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KPRARVAALALTAALLAGCGTEGAEPAASSTPAPSPASDVPPPLVPAMPLPENAVADAVAKLDGLAEDLM SKSGIPGMAVAVVHGGKAVYAKGFGVRNNTMSDEPHNEVDADTVFQLASLSKPLSATAVAALVGQNQVSW DTPIVSRLPWFALSDPAVTQMVTVGDMFSHRSGLPDHAGDQLEDLGYDRRQVLERLRQLPLDQFRTSYAY TNFGLTAGAEAVATGAGKSWEDLAADTLLRPLGMGATSYRFSDYESRRDRAVGHIRIDGGYQPRFVRDAQ AQSPAGGASSSVNDMTRWMAMVLADGRHDGNQLIDPTALLPAITPQVTSSRGSEPAMRSGFYGYGFNVGT TSAARTQLSHSGAFELGAATNVLFLPSADVAIVALTNATPTGIPETLTAQFADLVQFGEIRQDWYALYAK AFEDMDKPVGSLVGQQRPANAQAHGPLAAYTGVYRNDYWGPATVTERDGHLELALGPRGVFKLQPWDGNV FTFPVSSENAPPGTVSAATFDAGSLTLEYFDDEGKGVFTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4990 | - | - | 100% (531) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5895 | - | 1e-13 | 30.00% (270) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_2658 | - | 1e-12 | 25.08% (319) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0931 | - | 1e-176 | 59.11% (516) | hypothetical protein Mb0931 |
| M. gilvum PYR-GCK | Mflv_1757 | - | 0.0 | 87.01% (531) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0907 | - | 1e-176 | 59.34% (514) | hypothetical protein Rv0907 |
| M. leprae Br4923 | MLBr_00119 | lipE | 5e-08 | 22.65% (309) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4800 | - | 3e-13 | 27.59% (261) | putative beta-lactamase |
| M. marinum M | MMAR_4623 | - | 1e-178 | 58.08% (532) | penicillin binding protein |
| M. avium 104 | MAV_1030 | - | 1e-177 | 59.20% (527) | penicillin-binding protein 4 |
| M. smegmatis MC2 155 | MSMEG_5637 | - | 0.0 | 69.25% (530) | penicillin-binding protein 4 |
| M. thermoresistible (build 8) | TH_0096 | - | 0.0 | 63.74% (535) | penicillin-binding protein 4 |
| M. ulcerans Agy99 | MUL_1294 | - | 5e-10 | 24.56% (285) | hypothetical protein MUL_1294 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0931|M.bovis_AF2122/97 ---------MMLLT----------------LTGCGSTHQALGPPSGL---
Rv0907|M.tuberculosis_H37Rv ---------MATICGHDQTSGNGRHGDVADVNGCGSTHQALGPPSGL---
MMAR_4623|M.marinum_M ---------MTKRAAT-----TAVVMMFLALVGCAPKQSISNPPSTP---
MAV_1030|M.avium_104 ---------MSKRAAV-------LTAVLLGLTGCGSAQQPAGAPPRP---
Mvan_4990|M.vanbaalenii_PYR-1 ---MK----PRARVAA-------LALTAALLAGCGTEGAEPAASSTPAPS
Mflv_1757|M.gilvum_PYR-GCK ---MK----SRVGAVA-------LVMAVALLAGCAAESTEPAASSTPAPG
MSMEG_5637|M.smegmatis_MC2_155 MYSMRRSVFARAVGSA-------LVVGLAVSGCAGGDDTADAQRSAQPSQ
TH_0096|M.thermoresistible__bu ---------VLKRFAA-------VLTALVLLAGCRSGDDASTAHPS----
MUL_1294|M.ulcerans_Agy99 --------------------------------------------------
MAB_4800|M.abscessus_ATCC_1997 ----------------------------MKVPGSHATRVCAVATVLLALA
MLBr_00119|M.leprae_Br4923 ------------------------------MTSDGKIRVP----------
Mb0931|M.bovis_AF2122/97 --PDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHG
Rv0907|M.tuberculosis_H37Rv --PDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHG
MMAR_4623|M.marinum_M --SQLPPNEVSGIDIPPGRIDEAVAKVDGLVAELMKSTGIPGMAVAIVHG
MAV_1030|M.avium_104 --SDVSPNQVSALAIPAGRIDEAVAKVDGLVADLMRSSGIPGMAVAIVHG
Mvan_4990|M.vanbaalenii_PYR-1 PASDVPPPLVPAMPLPENAVADAVAKLDGLAEDLMSKSGIPGMAVAVVHG
Mflv_1757|M.gilvum_PYR-GCK PLSDVPPPLVPAMPLPENAVANAVAKLDGLAEDLMSTSGVPGMAVAVVHQ
MSMEG_5637|M.smegmatis_MC2_155 TFADEPPPLVPAMALPENAVENAVAKLDGIAEDLMRSSGIPGMAVAVVHG
TH_0096|M.thermoresistible__bu --SDLPPPLVAAVDLPADAVANAVARLDGLAADLLEQSGIPGLAVAVVHG
MUL_1294|M.ulcerans_Agy99 ----------------------------MAALDALDDWPVPAAAAAVIGP
MAB_4800|M.abscessus_ATCC_1997 GIPSCGRP-AQPITAPSIVPTGPFAPITTLVNDAVAAPRLPGAVVEIGHA
MLBr_00119|M.leprae_Br4923 --TDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHPAIQLCIRQH
. . *. :
Mb0931|M.bovis_AF2122/97 GKTLYAKGFGVRDVGK------GGGPDNKVDADTVFQLASVSKSVGATVV
Rv0907|M.tuberculosis_H37Rv GKTLYAKGFGVRDVGK------GGGPDNKVDADTVFQLASVSKSVGATVV
MMAR_4623|M.marinum_M GKTLYAKGFGVRDVSK------GDGQDNKVDTDTVFQLASMSKPIGATVV
MAV_1030|M.avium_104 GKVLYAKGFGVKDVTS------GQGRDNAVDTDTVFQLASVSKSVGATVV
Mvan_4990|M.vanbaalenii_PYR-1 GKAVYAKGFGVRNNTM------SDEPHNEVDADTVFQLASLSKPLSATAV
Mflv_1757|M.gilvum_PYR-GCK GKTVYAKGFGVKNNTQ------SDSPENRVDADTVFQLASLSKPLSATVV
MSMEG_5637|M.smegmatis_MC2_155 GKTVYAKGFGVRDVRN------GDVESNRVDPDTVFQLASLSKPIAATVV
TH_0096|M.thermoresistible__bu GKTVYAKGFGVKDIRT------GDP----VGADTVFQLASLSKPIGATVV
MUL_1294|M.ulcerans_Agy99 TGVLATHGN----------------------VEKVFALASVTKPMAARAA
MAB_4800|M.abscessus_ATCC_1997 GKIVFRQAFGWRKLPDEPGLNGSPAPAEPMTDDTIFDIASLTKPLATSVA
MLBr_00119|M.leprae_Br4923 GRVVLNRAIGHGWGNAP--TDPHDAEKIPVTTDTPFCAYSAAKAITATVV
: :. :. * * :*.: : ..
Mb0931|M.bovis_AF2122/97 AHAVTDN-VVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLP---
Rv0907|M.tuberculosis_H37Rv AHAVTDN-VVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLP---
MMAR_4623|M.marinum_M AHEVSTN-VVSWDTPVVSKLPEFALSDPYVTDHATIADLYSHRSGLP---
MAV_1030|M.avium_104 AHEVSDH-VVGWDTPVVSTLPWFALGDPYVTGHVTVGDLYSHRSGLP---
Mvan_4990|M.vanbaalenii_PYR-1 AALVGQN-QVSWDTPIVSRLPWFALSDPAVTQMVTVGDMFSHRSGLP---
Mflv_1757|M.gilvum_PYR-GCK AALVGQD-QVGWDTPVVSRLPWFALSDPTTTQMVTVGDMFSHRSGLP---
MSMEG_5637|M.smegmatis_MC2_155 AHQVGTG-AIGWDTPVVEHLPWFALSDPVTTRMVTVGDLFAHRSGLP---
TH_0096|M.thermoresistible__bu AHQVGTG-AISWDTPVISRLPWFRLSDPVVTERVTIGDMYAHRSGLP---
MUL_1294|M.ulcerans_Agy99 QIAIEEG-VVDLDTPAG-------------PPDSTIRHLLAHTSGLP---
MAB_4800|M.abscessus_ATCC_1997 VLQLYEGGRVHIDEPVQAYLPDFNPTNDPRRDQVTLRMLLTHTSGIGGDL
MLBr_00119|M.leprae_Br4923 HMLVERG-HFSLDDRVCEYLPTYTSYG---KHRTTIRHVLTHSAGVPFP-
: . * *: : :* :*:
Mb0931|M.bovis_AF2122/97 DHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGV-TAAAEAVAA
Rv0907|M.tuberculosis_H37Rv DHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGV-TAAAEAVAA
MMAR_4623|M.marinum_M DHAGDALEDLGYDTTQVLERLKYLPLDPFRISYAYTNFGV-TAAADAVAA
MAV_1030|M.avium_104 DHAGDKLEDLGYGRRQICERLRLLPLRPFRNSYAYTNYGI-TAAAEAVAA
Mvan_4990|M.vanbaalenii_PYR-1 DHAGDQLEDLGYDRRQVLERLRQLPLDQFRTSYAYTNFGL-TAGAEAVAT
Mflv_1757|M.gilvum_PYR-GCK DHAGDQLEDLGYDRRQVLDRLRQLPLAQFRTSYAYTNFGL-TAGAEAVAT
MSMEG_5637|M.smegmatis_MC2_155 DHAGDQLEDLGYDRRYILEHLRALPLDPFRNSYAYTNFGL-TAAAEAVAA
TH_0096|M.thermoresistible__bu DHAGDLLEDLGYDRRQVLEKLAQLPLAPFRISYAYTNFGX-TAAAEAVAA
MUL_1294|M.ulcerans_Agy99 MHTNQVLARPGTRR-------------------MYSNYGF-TALAEAVAQ
MAB_4800|M.abscessus_ATCC_1997 SHQGPWGLKQADKADGIHRALTTPLAFDPGTTFHYSDINF-IILGALVEK
MLBr_00119|M.leprae_Br4923 TGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREIIWT
* :
Mb0931|M.bovis_AF2122/97 AAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEAR
Rv0907|M.tuberculosis_H37Rv AAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEAR
MMAR_4623|M.marinum_M AAGKAWPDLSEEVLYRPLGMTSTSSRFADFLARPNHAVNHIKVGDRWEAR
MAV_1030|M.avium_104 AAGKTWEELSDEVLYRPLGMTSTSSRFADFLARPNRAVNHIKIGDSWQAR
Mvan_4990|M.vanbaalenii_PYR-1 GAGKSWEDLAADTLLRPLGMGATSYRFSDYESRRDRAVGHIRIDGGYQPR
Mflv_1757|M.gilvum_PYR-GCK GAGKSWEDLAADTLLRPLGMGVTSYRFEDYASRRDRAVGHIRIDDGYQPR
MSMEG_5637|M.smegmatis_MC2_155 AAGRSWEDLARDVLYRPLGMDSTSSRFADYEATQNRAVGHIRVDGRYEPQ
TH_0096|M.thermoresistible__bu DAGMPWEELSGRVLYEPLGMASTSSRFADYQARADRAVGHIHVDGGYQPF
MUL_1294|M.ulcerans_Agy99 ESGIEFSSYLAEAVFEPLGMSTS---------------------------
MAB_4800|M.abscessus_ATCC_1997 VTGQTLDIYVQDNIFAPLGMNETRYLPAAKACGPHHIVG---------TA
MLBr_00119|M.leprae_Br4923 ATGKEIRDILAAEILDPLGFRWTNFG---------------------VAE
:* : ***: :
Mb0931|M.bovis_AF2122/97 YQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLLVYT
Rv0907|M.tuberculosis_H37Rv YQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYT
MMAR_4623|M.marinum_M FQRDPDAQTPAGGVSSSLNDMAHWLTMVLANGEYNGQQIVSPEALLPAIT
MAV_1030|M.avium_104 FQRNPDAQSPAGGVSSSVRDMARWLMMLLDNGTHDGQHIASPEALLPALS
Mvan_4990|M.vanbaalenii_PYR-1 FVRDAQAQSPAGGASSSVNDMTRWMAMVLADGRHDGNQLIDPTALLPAIT
Mflv_1757|M.gilvum_PYR-GCK YVRDAQAQSPAGGASSSVNDMTRWMAMVLAEGRHDGNALIDPQALLPAIS
MSMEG_5637|M.smegmatis_MC2_155 YVRNADAQTPAGGVSASVDDMTRWLAMVLGDGVFEGERIVEESTLLPAIT
TH_0096|M.thermoresistible__bu YLRDPDAESPAGGVSSSVNDVARWLAMVLGDGSFEGRRIVDPDALLPALT
MUL_1294|M.ulcerans_Agy99 -KLEGGAAAAGFGATSTVGDLALFTGDLLRPSTVSPPMHAEAIAVQFPGL
MAB_4800|M.abscessus_ATCC_1997 ITLEEGPRAAPDCATGAWSTALLTRIAPTAHDEDTPGINPHYGRLIRGTV
MLBr_00119|M.leprae_Br4923 EDVPLVALSHATGRPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVP
. : . . :
Mb0931|M.bovis_AF2122/97 PQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLG----AAA
Rv0907|M.tuberculosis_H37Rv PQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLG----AAA
MMAR_4623|M.marinum_M PQVISSAARSPKARAGFYGHGFTVSVSSAGRTQYGHSGAFGLG----AAT
MAV_1030|M.avium_104 PQVVSAPATTPKARTGFYGYGFNTSVDASGRTEYSHSGAFDLG----AAT
Mvan_4990|M.vanbaalenii_PYR-1 PQVTSSRGSEPAMRSGFYGYGFNVGTTSAARTQLSHSGAFELG----AAT
Mflv_1757|M.gilvum_PYR-GCK PQVTSAPPTEPAMRPGFYGYGFNVGTTSAARTQLSHSGAFELG----AAT
MSMEG_5637|M.smegmatis_MC2_155 PQVVSDRASQPAMRSGFYGYGFNVGTTSAARTQLSHSGAFELG----AAT
TH_0096|M.thermoresistible__bu PQIVSSPATEPAMRSGFYGYGFNVGITSAARTELSHSGAFELG----TGT
MUL_1294|M.ulcerans_Agy99 DGVLPGFGVQ---RPNDWGLGFEIKSAKSPHWTGIRNSPRTYGHFGQAGG
MAB_4800|M.abscessus_ATCC_1997 HDPTARRMGGVAGSAGVFSTAGDVGRYCQALLDRLAGRPSTFP-------
MLBr_00119|M.leprae_Br4923 SSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECR-------
. : . .
Mb0931|M.bovis_AF2122/97 NFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKK
Rv0907|M.tuberculosis_H37Rv NFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKK
MMAR_4623|M.marinum_M NFVVLPSEDIAIVALTNAAPYGIPEALTAQFMDLVQYGEVREDWTNLYRQ
MAV_1030|M.avium_104 NFVVLPSEDLAIIALTNAAPYGIPETLTAEFMDLVQYGQIREDWAALYRK
Mvan_4990|M.vanbaalenii_PYR-1 NVLFLPSADVAIVALTNATPTGIPETLTAQFADLVQFGEIRQDWYALYAK
Mflv_1757|M.gilvum_PYR-GCK NVLFLPSADVAIIALTNATPTGVPETLTAQFADLVQFGEIRQDWAALYGK
MSMEG_5637|M.smegmatis_MC2_155 NFVILPSADVGIVALTNGTPAGIPETLTAEFADLVQFGEVRQDWRKLYAD
TH_0096|M.thermoresistible__bu NFVILPSADAGIVALTNATPSGVAEALTAQFADLVQFGEIREDWYRLYRE
MUL_1294|M.ulcerans_Agy99 FIWVDPEADLALVVLTDRDFG----------------DWAREPWPALSDS
MAB_4800|M.abscessus_ATCC_1997 ----LKRATLELMTSPAQPGHNDGQLKAANDAARLAIEKTSNSTDPLLAP
MLBr_00119|M.leprae_Br4923 --RLRPDFVVGLMPARWGTGFILGTNKFGPFG-----RNAPAAFGHLGLV
:: *
Mb0931|M.bovis_AF2122/97 AFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYWGPATVTYHDGQ
Rv0907|M.tuberculosis_H37Rv AFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYWGPATVTYHDGQ
MMAR_4623|M.marinum_M QMSPINTPEGSLVGKQPPVNPEPARPPSDYVGVYANDYWGPATVTERDGQ
MAV_1030|M.avium_104 AIGWLNNPLGSLVGKQPPSAPAPARPLRDYTGVYANDYWGPAVITEHDGA
Mvan_4990|M.vanbaalenii_PYR-1 AFEDMDKPVGSLVGQQRPANAQAHGPLAAYTGVYRNDYWGPATVTERDGH
Mflv_1757|M.gilvum_PYR-GCK AFADMDKPVGSLVGQQRHVNAQTHGPLDSYTGVYGNDYWGPATVTERDGR
MSMEG_5637|M.smegmatis_MC2_155 AFASMDGPEGELVGKKPPAVPAPARPLPDYVGVYRNDYWGPATVTEQDGA
TH_0096|M.thermoresistible__bu LMAPLEQPQGSLVGRPRPADPAPPAPLSTYVGTYHNDYWGPARVTERDGK
MUL_1294|M.ulcerans_Agy99 VLAEYA--------------------------------------------
MAB_4800|M.abscessus_ATCC_1997 GYPAIAGQNLRGLGWDIDTELSKPRGMLFPIGSFGHSGFTGVTLWLDPG-
MLBr_00119|M.leprae_Br4923 NIAIWADPQRSMAAGLISSGKPGQDPNAGRYGALMNTITAEIPVH-----
Mb0931|M.bovis_AF2122/97 LRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENALPGSISKATFA
Rv0907|M.tuberculosis_H37Rv LRLSLGPKN--------QTFDLTHWDGDTFTFTLSTENALPGSISKATFA
MMAR_4623|M.marinum_M LQLSMGPKN--------QTFDLTHWDGDTFTFALSTENALPGSISKATFA
MAV_1030|M.avium_104 LQLTMGPQH--------RTATLTHWDGDTFTFPLTGENAPPGTVSTATFT
Mvan_4990|M.vanbaalenii_PYR-1 LELALGPR---------GVFKLQPWDGNVFTFPVSSENAPPGTVSAATFD
Mflv_1757|M.gilvum_PYR-GCK LQLALGPR---------GVFELDAWDGNVFVFPVSSENAPPGTVSAATFD
MSMEG_5637|M.smegmatis_MC2_155 LQLALGPK---------FKARLTHWDGDVFTFRFVSENAPPGTISKATFA
TH_0096|M.thermoresistible__bu LVLDMGPPDARPQPGAPDEFPLTHWDGNVFTFTLVTENAPPGTISKATFD
MUL_1294|M.ulcerans_Agy99 --------------------------------------------------
MAB_4800|M.abscessus_ATCC_1997 --------------------------SDTYVVVLANVIHQRGGPPIVRLS
MLBr_00119|M.leprae_Br4923 --------------------------------------------------
Mb0931|M.bovis_AF2122/97 G---DTLNLEYYDADKLGTFTR
Rv0907|M.tuberculosis_H37Rv G---DTLNLEYYDADKLGTFTR
MMAR_4623|M.marinum_M G---DTLNLEYFDSNKLGTFTR
MAV_1030|M.avium_104 GSPAARLNLEYYDTDQLGTFTR
Mvan_4990|M.vanbaalenii_PYR-1 A---GSLTLEYFDDEGKGVFTR
Mflv_1757|M.gilvum_PYR-GCK G---GALTLEYFDQEGNGVFVR
MSMEG_5637|M.smegmatis_MC2_155 G---DKLTLEYFDEDGTGTFTR
TH_0096|M.thermoresistible__bu G---DRLTLEYYDDVHDGVFVK
MUL_1294|M.ulcerans_Agy99 ----------------------
MAB_4800|M.abscessus_ATCC_1997 G------HIATVAARMLDLYRN
MLBr_00119|M.leprae_Br4923 ----------------------