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MSKRAAVLTAVLLGLTGCGSAQQPAGAPPRPSDVSPNQVSALAIPAGRIDEAVAKVDGLVADLMRSSGIP GMAVAIVHGGKVLYAKGFGVKDVTSGQGRDNAVDTDTVFQLASVSKSVGATVVAHEVSDHVVGWDTPVVS TLPWFALGDPYVTGHVTVGDLYSHRSGLPDHAGDKLEDLGYGRRQICERLRLLPLRPFRNSYAYTNYGIT AAAEAVAAAAGKTWEELSDEVLYRPLGMTSTSSRFADFLARPNRAVNHIKIGDSWQARFQRNPDAQSPAG GVSSSVRDMARWLMMLLDNGTHDGQHIASPEALLPALSPQVVSAPATTPKARTGFYGYGFNTSVDASGRT EYSHSGAFDLGAATNFVVLPSEDLAIIALTNAAPYGIPETLTAEFMDLVQYGQIREDWAALYRKAIGWLN NPLGSLVGKQPPSAPAPARPLRDYTGVYANDYWGPAVITEHDGALQLTMGPQHRTATLTHWDGDTFTFPL TGENAPPGTVSTATFTGSPAARLNLEYYDTDQLGTFTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1030 | - | - | 100% (528) | penicillin-binding protein 4 |
| M. avium 104 | MAV_3991 | - | 2e-13 | 27.78% (252) | beta-lactamase |
| M. avium 104 | MAV_3395 | - | 2e-08 | 24.68% (308) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0931 | - | 0.0 | 72.97% (518) | hypothetical protein Mb0931 |
| M. gilvum PYR-GCK | Mflv_1757 | - | 1e-177 | 59.66% (528) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0907 | - | 0.0 | 72.96% (514) | hypothetical protein Rv0907 |
| M. leprae Br4923 | MLBr_01782 | - | 8e-07 | 25.85% (325) | hypothetical protein MLBr_01782 |
| M. abscessus ATCC 19977 | MAB_2179 | - | 2e-11 | 24.08% (382) | Beta-lactamase/esterase |
| M. marinum M | MMAR_4623 | - | 0.0 | 71.51% (530) | penicillin binding protein |
| M. smegmatis MC2 155 | MSMEG_5637 | - | 0.0 | 62.15% (531) | penicillin-binding protein 4 |
| M. thermoresistible (build 8) | TH_0096 | - | 0.0 | 59.89% (536) | penicillin-binding protein 4 |
| M. ulcerans Agy99 | MUL_1772 | - | 3e-10 | 23.90% (272) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_4990 | - | 1e-177 | 59.20% (527) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0931|M.bovis_AF2122/97 ---------MMLLT----------------LTGCGSTHQALGPPSGL---
Rv0907|M.tuberculosis_H37Rv ---------MATICGHDQTSGNGRHGDVADVNGCGSTHQALGPPSGL---
MMAR_4623|M.marinum_M ---------MTKRAAT-----TAVVMMFLALVGCAPKQSISNPPSTP---
MAV_1030|M.avium_104 ---------MSKRAAV-------LTAVLLGLTGCGSAQQPAGAPPRP---
Mflv_1757|M.gilvum_PYR-GCK ---MK----SRVGAVA-------LVMAVALLAGCAAESTEPAASSTPAPG
Mvan_4990|M.vanbaalenii_PYR-1 ---MK----PRARVAA-------LALTAALLAGCGTEGAEPAASSTPAPS
MSMEG_5637|M.smegmatis_MC2_155 MYSMRRSVFARAVGSA-------LVVGLAVSGCAGGDDTADAQRSAQPSQ
TH_0096|M.thermoresistible__bu ---------VLKRFAA-------VLTALVLLAGCRSGDDASTAHPS----
MLBr_01782|M.leprae_Br4923 --------------------------------------------------
MAB_2179|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1772|M.ulcerans_Agy99 --------------------------------MGVARPRWRGPRAAWFAG
Mb0931|M.bovis_AF2122/97 --PDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHG
Rv0907|M.tuberculosis_H37Rv --PDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHG
MMAR_4623|M.marinum_M --SQLPPNEVSGIDIPPGRIDEAVAKVDGLVAELMKSTGIPGMAVAIVHG
MAV_1030|M.avium_104 --SDVSPNQVSALAIPAGRIDEAVAKVDGLVADLMRSSGIPGMAVAIVHG
Mflv_1757|M.gilvum_PYR-GCK PLSDVPPPLVPAMPLPENAVANAVAKLDGLAEDLMSTSGVPGMAVAVVHQ
Mvan_4990|M.vanbaalenii_PYR-1 PASDVPPPLVPAMPLPENAVADAVAKLDGLAEDLMSKSGIPGMAVAVVHG
MSMEG_5637|M.smegmatis_MC2_155 TFADEPPPLVPAMALPENAVENAVAKLDGIAEDLMRSSGIPGMAVAVVHG
TH_0096|M.thermoresistible__bu --SDLPPPLVAAVDLPADAVANAVARLDGLAADLLEQSGIPGLAVAVVHG
MLBr_01782|M.leprae_Br4923 ----------------------------MVALDALDDWPVPTTAAAVVGP
MAB_2179|M.abscessus_ATCC_1997 ----------------MGSDSTLAERLDEVFGAALRERRVVGAVAVVARD
MUL_1772|M.ulcerans_Agy99 ARKPSDGRRLTRRPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQH
: ...:
Mb0931|M.bovis_AF2122/97 GKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVVAHAVTD
Rv0907|M.tuberculosis_H37Rv GKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVVAHAVTD
MMAR_4623|M.marinum_M GKTLYAKGFGVRDVSKGDGQDNKVDTDTVFQLASMSKPIGATVVAHEVST
MAV_1030|M.avium_104 GKVLYAKGFGVKDVTSGQGRDNAVDTDTVFQLASVSKSVGATVVAHEVSD
Mflv_1757|M.gilvum_PYR-GCK GKTVYAKGFGVKNNTQSDSPENRVDADTVFQLASLSKPLSATVVAALVGQ
Mvan_4990|M.vanbaalenii_PYR-1 GKAVYAKGFGVRNNTMSDEPHNEVDADTVFQLASLSKPLSATAVAALVGQ
MSMEG_5637|M.smegmatis_MC2_155 GKTVYAKGFGVRDVRNGDVESNRVDPDTVFQLASLSKPIAATVVAHQVGT
TH_0096|M.thermoresistible__bu GKTVYAKGFGVKDIRTGDP----VGADTVFQLASLSKPIGATVVAHQVGT
MLBr_01782|M.leprae_Br4923 TGVLAARG----------------DTEQVFPLASVTKPLVARAVQIAIEE
MAB_2179|M.abscessus_ATCC_1997 GQVQYRRAHGLADREGSLP----MREDTLFRLASVTKPIVTVAVLRLVGD
MUL_1772|M.ulcerans_Agy99 GEVLQVNEIGYRDVEAGLP----MQRDTLFRIASMTKPVTVAAAMSMVDE
. . : :* :**::*.: . .. :
Mb0931|M.bovis_AF2122/97 NVVTWDTPVVSKLPWF----ALRDPYVTG--------QVTIADLYSHRSG
Rv0907|M.tuberculosis_H37Rv NVVTWDTPVVSKLPWF----ALRDPYVTG--------QVTIADLYSHRSG
MMAR_4623|M.marinum_M NVVSWDTPVVSKLPEF----ALSDPYVTD--------HATIADLYSHRSG
MAV_1030|M.avium_104 HVVGWDTPVVSTLPWF----ALGDPYVTG--------HVTVGDLYSHRSG
Mflv_1757|M.gilvum_PYR-GCK DQVGWDTPVVSRLPWF----ALSDPTTTQ--------MVTVGDMFSHRSG
Mvan_4990|M.vanbaalenii_PYR-1 NQVSWDTPIVSRLPWF----ALSDPAVTQ--------MVTVGDMFSHRSG
MSMEG_5637|M.smegmatis_MC2_155 GAIGWDTPVVEHLPWF----ALSDPVTTR--------MVTVGDLFAHRSG
TH_0096|M.thermoresistible__bu GAISWDTPVISRLPWF----RLSDPVVTE--------RVTIGDMYAHRSG
MLBr_01782|M.leprae_Br4923 GVVDLDT--------------VAGPPGS-----------TIRHLLAHASG
MAB_2179|M.abscessus_ATCC_1997 ELIRLDDPVTRWLPDF----TPRLPDGSTP-------ALTIHHLLTHTAG
MUL_1772|M.ulcerans_Agy99 GKIALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSG
: * . : .: :* :*
Mb0931|M.bovis_AF2122/97 LPDHAGDL--------LEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGV
Rv0907|M.tuberculosis_H37Rv LPDHAGDL--------LEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGV
MMAR_4623|M.marinum_M LPDHAGDA--------LEDLGYDTTQVLERLKYLPLDPFRISYAYTNFGV
MAV_1030|M.avium_104 LPDHAGDK--------LEDLGYGRRQICERLRLLPLRPFRNSYAYTNYGI
Mflv_1757|M.gilvum_PYR-GCK LPDHAGDQ--------LEDLGYDRRQVLDRLRQLPLAQFRTSYAYTNFGL
Mvan_4990|M.vanbaalenii_PYR-1 LPDHAGDQ--------LEDLGYDRRQVLERLRQLPLDQFRTSYAYTNFGL
MSMEG_5637|M.smegmatis_MC2_155 LPDHAGDQ--------LEDLGYDRRYILEHLRALPLDPFRNSYAYTNFGL
TH_0096|M.thermoresistible__bu LPDHAGDL--------LEDLGYDRRQVLEKLAQLPLAPFRISYAYTNFGX
MLBr_01782|M.leprae_Br4923 LAMHSKYV--------MAPPGTRR-------------------IYSNYGF
MAB_2179|M.abscessus_ATCC_1997 LSYGLLEE--------PDSP------------------------FHALGI
MUL_1772|M.ulcerans_Agy99 LAYSFSVSGDISRAYMRLPFGHGSDAWLAELAALPLVHQPGERVTYSHAI
*. .
Mb0931|M.bovis_AF2122/97 TAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHV
Rv0907|M.tuberculosis_H37Rv TAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHV
MMAR_4623|M.marinum_M TAAADAVAAAAGKAWPDLSEEVLYRPLGMTSTSSRFADFLARPNHAVNHI
MAV_1030|M.avium_104 TAAAEAVAAAAGKTWEELSDEVLYRPLGMTSTSSRFADFLARPNRAVNHI
Mflv_1757|M.gilvum_PYR-GCK TAGAEAVATGAGKSWEDLAADTLLRPLGMGVTSYRFEDYASRRDRAVGHI
Mvan_4990|M.vanbaalenii_PYR-1 TAGAEAVATGAGKSWEDLAADTLLRPLGMGATSYRFSDYESRRDRAVGHI
MSMEG_5637|M.smegmatis_MC2_155 TAAAEAVAAAAGRSWEDLARDVLYRPLGMDSTSSRFADYEATQNRAVGHI
TH_0096|M.thermoresistible__bu TAAAEAVAADAGMPWEELSGRVLYEPLGMASTSSRFADYQARADRAVGHI
MLBr_01782|M.leprae_Br4923 RVLAETVQREAGIGFSRYLTEAVLEPLAMTATKLEDGTWAAG--------
MAB_2179|M.abscessus_ATCC_1997 SDGIDVVDFDLRENLRRLALAPLQFAPGSAWRYSLALDVLGAVVENATGL
MUL_1772|M.ulcerans_Agy99 DLLGVIMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAATMYRL
: : . .
Mb0931|M.bovis_AF2122/97 KVADRWEARYQRDPDAQSP-----AGGVSSSLNDMTHWLAMVLADGVYNG
Rv0907|M.tuberculosis_H37Rv KVADRWEARYQRDPDAQSP-----AGGVSSSLNDMTHWLAMVLADGVYNG
MMAR_4623|M.marinum_M KVGDRWEARFQRDPDAQTP-----AGGVSSSLNDMAHWLTMVLANGEYNG
MAV_1030|M.avium_104 KIGDSWQARFQRNPDAQSP-----AGGVSSSVRDMARWLMMLLDNGTHDG
Mflv_1757|M.gilvum_PYR-GCK RIDDGYQPRYVRDAQAQSP-----AGGASSSVNDMTRWMAMVLAEGRHDG
Mvan_4990|M.vanbaalenii_PYR-1 RIDGGYQPRFVRDAQAQSP-----AGGASSSVNDMTRWMAMVLADGRHDG
MSMEG_5637|M.smegmatis_MC2_155 RVDGRYEPQYVRNADAQTP-----AGGVSASVDDMTRWLAMVLGDGVFEG
TH_0096|M.thermoresistible__bu HVDGGYQPFYLRDPDAESP-----AGGVSSSVNDVARWLAMVLGDGSFEG
MLBr_01782|M.leprae_Br4923 -------------------------FGATSTVADLAAFANDLLRPATVSA
MAB_2179|M.abscessus_ATCC_1997 PLDLAVEKLVTSPLG----------MHESGFVARDLTRFAVPYANGEPEP
MUL_1772|M.ulcerans_Agy99 DELDQLRHDVMGPPHVRPPSFCNAGGGLWSTADDYLRFVRLLLGDGTIDG
. . .
Mb0931|M.bovis_AF2122/97 RRITSPEALLLVYTPQVISRHPVSPRARASFYG-YGFNVGVTSSGRTEYS
Rv0907|M.tuberculosis_H37Rv RRITSPEALLPVYTPQVISRHPVSPRARASFYG-YGFNVGVTSSGRTEYS
MMAR_4623|M.marinum_M QQIVSPEALLPAITPQVISSAARSPKARAGFYG-HGFTVSVSSAGRTQYG
MAV_1030|M.avium_104 QHIASPEALLPALSPQVVSAPATTPKARTGFYG-YGFNTSVDASGRTEYS
Mflv_1757|M.gilvum_PYR-GCK NALIDPQALLPAISPQVTSAPPTEPAMRPGFYG-YGFNVGTTSAARTQLS
Mvan_4990|M.vanbaalenii_PYR-1 NQLIDPTALLPAITPQVTSSRGSEPAMRSGFYG-YGFNVGTTSAARTQLS
MSMEG_5637|M.smegmatis_MC2_155 ERIVEESTLLPAITPQVVSDRASQPAMRSGFYG-YGFNVGTTSAARTQLS
TH_0096|M.thermoresistible__bu RRIVDPDALLPALTPQIVSSPATEPAMRSGFYG-YGFNVGITSAARTELS
MLBr_01782|M.leprae_Br4923 QIHAEATSVQFPDLDGVLPGHGVQ---RPNDWG-LGYEIKNSK-------
MAB_2179|M.abscessus_ATCC_1997 FRIADNVNVPLPQGIGVAVRFGPARVTRGDAYP-SGGAG-----------
MUL_1772|M.ulcerans_Agy99 VRVLSPESVRLMRTDRLSDEHKRHNFLGAPFWVGRGFGLN----------
. : : : *
Mb0931|M.bovis_AF2122/97 HSGAFGLGAAANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQ
Rv0907|M.tuberculosis_H37Rv HSGAFGLGAAANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQ
MMAR_4623|M.marinum_M HSGAFGLGAATNFVVLPSEDIAIVALTNAAPYGIPEALTAQFMDLVQYGE
MAV_1030|M.avium_104 HSGAFDLGAATNFVVLPSEDLAIIALTNAAPYGIPETLTAEFMDLVQYGQ
Mflv_1757|M.gilvum_PYR-GCK HSGAFELGAATNVLFLPSADVAIIALTNATPTGVPETLTAQFADLVQFGE
Mvan_4990|M.vanbaalenii_PYR-1 HSGAFELGAATNVLFLPSADVAIVALTNATPTGIPETLTAQFADLVQFGE
MSMEG_5637|M.smegmatis_MC2_155 HSGAFELGAATNFVILPSADVGIVALTNGTPAGIPETLTAEFADLVQFGE
TH_0096|M.thermoresistible__bu HSGAFELGTGTNFVILPSADAGIVALTNATPSGVAEALTAQFADLVQFGE
MLBr_01782|M.leprae_Br4923 ---------------LP-------------------HWTGTLNSARTYGH
MAB_2179|M.abscessus_ATCC_1997 -------------MYGTADDVLLLLEAIRAGDGFLAEELRTSMRTDHVGP
MUL_1772|M.ulcerans_Agy99 --------------------LSVVTDPVQSTPLFGPGGLGTFSWPGAYGT
*
Mb0931|M.bovis_AF2122/97 VREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYW
Rv0907|M.tuberculosis_H37Rv VREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYW
MMAR_4623|M.marinum_M VREDWTNLYRQQMSPINTPEGSLVGKQPPVNPEPARPPSDYVGVYANDYW
MAV_1030|M.avium_104 IREDWAALYRKAIGWLNNPLGSLVGKQPPSAPAPARPLRDYTGVYANDYW
Mflv_1757|M.gilvum_PYR-GCK IRQDWAALYGKAFADMDKPVGSLVGQQRHVNAQTHGPLDSYTGVYGNDYW
Mvan_4990|M.vanbaalenii_PYR-1 IRQDWYALYAKAFEDMDKPVGSLVGQQRPANAQAHGPLAAYTGVYRNDYW
MSMEG_5637|M.smegmatis_MC2_155 VRQDWRKLYADAFASMDGPEGELVGKKPPAVPAPARPLPDYVGVYRNDYW
TH_0096|M.thermoresistible__bu IREDWYRLYRELMAPLEQPQGSLVGRPRPADPAPPAPLSTYVGTYHNDYW
MLBr_01782|M.leprae_Br4923 FGQ----------------SGGFIWADPEAELALVVLTDRDFGEWALQLW
MAB_2179|M.abscessus_ATCC_1997 QAQTRGPGWGFGYG------GAVLADPAAADSPQSAGTIGWGGVYGHSWF
MUL_1772|M.ulcerans_Agy99 WWQADPG--------ADLILLYLIQHCPDLSVNAAAAVAGNPGLAKLRTA
: .: *
Mb0931|M.bovis_AF2122/97 GPATVTYHDGQLRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENA
Rv0907|M.tuberculosis_H37Rv GPATVTYHDGQLRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENA
MMAR_4623|M.marinum_M GPATVTERDGQLQLSMGPKN--------QTFDLTHWDGDTFTFALSTENA
MAV_1030|M.avium_104 GPAVITEHDGALQLTMGPQH--------RTATLTHWDGDTFTFPLTGENA
Mflv_1757|M.gilvum_PYR-GCK GPATVTERDGRLQLALGPR---------GVFELDAWDGNVFVFPVSSENA
Mvan_4990|M.vanbaalenii_PYR-1 GPATVTERDGHLELALGPR---------GVFKLQPWDGNVFTFPVSSENA
MSMEG_5637|M.smegmatis_MC2_155 GPATVTEQDGALQLALGPK---------FKARLTHWDGDVFTFRFVSENA
TH_0096|M.thermoresistible__bu GPARVTERDGKLVLDMGPPDARPQPGAPDEFPLTHWDGNVFTFTLVTENA
MLBr_01782|M.leprae_Br4923 PAISDAVISEYAR-------------------------------------
MAB_2179|M.abscessus_ATCC_1997 VDAARGLSVLLLTN-------------------TAYEGMTGPLTVEMRDA
MUL_1772|M.ulcerans_Agy99 QPRFVRRTYRALGL------------------------------------
Mb0931|M.bovis_AF2122/97 LPGSISKATFAG---DTLNLEYYDADKLGTFTR
Rv0907|M.tuberculosis_H37Rv LPGSISKATFAG---DTLNLEYYDADKLGTFTR
MMAR_4623|M.marinum_M LPGSISKATFAG---DTLNLEYFDSNKLGTFTR
MAV_1030|M.avium_104 PPGTVSTATFTGSPAARLNLEYYDTDQLGTFTR
Mflv_1757|M.gilvum_PYR-GCK PPGTVSAATFDG---GALTLEYFDQEGNGVFVR
Mvan_4990|M.vanbaalenii_PYR-1 PPGTVSAATFDA---GSLTLEYFDDEGKGVFTR
MSMEG_5637|M.smegmatis_MC2_155 PPGTISKATFAG---DKLTLEYFDEDGTGTFTR
TH_0096|M.thermoresistible__bu PPGTISKATFDG---DRLTLEYYDDVHDGVFVK
MLBr_01782|M.leprae_Br4923 ---------------------------------
MAB_2179|M.abscessus_ATCC_1997 VYAAD----------------------------
MUL_1772|M.ulcerans_Agy99 ---------------------------------