFLGLMLRAPFRLARDVLPHMRPG--SAIIN
MAV_5213|M.avium_104 NAGVGSPKPLHETDDETLDYFLNLMLRAPFRLAREVLPHLPPG--SAIIN
MMAR_0302|M.marinum_M AAGVGSPKPVHETDDESLDYVLSLMLRAPFRLTREVLPHLRPG--SAIIN
MUL_4820|M.ulcerans_Agy99 AAGEGSPKSVHETDDESLDYVLSLMLRAPFRLTREVLPHLRPG--SAIIN
MSMEG_5714|M.smegmatis_MC2_155 NAGIFIAKPFTEYTDADYDAITGVNLRGFFELTRAALGALPAG--GHIVN
MAB_2032|M.abscessus_ATCC_1997 NAGTHGAGLLLDIAPDYLEETVATNLLGPIRMTKAVVAHMLGQRYGRIIN
Mb1385|M.bovis_AF2122/97 NAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVN
Rv1350|M.tuberculosis_H37Rv NAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVN
MLBr_02565|M.leprae_Br4923 NAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIV
** . : * . . :. . ::
Mflv_1783|M.gilvum_PYR-GCK VTSTFAVVGGLRG--GAYSAAKGGLTALTSHIACQYGAQGIRCNAVAPGV
Mvan_4967|M.vanbaalenii_PYR-1 ITSTFAVVGGLRG--GAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGV
TH_4328|M.thermoresistible__bu ITSTFAVVGGLRG--GAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGV
MAV_5213|M.avium_104 VTSTFAVVGGLRG--GAYSAAKGGLTALTTHIACQYGASGIRCNAVAPGV
MMAR_0302|M.marinum_M ITSTFAVVGGLRG--GAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGV
MUL_4820|M.ulcerans_Agy99 ITSTFAVVGGLRG--GAYSAAKGGLAALTTHIACQYGAQGIRCNAVAPGV
MSMEG_5714|M.smegmatis_MC2_155 ISTSLVDVANSRVPSALASLTKGGLNAATRALAVENASCRIRVNAVALGS
MAB_2032|M.abscessus_ATCC_1997 ISSVAADKPDSGQ--STYAATKGGLESFTKAIAVEFASRNIISNAVAPGV
Mb1385|M.bovis_AF2122/97 MSSVSGKVGMVGQ--TNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGL
Rv1350|M.tuberculosis_H37Rv MSSVSGKVGMVGQ--TNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGL
MLBr_02565|M.leprae_Br4923 LSSMAGIAGNRGQ--TNYATAKAGVIGLTQALAPGLAEKGITINAVAPGF
::: : :*.*: . * * . * **:* *
Mflv_1783|M.gilvum_PYR-GCK TLTPMVAT-RLEDERFRKINTEMTPHQRLGRVEDIASTVAFLCSDGGEFI
Mvan_4967|M.vanbaalenii_PYR-1 TLTPMVAS-RLEDERFRKINTEMTPHQRLGRVEDVASTVAFLCSEGGSFI
TH_4328|M.thermoresistible__bu TLTPMVAT-RLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSPGAEFI
MAV_5213|M.avium_104 TVTPMVEN-RLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFI
MMAR_0302|M.marinum_M IQTAMTQH-RLADERFRRINVEMTPHQRLGTVDDVANTVAFLCSEGGAFI
MUL_4820|M.ulcerans_Agy99 IQTAMTQH-RLADERFRRLNVEITPHQRLGTVDDVANTVAFLCSEGGAFI
MSMEG_5714|M.smegmatis_MC2_155 IKTPMHDP-SSYD-----ALASLNPMRQLGDIDDAVDAVLYL--EQAKFV
MAB_2032|M.abscessus_ATCC_1997 VYTDMAEITRTHVPATFERLKAQILAKDFAKPEIVADAVLYLASPHNTYI
Mb1385|M.bovis_AF2122/97 IRSAMTEA---MPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYM
Rv1350|M.tuberculosis_H37Rv IRSAMTEA---MPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYM
MLBr_02565|M.leprae_Br4923 IETQMTAA---IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAV
: * . . . :: :
Mflv_1783|M.gilvum_PYR-GCK NGQTIVVDGGWSSTKYLSDFALNSEWVARQGTS-
Mvan_4967|M.vanbaalenii_PYR-1 NGQTIVVDGGWSTTKYLSDFALNAHWVER-----
TH_4328|M.thermoresistible__bu NGQTIVVDGGWSSTKYLSDHALTSEWVPR-----
MAV_5213|M.avium_104 NGQTIVVDGGWSSTKYLSEYALTSEWIAP-----
MMAR_0302|M.marinum_M NGQTIVVDGGWSSTKYLSDFALTAQWSPAQDDSK
MUL_4820|M.ulcerans_Agy99 NGQTIVVDGG------------------------
MSMEG_5714|M.smegmatis_MC2_155 TGEILRVDGGQSAGL-------------------
MAB_2032|M.abscessus_ATCC_1997 TGEVLHIDGGYKMK--------------------
Mb1385|M.bovis_AF2122/97 TGTVLDVTGGRFI---------------------
Rv1350|M.tuberculosis_H37Rv TGTVLDVTGGRFI---------------------
MLBr_02565|M.leprae_Br4923 TGNVIRVCGQAMLGA-------------------
.* : : *