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VNALKITNLSTAVAAAAVAAAAILGTAPAAFGDASAVTTSTLGSAAKLNNGDVVQAWTVTDLKPSSDTIP YEVRGKLWEVTATDEAVQGNVTPIVSNFNVRAADGTNYRALFQVATPQGVNPSTIPQGEKASGKIYFDVT GPEPTTVVYNAGGKDLLVWDKPAASATAPSGTGQSRPATASSPATAAPTAAAEAESEAATDAETEATPAP AAASTAEGGTEATPAGAGSRATDLPAATAAEAETEATATDAETTPVTEETPAAPAPEGTTPVSLGTPAAE GTPAVEGAPAGASAGNVATAVPPAAPAEGAPAEVADPALVPAGVQPTTTVPAPAPTTAPVSHGPAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5412 | - | - | 100% (346) | immunogenic protein MPT63 |
| M. smegmatis MC2 155 | MSMEG_0828 | - | 5e-77 | 48.57% (350) | immunogenic protein MPT63 |
| M. smegmatis MC2 155 | MSMEG_5617 | - | 2e-29 | 43.95% (157) | immunogenic protein MPT63 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1961c | mpt63 | 1e-36 | 51.59% (157) | immunogenic protein MPT63 (antigen MPT63/MPB63) (16 KD |
| M. gilvum PYR-GCK | Mflv_1515 | - | 2e-58 | 45.68% (324) | FHA domain-containing protein |
| M. tuberculosis H37Rv | Rv1926c | mpt63 | 1e-36 | 51.59% (157) | immunogenic protein MPT63 (antigen MPT63/MPB63) (16 kDa |
| M. leprae Br4923 | MLBr_00048 | - | 2e-07 | 29.65% (172) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_1026c | - | 1e-62 | 45.12% (328) | hypothetical protein MAB_1026c |
| M. marinum M | MMAR_2839 | - | 1e-37 | 51.92% (156) | immunogenic protein Mpt63 |
| M. avium 104 | MAV_3737 | - | 2e-30 | 38.02% (192) | hypothetical protein MAV_3737 |
| M. thermoresistible (build 8) | TH_4151 | - | 1e-28 | 42.31% (156) | PUTATIVE putative FHA domain containing protein |
| M. ulcerans Agy99 | MUL_2071 | - | 1e-20 | 40.15% (132) | hypothetical protein MUL_2071 |
| M. vanbaalenii PYR-1 | Mvan_5241 | - | 4e-63 | 47.00% (300) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVA
Mflv_1515|M.gilvum_PYR-GCK ------------------MKFKPALVAAATAAAATAVALGGAATAS----
Mvan_5241|M.vanbaalenii_PYR-1 ------------------MKFKPTVAAIITTAAAAAVGVVGAGSAS----
MAB_1026c|M.abscessus_ATCC_199 ------------------MKIN-VPITAAVAAAAAAAGLALMPTAG----
Mb1961c|M.bovis_AF2122/97 ------------------MKLTTMIKTAVAVVAMAAIATF-AAPVAL--A
Rv1926c|M.tuberculosis_H37Rv ------------------MKLTTMIKTAVAVVAMAAIATF-AAPVAL--A
MMAR_2839|M.marinum_M ------------------MKLTTMIKTAVAVVAIATIATI-TAPIAF--A
MSMEG_5412|M.smegmatis_MC2_155 ----------------MNALKITNLSTAVAAAAVAAAAILGTAPAAFGDA
MAV_3737|M.avium_104 -----------------MKVTKNAVLTAAAAGGIAAASVFAATPAV---A
MUL_2071|M.ulcerans_Agy99 -----------------MEFIATTMKTAVGAAAIAAASVFGAASAS---A
TH_4151|M.thermoresistible__bu -------------------MNSKILAAPVVLATAAGLALATAAPAP----
MLBr_00048|M.leprae_Br4923 SPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAP
. . .
Mflv_1515|M.gilvum_PYR-GCK ADTEVQWLGQPGELVN--GTVVQHWTVSHLKPSTDTIP-YQPVGTLWEAT
Mvan_5241|M.vanbaalenii_PYR-1 ADAEVQYLGQPGELVN--GSVIQHWTVTGLKPSSDVIP-YRPVGTLWEAT
MAB_1026c|M.abscessus_ATCC_199 ADTT---LGQQGRLTN--GDVVQAWTISDLKVSTDQLP-YQPKGTLWEAT
Mb1961c|M.bovis_AF2122/97 AYPITGKLGSELTMTDTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEAT
Rv1926c|M.tuberculosis_H37Rv AYPITGKLGSELTMTDTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEAT
MMAR_2839|M.marinum_M AYPITGKFGSELKMTDSVGQVVLGWTVSDLKSSSDVIPGYPVAGQVWEAT
MSMEG_5412|M.smegmatis_MC2_155 SAVTTSTLGSAAKLNN--GDVVQAWTVTDLKPSSDTIP-YEVRGKLWEVT
MAV_3737|M.avium_104 AP-NIQGFGVSEQLVD--GPLVTDYTVSNLQPSNVSIPGYTPKGTLYQAD
MUL_2071|M.ulcerans_Agy99 APPTIQGFGTSERLVD--GPMVTSYTVGNLQLSDVTIAGYLPQGQLYSAD
TH_4151|M.thermoresistible__bu ARPGVADFGATQHLHD--GGVTIAYTLEELEPSDDVVSNVALQGRLWEVS
MLBr_00048|M.leprae_Br4923 PRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATP
. : : . : . :. .
Mflv_1515|M.gilvum_PYR-GCK ASDEAVAG-------NVTPIISNLNAR-----------------------
Mvan_5241|M.vanbaalenii_PYR-1 ATDEAIAG-------TVTPIVSNLNAR-----------------------
MAB_1026c|M.abscessus_ATCC_199 ATDEAIQG-------SVIPIVANFNAK-----------------------
Mb1961c|M.bovis_AF2122/97 ATVNAIRG-------SVTPAVSQFNAR-----------------------
Rv1926c|M.tuberculosis_H37Rv ATVNAIRG-------SVTPAVSQFNAR-----------------------
MMAR_2839|M.marinum_M ATVNAISG-------PVTPAISQFNAR-----------------------
MSMEG_5412|M.smegmatis_MC2_155 ATDEAVQG-------NVTPIVSNFNVR-----------------------
MAV_3737|M.avium_104 ISVRSDGG-------VVTPMVHDFIAR-----------------------
MUL_2071|M.ulcerans_Agy99 VTGRSVTG-------TITPLVSSFSAR-----------------------
TH_4151|M.thermoresistible__bu VTVEAVEG-------AATPVIPFFNAR-----------------------
MLBr_00048|M.leprae_Br4923 MPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRP
. . * * : : .:
Mflv_1515|M.gilvum_PYR-GCK --------AKNGDTYRVLFGVATTQGVNPAPLAQGHKTSGKIYFDVTGEA
Mvan_5241|M.vanbaalenii_PYR-1 --------AENGDTYRVLFGVATEQGVNPSTLAQGQKTTGKIYFDVTGQQ
MAB_1026c|M.abscessus_ATCC_199 --------ANDGETYRVLYGVASAQGVNPGTLSQGEKTTGKIYFDVTGAN
Mb1961c|M.bovis_AF2122/97 --------TADGINYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPS
Rv1926c|M.tuberculosis_H37Rv --------TADGINYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPS
MMAR_2839|M.marinum_M --------TADGVNYRVLWQASGPNTISGATIPQGASSTGKIYFDVTGPA
MSMEG_5412|M.smegmatis_MC2_155 --------AADGTNYRALFQVATPQGVNPSTIPQGEKASGKIYFDVTGPE
MAV_3737|M.avium_104 --------GPNGQNYRVIDNVAVPNGLSPAPIPQGTESTGTLYFDVTGAP
MUL_2071|M.ulcerans_Agy99 --------AANGDTYGVVNEVPAPGGLNPAPILQGNSQSGVLYF------
TH_4151|M.thermoresistible__bu --------SADGQNYRALFTAVGEEALSGATLGQGQETEGNIYFDVTGAP
MLBr_00048|M.leprae_Br4923 SANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAE
* : . :
Mflv_1515|M.gilvum_PYR-GCK PDSVFYSTGDAEELLWLQAPPPATGSGTSGSTSGSSSSGASSAPSAAAET
Mvan_5241|M.vanbaalenii_PYR-1 PDSVFYSDGGSEVLLWLEAPP-APATGSAG--SGASGYGSEASPSAAADT
MAB_1026c|M.abscessus_ATCC_199 PETVTYTSGDEDLLTWKAAPAAAPAQRSGGS-TQSHGSTPAPATSTAPTT
Mb1961c|M.bovis_AF2122/97 PTIVAMNNGMEDLLIWEP--------------------------------
Rv1926c|M.tuberculosis_H37Rv PTIVAMNNGMEDLLIWEP--------------------------------
MMAR_2839|M.marinum_M PTIVAMNNGMEDLMIWGP--------------------------------
MSMEG_5412|M.smegmatis_MC2_155 PTTVVYNAGGKDLLVWDKPAASATAPSGTGQSRPATASSPATAAPTAAAE
MAV_3737|M.avium_104 PNGVVYNDGMQDVLMWTSNVPSS-APGAPNSPAPGAPNSPAPGAPPAPAA
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu PTEVVYNDAVQDRLIWR---------------------------------
MLBr_00048|M.leprae_Br4923 PAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRG
Mflv_1515|M.gilvum_PYR-GCK TAPETPAS---------------TPAAEPAAVGSATPASVPSGSSGTPLP
Mvan_5241|M.vanbaalenii_PYR-1 ATPETPGT---------------TPAAETPTSVVPTPVAAPAGSSGTPLP
MAB_1026c|M.abscessus_ATCC_199 ATPAPAAVPAGSQGTPLPAGSQGTPVDEQAPAATPTPTVAPVTATPTPAP
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 AESEAATDAETEATPAPAAASTAEGGTEATPAGAGSRATDLPAATAAEAE
MAV_3737|M.avium_104 HT------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 WRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAGK
Mflv_1515|M.gilvum_PYR-GCK E----GSSGTPLP-EGSSGTPLPEGSS-----------------GTPLPA
Mvan_5241|M.vanbaalenii_PYR-1 E----GSSGTPLP-EGSSGTPLPAGAAPVEA------------GPAPVPA
MAB_1026c|M.abscessus_ATCC_199 ATPTPGAEGTPLNSTAVPASPAPATATP----------------AVPVPE
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 TEATATDAETTPVTEETPAAPAPEGTTPVSLGTPAAEGTPAVEGAPAGAS
MAV_3737|M.avium_104 --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 TTVTVTLGSMFARVRNDRILVVDADTSCGNLADRAGRFSEANIADLLADK
Mflv_1515|M.gilvum_PYR-GCK NAAPPAEAAP-APVPAAA--------TPAPAAPTTTVAVPAPPA------
Mvan_5241|M.vanbaalenii_PYR-1 GVAPAPHGSSGTPLPAGAPAVEGVQPAPAPGAPTTTVVVPAPPA------
MAB_1026c|M.abscessus_ATCC_199 GAAPQTGTPPVAAVPGVP-AVPASDSVPHGQRAAGSQGTPVSTEG-----
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 AGNVATAVPPAAPAEGAPAEVADPALVPAGVQPTTTVPAPAPTTAPVSHG
MAV_3737|M.avium_104 --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 DVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSKYY
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 PAA-----------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 NVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLRHN
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2839|M.marinum_M --------------------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 GYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHI
Mflv_1515|M.gilvum_PYR-GCK ------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 ------------------------------------
MAB_1026c|M.abscessus_ATCC_199 ------------------------------------
Mb1961c|M.bovis_AF2122/97 ------------------------------------
Rv1926c|M.tuberculosis_H37Rv ------------------------------------
MMAR_2839|M.marinum_M ------------------------------------
MSMEG_5412|M.smegmatis_MC2_155 ------------------------------------
MAV_3737|M.avium_104 ------------------------------------
MUL_2071|M.ulcerans_Agy99 ------------------------------------
TH_4151|M.thermoresistible__bu ------------------------------------
MLBr_00048|M.leprae_Br4923 AAGTEIRLDRLDPLYRRRILELAAALSDDFERAGRH