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YSMRRSVFARAVGSALVVGLAVSGCAGGDDTADAQRSAQPSQTFADEPPPLVPAMALPENAVENAVAKLD GIAEDLMRSSGIPGMAVAVVHGGKTVYAKGFGVRDVRNGDVESNRVDPDTVFQLASLSKPIAATVVAHQV GTGAIGWDTPVVEHLPWFALSDPVTTRMVTVGDLFAHRSGLPDHAGDQLEDLGYDRRYILEHLRALPLDP FRNSYAYTNFGLTAAAEAVAAAAGRSWEDLARDVLYRPLGMDSTSSRFADYEATQNRAVGHIRVDGRYEP QYVRNADAQTPAGGVSASVDDMTRWLAMVLGDGVFEGERIVEESTLLPAITPQVVSDRASQPAMRSGFYG YGFNVGTTSAARTQLSHSGAFELGAATNFVILPSADVGIVALTNGTPAGIPETLTAEFADLVQFGEVRQD WRKLYADAFASMDGPEGELVGKKPPAVPAPARPLPDYVGVYRNDYWGPATVTEQDGALQLALGPKFKARL THWDGDVFTFRFVSENAPPGTISKATFAGDKLTLEYFDEDGTGTFTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5637 | - | - | 100% (538) | penicillin-binding protein 4 |
| M. smegmatis MC2 155 | MSMEG_4455 | - | 9e-13 | 22.56% (430) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_6784 | - | 3e-12 | 23.81% (357) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0931 | - | 0.0 | 62.07% (522) | hypothetical protein Mb0931 |
| M. gilvum PYR-GCK | Mflv_1757 | - | 0.0 | 67.36% (530) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0907 | - | 0.0 | 62.67% (517) | hypothetical protein Rv0907 |
| M. leprae Br4923 | MLBr_00119 | lipE | 5e-07 | 22.67% (375) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2179 | - | 6e-14 | 25.98% (381) | Beta-lactamase/esterase |
| M. marinum M | MMAR_4623 | - | 0.0 | 62.50% (528) | penicillin binding protein |
| M. avium 104 | MAV_1030 | - | 0.0 | 62.15% (531) | penicillin-binding protein 4 |
| M. thermoresistible (build 8) | TH_0096 | - | 0.0 | 67.60% (537) | penicillin-binding protein 4 |
| M. ulcerans Agy99 | MUL_2951 | lipD | 6e-13 | 34.30% (172) | lipase LipD |
| M. vanbaalenii PYR-1 | Mvan_4990 | - | 0.0 | 69.25% (530) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0931|M.bovis_AF2122/97 ---------MMLLT----------------LTGCGSTHQALGPPSGL---
Rv0907|M.tuberculosis_H37Rv ---------MATICGHDQTSGNGRHGDVADVNGCGSTHQALGPPSGL---
MMAR_4623|M.marinum_M ---------MTKRAAT-----TAVVMMFLALVGCAPKQSISNPPSTP---
MAV_1030|M.avium_104 ---------MSKRAAV-------LTAVLLGLTGCGSAQQPAGAPPRP---
Mflv_1757|M.gilvum_PYR-GCK ---MK----SRVGAVA-------LVMAVALLAGCAAESTEPAASSTPAPG
Mvan_4990|M.vanbaalenii_PYR-1 ---MK----PRARVAA-------LALTAALLAGCGTEGAEPAASSTPAPS
MSMEG_5637|M.smegmatis_MC2_155 MYSMRRSVFARAVGSA-------LVVGLAVSGCAGGDDTADAQRSAQPSQ
TH_0096|M.thermoresistible__bu ---------VLKRFAA-------VLTALVLLAGCRSGDDASTAHPS----
MAB_2179|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00119|M.leprae_Br4923 -------------------------------------MTSDGKIRVP---
MUL_2951|M.ulcerans_Agy99 --------------------------------------------------
Mb0931|M.bovis_AF2122/97 --PDASPNERSAIQIPAGRIDDAVAKVDGLV---GELMQNTGIPGMAVAI
Rv0907|M.tuberculosis_H37Rv --PDASPNERSAIQIPAGRIDDAVAKVDGLV---GELMQNTGIPGMAVAI
MMAR_4623|M.marinum_M --SQLPPNEVSGIDIPPGRIDEAVAKVDGLV---AELMKSTGIPGMAVAI
MAV_1030|M.avium_104 --SDVSPNQVSALAIPAGRIDEAVAKVDGLV---ADLMRSSGIPGMAVAI
Mflv_1757|M.gilvum_PYR-GCK PLSDVPPPLVPAMPLPENAVANAVAKLDGLA---EDLMSTSGVPGMAVAV
Mvan_4990|M.vanbaalenii_PYR-1 PASDVPPPLVPAMPLPENAVADAVAKLDGLA---EDLMSKSGIPGMAVAV
MSMEG_5637|M.smegmatis_MC2_155 TFADEPPPLVPAMALPENAVENAVAKLDGIA---EDLMRSSGIPGMAVAV
TH_0096|M.thermoresistible__bu --SDLPPPLVAAVDLPADAVANAVARLDGLA---ADLLEQSGIPGLAVAV
MAB_2179|M.abscessus_ATCC_1997 ----------------MGSDSTLAERLDEVF---GAALRERRVVGAVAVV
MLBr_00119|M.leprae_Br4923 --TDLDAVTAIGDEDHSDIDSAAVERIWQAT---RHWYQAGMHPAIQLCI
MUL_2951|M.ulcerans_Agy99 --MAQPSVPTTDDGLPSGVAGACDSRFSGVVRAFAGLYPGRKFGGGALSV
. :. . :
Mb0931|M.bovis_AF2122/97 VHGGKTLY----AKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATV
Rv0907|M.tuberculosis_H37Rv VHGGKTLY----AKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATV
MMAR_4623|M.marinum_M VHGGKTLY----AKGFGVRDVSKGDGQDNKVDTDTVFQLASMSKPIGATV
MAV_1030|M.avium_104 VHGGKVLY----AKGFGVKDVTSGQGRDNAVDTDTVFQLASVSKSVGATV
Mflv_1757|M.gilvum_PYR-GCK VHQGKTVY----AKGFGVKNNTQSDSPENRVDADTVFQLASLSKPLSATV
Mvan_4990|M.vanbaalenii_PYR-1 VHGGKAVY----AKGFGVRNNTMSDEPHNEVDADTVFQLASLSKPLSATA
MSMEG_5637|M.smegmatis_MC2_155 VHGGKTVY----AKGFGVRDVRNGDVESNRVDPDTVFQLASLSKPIAATV
TH_0096|M.thermoresistible__bu VHGGKTVY----AKGFGVKDIRTGDP----VGADTVFQLASLSKPIGATV
MAB_2179|M.abscessus_ATCC_1997 ARDGQVQY----RRAHGLADREGSLP----MREDTLFRLASVTKPIVTVA
MLBr_00119|M.leprae_Br4923 RQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAKAITATV
MUL_2951|M.ulcerans_Agy99 YTEGRQVVD--VWTGWADRNGE------VPWTADTGAMVFSATKGLAATV
*: . . ** * :* : :..
Mb0931|M.bovis_AF2122/97 VAHAVTDNVVTWDTPVVSKLPWFALRDP-YVTGQVTIADLYSHRSGLPD-
Rv0907|M.tuberculosis_H37Rv VAHAVTDNVVTWDTPVVSKLPWFALRDP-YVTGQVTIADLYSHRSGLPD-
MMAR_4623|M.marinum_M VAHEVSTNVVSWDTPVVSKLPEFALSDP-YVTDHATIADLYSHRSGLPD-
MAV_1030|M.avium_104 VAHEVSDHVVGWDTPVVSTLPWFALGDP-YVTGHVTVGDLYSHRSGLPD-
Mflv_1757|M.gilvum_PYR-GCK VAALVGQDQVGWDTPVVSRLPWFALSDP-TTTQMVTVGDMFSHRSGLPD-
Mvan_4990|M.vanbaalenii_PYR-1 VAALVGQNQVSWDTPIVSRLPWFALSDP-AVTQMVTVGDMFSHRSGLPD-
MSMEG_5637|M.smegmatis_MC2_155 VAHQVGTGAIGWDTPVVEHLPWFALSDP-VTTRMVTVGDLFAHRSGLPD-
TH_0096|M.thermoresistible__bu VAHQVGTGAISWDTPVISRLPWFRLSDP-VVTERVTIGDMYAHRSGLPD-
MAB_2179|M.abscessus_ATCC_1997 VLRLVGDELIRLDDPVTRWLPDFTPRLPDGSTPALTIHHLLTHTAGLSYG
MLBr_00119|M.leprae_Br4923 VHMLVERGHFSLDDRVCEYLPTYTSYGK----HRTTIRHVLTHSAGVPFP
MUL_2951|M.ulcerans_Agy99 IHRLVDRGLLDYDAPVADYWPEFGVKGK----SAITVSDLLRHRSGLSH-
: * . * : * : *: .: * :*:.
Mb0931|M.bovis_AF2122/97 ------------HAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFG
Rv0907|M.tuberculosis_H37Rv ------------HAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFG
MMAR_4623|M.marinum_M ------------HAGDALEDLGYDTTQVLERLKYLPLDPFRISYAYTNFG
MAV_1030|M.avium_104 ------------HAGDKLEDLGYGRRQICERLRLLPLRPFRNSYAYTNYG
Mflv_1757|M.gilvum_PYR-GCK ------------HAGDQLEDLGYDRRQVLDRLRQLPLAQFRTSYAYTNFG
Mvan_4990|M.vanbaalenii_PYR-1 ------------HAGDQLEDLGYDRRQVLERLRQLPLDQFRTSYAYTNFG
MSMEG_5637|M.smegmatis_MC2_155 ------------HAGDQLEDLGYDRRYILEHLRALPLDPFRNSYAYTNFG
TH_0096|M.thermoresistible__bu ------------HAGDLLEDLGYDRRQVLEKLAQLPLAPFRISYAYTNFG
MAB_2179|M.abscessus_ATCC_1997 LLEEPDSPFHALGISDGIDVVDFDLRENLRRLALAPLQFAPGSAWRYSLA
MLBr_00119|M.leprae_Br4923 -------------TGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHA
MUL_2951|M.ulcerans_Agy99 -------------LKGVGKKEILDHLRMEEKLAAAPLDRTHGKMAYHAVT
. . :
Mb0931|M.bovis_AF2122/97 VTAA---AEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHA
Rv0907|M.tuberculosis_H37Rv VTAA---AEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHA
MMAR_4623|M.marinum_M VTAA---ADAVAAAAGKAWPDLSEEVLYRPLGMTSTSSRFADFLARPNHA
MAV_1030|M.avium_104 ITAA---AEAVAAAAGKTWEELSDEVLYRPLGMTSTSSRFADFLARPNRA
Mflv_1757|M.gilvum_PYR-GCK LTAG---AEAVATGAGKSWEDLAADTLLRPLGMGVTSYRFEDYASRRDRA
Mvan_4990|M.vanbaalenii_PYR-1 LTAG---AEAVATGAGKSWEDLAADTLLRPLGMGATSYRFSDYESRRDRA
MSMEG_5637|M.smegmatis_MC2_155 LTAA---AEAVAAAAGRSWEDLARDVLYRPLGMDSTSSRFADYEATQNRA
TH_0096|M.thermoresistible__bu XTAA---AEAVAADAGMPWEELSGRVLYEPLGMASTSSRFADYQARADRA
MAB_2179|M.abscessus_ATCC_1997 LDVL---GAVVENATGLPLDLAVEKLVTSPLGMHESG-----FVARDLTR
MLBr_00119|M.leprae_Br4923 LTWGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFG---VAEEDVPL
MUL_2951|M.ulcerans_Agy99 YGWL--LSGLARAVTGKGMRDLFREELARPLDTDGLHLG--RPPGDAPTT
:* : **.
Mb0931|M.bovis_AF2122/97 VNHVKVADRWEARYQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGR
Rv0907|M.tuberculosis_H37Rv VNHVKVADRWEARYQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGR
MMAR_4623|M.marinum_M VNHIKVGDRWEARFQRDPDAQTPAGGVSSSLNDMAHWLTMVLANGEYNGQ
MAV_1030|M.avium_104 VNHIKIGDSWQARFQRNPDAQSPAGGVSSSVRDMARWLMMLLDNGTHDGQ
Mflv_1757|M.gilvum_PYR-GCK VGHIRIDDGYQPRYVRDAQAQSPAGGASSSVNDMTRWMAMVLAEGRHDGN
Mvan_4990|M.vanbaalenii_PYR-1 VGHIRIDGGYQPRFVRDAQAQSPAGGASSSVNDMTRWMAMVLADGRHDGN
MSMEG_5637|M.smegmatis_MC2_155 VGHIRVDGRYEPQYVRNADAQTPAGGVSASVDDMTRWLAMVLGDGVFEGE
TH_0096|M.thermoresistible__bu VGHIHVDGGYQPFYLRDPDAESPAGGVSSSVNDVARWLAMVLGDGSFEGR
MAB_2179|M.abscessus_ATCC_1997 FAVPYANGEPEPFRIADNVNVPLPQGIGVAVR------------------
MLBr_00119|M.leprae_Br4923 VALSHATGRPLPPIIAAIFRKAIGGTVHEVIPYTN---------------
MUL_2951|M.ulcerans_Agy99 AAQTLLPQSKIPTPLLDFIAPKVAGLSFSGLLG-----------------
. :
Mb0931|M.bovis_AF2122/97 RITSPEALLLVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHS
Rv0907|M.tuberculosis_H37Rv RITSPEALLPVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHS
MMAR_4623|M.marinum_M QIVSPEALLPAITPQVISSAARSPKARAGFYGHGFTVSVSSAGRTQYGHS
MAV_1030|M.avium_104 HIASPEALLPALSPQVVSAPATTPKARTGFYGYGFNTSVDASGRTEYSHS
Mflv_1757|M.gilvum_PYR-GCK ALIDPQALLPAISPQVTSAPPTEPAMRPGFYGYGFNVGTTSAARTQLSHS
Mvan_4990|M.vanbaalenii_PYR-1 QLIDPTALLPAITPQVTSSRGSEPAMRSGFYGYGFNVGTTSAARTQLSHS
MSMEG_5637|M.smegmatis_MC2_155 RIVEESTLLPAITPQVVSDRASQPAMRSGFYGYGFNVGTTSAARTQLSHS
TH_0096|M.thermoresistible__bu RIVDPDALLPALTPQIVSSPATEPAMRSGFYGYGFNVGITSAARTELSHS
MAB_2179|M.abscessus_ATCC_1997 -----------FGPARVTRGDAYPSGGAGMYG------------------
MLBr_00119|M.leprae_Br4923 ------------TPPFLTTIVPSSNTVS----------------------
MUL_2951|M.ulcerans_Agy99 ---------AVYFPGILSMLQDDMPFLDG---------------------
* :
Mb0931|M.bovis_AF2122/97 GAFGLGAAANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVR
Rv0907|M.tuberculosis_H37Rv GAFGLGAAANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVR
MMAR_4623|M.marinum_M GAFGLGAATNFVVLPSEDIAIVALTNAAPYGIPEALTAQFMDLVQYGEVR
MAV_1030|M.avium_104 GAFDLGAATNFVVLPSEDLAIIALTNAAPYGIPETLTAEFMDLVQYGQIR
Mflv_1757|M.gilvum_PYR-GCK GAFELGAATNVLFLPSADVAIIALTNATPTGVPETLTAQFADLVQFGEIR
Mvan_4990|M.vanbaalenii_PYR-1 GAFELGAATNVLFLPSADVAIVALTNATPTGIPETLTAQFADLVQFGEIR
MSMEG_5637|M.smegmatis_MC2_155 GAFELGAATNFVILPSADVGIVALTNGTPAGIPETLTAEFADLVQFGEVR
TH_0096|M.thermoresistible__bu GAFELGTGTNFVILPSADAGIVALTNATPSGVAEALTAQFADLVQFGEIR
MAB_2179|M.abscessus_ATCC_1997 --------------TADDVLLLLEAIRAGDGFLAEELRTSMRTDHVGPQA
MLBr_00119|M.leprae_Br4923 --------------TANELSRFAEIWLRGGELDGIRVLRSETLLGAVAEC
MUL_2951|M.ulcerans_Agy99 -----------EIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDAVS
. .
Mb0931|M.bovis_AF2122/97 EDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND-YVGVYANDYWG
Rv0907|M.tuberculosis_H37Rv EDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND-YVGVYANDYWG
MMAR_4623|M.marinum_M EDWTNLYRQQMSPINTPEGSLVGKQPPVNPEPARPPSD-YVGVYANDYWG
MAV_1030|M.avium_104 EDWAALYRKAIGWLNNPLGSLVGKQPPSAPAPARPLRD-YTGVYANDYWG
Mflv_1757|M.gilvum_PYR-GCK QDWAALYGKAFADMDKPVGSLVGQQRHVNAQTHGPLDS-YTGVYGNDYWG
Mvan_4990|M.vanbaalenii_PYR-1 QDWYALYAKAFEDMDKPVGSLVGQQRPANAQAHGPLAA-YTGVYRNDYWG
MSMEG_5637|M.smegmatis_MC2_155 QDWRKLYADAFASMDGPEGELVGKKPPAVPAPARPLPD-YVGVYRNDYWG
TH_0096|M.thermoresistible__bu EDWYRLYRELMAPLEQPQGSLVGRPRPADPAPPAPLST-YVGTYHNDYWG
MAB_2179|M.abscessus_ATCC_1997 QTRGPGWGFGYG------GAVLADPAAADSPQSAGTIG-WGGVYGHSWFV
MLBr_00119|M.leprae_Br4923 RRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWA
MUL_2951|M.ulcerans_Agy99 GLTGKAELWPDLNLGLPFTYHQGYQSPPVPGLLGGYGH--IGLGGTIGWA
. * :
Mb0931|M.bovis_AF2122/97 PATVTYHDGQLRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENAL
Rv0907|M.tuberculosis_H37Rv PATVTYHDGQLRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENAL
MMAR_4623|M.marinum_M PATVTERDGQLQLSMGPKN--------QTFDLTHWDGDTFTFALSTENAL
MAV_1030|M.avium_104 PAVITEHDGALQLTMGPQH--------RTATLTHWDGDTFTFPLTGENAP
Mflv_1757|M.gilvum_PYR-GCK PATVTERDGRLQLALGPR---------GVFELDAWDGNVFVFPVSSENAP
Mvan_4990|M.vanbaalenii_PYR-1 PATVTERDGHLELALGPR---------GVFKLQPWDGNVFTFPVSSENAP
MSMEG_5637|M.smegmatis_MC2_155 PATVTEQDGALQLALGPK---------FKARLTHWDGDVFTFRFVSENAP
TH_0096|M.thermoresistible__bu PARVTERDGKLVLDMGPPDARPQPGAPDEFPLTHWDGNVFTFTLVTENAP
MAB_2179|M.abscessus_ATCC_1997 DAARG----------------------------------LSVLLLTNTAY
MLBr_00119|M.leprae_Br4923 DPQRSMAAG-----------------------------------LISSGK
MUL_2951|M.ulcerans_Agy99 DPESGSAFGYVHNRLLTLL---------LFDIGSFAGLAPLLSSAVSTAR
. ...
Mb0931|M.bovis_AF2122/97 PGSISKATFAG---DTLNLEYYDADKLGTFTR
Rv0907|M.tuberculosis_H37Rv PGSISKATFAG---DTLNLEYYDADKLGTFTR
MMAR_4623|M.marinum_M PGSISKATFAG---DTLNLEYFDSNKLGTFTR
MAV_1030|M.avium_104 PGTVSTATFTGSPAARLNLEYYDTDQLGTFTR
Mflv_1757|M.gilvum_PYR-GCK PGTVSAATFDG---GALTLEYFDQEGNGVFVR
Mvan_4990|M.vanbaalenii_PYR-1 PGTVSAATFDA---GSLTLEYFDDEGKGVFTR
MSMEG_5637|M.smegmatis_MC2_155 PGTISKATFAG---DKLTLEYFDEDGTGTFTR
TH_0096|M.thermoresistible__bu PGTISKATFDG---DRLTLEYYDDVHDGVFVK
MAB_2179|M.abscessus_ATCC_1997 EGMTG----------PLTVEMRDAVYAAD---
MLBr_00119|M.leprae_Br4923 PGQDPNAGRYG----ALMNTITAEIPVH----
MUL_2951|M.ulcerans_Agy99 REGPLEVPHFG---ASYRETGQQPLAAGETS-