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MDLDFTPDQLEFRDRVRTWLDEHKPTEARPRDDAGIREYDLAWQRTQWEGGWAGIAWPKEYGGQGLTLMQ QLIWYEEYAARGFPGIDACFVGNSHAGPTLITRATDEQKSFHLPKILRGEVIWCQGFSEPEAGSDLAALR TKAVIDGDHLVVSGQKLWTSFATVADYQELLVRTDNTGSKHKGITWVICDMNTPGIDIRPIETIEGGSEF CEVFYDDVRIPLSNVVGDVGEGWSVAMATLSFERGTAFTANQVRLAKIVEDLIDYARDHVGPDGRRPAIA DDEFARRLARARASVASLRALTYTNICEAMKTETPGPRGSIVKLMYAELTKEIGKLAMDILGPASIRHSS RWDADGWAGYYYYGFSQAIGGGTSEIQRNIVGERVLGLPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1909 | - | - | 100% (390) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_2619 | - | 0.0 | 93.08% (390) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1268 | - | 6e-74 | 39.55% (402) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 5e-70 | 36.89% (412) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_4379 | - | 7e-69 | 38.31% (415) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 5e-70 | 36.89% (412) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-20 | 27.41% (343) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 3e-71 | 38.76% (387) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_2862 | fadE17 | 3e-69 | 36.03% (408) | acyl-CoA dehydrogenase FadE17 |
| M. smegmatis MC2 155 | MSMEG_5619 | - | 2e-70 | 42.28% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_4120 | - | 3e-76 | 41.97% (386) | PUTATIVE putative acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 8e-67 | 38.36% (391) | acyl-CoA dehydrogenase FadE30 |
| M. vanbaalenii PYR-1 | Mvan_4006 | - | 1e-70 | 35.77% (411) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
Rv1934c|M.tuberculosis_H37Rv -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
Mvan_4006|M.vanbaalenii_PYR-1 -----------MDVDYPPQAEAFRDRIRALLAEHLPPDWSGGGALAP--E
MMAR_2862|M.marinum_M -----------MDVAYPPEAEEFRERVRAFLDEHLPCGWSGPGALAV--Q
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MUL_4125|M.ulcerans_Agy99 --------------MQDV--EEFRAEVRGWLAANLVGEFATLKGLGGPGR
MAV_1909|M.avium_104 -----------MDLDFTPDQLEFRDRVRTWLDEHKPTEARPRD-------
MSMEG_5619|M.smegmatis_MC2_155 -------------MTHPENLDDFRATVRDWCAAHVPKDWRAAQTGVS---
TH_4120|M.thermoresistible__bu ------VNDRDYGVALTDADRAFRDEVREFLASSLTPDLLSRDGG-----
Mflv_4379|M.gilvum_PYR-GCK -----------MDLGWSATDLEFRDEVRAFLEEKLAPELRQAGRLMT--S
MLBr_00737|M.leprae_Br4923 -MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR---
.* :*
Mb1969c|M.bovis_AF2122/97 EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Mvan_4006|M.vanbaalenii_PYR-1 ERAAVARR--WRQSLAAAGLVAVSWPKAYGGAGLSVIEQVVLDEEFARAG
MMAR_2862|M.marinum_M DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MUL_4125|M.ulcerans_Agy99 EHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSTAHRVAFYEEYARAD
MAV_1909|M.avium_104 DAGIREYDLAWQRTQWEGGWAGIAWPKEYGGQGLTLMQQLIWYEEYAARG
MSMEG_5619|M.smegmatis_MC2_155 DDEFAAFQKAWFAELHSAGYAVPHWPAEWGG-GMSVPQQIVLYSELAAHD
TH_4120|M.thermoresistible__bu ETARLDRLRRWQGLLYDAGLAAISWPTEYGGRAATPTQQLIFNTEMAAAR
Mflv_4379|M.gilvum_PYR-GCK VYADHDASMAWQAILHERGWAAPAWPVAHGGCDWSLTQHYIFSRESTLAG
MLBr_00737|M.leprae_Br4923 ------FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
* * ** * :
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Mvan_4006|M.vanbaalenii_PYR-1 APERAENDLLGIQLLGNTLIALGTEEQKRHFLPRILSAEDRWCQGFSEPE
MMAR_2862|M.marinum_M APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997 APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MUL_4125|M.ulcerans_Agy99 APDKVNH--FGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPG
MAV_1909|M.avium_104 FPG-IDACFVGNSHAGPTLITRATDEQKSFHLPKILRGEVIWCQGFSEPE
MSMEG_5619|M.smegmatis_MC2_155 APR-LVLAFVGIHHAASTLLAAGTDAQRNRHLPAILDGE-IWVQGFSEPE
TH_4120|M.thermoresistible__bu AP--EPINRSAINQLGPTIIQWGTDEQRAYYLPRILSAEDVWCQGFSEPE
Mflv_4379|M.gilvum_PYR-GCK APS---LSPMGIRMVAHAIIKFGTDEQKDFFLPRILTGEVFFCQGYSEPE
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
. . :: .: : ** : . **
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
Mvan_4006|M.vanbaalenii_PYR-1 AGSDLASVRTRAVLDDDEWVINGQKIWTSAGPTANWIFVLARTDTEAPKH
MMAR_2862|M.marinum_M AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLDGGDWVINGQKVWTSLALQSQWCFVVARTEPGSSRH
MUL_4125|M.ulcerans_Agy99 AGSDLANVATTAELDGDQWVINGQKVWTSLAHLSQWCFVVARTEKGSKRH
MAV_1909|M.avium_104 AGSDLAALRTKAVIDGDHLVVSGQKLWTSFATVADYQELLVRTDNTGSKH
MSMEG_5619|M.smegmatis_MC2_155 AGSDLASLRTTARAEGDTFVVNGQKLWASGAMYADWCLLLARTDPNAPKR
TH_4120|M.thermoresistible__bu AGSDLASLKTRAVIDGDELVITGQKIWTSKATYANRIYLLARTDPDAPKR
Mflv_4379|M.gilvum_PYR-GCK AGSDLAALSMAARDDGDHLVCTGSKIWTTHAQEANWMFALVRTTRTDKKQ
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN
**** * : . :.. : .* * * : . : :. * .
Mb1969c|M.bovis_AF2122/97 RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRV
Rv1934c|M.tuberculosis_H37Rv RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRV
Mvan_4006|M.vanbaalenii_PYR-1 KGLSLLLVPIDQPGVVVRPIVNAAGH--ASFSEVFFTDARTPAVNVVGRV
MMAR_2862|M.marinum_M QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVANVVGEV
MAB_0597|M.abscessus_ATCC_1997 KGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTSADLVVGEP
MUL_4125|M.ulcerans_Agy99 AGLSYLLVPLDQPSVQIRPIVQITGT--AEFNEVFFDDARTDADLVVGAP
MAV_1909|M.avium_104 KGITWVICDMNTPGIDIRPIETIEGG--SEFCEVFYDDVRIPLSNVVGDV
MSMEG_5619|M.smegmatis_MC2_155 HGISYFMMDMKTPGVDVRPIRNAVGD--SHFCEIFLNDVVIPSANLVGPV
TH_4120|M.thermoresistible__bu EGISYILADLNTPGIEVRPIRQITGA--SEFCEVFLDSVRVPLANVLGPL
Mflv_4379|M.gilvum_PYR-GCK RGITFVLIDMATPGIEIRPLVMTSGE--EVQNQVFFDEVRVPKSNVIGQI
MLBr_00737|M.leprae_Br4923 -GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEP
*:: .: .. : * * ::: . ::*
Mb1969c|M.bovis_AF2122/97 GDGWSTAMTLLGFERGSHIATA-AIDFERDLQRLCELARDRGLH------
Rv1934c|M.tuberculosis_H37Rv GDGWSTAMTLLGFERGSHIATA-AIDFERDLQRLCELARDRGLH------
Mvan_4006|M.vanbaalenii_PYR-1 GDGWPAAMTVLGFERGSQVTTA-AINFGREMDRLRELARDRGLH------
MMAR_2862|M.marinum_M GSGWTAAMSLLGFERGAQATTG-AIDFARDLSRLCDLARARGLD------
MAB_0597|M.abscessus_ATCC_1997 GDGWRVAMGTLTFERGVSTLGN-QITYARELSRLAELAKSNGAA------
MUL_4125|M.ulcerans_Agy99 GDGWRVAMGTLTFERGVSTLGQ-QIVYARELSDLAALARRTGAA------
MAV_1909|M.avium_104 GEGWSVAMATLSFERGTAFTAN-QVRLAKIVEDLIDYARDHVGPDGRRPA
MSMEG_5619|M.smegmatis_MC2_155 NKGWQVAQATLGAERGMTMLEL-AERLG---NAGFRWLVDACSP------
TH_4120|M.thermoresistible__bu HGGWRVAKSTLGYER--VGQSR-THRIERRLGILVKMAQEPNALTDSG--
Mflv_4379|M.gilvum_PYR-GCK DDGWTVAKYLLEFERGGGAVAPGLQVMAENIATVAADQPGPGGGR----L
MLBr_00737|M.leprae_Br4923 GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESIS--
*: .* * *
Mb1969c|M.bovis_AF2122/97 -TDPRVRDGLAWCYARVQIMRYRGYRDLTLA-LTGRPPGAEAAITKVIWS
Rv1934c|M.tuberculosis_H37Rv -TDPRVRDGLAWCYARVQIMRYRGYRDLTLA-LTGRPPGAEAAITKVIWS
Mvan_4006|M.vanbaalenii_PYR-1 -TDARIRDGLAWCYSRVQIMRFQGYRGLTSL-LAGQRPGREAAISKVVWS
MMAR_2862|M.marinum_M -SDPRIRDRLAWCYSRTQIMRYRGYRSLTWA-LNGLLPGAEAAISKVIWS
MAB_0597|M.abscessus_ATCC_1997 -DDPAIRERLAQAYVGMRTMRAYALATMDEE-RPG-----QDNVSKLLWA
MUL_4125|M.ulcerans_Agy99 -DDPFIREHLTRAWTGLRAMRSYALATMDVE-QPG-----QDNVSKLLWA
MAV_1909|M.avium_104 IADDEFARRLARARASVASLRALTYTNICEAMKTETPGPR-GSIVKLMYA
MSMEG_5619|M.smegmatis_MC2_155 VDDPVVADRLAQFEIELTGLRGLCR-DLVERSETGEAGPADASIVKLYYS
TH_4120|M.thermoresistible__bu FDDSYVADRIVRYAAQVEALRQIAAQATAAGVRGVAPGPE-ASVAKLLTS
Mflv_4379|M.gilvum_PYR-GCK LDDPAFARKLADVRIRTEVLEILEYQVLAVVAGGGNPG-AKSSMLKVLGT
MLBr_00737|M.leprae_Br4923 -TFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFAS
. :. . * :
Mb1969c|M.bovis_AF2122/97 EYFRRYTDLAVEILGLEA----LGPRGPGNGGARLVPEAGTPNSPACWMD
Rv1934c|M.tuberculosis_H37Rv EYFRRYTDLAVEILGLEA----LGPRGPGNGGARLVPEAGTPNSPACWMD
Mvan_4006|M.vanbaalenii_PYR-1 EFFRRYTELAVEILGLEA----LSPAGPGNGEALIVPEPGTPNSAACWMD
MMAR_2862|M.marinum_M EYFQRYTELAVEILGLDA----LCPSGPGNGEARVVPQAGTANSPACWMD
MAB_0597|M.abscessus_ATCC_1997 NWHRDLGELAMEIIGTST----LLTN---------------AGEMDEWQR
MUL_4125|M.ulcerans_Agy99 NWHRSLGELAMDVIGKPG----LTLA---------------DGEFDEWQR
MAV_1909|M.avium_104 ELTKEIGKLAMDILGP---------ASIRHS---------SRWDADGWAG
MSMEG_5619|M.smegmatis_MC2_155 ELLQRMTDFGAQIAGLPA----HTVLTKPAS---------SGWESGAWML
TH_4120|M.thermoresistible__bu EVDQSMANFGVELAGAPG------VLERGSP---------GAAKRGNVAA
Mflv_4379|M.gilvum_PYR-GCK ELSQAITELAMEAAGPRGRVYQPHATYPGGPIAEFEPPEGDYVSGEPWQA
MLBr_00737|M.leprae_Br4923 DIAMEVTTDAVQLFGGAG--------------------YTSDFPVERFMR
: . : *
Mb1969c|M.bovis_AF2122/97 ----ELLYARAATIYAGSSQIQRNVIGERLLGLPKEPR------PEVLC-
Rv1934c|M.tuberculosis_H37Rv ----ELLYARAATIYAGSSQIQRNVIGERLLGLPKEPR------PEVLC-
Mvan_4006|M.vanbaalenii_PYR-1 ----ELLYARASTIYAGSSQIQRNVIGEQLLGLPREPRVPAGRVPEPAGR
MMAR_2862|M.marinum_M ----ELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPR------REAVH-
MAB_0597|M.abscessus_ATCC_1997 ----LFLFSRADTIYGGSNEIQRNIISERVLGLPREAR------------
MUL_4125|M.ulcerans_Agy99 ----LFLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG-----------
MAV_1909|M.avium_104 ----YYYYGFSQAIGGGTSEIQRNIVGERVLGLPR---------------
MSMEG_5619|M.smegmatis_MC2_155 ----DFIGSWEWTIPGGASEIQRTIIGERGLGLPREPSAV----------
TH_4120|M.thermoresistible__bu ----SYLLMRAATFGAGTSEIQRNVIAERLLGLPRDN-------------
Mflv_4379|M.gilvum_PYR-GCK VAPLRYFNDRAGSIYAGSNEIQRNILAKAALGL-----------------
MLBr_00737|M.leprae_Br4923 -------DAKITQIYEGTNQIQRVVMSRALLR------------------
: *:.:*** ::.. *
Mb1969c|M.bovis_AF2122/97 ---
Rv1934c|M.tuberculosis_H37Rv ---
Mvan_4006|M.vanbaalenii_PYR-1 GSN
MMAR_2862|M.marinum_M ---
MAB_0597|M.abscessus_ATCC_1997 ---
MUL_4125|M.ulcerans_Agy99 ---
MAV_1909|M.avium_104 ---
MSMEG_5619|M.smegmatis_MC2_155 ---
TH_4120|M.thermoresistible__bu ---
Mflv_4379|M.gilvum_PYR-GCK ---
MLBr_00737|M.leprae_Br4923 ---